A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions
2001 | journal article. A publication with affiliation to the University of Göttingen.
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Bitsch, Annette, T. Kuhlmann, Christine Stadelmann, Hans Lassmann, C. Lucchinetti, and Wolfgang W. Bruck. "A longitudinal MRI study of histopathologically defined hypointense multiple sclerosis lesions." Annals of Neurology 49, no. 6 (2001): 793-796. https://doi.org/10.1002/ana.1053.
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- Authors
- Bitsch, Annette; Kuhlmann, T.; Stadelmann, Christine ; Lassmann, Hans; Lucchinetti, C.; Bruck, Wolfgang W.
- Abstract
- Severe tissue destruction is the presumed histopathological correlate of hypointense multiple sclerosis (MS) lesions. In this study we correlated changes of lesion hypointensity over time with initial histopathological features in 14 biopsied MS lesions. The extent of hypointensity increased in initially demyelinated plaques and decreased in remyelinating lesions. The initial axonal loss determined the increase of hypointensity over time. In conclusion, both axonal loss and demyelinating activity determine the evolution of hypointensity over time.
- Issue Date
- 2001
- Status
- published
- Publisher
- Wiley-liss
- Journal
- Annals of Neurology
- ISSN
- 0364-5134