Aspergillus nidulans Synthesize Insect Juvenile Hormones upon Expression of a Heterologous Regulatory Protein and in Response to Grazing by Drosophila melanogaster Larvae
2013 | journal article. A publication with affiliation to the University of Göttingen.
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Nielsen, Morten Thrane, Marie Louise Klejnstrup, Marko Rohlfs, Diana Chinyere Anyaogu, Jakob Blsbjerg Nielsen, Charlotte Held Gotfredsen, Mikael Rordam Andersen, Bjarne Gram Hansen, Uffe Hasbro Mortensen, and Thomas Ostenfeld Larsen. "Aspergillus nidulans Synthesize Insect Juvenile Hormones upon Expression of a Heterologous Regulatory Protein and in Response to Grazing by Drosophila melanogaster Larvae." PLoS ONE 8, no. 8 (2013): e73369. https://doi.org/10.1371/journal.pone.0073369.
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- Authors
- Nielsen, Morten Thrane; Klejnstrup, Marie Louise; Rohlfs, Marko; Anyaogu, Diana Chinyere; Nielsen, Jakob Blsbjerg; Gotfredsen, Charlotte Held; Andersen, Mikael Rordam; Hansen, Bjarne Gram; Mortensen, Uffe Hasbro; Larsen, Thomas Ostenfeld
- Abstract
- Secondary metabolites are known to serve a wide range of specialized functions including communication, developmental control and defense. Genome sequencing of several fungal model species revealed that the majority of predicted secondary metabolite related genes are silent in laboratory strains, indicating that fungal secondary metabolites remain an underexplored resource of bioactive molecules. In this study, we combine heterologous expression of regulatory proteins in Aspergillus nidulans with systematic variation of growth conditions and observe induced synthesis of insect juvenile hormone-III and methyl farnesoate. Both compounds are sesquiterpenes belonging to the juvenile hormone class. Juvenile hormones regulate developmental and metabolic processes in insects and crustaceans, but have not previously been reported as fungal metabolites. We found that feeding by Drosophila melanogaster larvae induced synthesis of juvenile hormone in A. nidulans indicating a possible role of juvenile hormone biosynthesis in affecting fungal-insect antagonisms.
- Issue Date
- 2013
- Status
- published
- Publisher
- Public Library Science
- Journal
- PLoS ONE
- ISSN
- 1932-6203