The complete genome sequence of Propionibacterium acnes, a commensal of human skin
2004 | journal article. A publication with affiliation to the University of Göttingen.
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The complete genome sequence of Propionibacterium acnes, a commensal of human skin
Bruggemann, H.; Henne, A.; Hoster, F.; Liesegang, H.; Wiezer, A.; Strittmatter, A. W. & Hujer, S. et al. (2004)
Science, 305(5684) pp. 671-673. DOI: https://doi.org/10.1126/science.1100330
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Details
- Authors
- Bruggemann, H.; Henne, A.; Hoster, F.; Liesegang, Heiko; Wiezer, A.; Strittmatter, Axel W.; Hujer, S.; Durre, P.; Gottschalk, G.
- Abstract
- Propionibacterium acnes is a major inhabitant of adult human skin, where it resides within sebaceous follicles, usually as a harmless commensal although it has been implicated in acne vulgaris formation. The entire genome sequence of this Gram-positive bacterium encodes 2333 putative genes and revealed numerous gene products involved in degrading host molecules, including sialidases, neuraminidases, endoglycoceramidases, lipases, and pore-forming factors. Surface-associated and other immunogenic factors have been identified, which might be involved in triggering acne inflammation and other P. acnes-associated diseases.
- Issue Date
- 2004
- Status
- published
- Publisher
- Amer Assoc Advancement Science
- Journal
- Science
- ISSN
- 0036-8075
