VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism
2008 | journal article. A publication with affiliation to the University of Göttingen.
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Cite this publication
Bayram, Oezguer, Sven Krappmann, Min Ni, Jin Woo Bok, Kerstin Helmstaedt, Oliver Valerius, Susanna A. Braus-Stromeyer et al. "VelB/VeA/LaeA complex coordinates light signal with fungal development and secondary metabolism." Science 320, no. 5882 (2008): 1504-1506. https://doi.org/10.1126/science.1155888.
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Details
- Authors
- Bayram, Oezguer; Krappmann, Sven; Ni, Min; Bok, Jin Woo; Helmstaedt, Kerstin; Valerius, Oliver; Braus-Stromeyer, Susanna A.; Kwon, Nak-Jung; Keller, Nancy P.; Yu, Jae-Hyuk; Braus, Gerhard H.
- Abstract
- Differentiation and secondary metabolism are correlated processes in fungi that respond to light. In Aspergillus nidulans, light inhibits sexual reproduction as well as secondary metabolism. We identified the heterotrimeric velvet complex VelB/VeA/LaeA connecting light-responding developmental regulation and control of secondary metabolism. VeA, which is primarily expressed in the dark, physically interacts with VelB, which is expressed during sexual development. VeA bridges VelB to the nuclear master regulator of secondary metabolism, LaeA. Deletion of either velB or veA results in defects in both sexual fruiting-body formation and the production of secondary metabolites.
- Issue Date
- 2008
- Status
- published
- Publisher
- Amer Assoc Advancement Science
- Journal
- Science
- ISSN
- 0036-8075
