Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development
2010 | journal article; research paper. A publication with affiliation to the University of Göttingen.
Jump to: Cite & Linked | Documents & Media | Details | Version history
Cite this publication
Regulation of Rap2A by the Ubiquitin Ligase Nedd4-1 Controls Neurite Development
Kawabe, H.; Neeb, A.; Dimova, K.; Young, S. M. J.; Takeda, M.; Katsurabayashi, S. & Mitkovski, M. et al. (2010)
Neuron, 65(3) pp. 358-372. DOI: https://doi.org/10.1016/j.neuron.2010.01.007
Documents & Media
Details
- Authors
- Kawabe, Hiroshi; Neeb, Antje; Dimova, Kalina; Young, Samuel M., Jr.; Takeda, Michiko; Katsurabayashi, Shutaro; Mitkovski, Miso; Malakhova, Oxana A.; Zhang, Dong-Er; Ulmilkawa, Masato; Kariya, Ken-ichi; Goebbels, Sandra ; Nave, Klaus-Armin ; Rosenmund, Christian; Jahn, Olaf ; Rhee, Jeong-Seop ; Brose, Nils
- Abstract
- Nedd4-1 is a "neuronal precursor cell expressed and developmentally downregulated protein" and among the most abundant E3 ubiquitin ligases in mammalian neurons. In analyses of conventional and conditional Nedd4-1-deficient mice, we found that Nedd4-1 plays a critical role in dendrite formation. Nedd4-1, the serine/threonine kinase TNIK, and Rap2A form a complex that controls Nedd4-1-mediated ubiquitination of Rap2A. Ubiquitination by Nedd4-1 inhibits Rap2A function, which reduces the activity of Rap2 effector kinases of the TNIK family and promotes dendrite growth. We conclude that a Nedd4-1/Rap2A/TNIK signaling pathway regulates neurite growth and arborization in mammalian neurons.
- Issue Date
- 2010
- Journal
- Neuron
- ISSN
- 0896-6273
