SFB 1002 | D04: Bedeutung der Methylierung von RNA (m6A) und des Histons H3 (H3K4) in der Herzinsuffizienz RSS Feed


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  • 2024 | Journal Article
    ​ ​Low-flow in aortic valve stenosis patients with reduced ejection fraction does not depend on left ventricular function​
    Gersch, S.; Lange, T.; Beuthner, B. E.; Elkenani, M.; Paul, N.; Schnelle, M. & Zeisberg, E. et al.​ (2024) 
    Clinical Research in Cardiology,.​ DOI: https://doi.org/10.1007/s00392-023-02372-4 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article
    ​ ​Regulatory roles of the N6-methyladenosine demethylase FTO in cardiac remodeling​
    Annamalai, K.; Buchholz, E.; Castro, R.; Panyam, N.; Fischer, A. & Toischer, K.​ (2023) 
    European Heart Journal, 44(Supplement 2).​ DOI: https://doi.org/10.1093/eurheartj/ehad655.3143 
    ​Details  DOI 
  • 2023 | Journal Article | 
    ​ ​Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome​
    Chowdhury, A.; Boshnakovska, A.; Aich, A.; Methi, A.; Vergel Leon, A. M.; Silbern, I. & Lüchtenborg, C. et al.​ (2023) 
    EMBO Molecular Medicine, art. e17399​.​ DOI: https://doi.org/10.15252/emmm.202317399 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | 
    ​ ​Metabolomic Profiling in Patients with Different Hemodynamic Subtypes of Severe Aortic Valve Stenosis​
    Bengel, P.; Elkenani, M.; Beuthner, B. E.; Pietzner, M.; Mohamed, B. A.; Pollok-Kopp, B. & Krätzner, R. et al.​ (2023) 
    Biomolecules, 13(1) pp. 95​.​ DOI: https://doi.org/10.3390/biom13010095 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Hemodynamic stress-induced cardiac remodelling is not modulated by ablation of phosphodiesterase 4D interacting protein​
    Mohamed, B. A. ; Elkenani, M.; Mobarak, S.; Marques Rodrigues, D.; Annamalai, K.; Schnelle, M.   & Bader, M. et al.​ (2022) 
    Journal of Cellular and Molecular Medicine, 26(16) pp. 4440​-4452​.​ DOI: https://doi.org/10.1111/jcmm.17468 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Epigenetic gene expression links heart failure to memory impairment​
    Islam, M. R.; Lbik, D.; Sakib, M S.; Maximilian Hofmann, R.; Berulava, T.; Jiménez Mausbach, M. & Cha, J. et al.​ (2021) 
    EMBO Molecular Medicine, 13(3).​ DOI: https://doi.org/10.15252/emmm.201911900 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Impact of myocardial fibrosis on left ventricular remodelling, recovery, and outcome after transcatheter aortic valve implantation in different haemodynamic subtypes of severe aortic stenosis​
    Puls, M.; Beuthner, B. E.; Topci, R.; Vogelgesang, A.; Bleckmann, A.; Sitte, M. & Lange, T. et al.​ (2020) 
    European Heart Journal, 41(20) pp. 1903​-1914​.​ DOI: https://doi.org/10.1093/eurheartj/ehaa033 
    ​Details  DOI  PMID  PMC 
  • 2020 | Preprint
    ​ ​Epigenetic gene-expression links heart failure to memory impairment​
    Islam, R.; Lbik, D.; Sakib, S.; Hofmann, R. M.; Berulava, T.; Mausbach, M. J.& Cha, J. et al.​ (2020). DOI: https://doi.org/10.1101/2020.01.22.915637 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids​
    Zafeiriou, M.-P. ; Bao, G. ; Hudson, J. ; Halder, R. ; Blenkle, A.; Schreiber, M.-K. & Fischer, A.  et al.​ (2020) 
    Nature Communications, 11(1).​ DOI: https://doi.org/10.1038/s41467-020-17521-w 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Dysferlin links excitation-contraction coupling to structure and maintenance of the cardiac transverse-axial tubule system​
    Hofhuis, J. ; Bersch, K.; Wagner, S. ; Molina, C. E. ; Fakuade, F. E.; Iyer, L. M.   & Streckfuß-Bömeke, K.  et al.​ (2020) 
    Europace, 22(7) pp. 1119​-1131​.​ DOI: https://doi.org/10.1093/europace/euaa093 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​CRISPLD1: a novel conserved target in the transition to human heart failure​
    Khadjeh, S. ; Hindmarsh, V.; Weber, F.; Cyganek, L. ; Vidal, R. O. ; Torkieh, S. & Streckfuss-Bömeke, K.  et al.​ (2020) 
    Basic Research in Cardiology, 115(3).​ DOI: https://doi.org/10.1007/s00395-020-0784-4 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Assessing the role of extracellular signal‐regulated kinases 1 and 2 in volume overload‐induced cardiac remodelling​
    Jochmann, S.; Elkenani, M.; Mohamed, B. A.; Buchholz, E.; Lbik, D.; Binder, L. & Lorenz, K. et al.​ (2019) 
    ESC Heart Failure, 6(5) pp. 1015​-1026​.​ DOI: https://doi.org/10.1002/ehf2.12497 
    ​Details  DOI  PMID  PMC 
  • 2019 | Conference Paper
    ​ ​P5998The Phosphodiesterase 4D interacting protein averts volume overload - but not pressure overload-induced pathological myocardial remodeling​
    Mohamed, B. A.; Elkenani, M.; Jakubiczka-Smorag, J.; Bader, M.; Hasenfuss, G.   & Toischer, K. ​ (2019)
    European Heart Journal, 40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz746.0719 
    ​Details  DOI 
  • 2019 | Conference Paper
    ​ ​1180 Cardiomyocyte-specific deletion of Brd4 induces hypertrophic cardiomyopathy and suggests a novel function for the chromatin reader as co-repressor in the healthy heart​
    Lbik, D.; Buchholz, E.; Mohamed, B.; Fischer, A. ; Hasenfuss, G.   & Toischer, K. ​ (2019)
    European Heart Journal, 40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz748.0022 
    ​Details  DOI 
  • 2019 | Conference Paper
    ​ ​P1621m6A RNA-methylation in the progression of heart failure​
    Buchholz, E.; Berulava, T.; Ellerdashvilli, V.; Pena, T.; Lbik, D.; Mohamed, B. & Sloan, K. et al.​ (2019)
    European Heart Journal, 40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz748.0380 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Changes in m6A RNA methylation contribute to heart failure progression by modulating translation​
    Berulava, T.; Buchholz, E.; Elerdashvili, V.; Pena, T.; Islam, M. R.; Lbik, D. & Mohamed, B. A.  et al.​ (2019) 
    European Journal of Heart Failure, 22(1) pp. 54​-66​.​ DOI: https://doi.org/10.1002/ejhf.1672 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Genetic deletion of calcium/calmodulin-dependent protein kinase type II delta does not mitigate adverse myocardial remodeling in volume-overloaded hearts​
    Mohamed, B. A. ; Elkenani, M.; Jakubiczka-Smorag, J. ; Buchholz, E.; Koszewa, S.; Lbik, D. & Schnelle, M.  et al.​ (2019) 
    Scientific Reports, 9(1) art. 9889​.​ DOI: https://doi.org/10.1038/s41598-019-46332-3 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Proteasome-Dependent Regulation of Distinct Metabolic States During Long-Term Culture of Human iPSC-Derived Cardiomyocytes​
    Ebert, A. ; Joshi, A. U.; Andorf, S.; Dai, Y.; Sampathkumar, S.; Chen, H. & Li, Y. et al.​ (2019) 
    Circulation Research, 125(1) pp. 90​-103​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.118.313973 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​NADPH oxidase-4 promotes eccentric cardiac hypertrophy in response to volume overload​
    Schnelle, M. ; Sawyer, I.; Anilkumar, N.; Mohamed, B. A. ; Richards, D. A.; Toischer, K.   & Zhang, M. et al.​ (2019) 
    Cardiovascular Research, 117(1) pp. 178​-187​.​ DOI: https://doi.org/10.1093/cvr/cvz331 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia​
    Chowdhury, A. ; Aich, A. ; Jain, G.; Wozny, K.; Lüchtenborg, C.; Hartmann, M.   & Bernhard, O.  et al.​ (2018) 
    Cell Reports, 25(3) pp. 561​-570.e6​.​ DOI: https://doi.org/10.1016/j.celrep.2018.09.057 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression​
    Mohamed, B. A. ; Hartmann, N. ; Tirilomis, P.; Sekeres, K.; Li, W.; Neef, S. & Richter, C.  et al.​ (2018) 
    Science Translational Medicine, 10(458) art. eaan0724​.​ DOI: https://doi.org/10.1126/scitranslmed.aan0724 
    ​Details  DOI  PMID  PMC 
  • 2017 | Conference Abstract
    ​ ​P1334 - The relevant role of SR Ca leak in the development of heart failure​
    Mohamed, B. A.; Kattner, L.; Guan, K. ; Lehnart, S. E. ; Luther, S. ; Sossalla, S.   & Hasenfuß, G.  et al.​ (2017)
    European Journal of Heart Failure, 19(Suppl. 1) ​Heart Failure 2017 and the 4th World Congress on Acute Heart Failure​, Paris.
    ​Details 
  • 2017 | Conference Abstract
    ​ ​P41 - Studying beta-adrenergic signalling in a patient-specific induced pluripotent stem cell model for Takotsubo syndrome​
    Hübscher, D.; Borchert, T.; Lam, D.; Guessoum, C. I.; Templin, C.; Hasenfuß, G.   & Streckfuß-Bömeke, K.​ (2017)
    European Journal of Heart Failure, 19(Suppl. 1) ​Heart Failure 2017 and the 4th World Congress on Acute Heart Failure​, Paris.
    ​Details 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload​
    Toischer, K. ; Zhu, W.; Hünlich, M.; Mohamed, B. A.; Khadjeh, S.; Reuter, S. P. & Schäfer, K.  et al.​ (2017) 
    Journal of Clinical Investigation, 127(12) pp. 4285​-4296​.​ DOI: https://doi.org/10.1172/JCI81870 
    ​Details  DOI  PMID  PMC 

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