Dr. Annalen Bleckmann

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  • 2022 | Journal Article | Research Paper | 
    ​ ​Koenig JFL, Asendorf T, Simon A, Bleckmann A, Trümper L, Wulf GG, et al. ​“SpezPat”- common advance directives versus disease-centred advance directives: a randomised controlled pilot study on the impact on physicians’ understanding of non-small cell lung cancer patients’ end-of-life decisions​. ​​BMC Palliative Care. ​2022;​21​(1). ​doi:10.1186/s12904-022-01057-5. 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Shumilov E, Aperdannier L, Schmidt N, Szuszies C, Neesse A, Hoffknecht P, et al. ​Clinical Post-SARS-CoV-2 Infection Scenarios in Vaccinated and Non-Vaccinated Cancer Patients in Three German Cancer Centers: A Retrospective Analysis​. ​​Cancers. ​2022;​14​(15). ​doi:10.3390/cancers14153746. 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Wolfert C, Rohde V, Hussein A, Fiss I, Hernández-Durán S, Malzahn D, et al. ​Surgery for brain metastases: radiooncology scores predict survival-score index for radiosurgery, graded prognostic assessment, recursive partitioning analysis​. ​​Acta Neurochirurgica. ​2022;. ​doi:10.1007/s00701-022-05356-x. 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Kemper M, Evers G, Schulze AB, Sperveslage J, Schülke C, Lenz G, et al. ​Polyclonal on- and off-target resistance mutations in an EML4-ALK positive non-small cell lung cancer patient under ALK inhibition​. ​​Oncotarget. ​2021;​12​(19):​​1946​-1952​. ​doi:10.18632/oncotarget.28062. 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​De Oliveira T, Goldhardt T, Edelmann M, Rogge T, Rauch K, Kyuchukov ND, et al. ​Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo​. ​​Cancers. ​2021;​13​(5):​​1011​. ​doi:10.3390/cancers13051011. 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Menck K, Heinrichs S, Baden C, Bleckmann A. ​The WNT/ROR Pathway in Cancer: From Signaling to Therapeutic Intervention​. ​​Cells. ​2021;​10​(1):​​142​. ​doi:10.3390/cells10010142. 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Menck K, Sivaloganathan S, Bleckmann A, Binder C. ​Microvesicles in Cancer: Small Size, Large Potential​. ​​International Journal of Molecular Sciences. ​2020;​21​(15):​​5373​. ​doi:10.3390/ijms21155373. 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Overbeck TR, Cron DA, Schmitz K, Rittmeyer A, Körber W, Hugo S, et al. ​Top-level MET gene copy number gain defines a subtype of poorly differentiated pulmonary adenocarcinomas with poor prognosis​. ​​Translational Lung Cancer Research. ​2020;​9​(3):​​603​-616​. ​doi:10.21037/tlcr-19-339. 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Bleckmann A, Kirchner B, Nietert M, Peeck M, Balkenhol M, Egert D, et al. ​Impact of pre-OP independence in patients with limited brain metastases on long-term survival​. ​​BMC Cancer. ​2020;​20​(1). ​doi:10.1186/s12885-020-07459-z. 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Bleckmann A, Dierks S, Schildhaus, Hans-Ulrich, Hellige N, Bacher U, Trümper L, et al. ​Treatment response to idelalisib in a patient with immunodeficiency-associated Burkitt lymphoma harboring a PIK3CA H1047R mutation​. ​​Annals of Hematology. ​2020;. ​doi:10.1007/s00277-020-03974-y. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​BUENTZEL J, HEINZ J, BLECKMANN A, BAUER C, RÖVER C, BOHNENBERGER H, et al. ​Sarcopenia as Prognostic Factor in Lung Cancer Patients: A Systematic Review and Meta-analysis​. ​​Anticancer Research. ​2019;​39​(9):​​4603​-4612​. ​doi:10.21873/anticanres.13640. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Fiss I, Hussein A, Barrantes-Freer A, Sperling S, Hernandez-Duran S, Wolfert C, et al. ​Cerebral metastases: do size, peritumoral edema, or multiplicity predict infiltration into brain parenchyma?​. ​​Acta Neurochirurgica. ​2019;​161​(5):​​1037​-1045​. ​doi:10.1007/s00701-019-03842-3. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Kromer C, Bleckmann A, Schön M, Mitteldorf C. ​Marginal zone lymphoma presenting as macrocheilia​. ​​Journal of the European Academy of Dermatology and Venereology. ​2019;​34​(1). ​doi:10.1111/jdv.15867. 
    ​Details  DOI 
  • 2018 | Book Chapter
    ​ ​Wolff A, Perera-Bel J, Schildhaus, Hans-Ulrich, Homayounfar K, Schatlo B, Bleckmann A, et al. ​Using RNA-Seq Data for the Detection of a Panel of Clinically Relevant Mutations​. ​​German Medical Data Sciences: A Learning Healthcare System. ​2018. p. 217​-221​. ​(Studies in health technology and informatics;253). 
    ​Details 
  • 2018 | Journal Article | 
    ​ ​Heuer JF, Mirschel M, Bleckmann A, Quintel M, Moerer O. ​Interhospital transport of ARDS patients on extracorporeal membrane oxygenation​. ​​Journal of Artificial Organs. ​2018;​22​(1):​​53​-60​. ​doi:10.1007/s10047-018-1065-y. 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Perera-Bel J, Hutter B, Heining C, Bleckmann A, Fröhlich M, Fröhling S, et al. ​From somatic variants towards precision oncology: Evidence-driven reporting of treatment options in molecular tumor boards​. ​​Genome Medicine. ​2018;​10​(1):​​18​. ​doi:10.1186/s13073-018-0529-2. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Hünlich M, Lubos E, Beuthner BE, Puls M, Bleckmann A, Beißbarth T, et al. ​Acute and Long-Term Hemodynamic Effects of MitraClip Implantation on a Preexisting Secondary Right Heart Failure​. ​​BioMed Research International. ​2018;​2018​. ​doi:10.1155/2018/6817832. 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​Barrantes-Freer A, Engel AS, Rodríguez-Villagra OA, Winkler A, Bergmann M, Mawrin C, et al. ​Diagnostic red flags: steroid-treated malignant CNS lymphoma mimicking autoimmune inflammatory demyelination​. ​​Brain Pathology. ​2017;​28​(2):​​225​-233​. ​doi:10.1111/bpa.12496. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Menck K, Bleckmann A, Wachter A, Hennies B, Ries L, Schulz M, et al. ​Characterisation of tumour-derived microvesicles in cancer patients’ blood and correlation with clinical outcome​. ​​Journal of Extracellular Vesicles. ​2017;​6​(1):​​1340745​. ​doi:10.1080/20013078.2017.1340745. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Glass B, Dohm A, Truemper L, Pfreundschuh M, Bleckmann A, Wulf G, et al. ​Refractory or relapsed aggressive B-cell lymphoma failing (R)-CHOP: an analysis of patients treated on the RICOVER-60 trial​. ​​Annals of Oncology. ​2017;​28​(12):​​3058​-3064​. ​doi:10.1093/annonc/mdx556. 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Bocuk D, Wolff A, Krause P, Salinas G, Bleckmann A, Hackl C, et al. ​The adaptation of colorectal cancer cells when forming metastases in the liver: expression of associated genes and pathways in a mouse model​. ​​BMC Cancer. ​2017;​17​:​​342​. ​doi:10.1186/s12885-017-3342-1. 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | 
    ​ ​Bayerlová M, Menck K, Klemm F, Wolff A, Pukrop T, Binder C, et al. ​Ror2 Signaling and Its Relevance in Breast Cancer Progression.​. ​​Frontiers in Oncology. ​2017;​7​. ​doi:10.3389/fonc.2017.00135. 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​Shumilov E, Wulf G, Ströbel P, Hasenkamp J, Hellige N, Bleckmann A, et al. ​Osteolytic lesions occur rarely in patients with B-CLL and may respond well to ibrutinib​. ​​Leukemia & Lymphoma. ​2016;​57​(10):​​2476​-2480​. ​doi:10.3109/10428194.2016.1151510. 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Schroeter MR, Köhler H, Wachter A, Bleckmann A, Hasenfuß G, Schillinger W. ​Use of the Impella Device for Acute Coronary Syndrome Complicated by Cardiogenic Shock - Experience From a Single Heart Center With Analysis of Long-term Mortality​. ​​The Journal of invasive cardiology. ​2016;​28​(12):​​467​-472​. ​
    ​Details  PMID  PMC 
  • 2016 | Journal Article | 
    ​ ​Bleckmann A, Conradi, Lena-Christin, Menck K, Schmick NA, Schubert A, Rietkoetter E, et al. ​beta-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases​. ​​Clinical & Experimental Metastasis. ​2016;​33​(4):​​309​-323​. ​doi:10.1007/s10585-016-9780-3. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​Wlochowitz D, Haubrock M, Arackal J, Bleckmann A, Wolff A, Beißbarth T, et al. ​Computational Identification of Key Regulators in Two Different Colorectal Cancer Cell Lines​. ​​Frontiers in Genetics. ​2016;​7​. ​doi:10.3389/fgene.2016.00042. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Conference Abstract
    ​ ​Bleckmann A, Wachter A, Conradi, Lena-Christin, Wolff A, Hoppenau C, Korf U, et al. ​Heterogeneity of colorectal cancer liver metastasis - analysis of WNT pathway patterns via High-throughput and bioinformatics profiling​. ​​Oncology Research and Treatment. ​2015;​38​
    ​Details  WoS 
  • 2015 | Journal Article | 
    ​ ​Bayerlová M, Jung K, Kramer F, Klemm F, Bleckmann A, Beißbarth T. ​Comparative study on gene set and pathway topology-based enrichment methods​. ​​BMC Bioinformatics. ​2015;​16​. ​doi:10.1186/s12859-015-0751-5. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​Bleckmann A, Leha A, Artrnann S, Menck K, Salinas-Riester G, Binder C, et al. ​Integrated miRNA and mRNA profiling of tumor-educated macrophages identifies prognostic subgroups in estrogen receptor-positive breast cancer​. ​​Molecular Oncology. ​2015;​9​(1):​​155​-166​. ​doi:10.1016/j.molonc.2014.07.023. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​Bayerlová M, Klemm F, Kramer F, Pukrop T, Beißbarth T, Bleckmann A. ​Newly Constructed Network Models of Different WNT Signaling Cascades Applied to Breast Cancer Expression Data​. ​​PLoS ONE. ​2015;​10​(12). ​doi:10.1371/journal.pone.0144014. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Conference Abstract
    ​ ​Quack H, Stanek K, Wolff HA, Dröge LH, Binder L, Bleckmann A, et al. ​Effects of 5-FU dose monitoring under neoadjuvant radiochemotherapy for locally advanced rectal cancer​. ​​Oncology Research and Treatment. ​2014;​37​
    ​Details  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Puls M, Sobisiak B, Bleckmann A, Jacobshagen C, Danner BC, Huenlich M, et al. ​Impact of frailty on short- and long-term morbidity and mortality after transcatheter aortic valve implantation: risk assessment by Katz Index of activities of daily living​. ​​EuroIntervention. ​2014;​10​(5):​​609​-619​. ​doi:10.4244/EIJY14M08_03. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Puls M, Tichelbäcker T, Bleckmann A, Huenlich M, von der Ehe K, Beuthner BE, et al. ​Failure of acute procedural success predicts adverse outcome after percutaneous edge-to-edge mitral valve repair with MitraClip​. ​​EuroIntervention. ​2014;​9​(12):​​1407​-1417​. ​doi:10.4244/EIJV9I12A238. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Unsoeld BW, Kaul A, Sbroggi M, Schubert C, Regitz-Zagrosek V, Brancaccio M, et al. ​Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction​. ​​Cardiovascular Research. ​2014;​101​(1):​​97​-107​. ​doi:10.1093/cvr/cvt235. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Puls M, Bleckmann A, Jacobshagen C, Danner BC, Hasenfuß G, Seipelt R, et al. ​Diabetes increases short- and long-term mortality after transcatheter aortic valve implantation (TAVI)​. ​​DMW - Deutsche Medizinische Wochenschrift. ​2014;​139​(16):​​822​-828​. ​doi:10.1055/s-0034-1369863. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Conference Abstract
    ​ ​Bleckmann A, Leha A, Artmann S, Menck K, Binder C, Pukrop T, et al. ​Identification of prognostic miRNAs in breast cancer through profiling of tumor educated macrophages​. ​​Onkologie. ​2013;​36​
    ​Details  WoS 
  • 2013 | Conference Abstract
    ​ ​Conradi, Lena-Christin, Quack H, Sprenger T, Wolff HA, Binder L, Ghadimi MB, et al. ​5-FU dose monitoring under neoadjuvant radiochemotherapy and adjuvant chemotherapy for locally advanced rectal cancer​. ​​Onkologie. ​2013;​36​
    ​Details  WoS 
  • 2013 | Journal Article
    ​ ​Kramer F, Bayerlová M, Klemm F, Bleckmann A, Beißbarth T. ​rBiopaxParser-an R package to parse, modify and visualize BioPAX data​. ​​Bioinformatics. ​2013;​29​(4):​​520​-522​. ​doi:10.1093/bioinformatics/bts710. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Pelczar P, Zibat A, van Dop WA, Heijmans J, Bleckmann A, Gruber W, et al. ​Inactivation of Patched1 in Mice Leads to Development of Gastrointestinal Stromal-Like Tumors That Express Pdgfr alpha but Not Kit​. ​​Gastroenterology. ​2013;​144​(1):​​134​-U256​. ​doi:10.1053/j.gastro.2012.09.061. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | 
    ​ ​Homayounfar K, Bleckmann A, Conradi, Lena-Christin, Sprenger T, Lorf T, Niessner M, et al. ​Metastatic recurrence after complete resection of colorectal liver metastases: impact of surgery and chemotherapy on survival​. ​​International Journal of Colorectal Disease. ​2013;​28​(7):​​1009​-1017​. ​doi:10.1007/s00384-013-1648-2. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | 
    ​ ​Bleckmann A, Siam L, Klemm F, Rietkoetter E, Wegner C, Kramer, Franz-Josef, et al. ​Nuclear LEF1/TCF4 correlate with poor prognosis but not with nuclear beta-catenin in cerebral metastasis of lung adenocarcinomas​. ​​Clinical & Experimental Metastasis. ​2013;​30​(4):​​471​-482​. ​doi:10.1007/s10585-012-9552-7. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Conference Abstract
    ​ ​Bleckmann A, Bayerlova M, Kramer, Franz-Josef, Klemm F, Binder C, Pukrop T, et al. ​Analyzing breast-cancer gene expression data using a newly developed graph-based WNT model in breast cancer​. ​​Onkologie. ​2012;​35​
    ​Details  WoS 
  • 2012 | Conference Abstract
    ​ ​Conradi, Lena-Christin, Styczen H, Sprenger T, Homayounfar K, Wolff HA, Bleckmann A, et al. ​HER2 status in locally advanced rectal cancer and metachronous metastases: Opportunity for a new therapeutic approach?​. ​​Chicago, IL. ​Journal of Clinical Oncology. ​2012;​30​(15)
    ​Details  WoS 
  • 2012 | Journal Article | 
    ​ ​Artmann S, Jung K, Bleckmann A, Beißbarth T. ​Detection of Simultaneous Group Effects in MicroRNA Expression and Related Target Gene Sets​. ​​PLoS ONE. ​2012;​7​(6). ​doi:10.1371/journal.pone.0038365. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | 
    ​ ​Homayounfar K, Bleckmann A, Conradi, Lena-Christin, Sprenger T, Beißbarth T, Lorf T, et al. ​Bilobar spreading of colorectal liver metastases does not significantly affect survival after R0 resection in the era of interdisciplinary multimodal treatment​. ​​International Journal of Colorectal Disease. ​2012;​27​(10):​​1359​-1367​. ​doi:10.1007/s00384-012-1455-1. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | 
    ​ ​Heuer JF, Sauter PA, Pelosi P, Herrmann P, Brück W, Perske C, et al. ​Effects of pulmonary acid aspiration on the lungs and extra-pulmonary organs: a randomized study in pigs​. ​​CRITICAL CARE. ​2012;​16​(2). ​doi:10.1186/cc11214. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | 
    ​ ​Heuer JF, Sauter PA, Barwing J, Herrmann P, Crozier TA, Bleckmann A, et al. ​Effects of High-frequency Oscillatory Ventilation on Systemic and Cerebral Hemodynamics and Tissue Oxygenation: An Experimental Study in Pigs​. ​​Neurocritical Care. ​2012;​17​(2):​​281​-292​. ​doi:10.1007/s12028-011-9566-z. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Conference Abstract
    ​ ​Conradi, Lena-Christin, Bleckmann A, Sprenger T, Schirmer MA, Homayounfar K, Wolff HA, et al. ​Thymidylate Synthase as Biomarker in Rectal Cancer Patients After 5-FU-based Radiochemotherapy - Evaluation of the Prognostic Capacity in Pre-treatment Biopsies and Resected Adenocarcinoma​. ​ European Multidisciplinary Cancer Congress on Integrating Basic and Translational Science, Surgery, Radiotherapy, Medical oncology, Advocacy and Care; ​Stockholm, SWEDEN. ​European Journal of Cancer. ​2011;​47​
    ​Details  WoS 
  • 2011 | Conference Abstract
    ​ ​Conradi, Lena-Christin, Bleckmann A, Schirmer MA, Sprenger T, Homayounfar K, Wolff HA, et al. ​Biomarker study in rectal cancer patients after 5FU-based radiochemotherapy: Evaluation of the prognostic capacity of thymidylate synthase in pretreatment biopsies and resected adenocarcinoma.​. ​​Journal of Clinical Oncology. ​2011;​29​(4)
    ​Details  PMID  PMC  WoS 
  • 2011 | Journal Article
    ​ ​Klemm F, Bleckmann A, Siam L, Chuang, Han-Ning, Rietkoetter E, Behme D, et al. ​beta-catenin-independent WNT signaling in basal-like breast cancer and brain metastasis​. ​​Carcinogenesis. ​2011;​32​(3):​​434​-442​. ​doi:10.1093/carcin/bgq269. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | 
    ​ ​Conradi, Lena-Christin, Bleckmann A, Schirmer MA, Sprenger T, Jo P, Homayounfar K, et al. ​Thymidylate Synthase as a Prognostic Biomarker for Locally Advanced Rectal Cancer after multimodal Treatment​. ​​Annals of Surgical Oncology. ​2011;​18​(9):​​2442​-2452​. ​doi:10.1245/s10434-011-1608-4. 
    ​Details  DOI  PMID  PMC  WoS 

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