Dr. Jochen Hans Weishaupt

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  • 2019 | Journal Article
    ​ ​Dorst, Johannes, Lu Chen, Angela Rosenbohm, Jens Dreyhaupt, Annemarie Hübers, Joachim Schuster, Jochen H. Weishaupt et al. "Prognostic factors in ALS: a comparison between Germany and China​." ​Journal of Neurology ​266, no. 6 (2019): ​1516​-1525​. ​https://doi.org/10.1007/s00415-019-09290-4.
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  • 2018 | Journal Article
    ​ ​Ludolph, Albert C, Joachim Schuster, Johannes Dorst, Luc Dupuis, Jens Dreyhaupt, Jochen H Weishaupt, Jan Kassubek et al. "Safety and efficacy of rasagiline as an add-on therapy to riluzole in patients with amyotrophic lateral sclerosis: a randomised, double-blind, parallel-group, placebo-controlled, phase 2 trial​." ​The Lancet Neurology ​17, no. 8 (2018): ​681​-688​. ​https://doi.org/10.1016/S1474-4422(18)30176-5.
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  • 2015 | Journal Article | Research Paper
    ​ ​Büchner, A., P. Krumova, S. Ganesan, M. Bähr, K. Eckermann, and J. H. Weishaupt. "Sumoylation of p35 Modulates p35/Cyclin-Dependent Kinase (Cdk) 5 Complex Activity​." ​NeuroMolecular Medicine ​17, no. 1 (2015): ​12​-23​. ​https://doi.org/10.1007/s12017-014-8336-4.
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  • 2015 | Journal Article | Research Paper | 
    ​ ​Kunadt, Marcel, Katrin Eckermann, Anne Stuendl, Jing Gong, Belisa Russo, Katrin Strauss, Surya Rai et al. "Extracellular vesicle sorting of alpha-Synuclein is regulated by sumoylation​." ​Acta Neuropathologica ​129, no. 5 (2015): ​695​-713​. ​https://doi.org/10.1007/s00401-015-1408-1.
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  • 2015 | Journal Article | 
    ​ ​Wagner, J., S. Krauss, S. Shi, S. Ryazanov, J. Steffen, C. Miklitz, A. Leonov et al. "Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies​." ​Acta Neuropathologica ​130, no. 5 (2015): ​619​-631​. ​https://doi.org/10.1007/s00401-015-1483-3.
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  • 2014 | Journal Article | Research Paper
    ​ ​Liman, Jan, S. Deeg, A. Voigt, H. Voßfeldt, C. P. Dohm, A. Karch, Jochen Weishaupt, J. B. Schulz, M. Bähr, and P. Kermer. "CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration​." ​Journal of Neurochemistry ​129, no. 6 (2014): ​1013​-1023​. ​https://doi.org/10.1111/jnc.12684.
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  • 2014 | Journal Article | Research Paper
    ​ ​Tönges, L., R. Günther, M. Suhr, J. Jansen, A. Balck, K.-A. Saal, E. Barski et al. "Rho Kinase Inhibition Modulates Microglia Activation and Improves Survival in a Model of Amyotrophic Lateral Sclerosis​." ​Glia ​62, no. 2 (2014): ​217​-232​. ​https://doi.org/10.1002/glia.22601.
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  • 2013 | Journal Article | Research Paper | 
    ​ ​Wagner, J., S. Ryazanov, A. Leonov, J. Levin, S. Shi, F. Schmidt, C. Prix et al. "Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson's disease​." ​Acta Neuropathologica ​125, no. 6 (2013): ​795​-813​. ​https://doi.org/10.1007/s00401-013-1114-9.
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Letter Note
    ​ ​Weishaupt, J. H., C. Ganser, and M. Bähr. "Inflammatory demyelinating CNS disorder in a case of X-linked Charcot-Marie-Tooth disease: positive response to natalizumab​." ​Journal of Neurology ​259, no. 9 (2012): ​1967​-1969​. ​https://doi.org/10.1007/s00415-012-6467-9.
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  • 2012 | Journal Article | Research Paper | 
    ​ ​Tönges, L., T. Frank, L. Tatenhorst, K. A. Saal, J. C. Koch, E. M. Szego, M. Bähr, J. H. Weishaupt, and P. Lingor. "Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease​." ​Brain ​135, no. 11 (2012): ​3355​-3370​. ​https://doi.org/10.1093/brain/aws254.
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  • 2012 | Journal Article | Research Paper
    ​ ​Frank, T., F. Klinker, B. H. Falkenburger, R. Laage, F. Lühder, B. Göricke, A. Schneider et al. "Pegylated granulocyte colony-stimulating factor conveys long-term neuroprotection and improves functional outcome in a model of Parkinson's disease​." ​Brain ​135, no. 6 (2012): ​1914​-1925​. ​https://doi.org/10.1093/brain/aws054.
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  • 2011 | Journal Article | Research Paper | 
    ​ ​Krumova, P., E. Meulmeester, M. Garrido, M. Tirard, H.-H. Hsiao, G. Bossis, H. Urlaub et al. "Sumoylation inhibits alpha-synuclein aggregation and toxicity​." ​The Journal of Cell Biology ​194, no. 1 (2011): ​49​-60​. ​https://doi.org/10.1083/jcb.201010117.
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  • 2010 | Journal Article | Research Paper
    ​ ​Shevtsova, Z., M. Garrido, Jochen Weishaupt, P. Saftig, M. Bähr, F. Lühder, and Sebastian Kügler. "CNS-Expressed Cathepsin D Prevents Lymphopenia in a Murine Model of Congenital Neuronal Ceroid Lipofuscinosis​." ​The American Journal of Pathology ​177, no. 1 (2010): ​271​-279​. ​https://doi.org/10.2353/ajpath.2010.091267.
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  • 2009 | Journal Article | Research Paper
    ​ ​Bermel, C., L. Tönges, V. Planchamp, F. Gillardon, J. H. Weishaupt, G. P. H. Dietz, M. Bähr, and P. Lingor. "Combined inhibition of Cdk5 and ROCK additively increase cell survival, but not the regenerative response in regenerating retinal ganglion cells​." ​Molecular and Cellular Neuroscience ​42, no. 4 (2009): ​427​-437​. ​https://doi.org/10.1016/j.mcn.2009.09.005.
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  • 2008 | Journal Article | Research Paper
    ​ ​Rohde, G., P. Kermer, J. C. Reed, M. Bähr, and J. H. Weishaupt. "Neuron-specific overexpression of the co-chaperone Bcl-2-associated athanogene-1 in superoxide dismutase 1(G93A)-transgenic mice​." ​Neuroscience ​157, no. 4 (2008): ​844​-849​. ​https://doi.org/10.1016/j.neuroscience.2008.09.055.
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  • 2008 | Journal Article | Research Paper
    ​ ​Dietz, G. P. H., K. V. Stockhausen (née Peters), B. Dietz, B. H. Falkenburger, P. Valbuena, F. Opazo, P. Lingor et al. "Membrane-permeable Bcl-x(L) prevents MPTP-induced dopaminergic neuronal loss in the substantia nigra​." ​Journal of Neurochemistry ​104, no. 3 (2008): ​757​-765​. ​https://doi.org/10.1111/j.1471-4159.2007.05028.x.
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  • 2008 | Journal Article | Research Paper | 
    ​ ​Ganesan, S., G. Rohde, K. Eckermann, K. Sroka, M. K. E. Schaefer, C. P. Dohm, P. Kermer et al. "Mutant SOD1 detoxification mechanisms in intact single cells​." ​Cell Death and Differentiation ​15, no. 2 (2008): ​312​-321​. ​https://doi.org/10.1038/sj.cdd.4402262.
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  • 2007 | Journal Article | Research Paper
    ​ ​Liebetanz, D., P. C. Baier, W. Paulus, K. Meuer, M. Bähr, and J. H. Weishaupt. "A highly sensitive automated complex running wheel test to detect latent motor deficits in the mouse MPTP model of Parkinson's disease​." ​Experimental Neurology ​205, no. 1 (2007): ​207​-213​. ​https://doi.org/10.1016/j.expneurol.2007.01.030.
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  • 2007 | Review
    ​ ​Tönges, L., J. C. M. Schlachetzki, J. H. Weishaupt, and M. Bähr. "Hematopoietic cytokines - on the verge of conquering neurology​." Current Molecular Medicine ​7​, no. 2​ (2007): ​157​-170​. ​https://doi.org/10.2174/156652407780059186.
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  • 2007 | Journal Article | Research Paper | 
    ​ ​Meuer, K., I. E. Suppanz, P. Lingor, V. Planchamp, B. Göricke, L. Fichtner, G. H. Braus et al. "Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis​." ​Cell Death and Differentiation ​14, no. 4 (2007): ​651​-661​. ​https://doi.org/10.1038/sj.cdd.4402087.
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  • 2006 | Journal Article
    ​ ​Weishaupt, Jochen H., Claudia Bartels, Esther Pölking, Jeannine Dietrich, Gundula Rohde, Burkhard Poeggeler, Nina Mertens et al. "Reduced oxidative damage in ALS by high-dose enteral melatonin treatment​." ​Journal of Pineal Research ​41, no. 4 (2006): ​313​-323​. ​https://doi.org/10.1111/j.1600-079X.2006.00377.x.
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  • 2006 | Journal Article | Research Paper
    ​ ​Dietz, Gunnar P. H., Paola C. Valbuena, Birgit Dietz, Katrin Meuer, Patrick Müller, Jochen H. Weishaupt, and Mathias Bähr. "Application of a blood-brain-barrier-penetrating form of GDNF in a mouse model for Parkinson's disease​." ​Brain Research ​1082, no. 1 (2006): ​61​-66​. ​https://doi.org/10.1016/j.brainres.2006.01.083.
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  • 2006 | Journal Article | Research Paper
    ​ ​Meuer, Katrin, Claudia Pitzer, Peter Teismann, Carola Krüger, Bettina Göricke, Rico Laage, Paul Lingor et al. "Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease​." ​Journal of Neurochemistry ​97, no. 3 (2006): ​675​-686​. ​https://doi.org/10.1111/j.1471-4159.2006.03727.x.
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  • 2005 | Journal Article | Research Paper
    ​ ​Weishaupt, Jochen H., N. Klocker, and Mathias Bähr. "Axotomy-induced early down-regulation of POU-IV class transcription factors Brn-3a and Brn-3b in retinal ganglion cells​." ​Journal of Molecular Neuroscience ​26, no. 1 (2005): ​17​-25​. ​https://doi.org/10.1385/JMN:26:1:017.
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  • 2004 | Review
    ​ ​Kermer, Pawel, Jan Liman, Jochen H. Weishaupt, and Mathias Bähr. "Neuronal Apoptosis in Neurodegenerative Diseases: From Basic Research to Clinical Application​." Neurodegenerative Diseases ​1​, no. 1​ (2004): ​9​-19​. ​https://doi.org/10.1159/000076665.
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  • 2004 | Journal Article | Research Paper
    ​ ​Kilic, E., J. H. Weishaupt, Ü. Kilic, G. Rohde, B. Yulug, K. Peters, D. M. Hermann, and M. Bähr. "The superoxide dismutase1 (SOD1) G93A mutation does not promote neuronal injury after focal brain ischemia and optic nerve transection in mice​." ​Neuroscience ​128, no. 2 (2004): ​359​-364​. ​https://doi.org/10.1016/j.neuroscience.2004.06.064.
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  • 2004 | Journal Article | Research Paper
    ​ ​Weishaupt, Jochen H., Gundula Rohde, Esther Pölking, Anna-Leena Sirén, Hannelore Ehrenreich, and Mathias Bähr. "Effect of Erythropoietin Axotomy-Induced Apoptosis in Rat Retinal Ganglion Cells​." ​Investigative Ophthalmology & Visual Science ​45, no. 5 (2004): ​1514​-1522​. ​https://doi.org/10.1167/iovs.03-1039.
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  • 2003 | Journal Article
    ​ ​Jacob, Sonja, J. Finsterbusch, Jochen H. Weishaupt, D. Khorram-Sefat, Jens Frahm, and Hannelore Ehrenreich. "Diffusion tensor imaging for long-term follow-up of corticospinal tract degeneration in amyotrophic lateral sclerosis​." ​Neuroradiology no. 9 (2003): ​598​-600​. ​https://doi.org/10.1007/s00234-003-1014-0.
    ​Details  DOI 
  • 2003 | Review
    ​ ​Weishaupt, Jochen H., Clemens Neusch, and Mathias Bähr. "Cyclin-dependent kinase 5 (CDK5) and neuronal cell death​." Cell and Tissue Research ​312​, no. 1​ (2003): ​1​-8​. ​https://doi.org/10.1007/s00441-003-0703-7.
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  • 2003 | Review
    ​ ​Neusch, Clemens, Jochen H. Weishaupt, and Mathias Bähr. "Kir channels in the CNS: emerging new roles and implications for neurological diseases​." Cell and Tissue Research ​311​, no. 2​ (2003): ​131​-138​. ​https://doi.org/10.1007/s00441-002-0669-x.
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  • 2003 | Journal Article | Research Paper
    ​ ​Weishaupt, J. H., R. Diem, P. Kermer, S. Krajewski, J. C. Reed, and M. Bähr. "Contribution of caspase-8 to apoptosis of axotomized rat retinal ganglion cells in vivo​." ​Neurobiology of Disease ​13, no. 2 (2003): ​124​-135​. ​https://doi.org/10.1016/S0969-9961(03)00032-9.
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  • 2003 | Journal Article | Research Paper
    ​ ​Weishaupt, Jochen H., L Kussmaul, P. Grotsch, A. Hecke, Gundula Rohde, H. Romig, Mathias Bähr, and Frank Gillardon. "Inhibition of CDK5 is protective in necrotic and apoptotic paradigms of neuronal cell death and prevents mitochondrial dysfunction​." ​Molecular and Cellular Neuroscience ​24, no. 2 (2003): ​489​-502​. ​https://doi.org/10.1016/S1044-7431(03)00221-5.
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  • 2002 | Journal Article
    ​ ​Jacob, Sonja, Burkhard Poeggeler, Jochen H. Weishaupt, Anna-Leena Sirén, Rüdiger Hardeland, Mathias Bähr, and Hannelore Ehrenreich. "Melatonin as a candidate compound for neuroprotection in amyotrophic lateral sclerosis (ALS): high tolerability of daily oral melatonin administration in ALS patients​." ​Journal of Pineal Research ​33, no. 3 (2002): ​186​-187​. ​https://doi.org/10.1034/j.1600-079X.2002.02943.x.
    ​Details  DOI 
  • 2001 | Journal Article | Research Paper
    ​ ​Weishaupt, Jochen H., and Mathias Bähr. "Degeneration of axotomized retinal ganglion cells as a model for neuronal apoptosis in the central nervous system - molecular death and survival pathways​." ​Restorative neurology and neuroscience ​19, no. 1-2 (2001): ​19​-27​. ​
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  • 2001 | Journal Article | Research Paper
    ​ ​Diem, Ricarda, Ralf Meyer, Jochen H. Weishaupt, and Mathias Bähr. "Reduction of potassium currents and phosphatidylinositol 3-kinase-dependent Akt phosphorylation by tumor necrosis factor-alpha rescues axotomized retinal ganglion cells from retrograde cell death in vivo​." ​The Journal of neuroscience ​21, no. 6 (2001): ​2058​-2066​. ​
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  • 2001 | Journal Article | Research Paper
    ​ ​Kermer, Pawel, N. Klocker, Jochen H. Weishaupt, and Mathias Bähr. "Transection of the optic nerve in rats: studying neuronal death and survival in vivo​." ​Brain Research Protocols ​7, no. 3 (2001): ​255​-260​. ​https://doi.org/10.1016/S1385-299X(01)00076-9.
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  • 2000 | Journal Article | Research Paper
    ​ ​Klocker, N., Pawel Kermer, Jochen H. Weishaupt, M. Labes, R. Ankerhold, and Mathias Bähr. "Brain-derived neurotrophic factor-mediated neuroprotection of adult rat retinal ganglion cells in vivo does not exclusively depend on phosphatidyl-inositol-3 '-kinase/protein kinase B signaling​." ​The Journal of neuroscience ​20, no. 18 (2000): ​6962​-6967​. ​
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