Prof. Dr. Holger Stark

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  • 2023 | Journal Article
    ​ ​Structural snapshots of the acyl carrier protein along the yeast fatty acid synthesis cycle​
    Singh, K.; Bunzel, G.; Man Yip, K.; Stark, H.   & Chari, A.​ (2023) 
    Cell,.​
    ​Details 
  • 2020 | Journal Article
    ​ ​Discovery of a Regulatory Subunit of the Yeast Fatty Acid Synthase​
    Singh, K.; Graf, B.; Linden, A.; Sautner, V.; Urlaub, H. ; Tittmann, K.   & Stark, H.  et al.​ (2020) 
    Cell, 180(6) pp. 1130​-1143.e20​.​ DOI: https://doi.org/10.1016/j.cell.2020.02.034 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Atomic-resolution protein structure determination by cryo-EM​
    Yip, K. M.; Fischer, N. ; Paknia, E.; Chari, A. & Stark, H. ​ (2020) 
    Nature, 587(7832) pp. 157​-161​.​ DOI: https://doi.org/10.1038/s41586-020-2833-4 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Structural and Functional Analyses of the Human PDH Complex Suggest a “Division-of-Labor” Mechanism by Local E1 and E3 Clusters​
    Prajapati, S.; Haselbach, D.; Wittig, S.; Patel, M. S.; Chari, A.; Schmidt, C. & Stark, H.  et al.​ (2019) 
    Structure, 27(7) pp. 1124​-1136.e4​.​ DOI: https://doi.org/10.1016/j.str.2019.04.009 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Cryo-EM in drug discovery: achievements, limitations and prospects​
    Renaud, J.-P.; Chari, A.; Ciferri, C.; Liu, W.-t.; Rémigy, H.-W.; Stark, H.   & Wiesmann, C.​ (2018) 
    Nature Reviews Drug Discovery, 17(7) pp. 471​-492​.​ DOI: https://doi.org/10.1038/nrd.2018.77 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs​
    Haselbach, D.; Schrader, J.; Lambrecht, F.; Henneberg, F.; Chari, A. & Stark, H. ​ (2017) 
    Nature Communications, 8(1) art. 15578​.​ DOI: https://doi.org/10.1038/ncomms15578 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​The Ribosome Cooperates with the Assembly Chaperone pICln to Initiate Formation of snRNPs​
    Paknia, E.; Chari, A.; Stark, H.   & Fischer, U.​ (2016) 
    Cell Reports, 16(12) pp. 3103​-3112​.​ DOI: https://doi.org/10.1016/j.celrep.2016.08.047 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Molecular architecture of the Saccharomyces cerevisiae activated spliceosome​
    Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A. & Kumar, V. et al.​ (2016) 
    Science, 353(6306) pp. 1399​-1405​.​ DOI: https://doi.org/10.1126/science.aag1906 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design​
    Schrader, J.; Henneberg, F.; Mata, R. A. ; Tittmann, K. ; Schneider, T. R.; Stark, H.   & Bourenkov, G. P. et al.​ (2016) 
    Science, 353(6299) pp. 594​-598​.​ DOI: https://doi.org/10.1126/science.aaf8993 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​Sample preparation of biological macromolecular assemblies for the determination of high-resolution structures by cryo-electron microscopy​
    Stark, H.   & Chari, A.​ (2015) 
    Microscopy, 65(1) pp. 23​-34​.​ DOI: https://doi.org/10.1093/jmicro/dfv367 
    ​Details  DOI 
  • 2015 | Journal Article
    ​ ​ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space​
    Chari, A.; Haselbach, D.; Kirves, J.-M.; Ohmer, J.; Paknia, E.; Fischer, N.   & Ganichkin, O. et al.​ (2015) 
    Nature Methods, 12(9) pp. 859​-865​.​ DOI: https://doi.org/10.1038/nmeth.3493 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Structural Basis of Assembly Chaperone- Mediated snRNP Formation​
    Grimm, C.; Chari, A.; Pelz, J.-P.; Kuper, J.; Kisker, C.; Diederichs, K. & Stark, H.  et al.​ (2013) 
    Molecular Cell, 49(4) pp. 692​-703​.​ DOI: https://doi.org/10.1016/j.molcel.2012.12.009 
    ​Details  DOI 
  • 2008 | Journal Article
    ​ ​An Assembly Chaperone Collaborates with the SMN Complex to Generate Spliceosomal SnRNPs​
    Chari, A.; Golas, M. M.; Klingenhäger, M.; Neuenkirchen, N.; Sander, B.; Englbrecht, C. & Sickmann, A. et al.​ (2008) 
    Cell, 135(3) pp. 497​-509​.​ DOI: https://doi.org/10.1016/j.cell.2008.09.020 
    ​Details  DOI 

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