Prof. Dr. Reinhard Lührmann

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  • 2021 | Journal Article | 
    ​ ​Zhang, Zhenwei, et al. "Structural insights into how Prp5 proofreads the pre-mRNA branch site​." ​Nature, vol. 596, no. 7871, ​2021, pp. 296​-300​, ​doi: 10.1038/s41586-021-03789-5. 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Bertram, Karl, et al. "Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome​." ​Molecular Cell, vol. 80, no. 1, ​2020, pp. 127​-139.e6​, ​doi: 10.1016/j.molcel.2020.09.012. 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Zhang, Zhenwei, et al. "Molecular architecture of the human 17S U2 snRNP​." ​Nature, vol. 583, no. 7815, ​2020, pp. 310​-313​, ​doi: 10.1038/s41586-020-2344-3. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Kastner, Berthold, et al. "Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes​." ​Cold Spring Harbor Perspectives in Biology, vol. 11, no. 11, ​2019, p. a032417​, ​doi: 10.1101/cshperspect.a032417. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Haselbach, David, et al. "Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex​." ​Cell, vol. 172, no. 3, ​2018, pp. 454​-464.e11​, ​doi: 10.1016/j.cell.2018.01.010. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Bao, Penghui, et al. "The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated B act complex​." ​Genes & Development, vol. 31, no. 23-24, ​2018, pp. 2416​-2429​, ​doi: 10.1101/gad.308163.117. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​de Moura, Tales Rocha, et al. "Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors​." ​Molecular Cell, vol. 69, no. 6, ​2018, pp. 979​-992.e6​, ​doi: 10.1016/j.molcel.2018.02.022. 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Dybkov, Olexandr, et al. "Protein-Cross-Linking zur Aufklärung von komplexen Strukturen​." ​BIOspektrum, vol. 24, no. 3, ​2018, pp. 278​-282​, ​doi: 10.1007/s12268-018-0909-6. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Cretu, Constantin, et al. "Structural Basis of Splicing Modulation by Antitumor Macrolide Compounds​." ​Molecular Cell, vol. 70, no. 2, ​2018, pp. 265​-273.e8​, ​doi: 10.1016/j.molcel.2018.03.011. 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​Bertram, Karl, et al. "Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation​." ​Cell, vol. 170, no. 4, ​2017, pp. 701​-713.e11​, ​doi: 10.1016/j.cell.2017.07.011. 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Fourmann, Jean-Baptiste, et al. "Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2​." ​Nucleic Acids Research, vol. 45, no. 7, ​2017, pp. 4068​-4080​, ​doi: 10.1093/nar/gkw1225. 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Bao, Penghui, et al. "Yeast Prp2 liberates the 5′ splice site and the branch site adenosine for catalysis of pre-mRNA splicing​." ​RNA, vol. 23, no. 12, ​2017, pp. 1770​-1779​, ​doi: 10.1261/rna.063115.117. 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Bertram, Karl, et al. "Cryo-EM structure of a human spliceosome activated for step 2 of splicing​." ​Nature, vol. 542, no. 7641, ​2017, p. 318​, ​doi: 10.1038/nature21079. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Agafonov, Dmitry E., et al. "Molecular architecture of the human U4/U6.U5 tri-snRNP​." ​Science, vol. 351, no. 6280, ​2016, pp. 1416​-1420​, ​doi: 10.1126/science.aad2085. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Cretu, Constantin, et al. "Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations​." ​Molecular Cell, vol. 64, no. 2, ​2016, pp. 307​-319​, ​doi: 10.1016/j.molcel.2016.08.036. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Rauhut, Reinhard, et al. "Molecular architecture of the Saccharomyces cerevisiae activated spliceosome​." ​Science, vol. 353, no. 6306, ​2016, pp. 1399​-1405​, ​doi: 10.1126/science.aag1906. 
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  • 2016 | Journal Article | 
    ​ ​Fourmann, Jean-Baptiste, et al. "The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction​." ​eLife, vol. 5, ​2016, , ​doi: 10.7554/eLife.15564. 
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  • 2016 | Journal Article | Research Paper | 
    ​ ​Boesler, Carsten, et al. "A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity​." ​Nature Communications, vol. 7, ​2016, , ​doi: 10.1038/ncomms11997. 
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  • 2016 | Journal Article | Research Paper
    ​ ​Tauchert, Marcel J., et al. "Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum​." ​Acta Crystallographica Section F Structural Biology Communications, vol. 72, no. 2, ​2016, pp. 112​-120​, ​doi: 10.1107/S2053230X15024498. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Heininger, Annika U., et al. "Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways​." ​RNA Biology, vol. 13, no. 3, ​2016, pp. 320​-330​, ​doi: 10.1080/15476286.2016.1142038. 
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  • 2015 | Conference Abstract
    ​ ​Heininger, A. U., et al. "Sequestering and protein cofactor competition regulate a multifunctional RNA helicase in different pathways​." ​FEBS Journal, vol. 282, ​2015, pp. 209​-210​. ​
    ​Details  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Benito-Garagorri, Eva, et al. "HDAC inhibitor-dependent transcriptome and memory reinstatement in cognitive decline models​." ​Journal of Clinical Investigation, vol. 125, no. 9, ​2015, pp. 3572​-3584​, ​doi: 10.1172/JCI79942. 
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  • 2014 | Journal Article | Research Paper | 
    ​ ​Moehlmann, Sina, et al. "Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28​." ​Acta Crystallographica Section D Biological Crystallography, vol. 70, ​2014, pp. 1622​-1630​, ​doi: 10.1107/S1399004714006439. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Ohrt, Thomas, et al. "Molecular dissection of step 2 catalysis of yeast pre-mRNA splicing investigated in a purified system​." ​RNA, vol. 19, no. 7, ​2013, pp. 902​-915​, ​doi: 10.1261/rna.039024.113. 
    ​Details  DOI 
  • 2013 | Journal Article | Research Paper
    ​ ​Fourmann, Jean-Baptiste, et al. "Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system​." ​Genes & Development, vol. 27, no. 4, ​2013, pp. 413​-428​, ​doi: 10.1101/gad.207779.112. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Xiang, Shengqi, et al. "Phosphorylation Drives a Dynamic Switch in Serine/Arginine-Rich Proteins​." ​Structure, vol. 21, no. 12, ​2013, pp. 2162​-2174​, ​doi: 10.1016/j.str.2013.09.014. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​Prior, Mira, et al. "Single-Molecule Fluorescence Spectroscopy of the Structure and Dynamics of the Spliceosomal Complex​." ​Biophysical Journal, vol. 102, no. 3, ​2012, p. 47a​, ​doi: 10.1016/j.bpj.2011.11.287. 
    ​Details  DOI 
  • 2012 | Journal Article
    ​ ​Ohrt, Thomas, et al. "Prp2-mediated protein rearrangements at the catalytic core of the spliceosome as revealed by dcFCCS​." ​RNA, vol. 18, no. 6, ​2012, pp. 1244​-1256​, ​doi: 10.1261/rna.033316.112. 
    ​Details  DOI 
  • 2010 | Journal Article
    ​ ​Bessonov, S., et al. "Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis​." ​RNA, vol. 16, no. 12, ​2010, pp. 2384​-2403​, ​doi: 10.1261/rna.2456210. 
    ​Details  DOI 
  • 2010 | Journal Article
    ​ ​Golas, Mariola Monika, et al. "3D Cryo-EM Structure of an Active Step I Spliceosome and Localization of Its Catalytic Core​." ​Molecular Cell, vol. 40, no. 6, ​2010, pp. 927​-938​, ​doi: 10.1016/j.molcel.2010.11.023. 
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  • 2009 | Journal Article
    ​ ​Wolf, Elmar, et al. "Exon, intron and splice site locations in the spliceosomal B complex​." ​The EMBO Journal, vol. 28, no. 15, ​2009, pp. 2283​-2292​, ​doi: 10.1038/emboj.2009.171. 
    ​Details  DOI 
  • 2009 | Journal Article
    ​ ​Lührmann, Reinhard, and Holger Stark. "Structural mapping of spliceosomes by electron microscopy​." ​Current Opinion in Structural Biology, vol. 19, no. 1, ​2009, pp. 96​-102​, ​doi: 10.1016/j.sbi.2009.01.001. 
    ​Details  DOI 
  • 2009 | Journal Article | Research Paper
    ​ ​Warkocki, Zbigniew, et al. "Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components​." ​Nature Structural & Molecular Biology, vol. 16, no. 12, ​2009, pp. 1237​-U50​, ​doi: 10.1038/nsmb.1729. 
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  • 2009 | Journal Article
    ​ ​Fabrizio, Patrizia, et al. "The Evolutionarily Conserved Core Design of the Catalytic Activation Step of the Yeast Spliceosome​." ​Molecular Cell, vol. 36, no. 4, ​2009, pp. 593​-608​, ​doi: 10.1016/j.molcel.2009.09.040. 
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  • 2008 | Journal Article
    ​ ​Häcker, Irina, et al. "Localization of Prp8, Brr2, Snu114 and U4/U6 proteins in the yeast tri-snRNP by electron microscopy​." ​Nature Structural & Molecular Biology, vol. 15, no. 11, ​2008, pp. 1206​-1212​, ​doi: 10.1038/nsmb.1506. 
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  • 2008 | Journal Article | Research Paper
    ​ ​Mathew, Rebecca, et al. "Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome​." ​Nature Structural & Molecular Biology, vol. 15, no. 5, ​2008, pp. 435​-443​, ​doi: 10.1038/nsmb.1415. 
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  • 2008 | Journal Article
    ​ ​Karaduman, Ramazan, et al. "Structure of yeast U6 snRNPs: Arrangement of Prp24p and the LSm complex as revealed by electron microscopy​." ​RNA, vol. 14, no. 12, ​2008, pp. 2528​-2537​, ​doi: 10.1261/rna.1369808. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article
    ​ ​Kastner, Berthold, et al. "GraFix: sample preparation for single-particle electron cryomicroscopy​." ​Nature Methods, vol. 5, no. 1, ​2007, pp. 53​-55​, ​doi: 10.1038/nmeth1139. 
    ​Details  DOI 
  • 2007 | Journal Article
    ​ ​Behzadnia, Nastaran, et al. "Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes​." ​The EMBO Journal, vol. 26, no. 6, ​2007, pp. 1737​-1748​, ​doi: 10.1038/sj.emboj.7601631. 
    ​Details  DOI 
  • 2007 | Journal Article | Research Paper
    ​ ​Nielsen, Tine Kragh, et al. "Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2)​." ​Journal of Molecular Biology, vol. 369, no. 4, ​2007, pp. 902​-908​, ​doi: 10.1016/j.jmb.2007.03.077. 
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  • 2006 | Journal Article
    ​ ​Deckert, Jochen, et al. "Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions​." ​Molecular and Cellular Biology, vol. 26, no. 14, ​2006, pp. 5528​-5543​, ​doi: 10.1128/MCB.00582-06. 
    ​Details  DOI 
  • 2006 | Journal Article
    ​ ​Sander, Bjoern, et al. "Organization of Core Spliceosomal Components U5 snRNA Loop I and U4/U6 Di-snRNP within U4/U6.U5 Tri-snRNP as Revealed by Electron Cryomicroscopy​." ​Molecular Cell, vol. 24, no. 2, ​2006, pp. 267​-278​, ​doi: 10.1016/j.molcel.2006.08.021. 
    ​Details  DOI 
  • 2006 | Journal Article
    ​ ​Stark, Holger, and Reinhard Lührmann. "Cryo-Electron Microscopy of Spliceosomal Components​." ​Annual Review of Biophysics and Biomolecular Structure, vol. 35, no. 1, ​2006, pp. 435​-457​, ​doi: 10.1146/annurev.biophys.35.040405.101953. 
    ​Details  DOI 
  • 2006 | Journal Article
    ​ ​Schellenberg, M. J., et al. "Crystal structure of a core spliceosomal protein interface​." ​Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 5, ​2006, pp. 1266​-1271​, ​doi: 10.1073/pnas.0508048103. 
    ​Details  DOI 
  • 2006 | Journal Article | Research Paper
    ​ ​Donnert, Gerald, et al. "Macromolecular-scale resolution in biological fluorescence microscopy​." ​Proceedings of the National Academy of Sciences of the United States of America, vol. 103, no. 31, ​2006, pp. 11440​-11445​, ​doi: 10.1073/pnas.0604965103. 
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  • 2005 | Journal Article
    ​ ​Golas, Monika M., et al. "Major Conformational Change in the Complex SF3b upon Integration into the Spliceosomal U11/U12 di-snRNP as Revealed by Electron Cryomicroscopy​." ​Molecular Cell, vol. 17, no. 6, ​2005, pp. 869​-883​, ​doi: 10.1016/j.molcel.2005.02.016. 
    ​Details  DOI 
  • 2004 | Journal Article
    ​ ​Boehringer, Daniel, et al. "Three-dimensional structure of a pre-catalytic human spliceosomal complex B​." ​Nature Structural & Molecular Biology, vol. 11, no. 5, ​2004, pp. 463​-468​, ​doi: 10.1038/nsmb761. 
    ​Details  DOI 
  • 2003 | Journal Article | Research Paper
    ​ ​Golas, Monika M., et al. "Molecular Architecture of the Multiprotein Splicing Factor SF3b​." ​Science, vol. 300, no. 5621, ​2003, pp. 980​-984​, ​doi: 10.1126/science.1084155. 
    ​Details  DOI 
  • 2001 | Journal Article
    ​ ​Stark, Holger, et al. "Arrangement of RNA and proteins in the spliceosomal U1 small nuclear ribonucleoprotein particle​." ​Nature, vol. 409, no. 6819, ​2001, pp. 539​-542​, ​doi: 10.1038/35054102. 
    ​Details  DOI 
  • 2001 | Journal Article
    ​ ​Achsel, T., Holger Stark, and Reinhard Lührmann. "The Sm domain is an ancient RNA-binding motif with oligo(U) specificity​." ​Proceedings of the National Academy of Sciences of the United States of America, vol. 98, no. 7, ​2001, pp. 3685​-3689​, ​doi: 10.1073/pnas.071033998. 
    ​Details  DOI 

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