Prof. Dr. Reinhard Lührmann

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  • 2020 | Journal Article
    ​ ​Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome​
    Bertram, K.; El Ayoubi, L.; Dybkov, O.; Agafonov, D. E.; Will, C. L.; Hartmuth, K. & Urlaub, H.  et al.​ (2020) 
    Molecular Cell, 80(1) pp. 127​-139.e6​.​ DOI: https://doi.org/10.1016/j.molcel.2020.09.012 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Molecular architecture of the human 17S U2 snRNP​
    Zhang, Z.; Will, C. L.; Bertram, K.; Dybkov, O.; Hartmuth, K.; Agafonov, D. E. & Hofele, R. et al.​ (2020) 
    Nature, 583(7815) pp. 310​-313​.​ DOI: https://doi.org/10.1038/s41586-020-2344-3 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex​
    Haselbach, D.; Komarov, I.; Agafonov, D. E.; Hartmuth, K.; Graf, B.; Dybkov, O. & Urlaub, H.  et al.​ (2018) 
    Cell, 172(3) pp. 454​-464.e11​.​ DOI: https://doi.org/10.1016/j.cell.2018.01.010 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Yeast Prp2 liberates the 5′ splice site and the branch site adenosine for catalysis of pre-mRNA splicing​
    Bao, P.; Höbartner, C. ; Hartmuth, K. & Lührmann, R. ​ (2017) 
    RNA, 23(12) pp. 1770​-1779​.​ DOI: https://doi.org/10.1261/rna.063115.117 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Cryo-EM structure of a human spliceosome activated for step 2 of splicing​
    Bertram, K.; Agafonov, D. E.; Liu, W.-T.; Dybkov, O.; Will, C. L.; Hartmuth, K. & Urlaub, H.  et al.​ (2017) 
    Nature, 542(7641) pp. 318​.​ DOI: https://doi.org/10.1038/nature21079 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Molecular architecture of the Saccharomyces cerevisiae activated spliceosome​
    Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A. & Kumar, V. et al.​ (2016) 
    Science, 353(6306) pp. 1399​-1405​.​ DOI: https://doi.org/10.1126/science.aag1906 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper
    ​ ​Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome​
    Mathew, R.; Hartmuth, K.; Moehlmann, S.; Urlaub, H. ; Ficner, R.   & Luehrmann, R. ​ (2008) 
    Nature Structural & Molecular Biology, 15(5) pp. 435​-443​.​ DOI: https://doi.org/10.1038/nsmb.1415 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article
    ​ ​GraFix: sample preparation for single-particle electron cryomicroscopy​
    Kastner, B.; Fischer, N. ; Golas, M. M.; Sander, B.; Dube, P.; Boehringer, D. & Hartmuth, K. et al.​ (2007) 
    Nature Methods, 5(1) pp. 53​-55​.​ DOI: https://doi.org/10.1038/nmeth1139 
    ​Details  DOI 
  • 2007 | Journal Article
    ​ ​Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes​
    Behzadnia, N.; Golas, M. M.; Hartmuth, K.; Sander, B.; Kastner, B.; Deckert, J. & Dube, P. et al.​ (2007) 
    The EMBO Journal, 26(6) pp. 1737​-1748​.​ DOI: https://doi.org/10.1038/sj.emboj.7601631 
    ​Details  DOI 
  • 2006 | Journal Article
    ​ ​Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions​
    Deckert, J.; Hartmuth, K.; Boehringer, D.; Behzadnia, N.; Will, C. L.; Kastner, B. & Stark, H.  et al.​ (2006) 
    Molecular and Cellular Biology, 26(14) pp. 5528​-5543​.​ DOI: https://doi.org/10.1128/MCB.00582-06 
    ​Details  DOI 

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