Prof. Dr. Ralf Ficner

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  • 2023 | Journal Article
    ​ ​Structural and functional insights into tRNA recognition by human tRNA guanine transglycosylase​
    Sievers, K.; Neumann, P.; Sušac, L.; Da Vela, S.; Graewert, M.; Trowitzsch, S. & Svergun, D. et al.​ (2023) 
    Structure,.​ DOI: https://doi.org/10.1016/j.str.2023.12.006 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article
    ​ ​Highlight: integrative structural biology of dynamic macromolecular assemblies​
    Ficner, R. ​ (2023) 
    Biological Chemistry,.​ DOI: https://doi.org/10.1515/hsz-2023-0256 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Structure of angiogenin dimer bound to double‐stranded RNA​
    Sievers, K. & Ficner, R. ​ (2022) 
    Acta Crystallographica Section F, 78(9) pp. 330​-337​.​ DOI: https://doi.org/10.1107/S2053230X22008317 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper
    ​ ​Structural model of the M7G46 Methyltransferase TrmB in complex with tRNA​
    Blersch, K. F.; Burchert, J.-P.; Gleber, S.-C. ; Welp, L.; Neumann, P.; Köster, S.   & Urlaub, H.  et al.​ (2021) 
    RNA Biology, pp. 1​-14​.​ DOI: https://doi.org/10.1080/15476286.2021.1925477 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Regulation of DEAH-box RNA helicases by G-patch proteins​
    Bohnsack, K. E.; Ficner, R. ; Bohnsack, M. T.   & Jonas, S.​ (2021) 
    Biological Chemistry, 402(5) pp. 561​-579​.​ DOI: https://doi.org/10.1515/hsz-2020-0338 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Crystal structure of human CRM1, covalently modified by 2‐mercaptoethanol on Cys528, in complex with RanGTP​
    Shaikhqasem, A.; Schmitt, K.; Valerius, O. & Ficner, R. ​ (2021) 
    Acta Crystallographica Section F Structural Biology Communications, 77(3) pp. 70​-78​.​ DOI: https://doi.org/10.1107/S2053230X2100203X 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Bucky Ball Is a Novel Zebrafish Vasa ATPase Activator​
    Perera, R. P.; Shaikhqasem, A.; Rostam, N.; Dickmanns, A.; Ficner, R. ; Tittmann, K. & Dosch, R.​ (2021) 
    Biomolecules, 11(10) pp. 1507​.​ DOI: https://doi.org/10.3390/biom11101507 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper
    ​ ​Structural and functional insights into human tRNA guanine transgylcosylase​
    Sievers, K.; Welp, L.; Urlaub, H. & Ficner, R. ​ (2021) 
    RNA Biology, pp. 1​-15​.​ DOI: https://doi.org/10.1080/15476286.2021.1950980 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​The structure of Prp2 bound to RNA and ADP-BeF 3 − reveals structural features important for RNA unwinding by DEAH-box ATPases​
    Hamann, F.; Zimmerningkat, L. C.; Becker, R. A.; Garbers, T. B.; Neumann, P.; Hub, J. S. & Ficner, R. ​ (2021) 
    Acta Crystallographica Section D Structural Biology, 77(4) pp. 496​-509​.​ DOI: https://doi.org/10.1107/S2059798321001194 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article
    ​ ​Structural analysis of the intrinsically disordered splicing factor Spp2 and its binding to the DEAH-box ATPase Prp2​
    Hamann, F.; Schmitt, A.; Favretto, F. ; Hofele, R.; Neumann, P. ; Xiang, S. & Urlaub, H.  et al.​ (2020) 
    Proceedings of the National Academy of Sciences, 117(6) pp. 2948​-2956​.​ DOI: https://doi.org/10.1073/pnas.1907960117 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Characterization of Inhibition Reveals Distinctive Properties for Human and Saccharomyces cerevisiae CRM1​
    Shaikhqasem, A.; Dickmanns, A. ; Neumann, P.   & Ficner, R. ​ (2020) 
    Journal of Medicinal Chemistry, 63(14) pp. 7545​-7558​.​ DOI: https://doi.org/10.1021/acs.jmedchem.0c00143 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​OpenPepXL: An Open-Source Tool for Sensitive Identification of Cross-Linked Peptides in XL-MS​
    Netz, E.; Dijkstra, T. M.; Sachsenberg, T.; Zimmermann, L.; Walzer, M.; Monecke, T.   & Ficner, R.  et al.​ (2020) 
    Molecular & Cellular Proteomics, 19(12) pp. 2157​-2168​.​ DOI: https://doi.org/10.1074/mcp.TIR120.002186 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c‐di‐AMP in Listeria monocytogenes​
    Gibhardt, J.; Heidemann, J. L.; Bremenkamp, R.; Rosenberg, J.; Seifert, R.; Kaever, V. & Ficner, R.  et al.​ (2020) 
    Environmental Microbiology, 22(7) pp. 2771​-2791​.​ DOI: https://doi.org/10.1111/1462-2920.15008 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Crystal structure of the Rab33B/Atg16L1 effector complex​
    Metje-Sprink, J.; Groffmann, J.; Neumann, P. ; Barg-Kues, B.; Ficner, R. ; Kühnel, K. & Schalk, A. M. et al.​ (2020) 
    Scientific Reports, 10(1).​ DOI: https://doi.org/10.1038/s41598-020-69637-0 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Defining the architecture of the human TIM22 complex by chemical crosslinking​
    Valpadashi, A.; Callegari, S. ; Linden, A.; Neumann, P. ; Ficner, R. ; Urlaub, H.   & Deckers, M.  et al.​ (2020) 
    FEBS Letters, 595(2) pp. 157​-168​.​ DOI: https://doi.org/10.1002/1873-3468.13978 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​A Cross-linking Mass Spectrometry Approach Defines Protein Interactions in Yeast Mitochondria​
    Linden, A.; Deckers, M. ; Parfentev, I.; Pflanz, R.; Homberg, B.; Neumann, P.   & Ficner, R.  et al.​ (2020) 
    Molecular & Cellular Proteomics, 19(7) pp. 1161​-1178​.​ DOI: https://doi.org/10.1074/mcp.RA120.002028 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Atg21 organizes Atg8 lipidation at the contact of the vacuole with the phagophore​
    Munzel, L.; Neumann, P. ; Otto, F. B.; Krick, R. ; Metje-Sprink, J.; Kroppen, B.   & Karedla, N.  et al.​ (2020) 
    Autophagy, pp. 1​-21​.​ DOI: https://doi.org/10.1080/15548627.2020.1766332 
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  • 2019 | Journal Article
    ​ ​Crystal structures of the c-di-AMP–synthesizing enzyme CdaA​
    Heidemann, J. L.; Neumann, P. ; Dickmanns, A.   & Ficner, R. ​ (2019) 
    Journal of Biological Chemistry, 294(27) pp. 10463​-10470​.​ DOI: https://doi.org/10.1074/jbc.RA119.009246 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Making and Breaking of an Essential Poison: the Cyclases and Phosphodiesterases That Produce and Degrade the Essential Second Messenger Cyclic di-AMP in Bacteria​
    Commichau, F. M. ; Heidemann, J. L.; Ficner, R.   & Stülke, J. ​ (2019) 
    Journal of Bacteriology, 201(1).​ DOI: https://doi.org/10.1128/JB.00462-18 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​RNA translocation mechanism of spliceosomal DEAH-box ATPases​
    Hamann, F.; Schmitt, A.; Favretto, F.; Zweckstetter, M. & Ficner, R. ​ (2019) 
    Acta Crystallographica Section A Foundations and Advances, 75(a2) pp. e100​-e100​.​ DOI: https://doi.org/10.1107/S2053273319094567 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Assessment of model bias in crystallographic maps and its implications for validation of crystal structures​
    Neumann, P. & Ficner, R. ​ (2019) 
    Acta Crystallographica Section A Foundations and Advances, 75(a2) pp. e163​-e163​.​ DOI: https://doi.org/10.1107/S2053273319093938 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Structural basis for RNA translocation by DEAH-box ATPases​
    Hamann, F.; Enders, M. & Ficner, R. ​ (2019) 
    Nucleic Acids Research, 47(8) pp. 4349​-4362​.​ DOI: https://doi.org/10.1093/nar/gkz150 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Structural basis for the regulatory interaction of the methylglyoxal synthase MgsA with the carbon flux regulator Crh in Bacillus subtilis​
    Dickmanns, A. ; Zschiedrich, C. P.; Arens, J.; Parfentev, I.; Gundlach, J.; Hofele, R. & Neumann, P.  et al.​ (2018) 
    Journal of Biological Chemistry, 293(16) pp. 5781​-5792​.​ DOI: https://doi.org/10.1074/jbc.RA117.001289 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Validating Resolution Revolution​
    Neumann, P. ; Dickmanns, A.   & Ficner, R. ​ (2018) 
    Structure, 26(5) pp. 785​-795.e4​.​ DOI: https://doi.org/10.1016/j.str.2018.03.004 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Validating Resolution Revolution​
    Neumann, P.; Dickmanns, A. & Ficner, R. ​ (2018) 
    Structure, 26(12) pp. 1678​.​ DOI: https://doi.org/10.1016/j.str.2018.10.028 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Crystal structure of the spliceosomal DEAH-box ATPase Prp2​
    Schmitt, A.; Hamann, F.; Neumann, P.   & Ficner, R. ​ (2018) 
    Acta crystallographica. Section D, Structural biology, 74(7) pp. 643​-654​.​ DOI: https://doi.org/10.1107/S2059798318006356 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Structural insights into the stimulation of S. pombe Dnmt2 catalytic efficiency by the tRNA nucleoside queuosine​
    Johannsson, S.; Neumann, P. ; Wulf, A.; Welp, L. M.; Gerber, H.-D.; Krull, M. & Diederichsen, U.  et al.​ (2018) 
    Scientific Reports, 8(1).​ DOI: https://doi.org/10.1038/s41598-018-27118-5 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Sem1 links proteasome stability and specificity to multicellular development​
    Kolog Gulko, M.; Heinrich, G.; Gross, C.; Popova, B. ; Valerius, O. ; Neumann, P.   & Ficner, R.  et al.​ (2018) 
    PLOS Genetics, 14(2) art. e1007141​.​ DOI: https://doi.org/10.1371/journal.pgen.1007141 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Crystal Structure of the Human tRNA Guanine Transglycosylase Catalytic Subunit QTRT1​
    Johannsson, S.; Neumann, P. & Ficner, R. ​ (2018) 
    Biomolecules, 8(3) art. 81​.​ DOI: https://doi.org/10.3390/biom8030081 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Biallelic mutations in nucleoporin NUP88 cause lethal fetal akinesia deformation sequence​
    Bonnin, E.; Cabochette, P.; Filosa, A.; Jühlen, R.; Komatsuzaki, S.; Hezwani, M. & Dickmanns, A. et al.​ (2018) 
    PLOS Genetics, 14(12) art. e1007845​.​ DOI: https://doi.org/10.1371/journal.pgen.1007845 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​Studying structure and function of spliceosomal helicases​
    Ficner, R. ; Dickmanns, A.   & Neumann, P. ​ (2017) 
    Methods, 125 pp. 63​-69​.​ DOI: https://doi.org/10.1016/j.ymeth.2017.06.028 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2​
    Fourmann, J.-B.; Tauchert, M. J. ; Ficner, R. ; Fabrizio, P. & Lührmann, R. ​ (2017) 
    Nucleic Acids Research, 45(7) pp. 4068​-4080​.​ DOI: https://doi.org/10.1093/nar/gkw1225 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Activity-Dependent Phosphorylation by CaMKIIδ Alters the Ca2+ Affinity of the Multi-C2-Domain Protein Otoferlin​
    Meese, S. ; Cepeda, A. P. ; Gahlen, F.; Adams, C. M.; Ficner, R. ; Ricci, A. J. & Heller, S. et al.​ (2017) 
    Frontiers in Synaptic Neuroscience, 9 art. 13​.​ DOI: https://doi.org/10.3389/fnsyn.2017.00013 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Lipoxygenase 2 from Cyanothece sp. controls dioxygen insertion by steric shielding and substrate fixation​
    Newie, J.; Neumann, P. ; Werner, M.; Mata, R. A. ; Ficner, R.   & Feussner, I. ​ (2017) 
    Scientific Reports, 7(1) art. 2069​.​ DOI: https://doi.org/10.1038/s41598-017-02153-w 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Structural insights into RapZ-mediated regulation of bacterial amino-sugar metabolism​
    Gonzalez, G. M.; Durica-Mitic, S.; Hardwick, S. W.; Moncrieffe, M. C.; Resch, M.; Neumann, P.   & Ficner, R.  et al.​ (2017) 
    Nucleic Acids Research, 45(18) pp. 10845​-10860​.​ DOI: https://doi.org/10.1093/nar/gkx732 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Structural insights into the mechanism of the DEAH-box RNA helicase Prp43​
    Tauchert, M. J.; Fourmann, J.-B.; Lührmann, R. & Ficner, R. ​ (2017) 
    eLife, 6 art. e21510​.​ DOI: https://doi.org/10.7554/eLife.21510 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper
    ​ ​Impact of the crystallization condition on importin-β conformation​
    Tauchert, M. J. ; Hémonnot, C. ; Neumann, P. ; Köster, S. ; Ficner, R.   & Dickmanns, A. ​ (2016) 
    Acta crystallographica. Section D, Structural biology, 72(6) pp. 705​-717​.​ DOI: https://doi.org/10.1107/S2059798316004940 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Conference Abstract
    ​ ​How reliable are atomic models based on cryo-EM reconstructions? Improvements in model fitting and validation​
    Neumann, P. ; Fischer, N. ; Stark, H.   & Ficner, R. ​ (2016)
    ​Acta Crystallographica Section A, 72(Part a1) Acta Crystallographica Section A Foundations and Advances, (a1) pp. s45​-s45. (Vol. 72). , Basel, Switzerland. DOI: https://doi.org/10.1107/S2053273316099307 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Crystal structure of the 239 kDa nuclear export complex CRM1 - RanGTP - Snurportin1 - Nup214 - MBP​
    Ficner, R. ; Monecke, T. ; Port, S. A.; Weiß, M. S.; Kehlenbach, R. H.   & Dickmanns, A. ​ (2016) 
    Acta Crystallographica Section A Foundations and Advances, 72(a1) pp. s30​-s30​.​ DOI: https://doi.org/10.1107/S2053273316099526 
    ​Details  DOI 
  • 2016 | Journal Article | Research Paper
    ​ ​Structural analysis of the spliceosomal RNA helicase Prp28 from the thermophilic eukaryote Chaetomium thermophilum​
    Tauchert, M. J.   & Ficner, R. ​ (2016) 
    Acta Crystallographica Section F Structural Biology Communications, 72(5) pp. 409​-416​.​ DOI: https://doi.org/10.1107/S2053230X16006038 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​The pathway to GTPase activation of elongation factor SelB on the ribosome​
    Fischer, N. ; Neumann, P. ; Bock, L. V. ; Maracci, C. ; Wang, Z.; Paleskava, A.   & Konevega, A. L.  et al.​ (2016) 
    Nature, 540(7631) pp. 80​-85​.​ DOI: https://doi.org/10.1038/nature20560 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Combretastatin A-4 derived 5-(1-methyl-4-phenyl-imidazol-5-yl)indoles with superior cytotoxic and anti-vascular effects on chemoresistant cancer cells and tumors​
    Mahal, K.; Biersack, B.; Schruefer, S.; Resch, M.; Ficner, R. ; Schobert, R. & Mueller, T.​ (2016) 
    European Journal of Medicinal Chemistry, 118 pp. 9​-20​.​ DOI: https://doi.org/10.1016/j.ejmech.2016.04.045 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction​
    Fourmann, J.-B.; Dybkov, O.; Agafonov, D. E; Tauchert, M. J ; Urlaub, H. ; Ficner, R.   & Fabrizio, P. et al.​ (2016) 
    eLife, 5 art. e15564​.​ DOI: https://doi.org/10.7554/eLife.15564 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Crystal structure of a lipoxygenase from Cyanothece sp may reveal novel features for substrate acquisition​
    Newie, J.; Andreou, A.; Neumann, P. ; Einsle, O.; Feussner, I.   & Ficner, R. ​ (2016) 
    Journal of Lipid Research, 57(2) pp. 276​-287​.​ DOI: https://doi.org/10.1194/jlr.M064980 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity​
    Boesler, C.; Rigo, N.; Anokhina, M. M.; Tauchert, M. J. ; Agafonov, D. E.; Kastner, B. & Urlaub, H.  et al.​ (2016) 
    Nature Communications, 7 art. 11997​.​ DOI: https://doi.org/10.1038/ncomms11997 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum​
    Tauchert, M. J. ; Fourmann, J.-B.; Christian, H.; Lührmann, R.   & Ficner, R. ​ (2016) 
    Acta Crystallographica Section F Structural Biology Communications, 72(2) pp. 112​-120​.​ DOI: https://doi.org/10.1107/S2053230X15024498 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Crystal Structure of Alcohol Oxidase from Pichia pastoris​
    Koch, C.; Neumann, P. ; Valerius, O. ; Feussner, I.   & Ficner, R. ​ (2016) 
    PLoS ONE, 11(2) art. e0149846​.​ DOI: https://doi.org/10.1371/journal.pone.0149846 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Conference Abstract
    ​ ​Breaking the 3 angstrom resolution barrier in single particle cryo-EM​
    Fischer, N.; Neumann, P.; Bock, L.; Ficner, R. ; Rodnina, M.   & Stark, H. ​ (2015)
    European Biophysics Journal, 44 , Dresden, GERMANY.
    New york​: Springer.
    ​Details  WoS 
  • 2015 | Journal Article | 
    ​ ​Structural Basis of Targeting the Exportin CRM1 in Cancer​
    Dickmanns, A. ; Monecke, T.   & Ficner, R. ​ (2015) 
    Cells, 4(3) pp. 538​-568​.​ DOI: https://doi.org/10.3390/cells4030538 
    ​Details  DOI 
  • 2015 | Journal Article | Research Paper
    ​ ​MD Simulations and FRET Reveal an Environment: Sensitive Conformational Plasticity of Importin-beta​
    Halder, K.; Doelker, N.; Van, Q. ; Gregor, I. ; Dickmanns, A. ; Baade, I.   & Kehlenbach, R. H.  et al.​ (2015) 
    Biophysical Journal, 109(2) pp. 277​-286​.​ DOI: https://doi.org/10.1016/j.bpj.2015.06.014 
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  • 2015 | Journal Article | Research Paper
    ​ ​Disruption of adaptor protein 2μ (AP‐2μ) in cochlear hair cells impairs vesicle reloading of synaptic release sites and hearing​
    Jung, S. ; Maritzen, T.; Wichmann, C. ; Jing, Z.; Neef, A. ; Revelo, N. H.   & Al-Moyed, H. et al.​ (2015) 
    EMBO Journal, 34(21) pp. 2686​-2702​.​ DOI: https://doi.org/10.15252/embj.201591885 
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  • 2015 | Journal Article | Research Paper | 
    ​ ​Structure of the E. coli ribosome-EF-Tu complex at <3 Å resolution by Cs-corrected cryo-EM​
    Fischer, N. ; Neumann, P. ; Konevega, A. L. ; Bock, L. V. ; Ficner, R. ; Rodnina, M. V.   & Stark, H. ​ (2015) 
    Nature, 520(7548) pp. 567​-570​.​ DOI: https://doi.org/10.1038/nature14275 
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  • 2015 | Journal Article | Research Paper | 
    ​ ​Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2​
    Kuhle, B.; Eulig, N. K. & Ficner, R. ​ (2015) 
    Nucleic Acids Research, 43(20) pp. 9994​-10014​.​ DOI: https://doi.org/10.1093/nar/gkv930 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​A presequence-binding groove in Tom70 supports import of Mdl1 into mitochondria​
    Melin, J. ; Kilisch, M. ; Neumann, P. ; Lytovchenko, O. ; Gomkale, R.; Schendzielorz, A. B.   & Schmidt, B.  et al.​ (2015) 
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1853(8) pp. 1850​-1859​.​ DOI: https://doi.org/10.1016/j.bbamcr.2015.04.021 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Role of JNK and NF-κB in mediating the effect of combretastatin A-4 and brimamin on endothelial and carcinoma cells​
    Mahal, K.; Ahmad, A.; Sethi, S.; Resch, M.; Ficner, R. ; Sarkar, F. H. & Schobert, R. et al.​ (2015) 
    Cellular Oncology, 38(6) pp. 463​-478​.​ DOI: https://doi.org/10.1007/s13402-015-0243-7 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Structural and Biochemical Analysis of the Essential Diadenylate Cyclase CdaA from Listeria monocytogenes​
    Rosenberg, J. M.; Dickmanns, A. ; Neumann, P. ; Gunka, K. ; Arens, J.; Kaever, V. & Stuelke, J.  et al.​ (2015) 
    Journal of biological chemistry, 290(10) pp. 6596​-6606​.​ DOI: https://doi.org/10.1074/jbc.M114.630418 
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  • 2015 | Review
    ​ ​A jack of all trades: the multiple roles of the unique essential second messenger cyclic di-AMP​
    Commichau, F. M. ; Dickmanns, A. ; Gundlach, J.; Ficner, R.  & Stuelke, J. ​ (2015)
    Molecular Microbiology, 97​(2) pp. 189​-204​.​
    Wiley-blackwell. DOI: https://doi.org/10.1111/mmi.13026 
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  • 2015 | Journal Article | Research Paper | 
    ​ ​Structural and Functional Characterization of CRM1-Nup214 Interactions Reveals Multiple FG-Binding Sites Involved in Nuclear Export​
    Port, S. A.; Monecke, T. ; Dickmanns, A. ; Spillner, C.; Hofele, R.; Urlaub, H.   & Ficner, R.  et al.​ (2015) 
    Cell Reports, 13(4) pp. 690​-702​.​ DOI: https://doi.org/10.1016/j.celrep.2015.09.042 
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  • 2015 | Journal Article | Research Paper
    ​ ​Tuning and Switching Enantioselectivity of Asymmetric Carboligation in an Enzyme through Mutational Analysis of a Single Hot Spot​
    Wechsler, C.; Meyer, D.; Loschonsky, S.; Funk, L.-M. ; Neumann, P. ; Ficner, R.   & Brodhun, F.  et al.​ (2015) 
    ChemBioChem, 16(18) pp. 2580​-2584​.​ DOI: https://doi.org/10.1002/cbic.201500529 
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  • 2015 | Journal Article | Research Paper
    ​ ​Identification, Characterization, and Structure Analysis of the Cyclic di-AMP-binding P-II-like Signal Transduction Protein DarA​
    Gundlach, J.; Dickmanns, A. ; Schröder-Tittmann, K. ; Neumann, P. ; Kaesler, J.; Kampf, J. & Herzberg, C. et al.​ (2015) 
    Journal of biological chemistry, 290(5) pp. 3069​-3080​.​ DOI: https://doi.org/10.1074/jbc.M114.619619 
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  • 2015 | Journal Article | Research Paper
    ​ ​Combining dehydration, construct optimization and improved data collection to solve the crystal structure of a CRM1-RanGTP-SPN1-Nup214 quaternary nuclear export complex​
    Monecke, T. ; Dickmanns, A. ; Weiss, M. S.; Port, S. A.; Kehlenbach, R. H.   & Ficner, R. ​ (2015) 
    Acta Crystallographica Section F Structural Biology Communications, 71 pp. 1481​-1487​.​ DOI: https://doi.org/10.1107/S2053230X15021524 
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  • 2014 | Review
    ​ ​RNA synthesis and purification for structural studies​
    Ahmed, Y. L.& Ficner, R. ​ (2014)
    RNA Biology, 11​(5) pp. 427​-432​.​
    Taylor & Francis Inc. DOI: https://doi.org/10.4161/rna.28076 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Structural insight into the recognition of amino-acylated initiator tRNA by eIF5B in the 80S initiation complex​
    Kuhle, B. & Ficner, R. ​ (2014) 
    BMC Structural Biology, 14 art. 20​.​ DOI: https://doi.org/10.1186/s12900-014-0020-2 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28​
    Moehlmann, S.; Mathew, R.; Neumann, P. ; Schmitt, A.; Luehrmann, R.   & Ficner, R. ​ (2014) 
    Acta Crystallographica Section D Biological Crystallography, 70 pp. 1622​-1630​.​ DOI: https://doi.org/10.1107/S1399004714006439 
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  • 2014 | Journal Article | Research Paper
    ​ ​Crystal structures of two tetrameric β‐carbonic anhydrases from the filamentous ascomycete Sordaria macrospora​
    Lehneck, R.; Neumann, P. ; Vullo, D.; Elleuche, S.; Supuran, C. T.; Ficner, R.   & Pöggeler, S. ​ (2014) 
    FEBS Journal, 281(7) pp. 1759​-1772​.​ DOI: https://doi.org/10.1111/febs.12738 
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  • 2014 | Journal Article | Research Paper
    ​ ​A monovalent cation acts as structural and catalytic cofactor in translational GTPases​
    Kuhle, B. & Ficner, R. ​ (2014) 
    EMBO Journal, 33(21) pp. 2547​-2563​.​ DOI: https://doi.org/10.15252/embj.201488517 
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  • 2014 | Journal Article | Research Paper | 
    ​ ​Insights into the activation of the helicase Prp43 by biochemical studies and structural mass spectrometry​
    Christian, H.; Hofele, R. V.; Urlaub, H.   & Ficner, R. ​ (2014) 
    Nucleic Acids Research, 42(2) pp. 1162​-1179​.​ DOI: https://doi.org/10.1093/nar/gkt985 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Review | 
    ​ ​Allosteric control of the exportin CRM1 unraveled by crystal structure analysis​
    Monecke, T. ; Dickmanns, A.  & Ficner, R. ​ (2014)
    FEBS Journal, 281​(18) pp. 4179​-4194​.​
    Wiley-blackwell. DOI: https://doi.org/10.1111/febs.12842 
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  • 2014 | Journal Article | Research Paper | 
    ​ ​Structural integrity of the PCI domain of eIF3a/TIF32 is required for mRNA recruitment to the 43S pre-initiation complexes​
    Khoshnevis, S.; Gunisova, S.; Vlckova, V.; Kouba, T.; Neumann, P. ; Beznoskova, P. & Ficner, R.  et al.​ (2014) 
    Nucleic Acids Research, 42(6) pp. 4123​-4139​.​ DOI: https://doi.org/10.1093/nar/gkt1369 
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  • 2014 | Journal Article | Research Paper | 
    ​ ​Crystal Structures of the Novel Cytosolic 5'-Nucleotidase IIIB Explain Its Preference for m7GMP​
    Monecke, T. ; Buschmann, J.; Neumann, P. ; Wahle, E. & Ficner, R. ​ (2014) 
    PLoS ONE, 9(3) art. e90915​.​ DOI: https://doi.org/10.1371/journal.pone.0090915 
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  • 2014 | Journal Article | Research Paper
    ​ ​Effects of the Tumor-Vasculature-Disrupting Agent Verubulin and Two Heteroaryl Analogues on Cancer Cells, Endothelial Cells, and Blood Vessels​
    Mahal, K.; Resch, M.; Ficner, R. ; Schobert, R.; Biersack, B. & Mueller, T.​ (2014) 
    ChemMedChem, 9(4) pp. 847​-854​.​ DOI: https://doi.org/10.1002/cmdc.201300531 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Crystal structure of a 4-thiouridine synthetase-RNA complex reveals specificity of tRNA U8 modification​
    Neumann, P. ; Lakomek, K.; Naumann, P.-T.; Erwin, W. M.; Lauhon, C. T. & Ficner, R. ​ (2014) 
    Nucleic Acids Research, 42(10) pp. 6673​-6685​.​ DOI: https://doi.org/10.1093/nar/gku249 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​eIF5B employs a novel domain release mechanism to catalyze ribosomal subunit joining​
    Kuhle, B. & Ficner, R. ​ (2014) 
    EMBO Journal, 33(10) pp. 1177​-1191​.​ DOI: https://doi.org/10.1002/embj.201387344 
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  • 2014 | Journal Article | Research Paper
    ​ ​Translation Initiation Factor eIF3b Contains a Nine-Bladed β-Propeller and Interacts with the 40S Ribosomal Subunit​
    Liu, Y.; Neumann, P. ; Kuhle, B.; Monecke, T. ; Schell, S.; Chari, A. & Ficner, R. ​ (2014) 
    Structure, 22(6) pp. 923​-930​.​ DOI: https://doi.org/10.1016/j.str.2014.03.010 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Crystal structures of fungal velvet regulators reveal an unexpected similarity to NF-κB​
    Ficner, R. ​ (2013) 
    Acta Crystallographica Section A Foundations and Advances, 69(a1) pp. s70​.​ DOI: https://doi.org/10.1107/S0108767313099406 
    ​Details  DOI 
  • 2013 | Journal Article
    ​ ​Structural Determinants of Conformational Flexibility and Long-Range Allostery of the CRM1 Export Complex​
    Monecke, T. ; Haselbach, D.; Voß, B.; Russek, A.; Neumann, P. ; Thomson, E. & Hurt, E. et al.​ (2013) 
    Biophysical Journal, 104(2, Supplement 1) pp. 68a​.​ DOI: https://doi.org/10.1016/j.bpj.2012.11.411 
    ​Details  DOI 
  • 2013 | Journal Article | Research Paper
    ​ ​Crystallization and preliminary X-ray diffraction analysis of YhbJ from Escherichia coli, a key protein involved in the GlmYZ sRNA regulatory cascade​
    Resch, M.; Göpel, Y.; Görke, B. & Ficner, R. ​ (2013) 
    Acta Crystallographica Section F Structural Biology Communications, 69 pp. 109​-114​.​ DOI: https://doi.org/10.1107/S1744309112048622 
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  • 2013 | Journal Article | Research Paper
    ​ ​Sub-ångström-resolution crystallography reveals physical distortions that enhance reactivity of a covalent enzymatic intermediate​
    Lüdtke, S.; Neumann, P. ; Erixon, K. M.; Leeper, F.; Kluger, R.; Ficner, R.   & Tittmann, K. ​ (2013) 
    Nature Chemistry, 5(9) pp. 762​-767​.​ DOI: https://doi.org/10.1038/NCHEM.1728 
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  • 2013 | Journal Article | Research Paper
    ​ ​Structural basis for cooperativity of CRM1 export complex formation​
    Monecke, T. ; Haselbach, D.; Voss, B.; Russek, A.; Neumann, P. ; Thomson, E. & Hurt, E. et al.​ (2013) 
    Proceedings of the National Academy of Sciences, 110(3) pp. 960​-965​.​ DOI: https://doi.org/10.1073/pnas.1215214110 
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  • 2013 | Journal Article | Research Paper
    ​ ​Purification, crystallization and preliminary crystallographic analysis of a 4-thiouridine synthetase-RNA complex​
    Naumann, P.-T.; Lauhon, C. T. & Ficner, R. ​ (2013) 
    Acta Crystallographica Section F Structural Biology and Crystallization Communications, 69 pp. 421​-424​.​ DOI: https://doi.org/10.1107/S1744309113004077 
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  • 2013 | Journal Article | Research Paper
    ​ ​Phosphorylation Drives a Dynamic Switch in Serine/Arginine-Rich Proteins​
    Xiang, S.; Gapsys, V. ; Kim, H.-Y.; Bessonov, S.; Hsiao, H.-H.; Moehlmann, S. & Klaukien, V. et al.​ (2013) 
    Structure, 21(12) pp. 2162​-2174​.​ DOI: https://doi.org/10.1016/j.str.2013.09.014 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Structural Determinants and Mechanism of Mammalian CRM1 Allostery​
    Doelker, N.; Blanchet, C. E.; Voss, B.; Haselbach, D.; Kappel, C.; Monecke, T.   & Svergun, D. I. et al.​ (2013) 
    Structure, 21(8) pp. 1350​-1360​.​ DOI: https://doi.org/10.1016/j.str.2013.05.015 
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  • 2013 | Journal Article | Research Paper
    ​ ​Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system​
    Fourmann, J.-B.; Schmitzová, J.; Christian, H.; Urlaub, H. ; Ficner, R. ; Boon, K.-L.   & Fabrizio, P. et al.​ (2013) 
    Genes & Development, 27(4) pp. 413​-428​.​ DOI: https://doi.org/10.1101/gad.207779.112 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Crystal structure analysis of a fatty acid double-bond hydratase from Lactobacillus acidophilus​
    Volkov, A.; Khoshnevis, S.; Neumann, P. ; Herrfurth, C. ; Wohlwend, D.; Ficner, R.   & Feussner, I. ​ (2013) 
    Acta Crystallographica Section D Biological Crystallography, 69 pp. 648​-657​.​ DOI: https://doi.org/10.1107/S0907444913000991 
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  • 2013 | Journal Article | Research Paper | 
    ​ ​The Velvet Family of Fungal Regulators Contains a DNA-Binding Domain Structurally Similar to NF-κB​
    Ahmed, Y. L.; Gerke, J.; Park, H.-S.; Bayram, O.; Neumann, P. ; Ni, M. & Dickmanns, A.  et al.​ (2013) 
    PLoS Biology, 11(12) art. e1001750​.​ DOI: https://doi.org/10.1371/journal.pbio.1001750 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​Observation of a stable carbene at the active site of a thiamin enzyme​
    Meyer, D.; Neumann, P. ; Ficner, R.   & Tittmann, K. ​ (2013) 
    Nature Chemical Biology, 9(8) pp. 488​-U84​.​ DOI: https://doi.org/10.1038/nchembio.1275 
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  • 2012 | Journal Article | Research Paper
    ​ ​Unexpected tautomeric equilibria of the carbanion-enamine intermediate in pyruvate oxidase highlight unrecognized chemical versatility of thiamin​
    Meyer, D.; Neumann, P. ; Koers, E.; Sjuts, H.; Lüdtke, S.; Sheldrick, G. M.   & Ficner, R.  et al.​ (2012) 
    Proceedings of the National Academy of Sciences, 109(27) pp. 10867​-10872​.​ DOI: https://doi.org/10.1073/pnas.1201280109 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Research Paper
    ​ ​Structural analysis of the C-terminal domain of the spliceosomal helicase Prp22​
    Kudlinzki, D.; Schmitt, A.; Christian, H. & Ficner, R. ​ (2012) 
    Biological Chemistry, 393(10) pp. 1131​-1140​.​ DOI: https://doi.org/10.1515/hsz-2012-0158 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Research Paper
    ​ ​Novel insights into the architecture and protein interaction network of yeast eIF3​
    Khoshnevis, S.; Hauer, F.; Milon, P. ; Stark, H.   & Ficner, R. ​ (2012) 
    RNA, 18(12) pp. 2306​-2319​.​ DOI: https://doi.org/10.1261/rna.032532.112 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Research Paper | 
    ​ ​Structure Analysis of Entamoeba histolytica DNMT2 (EhMeth)​
    Schulz, E. C.; Roth, H. M.; Ankri, S. & Ficner, R. ​ (2012) 
    PLoS ONE, 7(6) art. e38728​.​ DOI: https://doi.org/10.1371/journal.pone.0038728 
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  • 2012 | Journal Article | Research Paper
    ​ ​Crystal Structures of Physcomitrella patens AOC1 and AOC2: Insights into the Enzyme Mechanism and Differences in Substrate Specificity​
    Neumann, P. ; Brodhun, F. ; Sauer, K.; Herrfurth, C. ; Hamberg, M.; Brinkmann, J. & Scholz, J. et al.​ (2012) 
    PLANT PHYSIOLOGY, 160(3) pp. 1251​-1266​.​ DOI: https://doi.org/10.1104/pp.112.205138 
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  • 2012 | Journal Article | Research Paper | 
    ​ ​The Aspergillus nidulans MAPK Module AnSte11-Ste50-Ste7-Fus3 Controls Development and Secondary Metabolism​
    Bayram, O.; Bayram, Ö. S.; Ahmed, Y. L.; Maruyama, J.-i.; Valerius, O. ; Rizzoli, S.   & Ficner, R.  et al.​ (2012) 
    PLOS Genetics, 8(7) art. e1002816​.​ DOI: https://doi.org/10.1371/journal.pgen.1002816 
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  • 2011 | Conference Abstract
    ​ ​Allostery in nuclear export: a hybrid methods approach​
    Doelker, N.; Blanchet, C.; Monecke, T.; Svergun, D. I.; Ficner, R. ; Grubmüller, H.   & Dickmanns, A.​ (2011)
    European Biophysics Journal, 40 pp. 104​-105. , Budapest, HUNGARY.
    New york​: Springer.
    ​Details  WoS 
  • 2011 | Journal Article | Research Paper
    ​ ​Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism​
    Lehwess-Litzmann, A.; Neumann, P. ; Parthier, C.; Luedtke, S.; Golbik, R.; Ficner, R.   & Tittmann, K. ​ (2011) 
    Nature Chemical Biology, 7(10) pp. 678​-684​.​ DOI: https://doi.org/10.1038/NCHEMBIO.633 
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  • 2011 | Journal Article | Research Paper
    ​ ​Structural Basis for the Broad Substrate Range of the UDP-Sugar Pyrophosphorylase from Leishmania major​
    Dickmanns, A. ; Damerow, S.; Neumann, P. ; Schulz, E.-C.; Lamerz, A.-C.; Routier, F. H. & Ficner, R. ​ (2011) 
    Journal of Molecular Biology, 405(2) pp. 461​-478​.​ DOI: https://doi.org/10.1016/j.jmb.2010.10.057 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper
    ​ ​Structure analysis of Entamoeba histolytica enolase​
    Schulz, E. C.; Tietzel, M.; Tovy, A.; Ankri, S. & Ficner, R. ​ (2011) 
    Acta Crystallographica Section D Biological Crystallography, 67 pp. 619​-627​.​ DOI: https://doi.org/10.1107/S0907444911016544 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper | 
    ​ ​Tim50's presequence receptor domain is essential for signal driven transport across the TIM23 complex​
    Schulz, C. ; Lytovchenko, O. ; Melin, J. ; Chacinska, A.; Guiard, B.; Neumann, P.   & Ficner, R.  et al.​ (2011) 
    The Journal of Cell Biology, 195(4) pp. 643​-656​.​ DOI: https://doi.org/10.1083/jcb.201105098 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper | 
    ​ ​Crystal Structure Analysis of the Polysialic Acid Specific O-Acetyltransferase NeuO​
    Schulz, E. C.; Bergfeld, A. K.; Ficner, R.   & Muehlenhoff, M.​ (2011) 
    PLoS ONE, 6(3) art. e17403​.​ DOI: https://doi.org/10.1371/journal.pone.0017403 
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  • 2011 | Journal Article | Research Paper
    ​ ​The Crystal Structure of the C(2)A Domain of Otoferlin Reveals an Unconventional Top Loop Region​
    Helfmann, S.; Neumann, P. ; Tittmann, K. ; Moser, T. ; Ficner, R.   & Reisinger, E. ​ (2011) 
    Journal of Molecular Biology, 406(3) pp. 479​-490​.​ DOI: https://doi.org/10.1016/j.jmb.2010.12.031 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper
    ​ ​Knitting and snipping: chaperones in beta-helix folding​
    Schulz, E. C. & Ficner, R. ​ (2011) 
    Current Opinion in Structural Biology, 21(2) pp. 232​-239​.​ DOI: https://doi.org/10.1016/j.sbi.2011.01.009 
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  • 2010 | Journal Article
    ​ ​Structural basis for CRM1 nuclear export complex assembly​
    Monecke, T. ; Güttler, T.; Neumann, P. ; Doelker, N.; Blanchet, C.; Dickmanns, A.   & Görlich, D. et al.​ (2010) 
    Acta Crystallographica. Section A, Foundations and Advances, 66(a1) pp. s30​-s31​.​ DOI: https://doi.org/10.1107/S0108767310099319 
    ​Details  DOI 
  • 2010 | Journal Article
    ​ ​Crystal structure of a homodimeric 4-thiouridine synthetase-RNA complex​
    Neumann, P.; Lakomek, K.; Naumann, P.-T.; Dickmanns, A.; Lauhon, C. T. & Ficner, R. ​ (2010) 
    Acta Crystallographica Section A Foundations of Crystallography, 66(a1) pp. s22​-s22​.​ DOI: https://doi.org/10.1107/S0108767310099514 
    ​Details  DOI 
  • 2010 | Journal Article
    ​ ​Structure of an intramolecular chaperone mediating triple-β-helix folding​
    Schulz, E. C.; Dickmanns, A.; Urlaub, H.; Schmitt, A.; Mühlenhoff, M.; Stummeyer, K. & Schwarzer, D. et al.​ (2010) 
    Acta Crystallographica Section A Foundations of Crystallography, 66(a1) pp. s25​-s25​.​ DOI: https://doi.org/10.1107/S0108767310099460 
    ​Details  DOI 
  • 2010 | Conference Abstract
    ​ ​Prokaryotic FAD-containing oxidoreductases are novel players in fatty acid metabolism​
    Volkov, A.; Liavonchanka, A.; Fiedler, T.; Khoshnevis, S.; Neumann, P.; Goebel, C. & Ficner, R.  et al.​ (2010)
    Chemistry and Physics of Lipids, 163 , Alhondiga Conf, Bilbao, SPAIN.
    Clare​: Elsevier Ireland Ltd. DOI: https://doi.org/10.1016/j.chemphyslip.2010.05.052 
    ​Details  DOI  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Crystal Structure of the RNA Recognition Motif of Yeast Translation Initiation Factor eIF3bw Reveals Differences to Human eIF3b​
    Khoshnevis, S.; Neumann, P.   & Ficner, R. ​ (2010) 
    PLoS ONE, 5(9) art. e12784​.​ DOI: https://doi.org/10.1371/journal.pone.0012784 
    ​Details  DOI  WoS 
  • 2010 | Journal Article | Research Paper
    ​ ​Crystal structure of an intramolecular chaperone mediating triple-beta-helix folding​
    Schulz, E. C.; Dickmanns, A. ; Urlaub, H. ; Schmitt, A.; Muehlenhoff, M.; Stummeyer, K. & Schwarzer, D. et al.​ (2010) 
    Nature Structural & Molecular Biology, 17(2) pp. 210​-U11​.​ DOI: https://doi.org/10.1038/nsmb.1746 
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  • 2010 | Journal Article | Research Paper | 
    ​ ​Mapping the binding site of snurportin 1 on native U1 snRNP by cross-linking and mass spectrometry​
    Kuehn-Hoelsken, E.; Lenz, C. ; Dickmanns, A. ; Hsiao, H.-H.; Richter, F. M.; Kastner, B. & Ficner, R.  et al.​ (2010) 
    Nucleic Acids Research, 38(16) pp. 5581​-5593​.​ DOI: https://doi.org/10.1093/nar/gkq272 
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  • 2010 | Journal Article | Research Paper | 
    ​ ​Structure analysis of endosialidase NF at 0.98 angstrom resolution​
    Schulz, E. C.; Neumann, P. ; Gerardy-Schahn, R.; Sheldrick, G. M.   & Ficner, R. ​ (2010) 
    Acta Crystallographica Section D Biological Crystallography, 66 pp. 176​-180​.​ DOI: https://doi.org/10.1107/S0907444909048720 
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  • 2010 | Journal Article | Research Paper
    ​ ​Crystal Structure Analysis of DNA Uridine Endonuclease Mth212 Bound to DNA​
    Lakomek, K.; Dickmanns, A. ; Ciirdaeva, E.; Schomacher, L. & Ficner, R. ​ (2010) 
    Journal of Molecular Biology, 399(4) pp. 604​-617​.​ DOI: https://doi.org/10.1016/j.jmb.2010.04.044 
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  • 2010 | Journal Article | Research Paper
    ​ ​Structural Basis for the Recognition and Cleavage of Polysialic Acid by the Bacteriophage K1F Tailspike Protein EndoNF​
    Schulz, E. C.; Schwarzer, D.; Frank, M.; Stummeyer, K.; Muehlenhoff, M.; Dickmanns, A.   & Gerardy-Schahn, R. et al.​ (2010) 
    Journal of Molecular Biology, 397(1) pp. 341​-351​.​ DOI: https://doi.org/10.1016/j.jmb.2010.01.028 
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  • 2010 | Journal Article | Research Paper
    ​ ​The iron-sulphur protein RNase L inhibitor functions in translation termination​
    Khoshnevis, S.; Gross, T.; Rotte, C.; Baierlein, C.; Ficner, R.   & Krebber, H. ​ (2010) 
    EMBO reports, 11(3) pp. 214​-219​.​ DOI: https://doi.org/10.1038/embor.2009.272 
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  • 2010 | Journal Article | Research Paper
    ​ ​NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1​
    Guettler, T.; Madl, T.; Neumann, P. ; Deichsel, D.; Corsini, L.; Monecke, T.   & Ficner, R.  et al.​ (2010) 
    Nature Structural & Molecular Biology, 17(11) pp. 1367​-U229​.​ DOI: https://doi.org/10.1038/nsmb.1931 
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  • 2009 | Journal Article
    ​ ​Novel Structural Insights into Class I and II Histone Deacetylases​
    Ficner, R. ​ (2009) 
    Current Topics in Medicinal Chemistry, 9(3) pp. 235​-240​.​ DOI: https://doi.org/10.2174/156802609788085304 
    ​Details  DOI 
  • 2009 | Journal Article | Research Paper | 
    ​ ​Molecular Determinants of Snurportin 1 Ligand Affinity and Structural Response upon Binding​
    Goette, M.; Stumpe, M. C.; Ficner, R.   & Grubmüller, H. ​ (2009) 
    Biophysical Journal, 97(2) pp. 581​-589​.​ DOI: https://doi.org/10.1016/j.bpj.2009.04.049 
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  • 2009 | Journal Article | Research Paper
    ​ ​Structural basis for m(7)G-cap hypermethylation of small nuclear, small nucleolar and telomerase RNA by the dimethyltransferase TGS1​
    Monecke, T. ; Dickmanns, A.   & Ficner, R. ​ (2009) 
    Nucleic Acids Research, 37(12) pp. 3865​-3877​.​ DOI: https://doi.org/10.1093/nar/gkp249 
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  • 2009 | Journal Article | Research Paper | 
    ​ ​Initial insight into the function of the lysosomal 66.3 kDa protein from mouse by means of X-ray crystallography​
    Lakomek, K.; Dickmanns, A. ; Kettwig, M.; Urlaub, H. ; Ficner, R.   & Luebke, T.​ (2009) 
    BMC Structural Biology, 9 art. 56​.​ DOI: https://doi.org/10.1186/1472-6807-9-56 
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  • 2009 | Journal Article | Research Paper
    ​ ​Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components​
    Warkocki, Z.; Odenwaelder, P. ; Schmitzova, J.; Platzmann, F.; Stark, H. ; Urlaub, H.   & Ficner, R.  et al.​ (2009) 
    Nature Structural & Molecular Biology, 16(12) pp. 1237​-U50​.​ DOI: https://doi.org/10.1038/nsmb.1729 
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  • 2009 | Journal Article | Research Paper
    ​ ​De novo sulfur SAD phasing of the lysosomal 66.3 kDa protein from mouse​
    Lakomek, K.; Dickmanns, A. ; Mueller, U.; Kollmann, K.; Deuschl, F.; Berndt, A. & Luebke, T. et al.​ (2009) 
    Acta Crystallographica Section D Biological Crystallography, 65 pp. 220​-228​.​ DOI: https://doi.org/10.1107/S0907444908041814 
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  • 2009 | Journal Article | Research Paper
    ​ ​A C-Terminal Phosphatase Module Conserved in Vertebrate CMP-Sialic Acid Synthetases Provides a Tetramerization Interface for the Physiologically Active Enzyme​
    Oschlies, M.; Dickmanns, A. ; Haselhorst, T.; Schaper, W.; Stummeyer, K.; Tiralongo, J. & Weinhold, B. et al.​ (2009) 
    Journal of Molecular Biology, 393(1) pp. 83​-97​.​ DOI: https://doi.org/10.1016/j.jmb.2009.08.003 
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  • 2009 | Journal Article | Research Paper
    ​ ​Crystallization and preliminary X-ray diffraction analysis of the C-terminal domain of the human spliceosomal DExD/H-box protein hPrp22​
    Kudlinzki, D.; Nagel, C. & Ficner, R. ​ (2009) 
    Acta Crystallographica Section F Structural Biology and Crystallization Communications, 65 pp. 956​-958​.​ DOI: https://doi.org/10.1107/S1744309109031844 
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  • 2009 | Journal Article | Research Paper
    ​ ​Structure analysis of the conserved methyltransferase domain of human trimethylguanosine synthase TGS1​
    Monecke, T. ; Dickmanns, A. ; Strasser, A. & Ficner, R. ​ (2009) 
    Acta Crystallographica Section D Biological Crystallography, 65 pp. 332​-338​.​ DOI: https://doi.org/10.1107/S0907444909003102 
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  • 2009 | Journal Article | Research Paper
    ​ ​Crystal Structure of the Nuclear Export Receptor CRM1 in Complex with Snurportin1 and RanGTP​
    Monecke, T. ; Guettler, T.; Neumann, P. ; Dickmanns, A. ; Goerlich, D. & Ficner, R. ​ (2009) 
    Science, 324(5930) pp. 1087​-1091​.​ DOI: https://doi.org/10.1126/science.1173388 
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  • 2009 | Journal Article | Research Paper | 
    ​ ​The Yeast HtrA Orthologue Ynm3 Is a Protease with Chaperone Activity that Aids Survival Under Heat Stress​
    Padmanabhan, N.; Fichtner, L. ; Dickmanns, A. ; Ficner, R. ; Schulz, J. B.   & Braus, G. H. ​ (2009) 
    Molecular Biology of the Cell, 20(1) pp. 68​-77​.​ DOI: https://doi.org/10.1091/mbc.E08-02-0178 
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  • 2008 | Journal Article
    ​ ​Host recognition of bacteriophage K1F: EndoNF in complex with helical polysialic acid​
    Schulz, E.; Stummeyer, K.; Dickmanns, A.; Gerardy-Schahn, R. & Ficner, R. ​ (2008) 
    Acta Crystallographica Section A Foundations of Crystallography, 64(a1) pp. C326​-C326​.​ DOI: https://doi.org/10.1107/S0108767308089587 
    ​Details  DOI 
  • 2008 | Journal Article
    ​ ​Structural requirements for recognition and nuclear import of spliceosomal UsnRNPs​
    Dickmanns, A.; Wohlwend, D.; Monecke, T.; Strasser, A. & Ficner, R. ​ (2008) 
    Acta Crystallographica Section A Foundations of Crystallography, 64(a1) pp. C309​-C309​.​ DOI: https://doi.org/10.1107/S0108767308090119 
    ​Details  DOI 
  • 2008 | Journal Article
    ​ ​Crystallographic studies on molecular motors and switches of the spliceosome​
    Ficner, R. ; Moehlmann, S.; Kudlinzki, D. & Dickmanns, A.​ (2008) 
    Acta Crystallographica Section A Foundations of Crystallography, 64(a1) pp. C309​-C310​.​ DOI: https://doi.org/10.1107/S0108767308090107 
    ​Details  DOI 
  • 2008 | Journal Article | Research Paper
    ​ ​Crystal structure of the RRM domain of poly(A)-specific ribonuclease reveals a novel m(7)G-cap-binding mode​
    Monecke, T. ; Schell, S.; Dickmanns, A.   & Ficner, R. ​ (2008) 
    Journal of Molecular Biology, 382(4) pp. 827​-834​.​ DOI: https://doi.org/10.1016/j.jmb.2008.07.073 
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  • 2008 | Journal Article | Research Paper
    ​ ​Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)​
    Schaefer, S.; Saunders, L.; Eliseeva, E.; Velena, A.; Jung, M.; Schwienhorst, A.   & Strasser, A. et al.​ (2008) 
    Bioorganic & Medicinal Chemistry, 16(4) pp. 2011​-2033​.​ DOI: https://doi.org/10.1016/j.bmc.2007.10.092 
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  • 2008 | Journal Article | Research Paper
    ​ ​Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome​
    Mathew, R.; Hartmuth, K.; Moehlmann, S.; Urlaub, H. ; Ficner, R.   & Luehrmann, R. ​ (2008) 
    Nature Structural & Molecular Biology, 15(5) pp. 435​-443​.​ DOI: https://doi.org/10.1038/nsmb.1415 
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  • 2007 | Journal Article | Research Paper
    ​ ​Structural basis for RanGTP independent entry of spliceosomal U snRNPs into the nucleus​
    Wohlwend, D.; Strasser, A.; Dickmanns, A.   & Ficner, R. ​ (2007) 
    Journal of Molecular Biology, 374(4) pp. 1129​-1138​.​ DOI: https://doi.org/10.1016/j.jmb.2007.09.065 
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  • 2007 | Journal Article | Research Paper
    ​ ​Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2)​
    Nielsen, T. K. ; Uu, S.; Luehrmann, R.   & Ficner, R. ​ (2007) 
    Journal of Molecular Biology, 369(4) pp. 902​-908​.​ DOI: https://doi.org/10.1016/j.jmb.2007.03.077 
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  • 2007 | Journal Article | Research Paper
    ​ ​Thermodynamic analysis of H1 nuclear import - Receptor tuning of importin beta/importin7​
    Wohlwend, D.; Strasser, A.; Dickmanns, A. ; Doenecke, D. & Ficner, R. ​ (2007) 
    Journal of biological chemistry, 282(14) pp. 10707​-10719​.​ DOI: https://doi.org/10.1074/jbc.M610409200 
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  • 2007 | Journal Article | Research Paper
    ​ ​Complex structure of a bacterial class 2 histone deacetylase homologue with a trifluoromethylketone inhibitor​
    Nielsen, T. K. ; Hildmann, C. ; Riester, D.; Wegener, D.; Schwienhorst, A.   & Ficner, R. ​ (2007) 
    Acta Crystallographica Section F Structural Biology and Crystallization Communications, 63 pp. 270​-273​.​ DOI: https://doi.org/10.1107/S1744309107012377 
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  • 2006 | Journal Article | Research Paper
    ​ ​Structure of the novel alpha-amylase AmyC from Thermotoga maritima​
    Dickmanns, A. ; Ballschmiter, M.; Liebl, W. & Ficner, R. ​ (2006) 
    Acta Crystallographica Section D Biological Crystallography, 62 pp. 262​-270​.​ DOI: https://doi.org/10.1107/S0907444905041363 
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  • 2006 | Journal Article | Research Paper
    ​ ​Crystal structure of Bacillus subtilis S-adenosylmethionine : tRNA ribosyltransferase-isomerase​
    Grimm, C.; Ficner, R. ; Sgraja, T.; Haebel, P.; Klebe, G. & Reuter, K.​ (2006) 
    Biochemical and Biophysical Research Communications, 351(3) pp. 695​-701​.​ DOI: https://doi.org/10.1016/j.bbrc.2006.10.096 
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  • 2006 | Conference Paper | Research Paper
    ​ ​Substrate and inhibitor specificity of class 1 and class 2 histone deacetylases​
    Hildmann, C. ; Wegener, D.; Riester, D.; Hempel, R.; Schober, A.; Merana, J. & Giurato, L. et al.​ (2006)
    ​Journal of Biotechnology (1) pp. 258​-270. (Vol. 124). , Wiesbaden, GERMANY.
    Amsterdam​: Elsevier Science Bv. DOI: https://doi.org/10.1016/j.jbiotec.2006.01.030 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Book Chapter
    ​ ​Role of the 5’-cap in the biogenesis of spliceosomal snRNPs​
    Ficner, R.  & Dickmanns, A. ​ (2005)
    In:​Grosjean, Henri​ (Ed.), Fine-Tuning of RNA Functions by Modification and Editing pp. 179​-204. (Vol. 12). ​Berlin Heidelberg: ​Springer. DOI: https://doi.org/10.1007/b106799 
    ​Details  DOI 
  • 2005 | Journal Article
    ​ ​Structural basis for specific recognition of the UsnRNP m 3 G-cap by snurportin1​
    Ficner, R. ; Strasser, A.; Dickmanns, A. & Lührmann, R.​ (2005) 
    Acta Crystallographica Section A Foundations of Crystallography, 61(a1) pp. c59​-c60​.​ DOI: https://doi.org/10.1107/S0108767305097473 
    ​Details  DOI 
  • 2005 | Journal Article
    ​ ​Molecular basis for MSD and catalytic mechanism of the human formylglycine generating enzyme​
    Rudolph, M. G.; Dierks, T.; Dickmanns, A.; Schmidt, B.; von Figura, K. & Ficner, R. ​ (2005) 
    Acta Crystallographica Section A Foundations of Crystallography, 61(a1) pp. c67​-c67​.​ DOI: https://doi.org/10.1107/S0108767305097163 
    ​Details  DOI 
  • 2005 | Journal Article | Research Paper
    ​ ​Crystal structure of human pFGE, the paralog of the C alpha-formylglycine-generating enzyme​
    Dickmanns, A. ; Schmidt, B. ; Rudolph, M.; Mariappan, M.; Dierks, T.; Von Figura, K.   & Ficner, R. ​ (2005) 
    Journal of biological chemistry, 280(15) pp. 15180​-15187​.​ DOI: https://doi.org/10.1074/jbc.M414317200 
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  • 2005 | Journal Article | Research Paper
    ​ ​Crystal structure of a subtilisin-like serine proteinase from a psychrotrophic Vibrio species reveals structural aspects of cold adaptation​
    Arnorsdottir, J.; Kristjansson, M. & Ficner, R. ​ (2005) 
    FEBS Journal, 272(3) pp. 832​-845​.​ DOI: https://doi.org/10.1111/j.1742-4658.2005.04523.x 
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  • 2005 | Journal Article | Research Paper | 
    ​ ​Molecular basis for multiple sulfatase deficiency and mechanism for formylglycine generation of the human formylglycine-generating enzyme​
    Dierks, T.; Dickmanns, A. ; Preusser-Kunze, A.; Schmidt, B. ; Mariappan, M.; Von Figura, K.   & Ficner, R.  et al.​ (2005) 
    Cell, 121(4) pp. 541​-552​.​ DOI: https://doi.org/10.1016/j.cell.2005.03.001 
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  • 2005 | Journal Article | Research Paper
    ​ ​Expression, purification and crystallization of the ammonium transporter Amt-1 from Archaeoglobus fulgidus​
    Andrade, S.; Dickmanns, A. ; Ficner, R.   & Einsle, O.​ (2005) 
    Acta Crystallographica Section F Structural Biology and Crystallization Communications, 61 pp. 861​-863​.​ DOI: https://doi.org/10.1107/S1744309105027004 
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  • 2005 | Journal Article | Research Paper
    ​ ​Structural basis for m(3)G-cap-mediated nuclear import of spliceosomal UsnRNPs by snurportin1​
    Strasser, A.; Dickmanns, A. ; Luhrmann, R. & Ficner, R. ​ (2005) 
    EMBO Journal, 24(13) pp. 2235​-2243​.​ DOI: https://doi.org/10.1038/sj.emboj.7600701 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​Crystal Structure of a Bacterial Class 2 Histone Deacetylase Homologue​
    Nielsen, T. K. ; Hildmann, C. ; Dickmanns, A. ; Schwienhorst, A.   & Ficner, R. ​ (2005) 
    Journal of Molecular Biology, 354(1) pp. 107​-120​.​ DOI: https://doi.org/10.1016/j.jmb.2005.09.065 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​Crystal structure of the polysialic acid-degrading endosialidase of bacteriophage K1F​
    Stummeyer, K.; Dickmanns, A. ; Mühlenhoff, M.; Gerardy-Schahn, R. & Ficner, R. ​ (2005) 
    Nature Structural & Molecular Biology, 12(1) pp. 90​-96​.​ DOI: https://doi.org/10.1038/nsmb874 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​Crystal structure of the archaeal ammonium transporter Amt-1 from Archaeoglobus fulgidus​
    Andrade, S.; Dickmanns, A. ; Ficner, R.   & Einsle, O.​ (2005) 
    Proceedings of the National Academy of Sciences, 102(42) pp. 14994​-14999​.​ DOI: https://doi.org/10.1073/pnas.0506254102 
    ​Details  DOI  PMID  PMC  WoS 
  • 2004 | Conference Abstract
    ​ ​Structure of the polysialic acid specific endosialidaseNF in complex with sialic acid​
    Stummeyer, K.; Dickmanns, A.; Mhlenhoff, M.; Gerardy-Schahn, R. & Ficner, R. ​ (2004)
    Glycobiology, 14(11) ​Joint Meeting of the Society-for-Glycobiology/Japanese-Society-for-Carbohydrate-Research​, Honolulu, HI.
    Cary​: Oxford Univ Press Inc.
    ​Details  WoS 
  • 2004 | Journal Article | Research Paper
    ​ ​Purification, crystallization and preliminary crystallographic data of the m(3)G cap-binding domain of human snRNP import factor snurportin 1​
    Strasser, A.; Dickmanns, A. ; Schmidt, U.; Penka, E.; Urlaub, H. ; Sekine, M. & Luhrmann, R. et al.​ (2004) 
    Acta Crystallographica Section D Biological Crystallography, 60 pp. 1628​-1631​.​ DOI: https://doi.org/10.1107/S0907444904015380 
    ​Details  DOI  PMID  PMC  WoS 
  • 2003 | Journal Article | Research Paper
    ​ ​Crystal structure of the Borna disease virus nucleoprotein​
    Rudolph, M.; Kraus, I. ; Dickmanns, A. ; Eickmann, M.; Garten, W. & Ficner, R. ​ (2003) 
    Structure, 11(10) pp. 1219​-1226​.​ DOI: https://doi.org/10.1016/j.str.2003.08.011 
    ​Details  DOI  PMID  PMC  WoS 
  • 2003 | Journal Article | Research Paper
    ​ ​Crystal structure of a complex between human spliceosomal cyclophilin H and a U4/U6 snRNP-60K peptide​
    Reidt, U.; Wahl, M.; Fasshauer, D.; Horowitz, D.; Luhrmann, R. & Ficner, R. ​ (2003) 
    Journal of Molecular Biology, 331(1) pp. 45​-56​.​ DOI: https://doi.org/10.1016/S0022-2836(03)00684-3 
    ​Details  DOI  PMID  PMC  WoS 
  • 2003 | Journal Article | Research Paper
    ​ ​Two protein-protein interaction sites on the spliceosome-associated human cyclophilin CypH​
    Ingelfinger, D.; Gothel, S.; Marahiel, M.; Reidt, U.; Ficner, R. ; Luhrmann, R. & Achsel, T.​ (2003) 
    Nucleic Acids Research, 31(16) pp. 4791​-4796​.​ DOI: https://doi.org/10.1093/nar/gkg660 
    ​Details  DOI  PMID  PMC  WoS 
  • 2001 | Journal Article | Research Paper
    ​ ​A new target for shigellosis: Rational design and crystallographic studies of inhibitors of tRNA-guanine transglycosylase​
    Gradler, U.; Gerber, H.; Goodenough-Lashua, D. M.; Garcia, G.; Ficner, R. ; Reuter, K. & Stubbs, M. et al.​ (2001) 
    Journal of Molecular Biology, 306(3) pp. 455​-467​.​ DOI: https://doi.org/10.1006/jmbi.2000.4256 
    ​Details  DOI  PMID  PMC  WoS 
  • 2001 | Conference Paper | Research Paper
    ​ ​3 alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni: biological significance, three-dimensional structure and gene regulation​
    Maser, E.; Xiong, G.; Grimm, C.; Ficner, R.   & Reuter, K.​ (2001)
    ​Chemico-Biological Interactions. (1-3) (Vol. 130). ​10th Conference on Enzymology and Molecular Biology of Carbonyl Metabolism​, TAOS, NEW MEXICO.
    Clare​: Elsevier Sci Ireland Ltd. DOI: https://doi.org/10.1016/S0009-2797(00)00302-1 
    ​Details  DOI  PMID  PMC  WoS 
  • 2000 | Journal Article
    ​ ​Crystallization and preliminary crystallographic studies of recombinant dimerization cofactor of transcription factor HNF1/pterin-4α-carbinolamine dehydratase from liver​
    Ficner, R. ; Sauer, U. H.; Ceska, T. A.; Stier, G. & Suck, D.​ (2000) 
    FEBS Letters, 357(1) pp. 62​-64​.​ DOI: https://doi.org/10.1016/0014-5793(94)01325-U 
    ​Details  DOI 
  • 2000 | Journal Article | Research Paper
    ​ ​The crystal structure of 3 alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni shows a novel oligomerization pattern within the short chain dehydrogenase/reductase family​
    Grimm, C.; Maser, E.; Mobus, E.; Klebe, G.; Reuter, K. & Ficner, R. ​ (2000) 
    Journal of biological chemistry, 275(52) pp. 41333​-41339​.​ DOI: https://doi.org/10.1074/jbc.M007559200 
    ​Details  DOI  PMID  PMC  WoS 
  • 2000 | Journal Article | Research Paper
    ​ ​Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment​
    Vidovic, I.; Nottrott, S.; Hartmuth, K.; Luhrmann, R. & Ficner, R. ​ (2000) 
    Molecular Cell, 6(6) pp. 1331​-1342​.​ DOI: https://doi.org/10.1016/S1097-2765(00)00131-3 
    ​Details  DOI  PMID  PMC  WoS 
  • 2000 | Journal Article | Research Paper
    ​ ​Screening orthologs as an important variable in crystallization: preliminary X-ray diffraction studies of the tRNA-modifying enzyme S-adenosylmethionine : tRNA ribosyl transferase/isomerase​
    Grimm, C.; Klebe, G.; Ficner, R.   & Reuter, K.​ (2000) 
    Acta Crystallographica Section D Biological Crystallography, 56 pp. 484​-488​.​ DOI: https://doi.org/10.1107/S0907444900001244 
    ​Details  DOI  PMID  PMC  WoS 
  • 2000 | Journal Article | Research Paper
    ​ ​Crystal structure of the human U4/U6 small nuclear ribonucleoprotein particle-specific SnuCyp-20, a nuclear cyclophilin​
    Reidt, U.; Reuter, K.; Achsel, T.; Ingelfinger, D.; Luhrmann, R. & Ficner, R. ​ (2000) 
    Journal of biological chemistry, 275(11) pp. 7439​-7442​.​ DOI: https://doi.org/10.1074/jbc.275.11.7439 
    ​Details  DOI  PMID  PMC  WoS 
  • 1999 | Journal Article
    ​ ​Structure and function of PCD/DCoH, an enzyme with regulatory properties​
    Suck, D. & Ficner, R. ​ (1999) 
    FEBS Letters, 389(1) pp. 35​-39​.​ DOI: https://doi.org/10.1016/0014-5793(96)00573-X 
    ​Details  DOI 
  • 1999 | Journal Article | Research Paper
    ​ ​Mutagenesis and crystallographic studies of Zymomonas mobilis tRNA-guanine transglycosylase to elucidate the role of serine 103 for enzymatic activity​
    Gradler, U.; Ficner, R. ; Garcia, G.; Stubbs, M.; Klebe, G. & Reuter, K.​ (1999) 
    FEBS Letters, 454(1-2) pp. 142​-146​.​ DOI: https://doi.org/10.1016/S0014-5793(99)00793-0 
    ​Details  DOI  PMID  PMC  WoS 
  • 1999 | Journal Article | Research Paper
    ​ ​Crystal structure of the surfactin synthetase-activating enzyme Sfp: a prototype of the 4 '-phosphopantetheinyl transferase superfamily​
    Reuter, K.; Mofid, M.; Marahiel, M. & Ficner, R. ​ (1999) 
    EMBO Journal, 18(23) pp. 6823​-6831​.​ DOI: https://doi.org/10.1093/emboj/18.23.6823 
    ​Details  DOI  PMID  PMC  WoS 
  • 1999 | Journal Article | Research Paper
    ​ ​Overproduction, purification, crystallization and preliminary X-ray diffraction studies of the human spliceosomal protein U5-15kD​
    Reuter, K. & Ficner, R. ​ (1999) 
    Acta Crystallographica Section D Biological Crystallography, 55 pp. 888​-890​.​ DOI: https://doi.org/10.1107/S0907444998016151 
    ​Details  DOI  PMID  PMC  WoS 
  • 1999 | Journal Article | Research Paper
    ​ ​Identification, characterization and crystal structure analysis of the human spliceosomal U5 snRNP-specific 15 kD protein​
    Reuter, K.; Nottrott, S.; Fabrizio, P.; Luhrmann, R. & Ficner, R. ​ (1999) 
    Journal of Molecular Biology, 294(2) pp. 515​-525​.​ DOI: https://doi.org/10.1006/jmbi.1999.3258 
    ​Details  DOI  PMID  PMC  WoS 
  • 1999 | Journal Article | Research Paper
    ​ ​Functional interaction of a novel 15.5kD [U4/U6 center dot U5] tri-snRNP protein with the 5 ' stem-loop of U4 snRNA​
    Nottrott, S.; Hartmuth, K.; Fabrizio, P.; Urlaub, H. ; Vidovic, I.; Ficner, R.   & Luhrmann, R.​ (1999) 
    EMBO Journal, 18(21) pp. 6119​-6133​.​ DOI: https://doi.org/10.1093/emboj/18.21.6119 
    ​Details  DOI  PMID  PMC  WoS 
  • 1999 | Journal Article | Research Paper
    ​ ​Crystallization and preliminary crystallographic studies of Sfp: a phosphopantetheinyl transferase of modular peptide synthetases​
    Mofid, M.; Marahiel, M.; Ficner, R.   & Reuter, K.​ (1999) 
    Acta Crystallographica Section D Biological Crystallography, 55 pp. 1098​-1100​.​ DOI: https://doi.org/10.1107/S0907444999003674 
    ​Details  DOI  PMID  PMC  WoS 
  • 1997 | Journal Article | 
    ​ ​Cloning and functional characterization of the genes encoding 3-dehydroquinate synthase (aroB) and tRNA-guanine transglycosylase (tgt) from Helicobacter pylori​
    Bereswill, S.; Faßbinder, F.; Völzing, C.; Haas, R.; Reuter, K.; Ficner, R.   & Kist, M.​ (1997) 
    Medical Microbiology and Immunology, 186(2-3) pp. 125​-134​.​ DOI: https://doi.org/10.1007/s004300050054 
    ​Details  DOI 
  • 1996 | Journal Article
    ​ ​Crystal structure of tRNA-guanine transglycosylase: RNA modification by base exchange.​
    Romier, C.; Reuter, K.; Suck, D. & Ficner, R. ​ (1996) 
    The EMBO Journal, 15(11) pp. 2850​-2857​.​ DOI: https://doi.org/10.1002/j.1460-2075.1996.tb00646.x 
    ​Details  DOI 
  • 1996 | Journal Article
    ​ ​Mutagenesis and Crystallographic Studies of Zymomonas mobilis tRNA-Guanine Transglycosylase Reveal Aspartate 102 as the Active Site Nucleophile ,​
    Romier, C.; Reuter, K.; Suck, D. & Ficner, R. ​ (1996) 
    Biochemistry, 35(49) pp. 15734​-15739​.​ DOI: https://doi.org/10.1021/bi962003n 
    ​Details  DOI 
  • 1996 | Journal Article
    ​ ​Crystallographic studies on the bifunctional pterin-4a-carbinolamine dehydratases from human liver and Pseudomonas aeruginosa​
    Suck, D.; Ficner, R. ; Sauer, U. H. & Stier, G.​ (1996) 
    Acta Crystallographica Section A Foundations of Crystallography, 52(a1) pp. C125​-C125​.​ DOI: https://doi.org/10.1107/S0108767396094184 
    ​Details  DOI 
  • 1996 | Journal Article
    ​ ​RNA modification by base exchange: structure of tRNA-guanine transglycosylase​
    Romier, C.; Reuter, K.; Suck, D. & Ficner, R. ​ (1996) 
    Acta Crystallographica Section A Foundations of Crystallography, 52(a1) pp. C162​-C163​.​ DOI: https://doi.org/10.1107/S0108767396092744 
    ​Details  DOI 
  • 1996 | Journal Article
    ​ ​Location of the Active Site and Proposed Catalytic Mechanism of Pterin-4A-Carbinolamine Dehydratase​
    Koster, S.; Stier, G.; Ficner, R. ; Holzer, M.; Curtius, H.-C.; Suck, D. & Ghisla, S.​ (1996) 
    European Journal of Biochemistry, 241(3) pp. 858​-864​.​ DOI: https://doi.org/10.1111/j.1432-1033.1996.00858.x 
    ​Details  DOI 
  • 1995 | Journal Article
    ​ ​Three-dimensional structure of the bifunctional protein PCD/DCoH, a cytoplasmic enzyme interacting with transcription factor HNF1.​
    Ficner, R. ; Sauer, U.; Stier, G. & Suck, D.​ (1995) 
    The EMBO Journal, 14(9) pp. 2034​-2042​.​ DOI: https://doi.org/10.1002/j.1460-2075.1995.tb07195.x 
    ​Details  DOI 
  • 1995 | Journal Article
    ​ ​Sequence analysis and overexpression of the Zymomonas mobilis tgt gene encoding tRNA-guanine transglycosylase: purification and biochemical characterization of the enzyme​
    Reuter, K. & Ficner, R. ​ (1995) 
    Journal of Bacteriology, 177(18) pp. 5284​-5288​.​ DOI: https://doi.org/10.1128/jb.177.18.5284-5288.1995 
    ​Details  DOI 
  • 1995 | Journal Article
    ​ ​Isolation, crystallization, crystal structure analysis and refinement of allophycocyanin from the cyanobacterium Spirulina platensis at 2.3 Å resolution​
    Brejc, K.; Ficner, R. ; Huber, R. & Steinbacher, S.​ (1995) 
    Journal of Molecular Biology, 249(2) pp. 424​-440​.​ DOI: https://doi.org/10.1006/jmbi.1995.0307 
    ​Details  DOI 
  • 1993 | Journal Article
    ​ ​Refined crystal structure of phycoerythrin from Porphyridium cruentum at 0.23-nm resolution and localization of the gamma subunit​
    Ficner, R.   & Huber, R.​ (1993) 
    European Journal of Biochemistry, 218(1) pp. 103​-106​.​ DOI: https://doi.org/10.1111/j.1432-1033.1993.tb18356.x 
    ​Details  DOI 
  • 1992 | Journal Article
    ​ ​Isolation, crystallization, crystal structure analysis and refinement of B-phycoerythrin from the red alga Porphyridium sordidum at 2·2 Å resolution​
    Ficner, R. ; Lobeck, K.; Schmidt, G. & Huber, R.​ (1992) 
    Journal of Molecular Biology, 228(3) pp. 935​-950​.​ DOI: https://doi.org/10.1016/0022-2836(92)90876-L 
    ​Details  DOI 

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