Andrei Leonov

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  • 2022 | Journal Article | 
    ​ ​The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils​
    Antonschmidt, L.; Matthes, D. ; Dervişoğlu, R.; Frieg, B.; Dienemann, C. ; Leonov, A.   & Nimerovsky, E. et al.​ (2022) 
    Nature Communications, 13(1).​ DOI: https://doi.org/10.1038/s41467-022-32797-w 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates​
    Kuebler, L.; Buss, S.; Leonov, A. ; Ryazanov, S. ; Schmidt, F.; Maurer, A. & Weckbecker, D. et al.​ (2020) 
    European Journal of Nuclear Medicine and Molecular Imaging,.​ DOI: https://doi.org/10.1007/s00259-020-05133-x 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization​
    Dominguez-Meijide, A.; Vasili, E.; König, A.; Cima-Omori, M.-S.; Ibáñez de Opakua, A.; Leonov, A.   & Ryazanov, S.  et al.​ (2020) 
    Scientific Reports, 10(1).​ DOI: https://doi.org/10.1038/s41598-020-69744-y 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau​
    Brendel, M.; Deussing, M.; Blume, T.; Kaiser, L.; Probst, F.; Overhoff, F. & Peters, F. et al.​ (2019) 
    Alzheimer's Research & Therapy, 11(1).​ DOI: https://doi.org/10.1186/s13195-019-0522-z 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers​
    Saravanan, M. S.; Ryazanov, S. ; Leonov, A. ; Nicolai, J.; Praest, P.; Giese, A. & Winter, R. et al.​ (2019) 
    Scientific Reports, 9(1).​ DOI: https://doi.org/10.1038/s41598-019-54919-z 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model​
    Wegrzynowicz, M.; Bar-On, D.; Calo’, L.; Anichtchik, O.; Iovino, M.; Xia, J. & Ryazanov, S.  et al.​ (2019) 
    Acta Neuropathologica, 138(4) pp. 575​-595​.​ DOI: https://doi.org/10.1007/s00401-019-02023-x 
    ​Details  DOI  PMID  PMC 

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Project:  EXC 2067: Multiscale Bioimaging

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