Andrea C. Vaiana

Staff Status
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  • 2019 Journal Article | 
    ​ ​Automated cryo-EM structure refinement using correlation-driven molecular dynamics​
    Igaev, M.; Kutzner, C.; Bock, L. V. ; Vaiana, A. C.   & Grubmüller, H. ​ (2019) 
    eLife8.​ DOI: https://doi.org/10.7554/eLife.43542 
    Details  DOI 
  • 2017 Journal Article
    ​ ​Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P​
    Huter, P.; Arenz, S.; Bock, L. V. ; Graf, M.; Frister, J. O.; Heuer, A. & Peil, L. et al.​ (2017) 
    Molecular cell68(3) pp. 515.e6​-527.e6​.​ DOI: https://doi.org/10.1016/j.molcel.2017.10.014 
    Details  DOI  PMID  PMC 
  • 2016 Journal Article | 
    ​ ​A combined cryo-EM and molecular dynamics approach reveals the mechanism of ErmBL-mediated translation arrest​
    Arenz, S.; Bock, L. V. ; Graf, M.; Innis, C. A.; Beckmann, R.; Grubmüller, H.   & Vaiana, A. C.  et al.​ (2016) 
    Nature communications7 art. 12026​.​ DOI: https://doi.org/10.1038/ncomms12026 
    Details  DOI  PMID  PMC 
  • 2016 Journal Article
    ​ ​ErmBL Translation on the Ribosome in the Presence of Erythromycin is Stalled by Inhibition of Peptide Bond Formation​
    Bock, L. V. ; Arenz, S.; Wilson, D. N.; Grubmüller, H.   & Vaiana, A. C. ​ (2016) 
    Biophysical Journal110(3) pp. 234a​.​ DOI: https://doi.org/10.1016/j.bpj.2015.11.1291 
    Details  DOI 
  • 2016 Journal Article
    ​ ​Low Energy Barriers and a Dynamic Contact Network between Ribosomal Subunits Enable Rapid tRNA Translocation​
    Bock, L. V. ; Blau, C. ; Vaiana, A. C.   & Grubmüller, H. ​ (2016) 
    Biophysical Journal110(3) pp. 3a​.​ DOI: https://doi.org/10.1016/j.bpj.2015.11.061 
    Details  DOI 
  • 2015 Journal Article
    ​ ​Dynamic contact network between ribosomal subunits enables rapid large-scale rotation during spontaneous translocation​
    Bock, L. V. ; Blau, C. ; Vaiana, A. C.   & Grubmüller, H. ​ (2015) 
    Nucleic Acids Research43(14) pp. 6747​-6760​.​ DOI: https://doi.org/10.1093/nar/gkv649 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article
    ​ ​Bayesian cryo-EM Refinement​
    Blau, C. ; Bock, L. ; Kutzner, C.; Vaiana, A.   & Grubmüller, H. ​ (2015) 
    Biophysical Journal108(2) pp. 470a​.​ DOI: https://doi.org/10.1016/j.bpj.2014.11.2571 
    Details  DOI 
  • 2015 Journal Article
    ​ ​Structural Determinants of Hybrid State Intermediates of the Bacterial Ribosome​
    Vaiana, A. C. ; Kutzner, C.; Bock, L. V. ; Blau, C.   & Grubmüller, H. ​ (2015) 
    Biophysical Journal108(2) pp. 318a​.​ DOI: https://doi.org/10.1016/j.bpj.2014.11.1730 
    Details  DOI 
  • 2015 Journal Article
    ​ ​Balanced Interactions between Ribosomal Subunits Allow Rapid Large-Scale Rotation​
    Bock, L. V. ; Blau, C. ; Vaiana, A. C.   & Grubmüller, H. ​ (2015) 
    Biophysical Journal108(2) pp. 26a​.​ DOI: https://doi.org/10.1016/j.bpj.2014.11.168 
    Details  DOI 
  • 2014 Journal Article
    ​ ​Refining Crystal Structures Against Cryo-EM Data using Molecular Dynamics Simulations to Obtain a Complete Atomistic Pathway of Transfer RNA Translocation​
    Vaiana, A. C. ; Kutzner, C.; Bock, L. V. ; Blau, C.   & Grubmüller, H. ​ (2014) 
    Biophysical Journal106(2) pp. 240a​.​ DOI: https://doi.org/10.1016/j.bpj.2013.11.1405 
    Details  DOI 
  • 2014 Journal Article
    ​ ​Concerted Interactions between Ribosomal Subunits Allow for Large-Scale Rotations​
    Bock, L. V. ; Blau, C. ; Vaiana, A. C.   & Grubmüller, H. ​ (2014) 
    Biophysical Journal106(2) pp. 491a​.​ DOI: https://doi.org/10.1016/j.bpj.2013.11.2748 
    Details  DOI 
  • 2014 Conference Abstract
    ​ ​Ribosomal Kinetics and Concerted Motions from Nanoseconds to Seconds​
    Blau, C. ; Bock, L. V. ; Schröder, G. F.; Davydov, I. I.; Fischer, N. ; Stark, H.   & Rodnina, M. V.  et al.​ (2014)
    ​Biophysical Journal , Volume 106 , Issue 2 , 250a p. 1266-Plat. ​58th Annual Meeting of the Biophysical-Society​, San Francisco, CA.
    Cambridge​: Cell Press. DOI: https://doi.org/10.1016/j.bpj.2013.11.1463 
    Details  DOI  WoS 
  • 2014 Conference Abstract
    ​ ​Rapid and Stable Transfer RNA Translocation through the Ribosome Ensured by Specific Contact Mechanisms​
    Bock, L. V. ; Blau, C. ; Schröder, G. F.; Davydov, I. I.; Fischer, N. ; Stark, H.   & Rodnina, M. V.  et al.​ (2014)
    ​Biophysical Journal, 106(Supplement 1), 493a-493a.. ​58th Annual Meeting of the Biophysical-Society​, San Francisco, CA.
    Cambridge​: Cell Press. DOI: https://doi.org/10.1016/j.bpj.2013.11.2758 
    Details  DOI  WoS 
  • 2013 Journal Article
    ​ ​Rate Estimates from Sampling Sparse Transitions: TRNA Motion Limits Transitions between Ribosomal Translocation Intermediates​
    Blau, C. ; Bock, L. V. ; Schröder, G. F.; Fischer, N. ; Stark, H. ; Rodnina, M. V.   & Vaiana, A. C.  et al.​ (2013) 
    Biophysical Journal104(2) pp. 663a​.​ DOI: https://doi.org/10.1016/j.bpj.2012.11.3662 
    Details  DOI 
  • 2013 Journal Article
    ​ ​Mechanisms for Efficient TRNA Translocation through the Ribosome​
    Bock, L. V. ; Blau, C. ; Schröder, G. F.; Fischer, N. ; Stark, H. ; Rodnina, M. V.   & Vaiana, A. C.  et al.​ (2013) 
    Biophysical Journal104(2) pp. 16a​.​ DOI: https://doi.org/10.1016/j.bpj.2012.11.118 
    Details  DOI 
  • 2013 Journal Article | Research Paper
    ​ ​Energy barriers and driving forces in tRNA translocation through the ribosome​
    Bock, L. V. ; Blau, C. ; Schroeder, G. F.; Davydov, I. I.; Fischer, N. ; Stark, H.   & Rodnina, M. V.  et al.​ (2013) 
    Nature Structural & Molecular Biology20(12) pp. 1390​-1396​.​ DOI: https://doi.org/10.1038/nsmb.2690 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article
    ​ ​Contacts Between Ribosome Parts Refined by Molecular Dynamics Simulations​
    Blau, C. ; Bock, L. V. ; Schroeder, G. F.; Fischer, N. ; Stark, H. ; Vaiana, A. C.   & Grubmüller, H. ​ (2012) 
    Biophysical Journal102(3) pp. 69a​.​ DOI: https://doi.org/10.1016/j.bpj.2011.11.405 
    Details  DOI 

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