Prof. Dr. Stefan Pöhlmann

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  • 2022 | Journal Article | Research Paper | 
    ​ ​Seidel, Alina, Michelle Zanoni, Rüdiger Groß, Daniela Krnavek, Sümeyye Erdemci-Evin, Pascal von Maltitz, Dan P. J. Albers et al. "BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA.1 in young adults​." ​Frontiers in Immunology ​13 (2022): ​882918​. ​https://doi.org/10.3389/fimmu.2022.882918.
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Jäger, Niklas, Markus Hoffmann, Stefan Pöhlmann, and Nadine Krüger. "Nafamostat-Mediated Inhibition of SARS-CoV-2 Ribosomal Frameshifting Is Insufficient to Impair Viral Replication in Vero Cells. Comment on Munshi et al. Identifying Inhibitors of −1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses. Viruses 2022, 14, 177​." ​Viruses ​14, no. 7 (2022): . ​https://doi.org/10.3390/v14071526.
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper
    ​ ​Runft, Sandra, Iris Färber, Johannes Krüger, Nadine Krüger, Federico Armando, Cheila Rocha, Stefan Pöhlmann et al. "Alternatives to animal models and their application in the discovery of species susceptibility to SARS-CoV-2 and other respiratory infectious pathogens: A review​." ​Veterinary Pathology / Veterinary / American College of Veterinary Pathologists (2022): ​030098582110736​. ​https://doi.org/10.1177/03009858211073678.
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Wettstein, Lukas, Philip Maximilian Knaff, Christian Kersten, Patrick Müller, Tatjana Weil, Carina Conzelmann, Janis A Müller et al. "Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture​." ​Communications Biology ​5, no. 1 (2022): . ​https://doi.org/10.1038/s42003-022-03613-4.
    ​Details  DOI 
  • 2022 | Journal Article | Erratum | 
    ​ ​Hoffmann, Markus, Yeonhwa Jin, and Stefan Pöhlmann. "Publisher Correction: Dalbavancin: novel candidate for COVID-19 treatment​." ​Cell Research (2022): . ​https://doi.org/10.1038/s41422-022-00713-y.
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Arora, Prerna, Lu Zhang, Inga Nehlmeier, Amy Kempf, Anne Cossmann, Alexandra Dopfer-Jablonka, Sebastian R Schulz et al. "The effect of cilgavimab and neutralisation by vaccine-induced antibodies in emerging SARS-CoV-2 BA.4 and BA.5 sublineages​." ​The Lancet Infectious Diseases ​22, no. 12 (2022): ​1665​-1666​. ​https://doi.org/10.1016/S1473-3099(22)00693-4.
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Hempel, Tim, Lluís Raich, Simon Olsson, Nurit P. Azouz, Andrea M. Klingler, Markus Hoffmann, Stefan Pöhlmann, Marc E. Rothenberg, and Frank Noé. "Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat​." ​Chemical Science ​12, no. 3 (2021): ​983​-992​. ​https://doi.org/10.1039/d0sc05064d.
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Carpinteiro, Alexander, Barbara Gripp, Markus Hoffmann, Stefan Pöhlmann, Nicolas Hoertel, Michael J. Edwards, Markus Kamler, Johannes Kornhuber, Katrin Anne Becker, and Erich Gulbins. "Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells​." ​Journal of Biological Chemistry ​296 (2021): ​S0021925821004907​. ​https://doi.org/10.1016/j.jbc.2021.100701.
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Hoffmann, Markus, and Stefan Pöhlmann. "How SARS-CoV-2 makes the cut​." ​Nature Microbiology ​6, no. 7 (2021): ​828​-829​. ​https://doi.org/10.1038/s41564-021-00931-x.
    ​Details  DOI 
  • 2020 | Lecture
    ​ ​Pöhlmann, Stefan. "Neuer Ansatz zur COVID-19-Therapie​." ​Lecture presented at the Ein Virus verändert die Welt: Göttinger Wissenschaftler*innen zur Corona-Pandemie​, virtuell, 2020. 
    ​Details 
  • 2020 | Journal Article
    ​ ​Kleine-Weber, Hannah, Simon Schroeder, Nadine Krüger, Alexander Prokscha, Hassan Y. Naim, Marcel A. Müller, Christian Drosten, Stefan Pöhlmann, and Markus Hoffmann. "Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus​." ​Emerging Microbes & Infections ​9, no. 1 (2020): ​155​-168​. ​https://doi.org/10.1080/22221751.2020.1713705.
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Hoffmann, Markus, Simon Schroeder, Hannah Kleine-Weber, Marcel A. Müller, Christian Drosten, and Stefan Pöhlmann. "Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19​." ​Antimicrobial Agents and Chemotherapy ​64, no. 6 (2020): . ​https://doi.org/10.1128/AAC.00754-20.
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Hoffmann, Markus, Hannah Kleine-Weber, and Stefan Pöhlmann. "A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells​." ​Molecular Cell ​78, no. 4 (2020): ​779​-784.e5​. ​https://doi.org/10.1016/j.molcel.2020.04.022.
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Wrapp, Daniel, Dorien De Vlieger, Kizzmekia S. Corbett, Gretel M. Torres, Nianshuang Wang, Wander Van Breedam, Kenny Roose et al. "Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies​." ​Cell ​181, no. 5 (2020): ​1004​-1015.e15​. ​https://doi.org/10.1016/j.cell.2020.04.031.
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Edwards, Michael J., Katrin Anne Becker, Barbara Gripp, Markus Hoffmann, Simone Keitsch, Barbara Wilker, Matthias Soddemann et al. "Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2​." ​Journal of Biological Chemistry ​295, no. 45 (2020): ​15174​-15182​. ​https://doi.org/10.1074/jbc.RA120.015249.
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Budhadev, Darshita, Emma Poole, Inga Nehlmeier, Yuanyuan Liu, James Hooper, Elizabeth Kalverda, Uchangi Satyaprasad Akshath et al. "Glycan-Gold Nanoparticles as Multifunctional Probes for Multivalent Lectin–Carbohydrate Binding: Implications for Blocking Virus Infection and Nanoparticle Assembly​." ​Journal of the American Chemical Society ​142, no. 42 (2020): ​18022​-18034​. ​https://doi.org/10.1021/jacs.0c06793.
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Hoffmann, Markus, Hannah Kleine-Weber, Simon Schroeder, Nadine Krüger, Tanja Herrler, Sandra Erichsen, Tobias S. Schiergens et al. "SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor​." ​Cell ​181, no. 2 (2020): ​271​-280.e8​. ​https://doi.org/10.1016/j.cell.2020.02.052.
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Lambertz, Ruth Lydia Olga, Ingo Gerhauser, Inga Nehlmeier, Sabine Gärtner, Michael Winkler, Sarah Rebecca Leist, Heike Kollmus, Stefan Pöhlmann, and Klaus Schughart. "H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice​." ​Virology Journal ​17, no. 1 (2020): . ​https://doi.org/10.1186/s12985-020-01323-z.
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Pfaender, Stephanie, Katrina B. Mar, Eleftherios Michailidis, Annika Kratzel, Ian N. Boys, Philip V’kovski, Wenchun Fan et al. "LY6E impairs coronavirus fusion and confers immune control of viral disease​." ​Nature Microbiology ​5, no. 11 (2020): ​1330​-1339​. ​https://doi.org/10.1038/s41564-020-0769-y.
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Hoffmann, Markus, Kirstin Mösbauer, Heike Hofmann-Winkler, Artur Kaul, Hannah Kleine-Weber, Nadine Krüger, Nils C. Gassen, Marcel A. Müller, Christian Drosten, and Stefan Pöhlmann. "Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2​." ​Nature ​585, no. 7826 (2020): ​588​-590​. ​https://doi.org/10.1038/s41586-020-2575-3.
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Bošnjak, Berislav, Saskia Catherina Stein, Stefanie Willenzon, Anne Katrin Cordes, Wolfram Puppe, Günter Bernhardt, Inga Ravens et al. "Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods​." ​Cellular & Molecular Immunology ​18, no. 4 (2020): ​936​-944​. ​https://doi.org/10.1038/s41423-020-00573-9.
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Lambertz, Ruth L. O., Ingo Gerhauser, Inga Nehlmeier, Sarah R. Leist, Heike Kollmus, Stefan Pöhlmann, and Klaus Schughart. "Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis​." ​Journal of General Virology ​100, no. 7 (2019): ​1073​-1078​. ​https://doi.org/10.1099/jgv.0.001274.
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​González-Hernández, Mariana, Andreas Müller, Thomas Hoenen, Markus Hoffmann, and Stefan Pöhlmann. "Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L​." ​Virology ​532 (2019): ​22​-29​. ​https://doi.org/10.1016/j.virol.2019.03.020.
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Kleine-Weber, Hannah, Mahmoud Tarek Elzayat, Lingshu Wang, Barney S. Graham, Marcel A. Müller, Christian Drosten, Stefan Pöhlmann, and Markus Hoffmann. "Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization​." ​Journal of Virology ​93, no. 2 (2019): . ​https://doi.org/10.1128/JVI.01381-18.
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Dhingra, Akshay, Tina Ganzenmueller, Elias Hage, Nicolás M. Suárez, Kerstin Mätz-Rensing, Dimitri Widmer, Stefan Pöhlmann, Andrew J. Davison, Thomas F. Schulz, and Artur Kaul. "Novel Virus Related to Kaposi’s Sarcoma–Associated Herpesvirus from Colobus Monkey​." ​Emerging Infectious Diseases ​25, no. 8 (2019): ​1548​-1551​. ​https://doi.org/10.3201/eid2508.181802.
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Wrensch, Florian, Gaëtan Ligat, Laura Heydmann, Catherine Schuster, Mirjam B. Zeisel, Patrick Pessaux, François Habersetzer et al. "Interferon‐Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection​." ​Hepatology ​70, no. 5 (2019): ​1506​-1520​. ​https://doi.org/10.1002/hep.30699.
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Grewer, Anna, Martina Bleyer, Kerstin Mätz-Rensing, Alexander S. Hahn, Tim Rüggeberg, Gregor Babaryka, Andre Zimmermann, Stefan Pöhlmann, and Artur Kaul. "Kaposi Sarcoma in Mantled Guereza​." ​Emerging Infectious Diseases ​25, no. 8 (2019): ​1552​-1555​. ​https://doi.org/10.3201/eid2508.181804.
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Laporte, Manon, Annelies Stevaert, Valerie Raeymaekers, Talitha Boogaerts, Inga Nehlmeier, Winston Chiu, Mohammed Benkheil, Bart Vanaudenaerde, Stefan Pöhlmann, and Lieve Naesens. "Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways​." ​Journal of Virology ​94, no. 1 (2019): . ​https://doi.org/10.1128/JVI.01430-19.
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Hoffmann, Markus, Inga Nehlmeier, Constantin Brinkmann, Verena Krähling, Laura Behner, Anna-Sophie Moldenhauer, Nadine Krüger et al. "Tetherin Inhibits Nipah Virus but Not Ebola Virus Replication in Fruit Bat Cells​." ​Journal of Virology ​93, no. 3 (2019): . ​https://doi.org/10.1128/JVI.01821-18.
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Kleine-Weber, Hannah, Stefan Pöhlmann, and Markus Hoffmann. "Spike proteins of novel MERS-coronavirus isolates from North- and West-African dromedary camels mediate robust viral entry into human target cells​." ​Virology ​535 (2019): ​261​-265​. ​https://doi.org/10.1016/j.virol.2019.07.016.
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Hoffmann, Markus, Enrika Schütze, Andreas Bernhard, Lennart Schlaphoff, Artur Kaul, Sandra Schöniger, and Stefan Pöhlmann. "Disease Manifestation and Viral Sequences in a Bonobo More Than 30 Years after Papillomavirus Infection​." ​Pathogens ​8, no. 1 (2019): ​13​. ​https://doi.org/10.3390/pathogens8010013.
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Zapatero-Belinchón, Francisco, Erik Dietzel, Olga Dolnik, Katinka Döhner, Rui Costa, Barbara Hertel, Barbora Veselkova et al. "Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors​." ​Viruses ​11, no. 3 (2019): ​275​. ​https://doi.org/10.3390/v11030275.
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Winkler, Michael, Florian Wrensch, Pascale Bosch, Maike Knoth, Michael Schindler, Sabine Gärtner, and Stefan Pöhlmann. "Analysis of IFITM-IFITM Interactions by a Flow Cytometry-Based FRET Assay​." ​International Journal of Molecular Sciences ​20, no. 16 (2019): ​3859​. ​https://doi.org/10.3390/ijms20163859.
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Chukhno, Ekaterina, Sabine Gärtner, Abdul Rahman Siregar, Alexander Mehr, Marie Wende, Stoyan Petkov, Jasper Götting et al. "A Fosmid-Based System for the Generation of Recombinant Cercopithecine Alphaherpesvirus 2 Encoding Reporter Genes​." ​Viruses ​11, no. 11 (2019): ​1026​. ​https://doi.org/10.3390/v11111026.
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Hoffmann, Markus, Svenja Victoria Kaufmann, Carina Fischer, Wiebke Maurer, Anna-Sophie Moldenhauer, and Stefan Pöhlmann. "Analysis of Resistance of Ebola Virus Glycoprotein-Driven Entry Against MDL28170, An Inhibitor of Cysteine Cathepsins​." ​Pathogens ​8, no. 4 (2019): ​192​. ​https://doi.org/10.3390/pathogens8040192.
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Korniy, Natalia, Akanksha Goyal, Markus Hoffmann, Ekaterina Samatova, Frank Peske, Stefan Pöhlmann, and Marina V Rodnina. "Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance​." ​Nucleic Acids Research ​47, no. 10 (2019): ​5210​-5222​. ​https://doi.org/10.1093/nar/gkz202.
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Winkler, Michael, Sabine Gärtner, Lara Markus, Markus Hoffmann, Inga Nehlmeier, Michael Krawczak, Ulrike Sauermann, and Stefan Pöhlmann. "Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques​." ​PLoS One ​14, no. 11 (2019): ​e0224082​. ​https://doi.org/10.1371/journal.pone.0224082.
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article
    ​ ​Zmora, Pawel, Markus Hoffmann, Heike Kollmus, Anna-Sophie Moldenhauer, Olga Danov, Armin Braun, Michael Winkler, Klaus Schughart, and Stefan Pöhlmann. "TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1​." ​Journal of Biological Chemistry ​293, no. 36 (2018): ​13863​-13873​. ​https://doi.org/10.1074/jbc.RA118.001273.
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Kleine-Weber, Hannah, Mahmoud Tarek Elzayat, Markus Hoffmann, and Stefan Pöhlmann. "Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein​." ​Scientific Reports ​8, no. 1 (2018): ​16597​. ​https://doi.org/10.1038/s41598-018-34859-w.
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Brinkmann, Constantin, Markus Hoffmann, Anastasia Lübke, Inga Nehlmeier, Annika Krämer-Kühl, Michael Winkler, and Stefan Pöhlmann. "The glycoprotein of vesicular stomatitis virus promotes release of virus-like particles from tetherin-positive cells​." ​PLoS One ​12, no. 12 (2017): ​e0189073​. ​https://doi.org/10.1371/journal.pone.0189073.
    ​Details  DOI 
  • 2014 | Journal Article | 
    ​ ​Eckert, Nadine, Florian Wrensch, Sabine Gärtner, Navaneethan Palanisamy, Ulrike Goedecke, Nils Jäger, Stefan Pöhlmann, and Michael Winkler. "Influenza A Virus Encoding Secreted Gaussia Luciferase as Useful Tool to Analyze Viral Replication and Its Inhibition by Antiviral Compounds and Cellular Proteins​." ​PLOS ONE ​9, no. 5 (2014): ​e97695​. ​https://doi.org/10.1371/journal.pone.0097695.
    ​Details  DOI  PMID  PMC 

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