Prof. Dr. Stefan Pöhlmann

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  • 2022 | Journal Article | Research Paper | 
    ​ ​BNT162b2 booster after heterologous prime-boost vaccination induces potent neutralizing antibodies and T cell reactivity against SARS-CoV-2 Omicron BA.1 in young adults​
    Seidel, A.; Zanoni, M.; Groß, R.; Krnavek, D.; Erdemci-Evin, S.; von Maltitz, P. & Albers, D. P. J. et al.​ (2022) 
    Frontiers in Immunology, 13 art. 882918​.​ DOI: https://doi.org/10.3389/fimmu.2022.882918 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Nafamostat-Mediated Inhibition of SARS-CoV-2 Ribosomal Frameshifting Is Insufficient to Impair Viral Replication in Vero Cells. Comment on Munshi et al. Identifying Inhibitors of −1 Programmed Ribosomal Frameshifting in a Broad Spectrum of Coronaviruses. Viruses 2022, 14, 177​
    Jäger, N.; Hoffmann, M.; Pöhlmann, S.   & Krüger, N.​ (2022) 
    Viruses, 14(7).​ DOI: https://doi.org/10.3390/v14071526 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper
    ​ ​Alternatives to animal models and their application in the discovery of species susceptibility to SARS-CoV-2 and other respiratory infectious pathogens: A review​
    Runft, S.; Färber, I.; Krüger, J.; Krüger, N.; Armando, F.; Rocha, C. & Pöhlmann, S.  et al.​ (2022) 
    Veterinary Pathology / Veterinary / American College of Veterinary Pathologists, pp. 030098582110736​.​ DOI: https://doi.org/10.1177/03009858211073678 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Peptidomimetic inhibitors of TMPRSS2 block SARS-CoV-2 infection in cell culture​
    Wettstein, L.; Knaff, P. M.; Kersten, C.; Müller, P. ; Weil, T.; Conzelmann, C. & Müller, J. A et al.​ (2022) 
    Communications Biology, 5(1).​ DOI: https://doi.org/10.1038/s42003-022-03613-4 
    ​Details  DOI 
  • 2022 | Journal Article | Erratum | 
    ​ ​Publisher Correction: Dalbavancin: novel candidate for COVID-19 treatment​
    Hoffmann, M.; Jin, Y. & Pöhlmann, S. ​ (2022) 
    Cell Research,.​ DOI: https://doi.org/10.1038/s41422-022-00713-y 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​The effect of cilgavimab and neutralisation by vaccine-induced antibodies in emerging SARS-CoV-2 BA.4 and BA.5 sublineages​
    Arora, P.; Zhang, L.; Nehlmeier, I.; Kempf, A.; Cossmann, A.; Dopfer-Jablonka, A. & Schulz, S. R et al.​ (2022) 
    The Lancet Infectious Diseases, 22(12) pp. 1665​-1666​.​ DOI: https://doi.org/10.1016/S1473-3099(22)00693-4 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Molecular mechanism of inhibiting the SARS-CoV-2 cell entry facilitator TMPRSS2 with camostat and nafamostat​
    Hempel, T.; Raich, L.; Olsson, S.; Azouz, N. P.; Klingler, A. M.; Hoffmann, M. & Pöhlmann, S.  et al.​ (2021) 
    Chemical Science, 12(3) pp. 983​-992​.​ DOI: https://doi.org/10.1039/d0sc05064d 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells​
    Carpinteiro, A.; Gripp, B.; Hoffmann, M.; Pöhlmann, S. ; Hoertel, N.; Edwards, M. J. & Kamler, M. et al.​ (2021) 
    Journal of Biological Chemistry, 296 art. S0021925821004907​.​ DOI: https://doi.org/10.1016/j.jbc.2021.100701 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​How SARS-CoV-2 makes the cut​
    Hoffmann, M. & Pöhlmann, S. ​ (2021) 
    Nature Microbiology, 6(7) pp. 828​-829​.​ DOI: https://doi.org/10.1038/s41564-021-00931-x 
    ​Details  DOI 
  • 2020 | Lecture
    ​ ​Neuer Ansatz zur COVID-19-Therapie​
    Pöhlmann, S. ​ (2020)
    Ein Virus verändert die Welt: Göttinger Wissenschaftler*innen zur Corona-Pandemie; 2020-04-28​, virtuell.
    ​Details 
  • 2020 | Journal Article
    ​ ​Polymorphisms in dipeptidyl peptidase 4 reduce host cell entry of Middle East respiratory syndrome coronavirus​
    Kleine-Weber, H.; Schroeder, S.; Krüger, N.; Prokscha, A.; Naim, H. Y.; Müller, M. A. & Drosten, C. et al.​ (2020) 
    Emerging Microbes & Infections, 9(1) pp. 155​-168​.​ DOI: https://doi.org/10.1080/22221751.2020.1713705 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Nafamostat Mesylate Blocks Activation of SARS-CoV-2: New Treatment Option for COVID-19​
    Hoffmann, M.; Schroeder, S.; Kleine-Weber, H.; Müller, M. A.; Drosten, C. & Pöhlmann, S. ​ (2020) 
    Antimicrobial Agents and Chemotherapy, 64(6).​ DOI: https://doi.org/10.1128/AAC.00754-20 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​A Multibasic Cleavage Site in the Spike Protein of SARS-CoV-2 Is Essential for Infection of Human Lung Cells​
    Hoffmann, M.; Kleine-Weber, H. & Pöhlmann, S. ​ (2020) 
    Molecular Cell, 78(4) pp. 779​-784.e5​.​ DOI: https://doi.org/10.1016/j.molcel.2020.04.022 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Structural Basis for Potent Neutralization of Betacoronaviruses by Single-Domain Camelid Antibodies​
    Wrapp, D.; De Vlieger, D.; Corbett, K. S.; Torres, G. M.; Wang, N.; Van Breedam, W. & Roose, K. et al.​ (2020) 
    Cell, 181(5) pp. 1004​-1015.e15​.​ DOI: https://doi.org/10.1016/j.cell.2020.04.031 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Sphingosine prevents binding of SARS–CoV-2 spike to its cellular receptor ACE2​
    Edwards, M. J.; Becker, K. A.; Gripp, B.; Hoffmann, M.; Keitsch, S.; Wilker, B. & Soddemann, M. et al.​ (2020) 
    Journal of Biological Chemistry, 295(45) pp. 15174​-15182​.​ DOI: https://doi.org/10.1074/jbc.RA120.015249 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Glycan-Gold Nanoparticles as Multifunctional Probes for Multivalent Lectin–Carbohydrate Binding: Implications for Blocking Virus Infection and Nanoparticle Assembly​
    Budhadev, D.; Poole, E.; Nehlmeier, I.; Liu, Y.; Hooper, J.; Kalverda, E. & Akshath, U. S. et al.​ (2020) 
    Journal of the American Chemical Society, 142(42) pp. 18022​-18034​.​ DOI: https://doi.org/10.1021/jacs.0c06793 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor​
    Hoffmann, M.; Kleine-Weber, H.; Schroeder, S.; Krüger, N.; Herrler, T.; Erichsen, S. & Schiergens, T. S. et al.​ (2020) 
    Cell, 181(2) pp. 271​-280.e8​.​ DOI: https://doi.org/10.1016/j.cell.2020.02.052 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​H2 influenza A virus is not pathogenic in Tmprss2 knock-out mice​
    Lambertz, R. L. O.; Gerhauser, I.; Nehlmeier, I.; Gärtner, S.; Winkler, M. ; Leist, S. R. & Kollmus, H. et al.​ (2020) 
    Virology Journal, 17(1).​ DOI: https://doi.org/10.1186/s12985-020-01323-z 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​LY6E impairs coronavirus fusion and confers immune control of viral disease​
    Pfaender, S.; Mar, K. B.; Michailidis, E.; Kratzel, A.; Boys, I. N.; V’kovski, P. & Fan, W. et al.​ (2020) 
    Nature Microbiology, 5(11) pp. 1330​-1339​.​ DOI: https://doi.org/10.1038/s41564-020-0769-y 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Chloroquine does not inhibit infection of human lung cells with SARS-CoV-2​
    Hoffmann, M.; Mösbauer, K.; Hofmann-Winkler, H.; Kaul, A.; Kleine-Weber, H.; Krüger, N. & Gassen, N. C. et al.​ (2020) 
    Nature, 585(7826) pp. 588​-590​.​ DOI: https://doi.org/10.1038/s41586-020-2575-3 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods​
    Bošnjak, B.; Stein, S. C.; Willenzon, S.; Cordes, A. K.; Puppe, W.; Bernhardt, G. & Ravens, I. et al.​ (2020) 
    Cellular & Molecular Immunology, 18(4) pp. 936​-944​.​ DOI: https://doi.org/10.1038/s41423-020-00573-9 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Tmprss2 knock-out mice are resistant to H10 influenza A virus pathogenesis​
    Lambertz, R. L. O.; Gerhauser, I.; Nehlmeier, I.; Leist, S. R.; Kollmus, H.; Pöhlmann, S.   & Schughart, K.​ (2019) 
    Journal of General Virology, 100(7) pp. 1073​-1078​.​ DOI: https://doi.org/10.1099/jgv.0.001274 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Calu-3 cells are largely resistant to entry driven by filovirus glycoproteins and the entry defect can be rescued by directed expression of DC-SIGN or cathepsin L​
    González-Hernández, M.; Müller, A.; Hoenen, T.; Hoffmann, M. & Pöhlmann, S. ​ (2019) 
    Virology, 532 pp. 22​-29​.​ DOI: https://doi.org/10.1016/j.virol.2019.03.020 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization​
    Kleine-Weber, H.; Elzayat, M. T.; Wang, L.; Graham, B. S.; Müller, M. A.; Drosten, C. & Pöhlmann, S.  et al.​ (2019) 
    Journal of Virology, 93(2).​ DOI: https://doi.org/10.1128/JVI.01381-18 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Novel Virus Related to Kaposi’s Sarcoma–Associated Herpesvirus from Colobus Monkey​
    Dhingra, A.; Ganzenmueller, T.; Hage, E.; Suárez, N. M.; Mätz-Rensing, K. ; Widmer, D. & Pöhlmann, S.  et al.​ (2019) 
    Emerging Infectious Diseases, 25(8) pp. 1548​-1551​.​ DOI: https://doi.org/10.3201/eid2508.181802 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Interferon‐Induced Transmembrane Proteins Mediate Viral Evasion in Acute and Chronic Hepatitis C Virus Infection​
    Wrensch, F.; Ligat, G.; Heydmann, L.; Schuster, C.; Zeisel, M. B.; Pessaux, P. & Habersetzer, F. et al.​ (2019) 
    Hepatology, 70(5) pp. 1506​-1520​.​ DOI: https://doi.org/10.1002/hep.30699 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Kaposi Sarcoma in Mantled Guereza​
    Grewer, A.; Bleyer, M.; Mätz-Rensing, K. ; Hahn, A. S. ; Rüggeberg, T.; Babaryka, G. & Zimmermann, A. et al.​ (2019) 
    Emerging Infectious Diseases, 25(8) pp. 1552​-1555​.​ DOI: https://doi.org/10.3201/eid2508.181804 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Hemagglutinin Cleavability, Acid Stability, and Temperature Dependence Optimize Influenza B Virus for Replication in Human Airways​
    Laporte, M.; Stevaert, A.; Raeymaekers, V.; Boogaerts, T.; Nehlmeier, I.; Chiu, W. & Benkheil, M. et al.​ (2019) 
    Journal of Virology, 94(1).​ DOI: https://doi.org/10.1128/JVI.01430-19 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Tetherin Inhibits Nipah Virus but Not Ebola Virus Replication in Fruit Bat Cells​
    Hoffmann, M.; Nehlmeier, I.; Brinkmann, C.; Krähling, V.; Behner, L.; Moldenhauer, A.-S. & Krüger, N. et al.​ (2019) 
    Journal of Virology, 93(3).​ DOI: https://doi.org/10.1128/JVI.01821-18 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Spike proteins of novel MERS-coronavirus isolates from North- and West-African dromedary camels mediate robust viral entry into human target cells​
    Kleine-Weber, H.; Pöhlmann, S.   & Hoffmann, M.​ (2019) 
    Virology, 535 pp. 261​-265​.​ DOI: https://doi.org/10.1016/j.virol.2019.07.016 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Disease Manifestation and Viral Sequences in a Bonobo More Than 30 Years after Papillomavirus Infection​
    Hoffmann, M.; Schütze, E.; Bernhard, A. ; Schlaphoff, L.; Kaul, A.; Schöniger, S. & Pöhlmann, S. ​ (2019) 
    Pathogens, 8(1) pp. 13​.​ DOI: https://doi.org/10.3390/pathogens8010013 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Characterization of the Filovirus-Resistant Cell Line SH-SY5Y Reveals Redundant Role of Cell Surface Entry Factors​
    Zapatero-Belinchón, F.; Dietzel, E.; Dolnik, O.; Döhner, K.; Costa, R.; Hertel, B. & Veselkova, B. et al.​ (2019) 
    Viruses, 11(3) pp. 275​.​ DOI: https://doi.org/10.3390/v11030275 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Analysis of IFITM-IFITM Interactions by a Flow Cytometry-Based FRET Assay​
    Winkler, M. ; Wrensch, F.; Bosch, P.; Knoth, M.; Schindler, M.; Gärtner, S. & Pöhlmann, S. ​ (2019) 
    International Journal of Molecular Sciences, 20(16) pp. 3859​.​ DOI: https://doi.org/10.3390/ijms20163859 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​A Fosmid-Based System for the Generation of Recombinant Cercopithecine Alphaherpesvirus 2 Encoding Reporter Genes​
    Chukhno, E.; Gärtner, S.; Rahman Siregar, A.; Mehr, A.; Wende, M.; Petkov, S. & Götting, J. et al.​ (2019) 
    Viruses, 11(11) pp. 1026​.​ DOI: https://doi.org/10.3390/v11111026 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Analysis of Resistance of Ebola Virus Glycoprotein-Driven Entry Against MDL28170, An Inhibitor of Cysteine Cathepsins​
    Hoffmann, M.; Kaufmann, S. V.; Fischer, C.; Maurer, W.; Moldenhauer, A.-S. & Pöhlmann, S. ​ (2019) 
    Pathogens, 8(4) pp. 192​.​ DOI: https://doi.org/10.3390/pathogens8040192 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Modulation of HIV-1 Gag/Gag-Pol frameshifting by tRNA abundance​
    Korniy, N.; Goyal, A. ; Hoffmann, M.; Samatova, E. ; Peske, F. ; Pöhlmann, S.   & Rodnina, M. V ​ (2019) 
    Nucleic Acids Research, 47(10) pp. 5210​-5222​.​ DOI: https://doi.org/10.1093/nar/gkz202 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Role of rhesus macaque IFITM3(2) in simian immunodeficiency virus infection of macaques​
    Winkler, M. ; Gärtner, S.; Markus, L.; Hoffmann, M.; Nehlmeier, I.; Krawczak, M.   & Sauermann, U. et al.​ (2019) 
    PLoS One, 14(11) art. e0224082​.​ DOI: https://doi.org/10.1371/journal.pone.0224082 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article
    ​ ​TMPRSS11A activates the influenza A virus hemagglutinin and the MERS coronavirus spike protein and is insensitive against blockade by HAI-1​
    Zmora, P.; Hoffmann, M.; Kollmus, H.; Moldenhauer, A.-S.; Danov, O.; Braun, A. & Winkler, M.  et al.​ (2018) 
    Journal of Biological Chemistry, 293(36) pp. 13863​-13873​.​ DOI: https://doi.org/10.1074/jbc.RA118.001273 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Functional analysis of potential cleavage sites in the MERS-coronavirus spike protein​
    Kleine-Weber, H.; Elzayat, M. T.; Hoffmann, M. & Pöhlmann, S. ​ (2018) 
    Scientific Reports, 8(1) art. 16597​.​ DOI: https://doi.org/10.1038/s41598-018-34859-w 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​The glycoprotein of vesicular stomatitis virus promotes release of virus-like particles from tetherin-positive cells​
    Brinkmann, C.; Hoffmann, M.; Lübke, A.; Nehlmeier, I.; Krämer-Kühl, A.; Winkler, M.   & Pöhlmann, S. ​ (2017) 
    PLoS One, 12(12) art. e0189073​.​ DOI: https://doi.org/10.1371/journal.pone.0189073 
    ​Details  DOI 
  • 2014 | Journal Article | 
    ​ ​Influenza A Virus Encoding Secreted Gaussia Luciferase as Useful Tool to Analyze Viral Replication and Its Inhibition by Antiviral Compounds and Cellular Proteins​
    Eckert, N. ; Wrensch, F.; Gärtner, S.; Palanisamy, N.; Goedecke, U.; Jäger, N. & Pöhlmann, S.  et al.​ (2014) 
    PLOS ONE, 9(5) art. e97695​.​ DOI: https://doi.org/10.1371/journal.pone.0097695 
    ​Details  DOI  PMID  PMC 

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