Dr. med. Thomas Horst Fischer

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  • 2022 | Journal Article | Research Paper
    ​ ​Herting J, Fischer TH, Maack C. ​Herzinsuffizienz​. ​​Der Nephrologe. ​2022;​17​(3):​​197​-207​. ​doi:10.1007/s11560-022-00575-w. 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Eiringhaus J, Wünsche CM, Tirilomis P, Herting J, Bork N, Nikolaev VO, et al. ​Sacubitrilat reduces pro‐arrhythmogenic sarcoplasmic reticulum Ca 2+ leak in human ventricular cardiomyocytes of patients with end‐stage heart failure​. ​​ESC Heart Failure. ​2020;​7​(5):​​2992​-3002​. ​doi:10.1002/ehf2.12918. 
    ​Details  DOI  PMID  PMC 
  • 2019 | Conference Paper
    ​ ​Eiringhaus J, Wuensche C, Herting J, Hasenfuss G, Sossalla S, Fischer T. ​P3829 Antiarrhythmic effects of Sacubitrilat (LBQ657) on Ca2+ homeostasis in ventricular cardiomyocytes​. ​ ESC Congress 2019 together with World Congress of Cardiology; ​2019-08-31​ - 2019-09-04​; ​​Paris. ​European Heart Journal. ​2019;​40​(Suppl. 1)doi:10.1093/eurheartj/ehz745.0671.
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper
    ​ ​Eiringhaus J, Herting J, Schatter F, Nikolaev VO, Sprenger J, Wang Y, et al. ​Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling​. ​​Basic Research in Cardiology. ​2019;​114​(2):​​13​. ​doi:10.1007/s00395-019-0720-7. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Bergau L, Willems R, Sprenkeler D, Fischer TH, Flevari P, Hasenfuß G, et al. ​Data on differential multivariable risk prediction of appropriate shock vs. competing mortality​. ​​Data in Brief. ​2018;​21​:​​2110​-2116​. ​doi:10.1016/j.dib.2018.11.025. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Pabel S, Wagner S, Bollenberg H, Bengel P, Kovács Á, Schach C, et al. ​Empagliflozin directly improves diastolic function in human heart failure​. ​​European Journal of Heart Failure. ​2018;​20​(12):​​1690​-1700​. ​doi:10.1002/ejhf.1328. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Iyer L, Nagarajan S, Woelfer M, Schoger E, Khadjeh S, Zafiriou MP, et al. ​A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart​. ​​Nucleic Acids Research. ​2018;​46​(6):​​2850​-2867​. ​doi:10.1093/nar/gky049. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Dybkova N, Ahmad S, Pabel S, Tirilomis P, Hartmann N, Fischer T, et al. ​Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart​. ​​Cardiovascular Research. ​2018;​114​(13):​​1728​-1737​. ​doi:10.1093/cvr/cvy152. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Bergau L, Willems R, Sprenkeler DJ, Fischer TH, Flevari P, Hasenfuß G, et al. ​Differential multivariable risk prediction of appropriate shock versus competing mortality - A prospective cohort study to estimate benefits from ICD therapy​. ​​International Journal of Cardiology. ​2018;​272​:​​102​-107​. ​doi:10.1016/j.ijcard.2018.06.103. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Fischer TH, Eiringhaus J, Dybkova N, Saadatmand A, Pabel S, Weber S, et al. ​Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure​. ​​European Journal of Heart Failure. ​2018;​20​(12):​​1673​-1685​. ​doi:10.1002/ejhf.1297. 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Eiringhaus J, Fischer TH, Kohn M, Wang Y, Maier LS, Hasenfuss G, et al. ​PP1 activation as novel antiarrhythmic approach in human heart failure​. ​​European Heart Journal. ​2017;​38​(suppl_1):​​1236​. ​doi:10.1093/eurheartj/ehx493.P5841. 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Perera RK, Fischer TH, Wagner M, Dewenter M, Vettel C, Bork NI, et al. ​Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4​. ​​Scientific Reports. ​2017;​7​(1). ​doi:10.1038/s41598-017-15632-x. 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​Bergau L, Tichelbaecker T, Kowallick JT, Lüthje L, Fischer TH, Unterberg-Buchwald C, et al. ​Serial assessment of left atrial deformation in patients undergoing pulmonary vein isolation: a cardiovascular magnetic resonance feasibility study​. ​​Journal of Cardiovascular Magnetic Resonance. ​2016;​18​(Suppl 1). ​doi:10.1186/1532-429x-18-s1-p362. 
    ​Details  DOI 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Sprenger JU, Bork NI, Herting J, Fischer TH, Nikolaev VO. ​Interactions of Calcium Fluctuations during Cardiomyocyte Contraction with Real-Time cAMP Dynamics Detected by FRET​. ​​PLoS One. ​2016;​11​(12). ​doi:10.1371/journal.pone.0167974. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Seegers J, Bergau L, Exposito PM, Bauer A, Fischer TH, Luethje L, et al. ​Prediction of Appropriate Shocks Using 24-Hour Holter Variables and T-Wave Alternans After First Implantable Cardioverter-Defibrillator Implantation in Patients With Ischemic or Nonischemic Cardiomyopathy​. ​​The American Journal of Cardiology. ​2016;​118​(1):​​86​-94​. ​doi:10.1016/j.amjcard.2016.04.016. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Fischer TH, Herting J, Eiringhaus J, Pabel S, Hartmann NH, Ellenberger D, et al. ​Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure​. ​​EP Europace. ​2016;​18​(9):​​1440​-1448​. ​doi:10.1093/europace/euv313. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Fischer TH, Kleinwächter A, Herting J, Eiringhaus J, Hartmann N, Renner A, et al. ​Inhibition of CaMKII Attenuates Progressing Disruption of Ca2+ Homeostasis Upon Left Ventricular Assist Device Implantation in Human Heart Failure​. ​​Artificial Organs. ​2016;​40​(8):​​719​-726​. ​doi:10.1111/aor.12677. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Seegers J, Conen D, Jung K, Bergau L, Dorenkamp M, Luethje L, et al. ​Sex difference in appropriate shocks but not mortality during long-term follow-up in patients with implantable cardioverter-defibrillators​. ​​EP Europace. ​2016;​18​(8):​​1194​-1202​. ​doi:10.1093/europace/euv361. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Hartmann NH, Mason FE, Braun I, Pabel S, Voigt N, Schotola H, et al. ​The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology​. ​​Journal of Molecular and Cellular Cardiology. ​2016;​94​:​​95​-106​. ​doi:10.1016/j.yjmcc.2016.03.012. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Conference Abstract
    ​ ​Hartmann N, Mason F, Braun I, Voigt N, Fischer TH, Hasenfuß G, et al. ​The combined effects of ranolazine and low dose dronedarone on atrial vs. ventricular electrophysiology; a novel therapeutic hope?​. ​​London, ENGLAND. ​European Heart Journal. ​2015;​36​:1067​-1068​. ​
    ​Details  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Fischer TH, Herting J, Mason FE, Hartmann N, Watanabe S, Nikolaev VO, et al. ​Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII​. ​​Cardiovascular Research. ​2015;​107​(1):​​184​-196​. ​doi:10.1093/cvr/cvv153. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Sag CM, Mallwitz A, Wagner S, Hartmann N, Schotola H, Fischer TH, et al. ​Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner​. ​​Journal of Molecular and Cellular Cardiology. ​2014;​76​:​​94​-105​. ​doi:10.1016/j.yjmcc.2014.08.016. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Fischer TH, Eiringhaus J, Dybkova N, Foerster A, Herting J, Kleinwaechter A, et al. ​Ca2+/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy​. ​​European Journal of Heart Failure. ​2014;​16​(12):​​1292​-1300​. ​doi:10.1002/ejhf.163. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​Fischer TH, Neef S, Maier LS. ​The Ca-calmodulin dependent kinase II: A promising target for future antiarrhythmic therapies?​. ​​Journal of Molecular and Cellular Cardiology. ​2013;​58​:​​182​-187​. ​doi:10.1016/j.yjmcc.2012.11.003. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Toischer K, Hartmann N, Wagner S, Fischer TH, Herting J, Danner BC, et al. ​Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease​. ​​Journal of Molecular and Cellular Cardiology. ​2013;​61​:​​111​-122​. ​doi:10.1016/j.yjmcc.2013.03.021. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Fischer TH, Herting J, Tirilomis T, Renner A, Neef S, Toischer K, et al. ​Ca2+/Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca2+ Leak in Human Cardiac Pathology​. ​​Circulation. ​2013;​128​(9):​​970​-981​. ​doi:10.1161/CIRCULATIONAHA.113.001746. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​Fischer TH, Maier LS, Sossalla ST. ​The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis​. ​​Heart Failure Reviews. ​2013;​18​(4):​​475​-483​. ​doi:10.1007/s10741-012-9339-6. 
    ​Details  DOI  PMID  PMC  WoS 

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