Dr. med. Dr. rer. nat. Lena-Christin Conradi

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  • 2023 | Journal Article | 
    ​ ​Fleischer, Johannes R., et al. "Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution​." ​Molecular Cancer, vol. 22, no. 1, ​2023, , ​doi: 10.1186/s12943-023-01713-1. 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Hettler, Madelaine, et al. "Comparing Apparent Diffusion Coefficient and FNCLCC Grading to Improve Pretreatment Grading of Soft Tissue Sarcoma—A Translational Feasibility Study on Fusion Imaging​." ​Cancers, vol. 14, no. 17, ​2022, p. 4331​, ​doi: 10.3390/cancers14174331. 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Kaplaneris, Nikolaos, et al. "Late-stage stitching enabled by manganese-catalyzed C─H activation: Peptide ligation and access to cyclopeptides​." ​Science Advances, vol. 7, no. 9, ​2021, p. eabe6202​, ​doi: 10.1126/sciadv.abe6202. 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Nöpel-Dünnebacke, Stefanie, et al. "Einfluss der Molekularpathologie auf die onkologische Chirurgie des kolorektalen Karzinoms​." ​Der Chirurg, ​2021, , ​doi: 10.1007/s00104-021-01486-7. 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​De Oliveira, Tiago, et al. "Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo​." ​Cancers, vol. 13, no. 5, ​2021, p. 1011​, ​doi: 10.3390/cancers13051011. 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Koerdel, Kristin, et al. "NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy​." ​Cancers, vol. 13, no. 3, ​2021, p. 455​, ​doi: 10.3390/cancers13030455. 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Nöpel-Dünnebacke, Stefanie, et al. "Therapeutische Relevanz molekularer Marker beim kolorektalen Karzinom​." ​Der Onkologe, vol. 26, no. 8, ​2020, pp. 685​-697​, ​doi: 10.1007/s00761-020-00777-8. 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Goveia, Jermaine, et al. "An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates​." ​Cancer Cell, vol. 37, no. 1, ​2020, pp. 21​-36.e13​, ​doi: 10.1016/j.ccell.2019.12.001. 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Rohlenova, Katerina, et al. "Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis​." ​Cell Metabolism, vol. 31, no. 4, ​2020, pp. 862​-877.e14​, ​doi: 10.1016/j.cmet.2020.03.009. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Khan, Shawez, et al. "EndoDB: a database of endothelial cell transcriptomics data​." ​Nucleic Acids Research, vol. 47, no. D1, ​2018, pp. D736​-D744​, ​doi: 10.1093/nar/gky997. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Schulz-Heddergott, Ramona, et al. "Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion​." ​Cancer Cell, vol. 34, no. 2, ​2018, pp. 298​-314.e7​, ​doi: 10.1016/j.ccell.2018.07.004. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Oberthür, Rabea, et al. "Simultaneous inhibition of IGF1R and EGFR enhances the efficacy of standard treatment for colorectal cancer by the impairment of DNA repair and the induction of cell death​." ​Cancer Letters, vol. 407, ​2017, pp. 93​-105​, ​doi: 10.1016/j.canlet.2017.08.009. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Sahlmann, Carsten-Oliver, et al. "Repeated Adjuvant Anti-CEA Radioimmunotherapy After Resection of Colorectal Liver Metastases: Safety, Feasibility, and Long-Term Efficacy Results of a Prospective Phase 2 Study​." ​Cancer, vol. 123, no. 4, ​2017, pp. 638​-649​, ​doi: 10.1002/cncr.30390. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article | 
    ​ ​Rühlmann, Felix, et al. "The Prognostic Value of Tyrosine Kinase SRC Expression in Locally Advanced Rectal Cancer​." ​Journal of Cancer, vol. 8, no. 7, ​2017, pp. 1229​-1237​, ​doi: 10.7150/jca.16980. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article | 
    ​ ​Lowes, Markus, et al. "The utilization of multidisciplinary tumor boards (MDT) in clinical routine: results of a health care research study focusing on patients with metastasized colorectal cancer​." ​International Journal of Colorectal Disease, vol. 32, no. 10, ​2017, pp. 1463​-1469​, ​doi: 10.1007/s00384-017-2871-z. 
    ​Details  DOI  PMID  PMC 
  • 2016 | Conference Abstract
    ​ ​Sprenger, Thilo, et al. "The prognostic role of the host immune response in rectal cancer patients treated with neoadjuvant chemoradiation.​." ​vol. 34, no. 4, ​2016, pp. 575​-575​. ​doi: 10.1200/jco.2016.34.4_suppl.575. 
    ​Details  DOI  WoS 
  • 2016 | Conference Abstract
    ​ ​Homayounfar, Kia, et al. "Repeated anti-CEA radioimmunotherapy (RIT) with 131I-Labetuzumab after complete resection of colorectal liver metastases - safety, feasibility and long-term efficacy results of a prospective phase-II-study​." ​Oncology Research and Treatment, vol. 39, ​2016, . ​
    ​Details  WoS 
  • 2016 | Conference Abstract
    ​ ​Jo, Peter, et al. "Neoadjuvant therapy in rectal cancer - challenges of biobanking tumor biopsies taken prior to treatment​." ​Oncology Research and Treatment, vol. 39, ​2016, . ​
    ​Details  WoS 
  • 2016 | Journal Article
    ​ ​Sprenger, Thilo, et al. "Lymph nodemetastases in ypT1/2 rectal cancer after neoadjuvant chemoradiotherapy. The Achilles heel of organ-preserving operative procedures?​." ​Der Chirurg, vol. 87, no. 7, ​2016, pp. 593​-601​, ​doi: 10.1007/s00104-016-0170-9. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​Bleckmann, Annalen, et al. "beta-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases​." ​Clinical & Experimental Metastasis, vol. 33, no. 4, ​2016, pp. 309​-323​, ​doi: 10.1007/s10585-016-9780-3. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​Jo, Peter, et al. "Neoadjuvant Therapy in Rectal Cancer - Biobanking of Preoperative Tumor Biopsies​." ​Scientific Reports, vol. 6, ​2016, , ​doi: 10.1038/srep35589. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Sprenger, Thilo, et al. "Stage-Dependent Frequency of Lymph Node Metastases in Patients With Rectal Carcinoma After Preoperative Chemoradiation: Results from the CAO/ARO/AIO-94 Trial and From a Comparative Prospective Evaluation With Extensive Pathological Workup​." ​Diseases of the Colon & Rectum, vol. 59, no. 5, ​2016, pp. 377​-385​, ​doi: 10.1097/DCR.0000000000000570. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Conference Abstract
    ​ ​Bleckmann, Annalen, et al. "Heterogeneity of colorectal cancer liver metastasis - analysis of WNT pathway patterns via High-throughput and bioinformatics profiling​." ​Oncology Research and Treatment, vol. 38, ​2015, . ​
    ​Details  WoS 
  • 2015 | Journal Article
    ​ ​Styczen, Hanna, et al. "HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer​." ​Oncotarget, vol. 6, no. 17, ​2015, pp. 15065​-15076​. ​
    ​Details  PMID  PMC  WoS 
  • 2014 | Conference Abstract
    ​ ​Quack, H., et al. "Effects of 5-FU dose monitoring under neoadjuvant radiochemotherapy for locally advanced rectal cancer​." ​Oncology Research and Treatment, vol. 37, ​2014, . ​
    ​Details  WoS 
  • 2014 | Conference Abstract
    ​ ​Ruehlmann, Felix, et al. "SRC expression in locally advanced rectal cancer-before and after neoadjuvant chemoradiotherapy​." ​Oncology Research and Treatment, vol. 37, ​2014, . ​
    ​Details  WoS 
  • 2014 | Conference Abstract
    ​ ​Sprenger, Thilo, et al. "Residual rectal cancer after preoperative radiochemotherapy (ypT1-2): An indication for local excision instead of radical surgery?​." ​Journal of Clinical Oncology, vol. 32, no. 3, ​2014, . ​
    ​Details  WoS 
  • 2014 | Conference Abstract
    ​ ​Dröge, Leif Hendrik, et al. "Cytokinesis-block micronucleus cytome assay for in vivo and in vitro lymphocyte radiosensitivity in patients undergoing radiochemotherapy for locally advanced rectal cancer​." ​Strahlentherapie und Onkologie, vol. 190, ​2014, . ​
    ​Details  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Ilgen, Peter, et al. "STED Super-Resolution Microscopy of Clinical Paraffin-Embedded Human Rectal Cancer Tissue​." ​PLOS ONE, vol. 9, no. 7, ​2014, , ​doi: 10.1371/journal.pone.0101563. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Sprenger, Thilo, et al. "Lymph Node Metastases in Rectal Cancer After Preoperative Radiochemotherapy Impact of Intramesorectal Distribution and Residual Micrometastatic Involvement​." ​American Journal of Surgical Pathology, vol. 37, no. 8, ​2013, pp. 1283​-1289​. ​
    ​Details  PMID  PMC  WoS 
  • 2013 | Conference Abstract
    ​ ​Conradi, Lena-Christin, et al. "HER-2 and HER-3 expression in locally advanced rectal cancer and metachronous metastases: new targets for treatment approaches?​." ​Onkologie, vol. 36, ​2013, . ​
    ​Details  WoS 
  • 2013 | Conference Abstract
    ​ ​Conradi, Lena-Christin, et al. "5-FU dose monitoring under neoadjuvant radiochemotherapy and adjuvant chemotherapy for locally advanced rectal cancer​." ​Onkologie, vol. 36, ​2013, . ​
    ​Details  WoS 
  • 2013 | Conference Abstract
    ​ ​Wolff, Hendrik Andreas, et al. "Gender influences acute Toxicity during Chemoradiotherapy in Patients with Rectal cancer: Long-term results of the CAO/ARO/AIO 94 Trial​." ​Strahlentherapie und Onkologie, vol. 189, ​2013, . ​
    ​Details  WoS 
  • 2013 | Conference Abstract
    ​ ​Droege, Leif Hendrik, et al. "Context of persistent DNA Damage (Micronuclei) and Late Side Effects after Multimodal Radiochemotherapy in Patients with locally advanced Rectal cancer​." ​Strahlentherapie und Onkologie, vol. 189, ​2013, . ​
    ​Details  WoS 
  • 2013 | Conference Abstract
    ​ ​Sprenger, Thilo, et al. "Association of CD133 expression levels with the k-ras mutation status in rectal cancers before and after preoperative radiochemotherapy​." ​Journal of Clinical Oncology, vol. 31, no. 4, ​2013, . ​
    ​Details  WoS 
  • 2013 | Journal Article
    ​ ​Sprenger, Thilo, et al. "Enrichment of CD133-expressing cells in rectal cancers treated with preoperative radiochemotherapy is an independent marker for metastasis and survival​." ​Cancer, vol. 119, no. 1, ​2013, pp. 26​-35​, ​doi: 10.1002/cncr.27703. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | 
    ​ ​Homayounfar, Kia, et al. "Metastatic recurrence after complete resection of colorectal liver metastases: impact of surgery and chemotherapy on survival​." ​International Journal of Colorectal Disease, vol. 28, no. 7, ​2013, pp. 1009​-1017​, ​doi: 10.1007/s00384-013-1648-2. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | 
    ​ ​Wolff, Hendrik Andreas, et al. "Gender affects acute organ toxicity during radiochemotherapy for rectal cancer: Long-term results of the German CAO/ARO/AIO-94 phase III trial​." ​Radiotherapy and Oncology, vol. 108, no. 1, ​2013, pp. 48​-54​, ​doi: 10.1016/j.radonc.2013.05.009. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Conradi, Lena-Christin, et al. "Frequency of HER-2 Positivity in Rectal Cancer and Prognosis​." ​American Journal of Surgical Pathology, vol. 37, no. 4, ​2013, pp. 522​-531​, ​doi: 10.1097/PAS.0b013e318272ff4d. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Fokas, Emmanouil, et al. "Preoperative Chemoradiation Therapy With Capecitabine/Oxaliplatin and Cetuximab in Rectal Cancer: Long-Term Results of a Prospective Phase 1/2 Study​." ​International Journal of Radiation Oncology*Biology*Physics, vol. 87, no. 5, ​2013, pp. 992​-999​, ​doi: 10.1016/j.ijrobp.2013.09.011. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Conference Abstract
    ​ ​Sprenger, Thilo, et al. "Clinical significance and prognostic impact of CD133 expression in rectal cancer treated with preoperative radiochemotherapy​." ​Journal of Clinical Oncology, vol. 30, no. 15, ​2012, . ​
    ​Details  WoS 
  • 2012 | Conference Abstract
    ​ ​Liersch, Torsten, et al. "Cetuximab, capecitabine, oxaliplatin, and radiotherapy as preoperative triple treatment for rectal cancer (CET-CAPOX-RT-Phase-I/II Study): Influence on long-term survival and relevance of biomarkers​." ​Journal of Clinical Oncology, vol. 30, no. 15, ​2012, . ​
    ​Details  WoS 
  • 2012 | Conference Abstract
    ​ ​Conradi, Lena-Christin, et al. "HER-2 in locally advanced rectal cancer (cUICC II/III): positivity rate and prognostic value​." ​British Journal of Surgery, vol. 99, ​2012, . ​
    ​Details  WoS 
  • 2012 | Conference Abstract
    ​ ​Conradi, Lena-Christin, et al. "HER2 status in locally advanced rectal cancer and metachronous metastases: Opportunity for a new therapeutic approach?​." ​Journal of Clinical Oncology, vol. 30, no. 15, ​2012, . ​
    ​Details  WoS 
  • 2012 | Journal Article | 
    ​ ​Homayounfar, Kia, et al. "Bilobar spreading of colorectal liver metastases does not significantly affect survival after R0 resection in the era of interdisciplinary multimodal treatment​." ​International Journal of Colorectal Disease, vol. 27, no. 10, ​2012, pp. 1359​-1367​, ​doi: 10.1007/s00384-012-1455-1. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​Schirmer, Markus Anton, et al. "Acute Toxicity of Radiochemotherapy in Rectal Cancer Patients: A Risk Particularly for Carriers of the TGFB1 Pro25 variant​." ​International Journal of Radiation Oncology*Biology*Physics, vol. 83, no. 1, ​2012, pp. 149​-157​, ​doi: 10.1016/j.ijrobp.2011.05.063. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​Jo, Peter, et al. "CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer​." ​Surgery, vol. 151, no. 4, ​2012, pp. 564​-570​, ​doi: 10.1016/j.surg.2011.08.013. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Conference Abstract
    ​ ​Conradi, Lena-Christin, et al. "Thymidylate Synthase as Biomarker in Rectal Cancer Patients After 5-FU-based Radiochemotherapy - Evaluation of the Prognostic Capacity in Pre-treatment Biopsies and Resected Adenocarcinoma​." ​European Journal of Cancer, vol. 47, ​2011, . ​
    ​Details  WoS 
  • 2011 | Conference Abstract
    ​ ​Conradi, Lena-Christin, et al. "Biomarker study in rectal cancer patients after 5FU-based radiochemotherapy: Evaluation of the prognostic capacity of thymidylate synthase in pretreatment biopsies and resected adenocarcinoma.​." ​Journal of Clinical Oncology, vol. 29, no. 4, ​2011, . ​
    ​Details  PMID  PMC  WoS 
  • 2011 | Conference Abstract
    ​ ​Sprenger, Thilo, et al. "Association of survivin expression following neoadjuvant radiochemotherapy in rectal cancer with distant metastases and survival.​." ​Journal of Clinical Oncology, vol. 29, no. 4, ​2011, . ​
    ​Details  PMID  PMC  WoS 
  • 2011 | Conference Abstract
    ​ ​Sprenger, Thilo, et al. "Survivin Expression in Rectal Cancer During Preoperative Radiochemotherapy and Its Impact on Metastasis and Patients' Survival​." ​European Journal of Cancer, vol. 47, ​2011, . ​
    ​Details  WoS 
  • 2011 | Conference Abstract
    ​ ​Christiansen, H., et al. "TGFB1 Pro25 allele as a risk marker for higher-grade acute Organ toxicity (CTC >= Grad2) during neoadjuvant Chemoradiotherapy in patients with locally advanced Rectal cancer (UICC Stage II/III)​." ​Strahlentherapie und Onkologie, vol. 187, ​2011, . ​
    ​Details  WoS 
  • 2011 | Conference Abstract
    ​ ​Roedel, Franz, et al. "A lack of down-regulation of survivin after neoadjuvant Chemoradiotherapy for Rectal cancer with distant metastasis and Reduced survival rate linked​." ​Strahlentherapie und Onkologie, vol. 187, ​2011, . ​
    ​Details  WoS 
  • 2011 | Journal Article | 
    ​ ​Conradi, Lena-Christin, et al. "Thymidylate Synthase as a Prognostic Biomarker for Locally Advanced Rectal Cancer after multimodal Treatment​." ​Annals of Surgical Oncology, vol. 18, no. 9, ​2011, pp. 2442​-2452​, ​doi: 10.1245/s10434-011-1608-4. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article
    ​ ​Wolff, Hendrik Andreas, et al. "Gender-Specific Acute Organ Toxicity during Intensified Preoperative Radiochemotherapy for Rectal Cancer​." ​The Oncologist, vol. 16, no. 5, ​2011, pp. 621​-631​, ​doi: 10.1634/theoncologist.2010-0414. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | 
    ​ ​Sprenger, Thilo, et al. "Failure of Downregulation of Survivin Following Neoadjuvant Radiochemotherapy in Rectal Cancer Is Associated with Distant Metastases and Shortened Survival​." ​Clinical Cancer Research, vol. 17, no. 6, ​2011, pp. 1623​-1631​, ​doi: 10.1158/1078-0432.CCR-10-2592. 
    ​Details  DOI  PMID  PMC  WoS 

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