Dr. med. Dr. rer. nat. Lena-Christin Conradi

 
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  • 2023 Journal Article | 
    ​ ​Fleischer JR, Schmitt AM, Haas G, Xu X, Zeisberg EM, Bohnenberger H, et al. ​Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution​. ​​Molecular Cancer. ​2023;​22​(1). ​doi:10.1186/s12943-023-01713-1. 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​Hettler M, Kitz J, Hosseini ASA, Guhlich M, Panahi B, Ernst J, et al. ​Comparing Apparent Diffusion Coefficient and FNCLCC Grading to Improve Pretreatment Grading of Soft Tissue Sarcoma—A Translational Feasibility Study on Fusion Imaging​. ​​Cancers. ​2022;​14​(17):​​4331​. ​doi:10.3390/cancers14174331. 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Kaplaneris N, Kaltenhӓuser F, Sirvinskaite G, Fan S, De Oliveira T, Conradi, Lena-Christin, et al. ​Late-stage stitching enabled by manganese-catalyzed C─H activation: Peptide ligation and access to cyclopeptides​. ​​Science Advances. ​2021;​7​(9):​​eabe6202​. ​doi:10.1126/sciadv.abe6202. 
    Details  DOI 
  • 2021 Journal Article
    ​ ​Nöpel-Dünnebacke S, Conradi, Lena-Christin, Reinacher-Schick A, Ghadimi M. ​Einfluss der Molekularpathologie auf die onkologische Chirurgie des kolorektalen Karzinoms​. ​​Der Chirurg. ​2021;. ​doi:10.1007/s00104-021-01486-7. 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​De Oliveira T, Goldhardt T, Edelmann M, Rogge T, Rauch K, Kyuchukov ND, et al. ​Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo​. ​​Cancers. ​2021;​13​(5):​​1011​. ​doi:10.3390/cancers13051011. 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Koerdel K, Spitzner M, Meyer T, Engels N, Krause F, Gaedcke J, et al. ​NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy​. ​​Cancers. ​2021;​13​(3):​​455​. ​doi:10.3390/cancers13030455. 
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  • 2020 Journal Article
    ​ ​Nöpel-Dünnebacke S, Conradi, Lena-Christin, Reinacher-Schick A, Ghadimi M. ​Therapeutische Relevanz molekularer Marker beim kolorektalen Karzinom​. ​​Der Onkologe. ​2020;​26​(8):​​685​-697​. ​doi:10.1007/s00761-020-00777-8. 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Goveia J, Rohlenova K, Taverna F, Treps L, Conradi, Lena-Christin, Pircher A, et al. ​An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates​. ​​Cancer Cell. ​2020;​37​(1):​​21​-36.e13​. ​doi:10.1016/j.ccell.2019.12.001. 
    Details  DOI 
  • 2020 Journal Article
    ​ ​Rohlenova K, Goveia J, García-Caballero M, Subramanian A, Kalucka J, Treps L, et al. ​Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis​. ​​Cell Metabolism. ​2020;​31​(4):​​862​-877.e14​. ​doi:10.1016/j.cmet.2020.03.009. 
    Details  DOI 
  • 2018 Journal Article
    ​ ​Khan S, Taverna F, Rohlenova K, Treps L, Geldhof V, de Rooij L, et al. ​EndoDB: a database of endothelial cell transcriptomics data​. ​​Nucleic Acids Research. ​2018;​47​(D1):​​D736​-D744​. ​doi:10.1093/nar/gky997. 
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  • 2018 Journal Article
    ​ ​Schulz-Heddergott R, Stark N, Edmunds SJ, Li J, Conradi, Lena-Christin, Bohnenberger H, et al. ​Therapeutic Ablation of Gain-of-Function Mutant p53 in Colorectal Cancer Inhibits Stat3-Mediated Tumor Growth and Invasion​. ​​Cancer Cell. ​2018;​34​(2):​​298​-314.e7​. ​doi:10.1016/j.ccell.2018.07.004. 
    Details  DOI 
  • 2017 Journal Article
    ​ ​Oberthür R, Seemann H, Gehrig J, Rave-Fränk M, Bremmer F, Halpape R, et al. ​Simultaneous inhibition of IGF1R and EGFR enhances the efficacy of standard treatment for colorectal cancer by the impairment of DNA repair and the induction of cell death​. ​​Cancer Letters. ​2017;​407​:​​93​-105​. ​doi:10.1016/j.canlet.2017.08.009. 
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  • 2017 Journal Article
    ​ ​Sahlmann, Carsten-Oliver, Homayounfar K, Niessner M, Dyczkowski J, Conradi, Lena-Christin, Braulke F, et al. ​Repeated Adjuvant Anti-CEA Radioimmunotherapy After Resection of Colorectal Liver Metastases: Safety, Feasibility, and Long-Term Efficacy Results of a Prospective Phase 2 Study​. ​​Cancer. ​2017;​123​(4):​​638​-649​. ​doi:10.1002/cncr.30390. 
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  • 2017 Journal Article | 
    ​ ​Rühlmann F, Nietert MM, Sprenger T, Wolff HA, Homayounfar K, Middel P, et al. ​The Prognostic Value of Tyrosine Kinase SRC Expression in Locally Advanced Rectal Cancer​. ​​Journal of Cancer. ​2017;​8​(7):​​1229​-1237​. ​doi:10.7150/jca.16980. 
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  • 2017 Journal Article | 
    ​ ​Lowes M, Kleiss M, Lueck R, Detken S, König AO, Nietert MM, et al. ​The utilization of multidisciplinary tumor boards (MDT) in clinical routine: results of a health care research study focusing on patients with metastasized colorectal cancer​. ​​International Journal of Colorectal Disease. ​2017;​32​(10):​​1463​-1469​. ​doi:10.1007/s00384-017-2871-z. 
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  • 2016 Conference Abstract
    ​ ​Sprenger T, Wirtz R, Pektas S, Bohnenberger H, Kauffels A, Conradi, Lena-Christin, et al. ​The prognostic role of the host immune response in rectal cancer patients treated with neoadjuvant chemoradiation.​. ​ Gastrointestinal Cancers Symposium; ​San Francisco, CA. -575​. ​doi:10.1200/jco.2016.34.4_suppl.575.
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  • 2016 Conference Abstract
    ​ ​Homayounfar K, Sahlmann, Carsten-Oliver, Niessner M, Dyczkowski J, Conradi, Lena-Christin, Braulke F, et al. ​Repeated anti-CEA radioimmunotherapy (RIT) with 131I-Labetuzumab after complete resection of colorectal liver metastases - safety, feasibility and long-term efficacy results of a prospective phase-II-study​. ​​Oncology Research and Treatment. ​2016;​39​
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  • 2016 Conference Abstract
    ​ ​Jo P, Gusky L, Nietert MM, Kitz J, Conradi, Lena-Christin, Müller-Dornieden A, et al. ​Neoadjuvant therapy in rectal cancer - challenges of biobanking tumor biopsies taken prior to treatment​. ​​Oncology Research and Treatment. ​2016;​39​
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  • 2016 Journal Article
    ​ ​Sprenger T, Rothe H, Beißbarth T, Conradi, Lena-Christin, Kauffels A, Homayounfar K, et al. ​Lymph nodemetastases in ypT1/2 rectal cancer after neoadjuvant chemoradiotherapy. The Achilles heel of organ-preserving operative procedures?​. ​​Der Chirurg. ​2016;​87​(7):​​593​-601​. ​doi:10.1007/s00104-016-0170-9. 
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  • 2016 Journal Article | 
    ​ ​Bleckmann A, Conradi, Lena-Christin, Menck K, Schmick NA, Schubert A, Rietkoetter E, et al. ​beta-catenin-independent WNT signaling and Ki67 in contrast to the estrogen receptor status are prognostic and associated with poor prognosis in breast cancer liver metastases​. ​​Clinical & Experimental Metastasis. ​2016;​33​(4):​​309​-323​. ​doi:10.1007/s10585-016-9780-3. 
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  • 2016 Journal Article | 
    ​ ​Jo P, Nietert MM, Gusky L, Kitz J, Conradi, Lena-Christin, Müller-Dornieden A, et al. ​Neoadjuvant Therapy in Rectal Cancer - Biobanking of Preoperative Tumor Biopsies​. ​​Scientific Reports. ​2016;​6​. ​doi:10.1038/srep35589. 
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  • 2016 Journal Article
    ​ ​Sprenger T, Rothe H, Conradi, Lena-Christin, Beissbarth T, Kauffels A, Kitz J, et al. ​Stage-Dependent Frequency of Lymph Node Metastases in Patients With Rectal Carcinoma After Preoperative Chemoradiation: Results from the CAO/ARO/AIO-94 Trial and From a Comparative Prospective Evaluation With Extensive Pathological Workup​. ​​Diseases of the Colon & Rectum. ​2016;​59​(5):​​377​-385​. ​doi:10.1097/DCR.0000000000000570. 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Conference Abstract
    ​ ​Bleckmann A, Wachter A, Conradi, Lena-Christin, Wolff A, Hoppenau C, Korf U, et al. ​Heterogeneity of colorectal cancer liver metastasis - analysis of WNT pathway patterns via High-throughput and bioinformatics profiling​. ​​Oncology Research and Treatment. ​2015;​38​
    Details  WoS 
  • 2015 Journal Article
    ​ ​Styczen H, Nagelmeier I, Beißbarth T, Nietert MM, Homayounfar K, Sprenger T, et al. ​HER-2 and HER-3 expression in liver metastases of patients with colorectal cancer​. ​​Oncotarget. ​2015;​6​(17):​​15065​-15076​. ​
    Details  PMID  PMC  WoS 
  • 2014 Conference Abstract
    ​ ​Quack H, Stanek K, Wolff HA, Dröge LH, Binder L, Bleckmann A, et al. ​Effects of 5-FU dose monitoring under neoadjuvant radiochemotherapy for locally advanced rectal cancer​. ​​Oncology Research and Treatment. ​2014;​37​
    Details  WoS 
  • 2014 Conference Abstract
    ​ ​Ruehlmann F, Nietert MM, Sprenger T, Wolff HA, Homayounfar K, Ghadimi MB, et al. ​SRC expression in locally advanced rectal cancer-before and after neoadjuvant chemoradiotherapy​. ​​Oncology Research and Treatment. ​2014;​37​
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  • 2014 Conference Abstract
    ​ ​Sprenger T, Rothe H, Conradi, Lena-Christin, Homayounfar K, Beißbarth T, Ghadimi MB, et al. ​Residual rectal cancer after preoperative radiochemotherapy (ypT1-2): An indication for local excision instead of radical surgery?​. ​ Gastrointestinal Cancers Symposium; ​San Francisco, CA. ​Journal of Clinical Oncology. ​2014;​32​(3)
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  • 2014 Conference Abstract
    ​ ​Dröge LH, Hennies S, Beißbarth T, Lorenzen S, Conradi, Lena-Christin, Quack H, et al. ​Cytokinesis-block micronucleus cytome assay for in vivo and in vitro lymphocyte radiosensitivity in patients undergoing radiochemotherapy for locally advanced rectal cancer​. ​ 20th Annual Congress of the German-Society-for-Radiation-Oncology; ​Dusseldorf, GERMANY. ​Strahlentherapie und Onkologie. ​2014;​190​
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  • 2014 Journal Article | Research Paper | 
    ​ ​Ilgen P, Stoldt S, Conradi, Lena-Christin, Wurm CA, Rüschoff J, Ghadimi BM, et al. ​STED Super-Resolution Microscopy of Clinical Paraffin-Embedded Human Rectal Cancer Tissue​. ​​PLOS ONE. ​2014;​9​(7). ​doi:10.1371/journal.pone.0101563. 
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  • 2013 Journal Article
    ​ ​Sprenger T, Rothe H, Becker H, Beißbarth T, Homayounfar K, Gauss K, et al. ​Lymph Node Metastases in Rectal Cancer After Preoperative Radiochemotherapy Impact of Intramesorectal Distribution and Residual Micrometastatic Involvement​. ​​American Journal of Surgical Pathology. ​2013;​37​(8):​​1283​-1289​. ​
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  • 2013 Conference Abstract
    ​ ​Conradi, Lena-Christin, Styczen H, Sprenger T, Wolff HA, Middel P, Nagelmeier I, et al. ​HER-2 and HER-3 expression in locally advanced rectal cancer and metachronous metastases: new targets for treatment approaches?​. ​​Onkologie. ​2013;​36​
    Details  WoS 
  • 2013 Conference Abstract
    ​ ​Conradi, Lena-Christin, Quack H, Sprenger T, Wolff HA, Binder L, Ghadimi MB, et al. ​5-FU dose monitoring under neoadjuvant radiochemotherapy and adjuvant chemotherapy for locally advanced rectal cancer​. ​​Onkologie. ​2013;​36​
    Details  WoS 
  • 2013 Conference Abstract
    ​ ​Wolff HA, Conradi, Lena-Christin, Beißbarth T, Leha A, Hohenberger W, Merkel S, et al. ​Gender influences acute Toxicity during Chemoradiotherapy in Patients with Rectal cancer: Long-term results of the CAO/ARO/AIO 94 Trial​. ​ 19th Annual Congress of the German-Society-for-Radiation-Oncology; ​Berlin, GERMANY. ​Strahlentherapie und Onkologie. ​2013;​189​
    Details  WoS 
  • 2013 Conference Abstract
    ​ ​Droege LH, Hennies S, Beißbarth T, Conradi, Lena-Christin, Helms C, Hess CF, et al. ​Context of persistent DNA Damage (Micronuclei) and Late Side Effects after Multimodal Radiochemotherapy in Patients with locally advanced Rectal cancer​. ​ 19th Annual Congress of the German-Society-for-Radiation-Oncology; ​Berlin, GERMANY. ​Strahlentherapie und Onkologie. ​2013;​189​
    Details  WoS 
  • 2013 Conference Abstract
    ​ ​Sprenger T, Gaedcke J, Conradi, Lena-Christin, Jo P, Jung K, Beißbarth T, et al. ​Association of CD133 expression levels with the k-ras mutation status in rectal cancers before and after preoperative radiochemotherapy​. ​ Gastrointestinal Cancers Symposium of the American-Society-of-Clinical-Oncology (ASCO); ​San Francisco, CA. ​Journal of Clinical Oncology. ​2013;​31​(4)
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  • 2013 Journal Article
    ​ ​Sprenger T, Conradi, Lena-Christin, Beißbarth T, Ermert H, Homayounfar K, Middel P, et al. ​Enrichment of CD133-expressing cells in rectal cancers treated with preoperative radiochemotherapy is an independent marker for metastasis and survival​. ​​Cancer. ​2013;​119​(1):​​26​-35​. ​doi:10.1002/cncr.27703. 
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  • 2013 Journal Article | 
    ​ ​Homayounfar K, Bleckmann A, Conradi, Lena-Christin, Sprenger T, Lorf T, Niessner M, et al. ​Metastatic recurrence after complete resection of colorectal liver metastases: impact of surgery and chemotherapy on survival​. ​​International Journal of Colorectal Disease. ​2013;​28​(7):​​1009​-1017​. ​doi:10.1007/s00384-013-1648-2. 
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  • 2013 Journal Article | 
    ​ ​Wolff HA, Conradi, Lena-Christin, Beißbarth T, Leha A, Hohenberger W, Merkel S, et al. ​Gender affects acute organ toxicity during radiochemotherapy for rectal cancer: Long-term results of the German CAO/ARO/AIO-94 phase III trial​. ​​Radiotherapy and Oncology. ​2013;​108​(1):​​48​-54​. ​doi:10.1016/j.radonc.2013.05.009. 
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  • 2013 Journal Article
    ​ ​Conradi, Lena-Christin, Styczen H, Sprenger T, Wolff HA, Roedel C, Nietert MM, et al. ​Frequency of HER-2 Positivity in Rectal Cancer and Prognosis​. ​​American Journal of Surgical Pathology. ​2013;​37​(4):​​522​-531​. ​doi:10.1097/PAS.0b013e318272ff4d. 
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  • 2013 Journal Article
    ​ ​Fokas E, Conradi, Lena-Christin, Weiss C, Sprenger T, Middel P, Rau T, et al. ​Preoperative Chemoradiation Therapy With Capecitabine/Oxaliplatin and Cetuximab in Rectal Cancer: Long-Term Results of a Prospective Phase 1/2 Study​. ​​International Journal of Radiation Oncology*Biology*Physics. ​2013;​87​(5):​​992​-999​. ​doi:10.1016/j.ijrobp.2013.09.011. 
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  • 2012 Conference Abstract
    ​ ​Sprenger T, Conradi, Lena-Christin, Beißbarth T, Homayounfar K, Rüschoff JR, Roedel C, et al. ​Clinical significance and prognostic impact of CD133 expression in rectal cancer treated with preoperative radiochemotherapy​. ​ 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO); ​Chicago, IL. ​Journal of Clinical Oncology. ​2012;​30​(15)
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  • 2012 Conference Abstract
    ​ ​Liersch T, Conradi, Lena-Christin, Sprenger T, Middel P, Suelberg H, Roedel F, et al. ​Cetuximab, capecitabine, oxaliplatin, and radiotherapy as preoperative triple treatment for rectal cancer (CET-CAPOX-RT-Phase-I/II Study): Influence on long-term survival and relevance of biomarkers​. ​ 48th Annual Meeting of the American-Society-of-Clinical-Oncology (ASCO); ​Chicago, IL. ​Journal of Clinical Oncology. ​2012;​30​(15)
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  • 2012 Conference Abstract
    ​ ​Conradi, Lena-Christin, Styczen H, Sprenger T, Wolff HA, Homayounfar K, Becker H, et al. ​HER-2 in locally advanced rectal cancer (cUICC II/III): positivity rate and prognostic value​. ​ 99th Annual Congress of the Swiss-Society-of-Surgery; ​Davos, SWITZERLAND. ​British Journal of Surgery. ​2012;​99​
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  • 2012 Conference Abstract
    ​ ​Conradi, Lena-Christin, Styczen H, Sprenger T, Homayounfar K, Wolff HA, Bleckmann A, et al. ​HER2 status in locally advanced rectal cancer and metachronous metastases: Opportunity for a new therapeutic approach?​. ​​Chicago, IL. ​Journal of Clinical Oncology. ​2012;​30​(15)
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  • 2012 Journal Article | 
    ​ ​Homayounfar K, Bleckmann A, Conradi, Lena-Christin, Sprenger T, Beißbarth T, Lorf T, et al. ​Bilobar spreading of colorectal liver metastases does not significantly affect survival after R0 resection in the era of interdisciplinary multimodal treatment​. ​​International Journal of Colorectal Disease. ​2012;​27​(10):​​1359​-1367​. ​doi:10.1007/s00384-012-1455-1. 
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  • 2012 Journal Article
    ​ ​Schirmer MA, Mergler CPN, Rave-Fränk M, Herrmann MKA, Hennies S, Gaedcke J, et al. ​Acute Toxicity of Radiochemotherapy in Rectal Cancer Patients: A Risk Particularly for Carriers of the TGFB1 Pro25 variant​. ​​International Journal of Radiation Oncology*Biology*Physics. ​2012;​83​(1):​​149​-157​. ​doi:10.1016/j.ijrobp.2011.05.063. 
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  • 2012 Journal Article
    ​ ​Jo P, Jung K, Grade M, Conradi, Lena-Christin, Wolff HA, Kitz J, et al. ​CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer​. ​​Surgery. ​2012;​151​(4):​​564​-570​. ​doi:10.1016/j.surg.2011.08.013. 
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  • 2011 Conference Abstract
    ​ ​Conradi, Lena-Christin, Bleckmann A, Sprenger T, Schirmer MA, Homayounfar K, Wolff HA, et al. ​Thymidylate Synthase as Biomarker in Rectal Cancer Patients After 5-FU-based Radiochemotherapy - Evaluation of the Prognostic Capacity in Pre-treatment Biopsies and Resected Adenocarcinoma​. ​ European Multidisciplinary Cancer Congress on Integrating Basic and Translational Science, Surgery, Radiotherapy, Medical oncology, Advocacy and Care; ​Stockholm, SWEDEN. ​European Journal of Cancer. ​2011;​47​
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  • 2011 Conference Abstract
    ​ ​Conradi, Lena-Christin, Bleckmann A, Schirmer MA, Sprenger T, Homayounfar K, Wolff HA, et al. ​Biomarker study in rectal cancer patients after 5FU-based radiochemotherapy: Evaluation of the prognostic capacity of thymidylate synthase in pretreatment biopsies and resected adenocarcinoma.​. ​​Journal of Clinical Oncology. ​2011;​29​(4)
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  • 2011 Conference Abstract
    ​ ​Sprenger T, Roedel F, Beißbarth T, Conradi, Lena-Christin, Homayounfar K, Ghadimi MB, et al. ​Association of survivin expression following neoadjuvant radiochemotherapy in rectal cancer with distant metastases and survival.​. ​​Journal of Clinical Oncology. ​2011;​29​(4)
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  • 2011 Conference Abstract
    ​ ​Sprenger T, Roedel F, Beißbarth T, Conradi, Lena-Christin, Yildirim M, Ghadimi MB, et al. ​Survivin Expression in Rectal Cancer During Preoperative Radiochemotherapy and Its Impact on Metastasis and Patients' Survival​. ​ European Multidisciplinary Cancer Congress on Integrating Basic and Translational Science, Surgery, Radiotherapy, Medical oncology, Advocacy and Care; ​Stockholm, SWEDEN. ​European Journal of Cancer. ​2011;​47​
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  • 2011 Conference Abstract
    ​ ​Christiansen H, Schirmer MA, Mergler CPN, Rave-Fränk M, Hennies S, Gaedcke J, et al. ​TGFB1 Pro25 allele as a risk marker for higher-grade acute Organ toxicity (CTC >= Grad2) during neoadjuvant Chemoradiotherapy in patients with locally advanced Rectal cancer (UICC Stage II/III)​. ​​Wiesbaden, GERMANY. ​Strahlentherapie und Onkologie. ​2011;​187​
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  • 2011 Conference Abstract
    ​ ​Roedel F, Sprenger T, Beißbarth T, Conradi, Lena-Christin, Rothe H, Homayonfaur K, et al. ​A lack of down-regulation of survivin after neoadjuvant Chemoradiotherapy for Rectal cancer with distant metastasis and Reduced survival rate linked​. ​ 17th Annual Meeting of the German-Society-for-Radiation-Oncology; ​Wiesbaden, GERMANY. ​Strahlentherapie und Onkologie. ​2011;​187​
    Details  WoS 
  • 2011 Journal Article | 
    ​ ​Conradi, Lena-Christin, Bleckmann A, Schirmer MA, Sprenger T, Jo P, Homayounfar K, et al. ​Thymidylate Synthase as a Prognostic Biomarker for Locally Advanced Rectal Cancer after multimodal Treatment​. ​​Annals of Surgical Oncology. ​2011;​18​(9):​​2442​-2452​. ​doi:10.1245/s10434-011-1608-4. 
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  • 2011 Journal Article
    ​ ​Wolff HA, Conradi, Lena-Christin, Schirmer MA, Beißbarth T, Sprenger T, Rave-Fränk M, et al. ​Gender-Specific Acute Organ Toxicity during Intensified Preoperative Radiochemotherapy for Rectal Cancer​. ​​The Oncologist. ​2011;​16​(5):​​621​-631​. ​doi:10.1634/theoncologist.2010-0414. 
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  • 2011 Journal Article | 
    ​ ​Sprenger T, Roedel F, Beißbarth T, Conradi, Lena-Christin, Rothe H, Homayounfar K, et al. ​Failure of Downregulation of Survivin Following Neoadjuvant Radiochemotherapy in Rectal Cancer Is Associated with Distant Metastases and Shortened Survival​. ​​Clinical Cancer Research. ​2011;​17​(6):​​1623​-1631​. ​doi:10.1158/1078-0432.CCR-10-2592. 
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