Dr. rer. nat. Lukas Cyganek

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  • 2023 | Journal Article | 
    ​ ​Seibertz F, Sutanto H, Dülk R, Pronto JRD, Springer R, Rapedius M, et al. ​Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes​. ​​Basic Research in Cardiology. ​2023;​118​(1):​​14​. ​doi:10.1007/s00395-022-00973-0. 
    ​Details  DOI  PMID  PMC 
  • 2023 | Preprint
    ​ ​Busley AV, Gutiérrez-Gutiérrez Ó, Hammer E, Steinegger M, Böhmer L, Schroeder H, et al. ​LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome​. ​​2023. Available from: https://mbexc.uni-goettingen.de/literature/publications/646 https://sfb1002.med.uni-goettingen.de/production/literature/publications/465 doi: https://doi.org/10.1101/2023.01.10.523203​
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Li W, Luo X, Poetsch MS, Oertel R, Nichani K, Schneider M, et al. ​Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration​. ​​Pharmaceuticals. ​2022;​15​(2). ​doi:10.3390/ph15020220. 
    ​Details  DOI 
  • 2022 | Journal Article | Overview | 
    ​ ​Pavez-Giani MG, Cyganek L. ​Recent Advances in Modeling Mitochondrial Cardiomyopathy Using Human Induced Pluripotent Stem Cells​. ​​Frontiers in Cell and Developmental Biology. ​2022;​9​. ​doi:10.3389/fcell.2021.800529. 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article
    ​ ​Zhong R, Zhang F, Yang Z, Li Y, Xu Q, Lan H, et al. ​Epigenetic mechanism of L-type calcium channel β-subunit downregulation in short QT human induced pluripotent stem cell-derived cardiomyocytes with CACNB2 mutation​. ​​EP Europace. ​2022;. ​doi:10.1093/europace/euac091. 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Fan X, Cyganek L, Nitschke K, Uhlig S, Nuhn P, Bieback K, et al. ​Functional Characterization of Human Induced Pluripotent Stem Cell-Derived Endothelial Cells​. ​​International Journal of Molecular Sciences. ​2022;​23​(15):​​8507​. ​doi:10.3390/ijms23158507. 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Lyra-Leite DM, Gutiérrez-Gutiérrez Ó, Wang M, Zhou Y, Cyganek L, Burridge PW. ​A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming​. ​​STAR Protocols. ​2022;​3​(3). ​doi:10.1016/j.xpro.2022.101560. 
    ​Details  DOI 
  • 2022 | Preprint
    ​ ​Nakhaei-Rad S, Bazgir F, Dahlmann J, Busley AV, Buchholzer M, Haghighi F, et al. ​Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs​. ​​2022. Available from: https://mbexc.uni-goettingen.de/literature/publications/575 https://sfb1002.med.uni-goettingen.de/production/literature/publications/477 doi: https://doi.org/10.1101/2022.01.22.477319​
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Seibertz F, Rapedius M, Fakuade FE, Tomsits P, Liutkute A, Cyganek L, et al. ​A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes​. ​​Communications Biology. ​2022;​5​(1). ​doi:10.1038/s42003-022-03871-2. 
    ​Details  DOI  PMID  PMC 
  • 2021 | Preprint
    ​ ​Gönenc II, Wolff A, Schmidt J, Zibat A, Müller C, Cyganek L, et al. ​Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures​. ​​2021. Available from: https://mbexc.uni-goettingen.de/literature/publications/430 doi: https://doi.org/10.1101/2021.10.01.462717​
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper
    ​ ​Fomin A, Gärtner A, Cyganek L, Tiburcy M, Tuleta I, Wellers L, et al. ​Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations​. ​​Science Translational Medicine. ​2021;​13​(618). ​doi:10.1126/scitranslmed.abd3079. 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Schoger E, Rosa K, Rocha C, Jassyk M, Doroudgar S, Mueller O, et al. ​Abstract MP217: Nuclease-deficient Cas9 Transcription Factors Restore Krueppel-like Factor 15 Expression In Stressed Mouse And Human Cardiomyocytes​. ​​Circulation Research. ​2021;​129​(Suppl_1). ​doi:10.1161/res.129.suppl_1.MP217. 
    ​Details  DOI 
  • 2021 | Journal Article
    ​ ​Huang M, Fan X, Yang Z, Cyganek L, Li X, Yuecel G, et al. ​Alpha 1-adrenoceptor signalling contributes to toxic effects of catecholamine on electrical properties in cardiomyocytes​. ​​Europace. ​2021;​23​(7):​​1137​-1148​. ​doi:10.1093/europace/euab008. 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Sattler K, El-Battrawy I, Cyganek L, Lang S, Lan H, Li X, et al. ​TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes​. ​​Scientific Reports. ​2021;​11​(1). ​doi:10.1038/s41598-021-93958-3. 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Schoger E, Zimmermann, Wolfram-Hubertus, Cyganek L, Zelarayán LC. ​Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation​. ​​Stem Cell Research. ​2021;​56​:​​102518​. ​doi:10.1016/j.scr.2021.102518. 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Yousefi R, Fornasiero E, Cyganek L, Montoya J, Jakobs S, Rizzoli S, et al. ​Monitoring mitochondrial translation in living cells​. ​​EMBO reports. ​2021;​22​(4). ​doi:10.15252/embr.202051635. 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Rössler U, Hennig AF, Stelzer N, Bose S, Kopp J, Søe K, et al. ​Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7 ‐related osteopetrosis​. ​​Journal of Bone and Mineral Research. ​2021;​36​(8):​​1621​-1635​. ​doi:10.1002/jbmr.4322. 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Schoger E, Zimmermann, Wolfram-Hubertus, Cyganek L, Zelarayán LC. ​Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression​. ​​Stem Cell Research. ​2021;​55​:​​102473​. ​doi:10.1016/j.scr.2021.102473. 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article
    ​ ​Li W, Stauske M, Luo X, Wagner S, Vollrath M, Mehnert CS, et al. ​Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation​. ​​Frontiers in Cell and Developmental Biology. ​2020;​8​. ​doi:10.3389/fcell.2020.592893. 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Lan H, Xu Q, El-Battrawy I, Zhong R, Li X, Lang S, et al. ​Ionic Mechanisms of Disopyramide Prolonging Action Potential Duration in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1​. ​​Frontiers in Pharmacology. ​2020;​11​. ​doi:10.3389/fphar.2020.554422. 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Buljubasic F, El-Battrawy I, Lan H, Lomada SK, Chatterjee A, Zhao Z, et al. ​Nucleoside Diphosphate Kinase B Contributes to Arrhythmogenesis in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes from a Patient with Arrhythmogenic Right Ventricular Cardiomyopathy​. ​​Journal of Clinical Medicine. ​2020;​9​(2):​​486​. ​doi:10.3390/jcm9020486. 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Grunert M, Appelt S, Schönhals S, Mika K, Cui H, Cooper A, et al. ​Induced pluripotent stem cells of patients with Tetralogy of Fallot reveal transcriptional alterations in cardiomyocyte differentiation​. ​​Scientific Reports. ​2020;​10​(1). ​doi:10.1038/s41598-020-67872-z. 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Beuthner BEC, Topci R, Derks M, Franke T, Seelke S, Puls M, et al. ​Interdisciplinary Research on Aortic Valve Stenosis: A Longitudinal Collection of Biospecimens and Clinical Data of Patients Undergoing Transcatheter Aortic Valve Replacement​. ​​Open Journal of Bioresources. ​2020;​7​. ​doi:10.5334/ojb.65. 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Kleinsorge M, Cyganek L. ​Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes​. ​​STAR Protocols. ​2020;​1​(1). ​doi:10.1016/j.xpro.2020.100026. 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Ganapathi M, Argyriou L, Martínez-Azorín F, Morlot S, Yigit G, Lee TM, et al. ​Bi-allelic missense disease-causing variants in RPL3L associate neonatal dilated cardiomyopathy with muscle-specific ribosome biogenesis​. ​​Human Genetics. ​2020;​139​(11):​​1443​-1454​. ​doi:10.1007/s00439-020-02188-6. 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Schoger E, Argyriou L, Zimmermann, Wolfram-Hubertus, Cyganek L, Zelarayán LC. ​Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation​. ​​Stem Cell Research. ​2020;​48​:​​101944​. ​doi:10.1016/j.scr.2020.101944. 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Khadjeh S, Hindmarsh V, Weber F, Cyganek L, Vidal RO, Torkieh S, et al. ​CRISPLD1: a novel conserved target in the transition to human heart failure​. ​​Basic Research in Cardiology. ​2020;​115​(3). ​doi:10.1007/s00395-020-0784-4. 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Luo X, Li W, Künzel K, Henze S, Cyganek L, Strano A, et al. ​IP3R-Mediated Compensatory Mechanism for Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes With Cardiac Ryanodine Receptor Deficiency​. ​​Frontiers in Cell and Developmental Biology. ​2020;​8​. ​doi:10.3389/fcell.2020.00772. 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper
    ​ ​Hanses U, Kleinsorge M, Roos L, Yigit G, Li Y, Barbarics B, et al. ​Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome–Associated Cardiomyopathy​. ​​Circulation. ​2020;​142​(11):​​1059​-1076​. ​doi:10.1161/CIRCULATIONAHA.119.044794. 
    ​Details  DOI  PMID  PMC 
  • 2019 | Conference Paper
    ​ ​Springer R, Seibertz F, Solano RA, Rubio T, Cyganek L, Zimmermann, Wolfram-Hubertus, et al. ​P1235Acetylcholine-activated inward-rectifier potassium currents in atrial cardiomyocytes derived from induced pluripotent stem cells and atrial engineered heart muscle preparations​. ​ ESC Congress 2019 together with World Congress of Cardiology; ​2019-08-31​ - 2019-09-04​; ​​Paris. ​European Heart Journal. ​2019;​40​(Suppl. 1)doi:10.1093/eurheartj/ehz748.0193.
    ​Details  DOI 
  • 2019 | Conference Abstract
    ​ ​Lehmann C, Suhr M, Umbach N, Cyganek L, Kleinsorge M, Nussbeck SY, et al. ​Leaving spreadsheets behind – FAIR documentation and representation of human stem cell lines in the Collaborative Research Centre 1002 Meeting Abstract​. ​ 64. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS); ​2019-09-08​ - 2019-09-11​; ​​Dortmund. ​GMS German Medical Science. ​2019;doi:10.3205/19gmds037.
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​El-Battrawy I, Cyganek L, Zhou X, Akin I. ​‘Mature’ resting membrane potentials in hiPSC-CMs: fact or artefact?—Authors’ reply​. ​​Europace. ​2019;​21​(12):​​1928​-1929​. ​doi:10.1093/europace/euz274. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​El-Battrawy I, Besler J, Ansari U, Liebe V, Schimpf R, Tülümen E, et al. ​Long-term follow-up of implantable cardioverter-defibrillators in Short QT syndrome​. ​​Clinical Research in Cardiology. ​2019;​108​(10):​​1140​-1146​. ​doi:10.1007/s00392-019-01449-3. 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Sattler K, El-Battrawy I, Zhao Z, Schrottenberg C, Yücel G, Lan H, et al. ​Serum of patients with acute myocardial infarction prevents inflammation in iPSC-cardiomyocytes​. ​​Scientific Reports. ​2019;​9​(1). ​doi:10.1038/s41598-019-42079-z. 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​El-Battrawy I, Albers S, Cyganek L, Zhao Z, Lan H, Li X, et al. ​A cellular model of Brugada syndrome with SCN10A variants using human-induced pluripotent stem cell-derived cardiomyocytes​. ​​Europace. ​2019;​21​(9):​​1410​-1421​. ​doi:10.1093/europace/euz122. 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | 
    ​ ​El-Battrawy I, Müller J, Zhao Z, Cyganek L, Zhong R, Zhang F, et al. ​Studying Brugada Syndrome With an SCN1B Variants in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes​. ​​Frontiers in Cell and Developmental Biology. ​2019;​7​. ​doi:10.3389/fcell.2019.00261. 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Zhao Z, Li X, El‐Battrawy I, Lan H, Zhong R, Xu Q, et al. ​Drug Testing in Human‐Induced Pluripotent Stem Cell–Derived Cardiomyocytes From a Patient With Short QT Syndrome Type 1​. ​​Clinical Pharmacology & Therapeutics. ​2019;​106​(3):​​642​-651​. ​doi:10.1002/cpt.1449. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Cyganek L, Tiburcy M, Sekeres K, Gerstenberg K, Bohnenberger H, Lenz C, et al. ​Deep phenotyping of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes​. ​​JCI Insight. ​2018;​3​(12):​​1​-17​. ​doi:10.1172/jci.insight.99941. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​El-Battrawy I, Zhao Z, Lan H, Li X, Yücel G, Lang S, et al. ​Ion Channel Dysfunctions in Dilated Cardiomyopathy in Limb-Girdle Muscular Dystrophy​. ​​Circulation: Genomic and Precision Medicine. ​2018;​11​(3). ​doi:10.1161/CIRCGEN.117.001893. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​El-Battrawy I, Zhao Z, Lan H, Cyganek L, Tombers C, Li X, et al. ​Electrical dysfunctions in human-induced pluripotent stem cell-derived cardiomyocytes from a patient with an arrhythmogenic right ventricular cardiomyopathy​. ​​Europace. ​2018;​20​(FI1):​​f46​-f56​. ​doi:10.1093/europace/euy042. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​El‐Battrawy I, Lan H, Cyganek L, Zhao Z, Li X, Buljubasic F, et al. ​Modeling Short QT Syndrome Using Human‐Induced Pluripotent Stem Cell–Derived Cardiomyocytes​. ​​Journal of the American Heart Association. ​2018;​7​(7). ​doi:10.1161/JAHA.117.007394. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Zhao Z, Lan H, El-Battrawy I, Li X, Buljubasic F, Sattler K, et al. ​Ion Channel Expression and Characterization in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes​. ​​Stem Cells International. ​2018;​2018​:​​1​-14​. ​doi:10.1155/2018/6067096. 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​El-Battrawy I, Zhao Z, Lan H, Schünemann, Jan-Dierk, Sattler K, Buljubasic F, et al. ​Estradiol protection against toxic effects of catecholamine on electrical properties in human-induced pluripotent stem cell derived cardiomyocytes​. ​​International Journal of Cardiology. ​2018;​254​:​​195​-202​. ​doi:10.1016/j.ijcard.2017.11.007. 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | 
    ​ ​Yücel G, Zhao Z, El-Battrawy I, Lan H, Lang S, Li X, et al. ​Lipopolysaccharides induced inflammatory responses and electrophysiological dysfunctions in human-induced pluripotent stem cell derived cardiomyocytes​. ​​Scientific Reports. ​2017;​7​(1). ​doi:10.1038/s41598-017-03147-4. 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper
    ​ ​Chowdhury SK, Liu W, Zi M, Li Y, Wang S, Tsui H, et al. ​Stress-Activated Kinase Mitogen-Activated Kinase Kinase-7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention​. ​​Circulation. ​2017;​135​(7):​​683​-699​. ​doi:10.1161/CIRCULATIONAHA.116.022941. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Borchert T, Hübscher D, Guessoum CI, Lam, Tuan-Dinh D., Ghadri JR, Schellinger IN, et al. ​Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy​. ​​Journal of the American College of Cardiology. ​2017;​70​(8):​​975​-991​. ​doi:10.1016/j.jacc.2017.06.061. 
    ​Details  DOI  PMID  PMC 
  • 2015 | Conference Abstract
    ​ ​Cyganek LL, Sekeres K, Henze S, Li W, Guan K. ​Custom-tailored cardiomyocytes: a directed in vitro differentiation of human pluripotent stem cells into defined cardiomyocyte subtypes​. ​​European Journal of Heart Failure. ​2015;​17​
    ​Details  WoS 
  • 2015 | Conference Abstract
    ​ ​Streckfuss-Boemeke K, Haupt L, Fomin VM, Wagner S, Sossalla ST, Cyganek L, et al. ​A model of anthracycline-induced cardiotoxicity using induced pluripotent stem cell-derived cardiomyocytes​. ​​London, ENGLAND. ​European Heart Journal. ​2015;​36​
    ​Details  WoS 
  • 2015 | Conference Abstract
    ​ ​Cyganek LL, Li W, Henze S, Chen S, Bezzina CR, Wilde AAM, et al. ​Functional analysis of distinct ryanodine receptor type 2 mutations in induced pluripotent stem cell-derived cardiomyocytes from CPVT patients​. ​​European Journal of Heart Failure. ​2015;​17​
    ​Details  WoS 
  • 2015 | Journal Article | Research Paper | 
    ​ ​Kruse V, Hamann C, Monecke S, Cyganek L, Elsner L, Huebscher D, et al. ​Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1​. ​​PLoS One. ​2015;​10​(5). ​doi:10.1371/journal.pone.0125544. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​Cyganek L, Chen S, Borchert T, Guan K. ​Cardiac Progenitor Cells and their Therapeutic Application for Cardiac Repair​. ​​Journal of Clinical & Experimental Cardiology. ​2013;​S11​:​​1​-12​. ​doi:10.4172/2155-9880.S11-008. 
    ​Details  DOI 

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