Prof. Dr. med. Jochen Gaedcke

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  • 2021 | Journal Article | 
    ​ ​Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo​
    De Oliveira, T.; Goldhardt, T.; Edelmann, M.; Rogge, T. ; Rauch, K. ; Kyuchukov, N. D. & Menck, K.  et al.​ (2021) 
    Cancers, 13(5) pp. 1011​.​ DOI: https://doi.org/10.3390/cancers13051011 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy​
    Koerdel, K.; Spitzner, M. ; Meyer, T. ; Engels, N.; Krause, F.; Gaedcke, J.   & Conradi, L.-C.  et al.​ (2021) 
    Cancers, 13(3) pp. 455​.​ DOI: https://doi.org/10.3390/cancers13030455 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Intensified Histopathological Work-Up after Pancreatic Head Resection Reveals Relevant Prognostic Markers​
    Dusch, N.; Oldani, M.; Steffen, T.; Kitz, J. ; Koenig, U.; Azizian, A.   & König, A. et al.​ (2020) 
    Digestion, pp. 1​-9​.​ DOI: https://doi.org/10.1159/000504648 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells.​
    Wolff, A. ; Bayerlová, M. ; Gaedcke, J. ; Kube, D.   & Beißbarth, T. ​ (2018) 
    PLOS ONE, 13(5) art. e0197162​.​ DOI: https://doi.org/10.1371/journal.pone.0197162 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy​
    Jo, P. ; Azizian, A. ; Salendo, J. ; Kramer, F. ; Bernhardt, M. ; Wolff, H. A.   & Gruber, J. et al.​ (2017) 
    International Journal of Molecular Sciences, 18(6) art. 1140​.​ DOI: https://doi.org/10.3390/ijms18061140 
    ​Details  DOI  WoS 
  • 2017 | Journal Article
    ​ ​Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling​
    Emons, G. ; Spitzner, M. ; Reineke, S. ; Möller, J.; Auslander, N.; Kramer, F.   & Hu, Y. et al.​ (2017) 
    Molecular Cancer Research, 15(11) pp. 1481​-1490​.​ DOI: https://doi.org/10.1158/1541-7786.MCR-17-0205 
    ​Details  DOI  PMID  PMC 
  • 2016 | Conference Abstract
    ​ ​Neoadjuvant therapy in rectal cancer - challenges of biobanking tumor biopsies taken prior to treatment​
    Jo, P. ; Gusky, L.; Nietert, M. M. ; Kitz, J. ; Conradi, L.-C. ; Müller-Dornieden, A. & Schueler, P. et al.​ (2016)
    Oncology Research and Treatment, 39 
    Basel​: Karger.
    ​Details  WoS 
  • 2016 | Journal Article
    ​ ​The putative oncogene CEP72 inhibits the mitotic function of BRCA1 and induces chromosomal instability​
    Lueddecke, S.; Ertych, N. ; Stenzinger, A.; Weichert, W.; Beißbarth, T. ; Dyczkowski, J. & Gaedcke, J.  et al.​ (2016) 
    Oncogene, 35(18) pp. 2398​-2406​.​ DOI: https://doi.org/10.1038/onc.2015.290 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​Neoadjuvant Therapy in Rectal Cancer - Biobanking of Preoperative Tumor Biopsies​
    Jo, P. ; Nietert, M. M. ; Gusky, L.; Kitz, J. ; Conradi, L.-C. ; Müller-Dornieden, A. & Schueler, P. et al.​ (2016) 
    Scientific Reports, 6 art. 35589​.​ DOI: https://doi.org/10.1038/srep35589 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.​
    Srinivas, U. S.; Dyczkowski, J.; Beißbarth, T. ; Gaedcke, J. ; Mansour, W. Y.; Borgmann, K. & Dobbelstein, M. ​ (2015) 
    Oncotarget, 6(14) pp. 12574​-12586​.​ DOI: https://doi.org/10.18632/oncotarget.3728 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | 
    ​ ​EEPD1 Rescues Stressed Replication Forks and Maintains Genome Stability by Promoting End Resection and Homologous Recombination Repair​
    Wu, Y.; Lee, S.-H.; Williamson, E. A.; Reinert, B. L.; Cho, J. H.; Xia, F. & Jaiswal, A. S. et al.​ (2015) 
    PLoS Genetics, 11(12) art. e1005675​.​ DOI: https://doi.org/10.1371/journal.pgen.1005675 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​MicroRNA-101 Suppresses Tumor Cell Proliferation by Acting as an Endogenous Proteasome Inhibitor via Targeting the Proteasome Assembly Factor POMP​
    Zhang, X.; Schulz, R.; Edmunds, S. ; Krueger, E.; Markert, E.; Gaedcke, J.   & Cormet-Boyaka, E. et al.​ (2015) 
    Molecular Cell, 59(2) pp. 243​-257​.​ DOI: https://doi.org/10.1016/j.molcel.2015.05.036 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​Preoperative Prediction of Lymph Node Status by Circulating Mir-18b and Mir-20a During Chemoradiotherapy in Patients with Rectal Cancer​
    Azizian, A. ; Kramer, F. ; Jo, P. ; Wolff, H. A. ; Beißbarth, T. ; Skarupke, R. & Bernhardt, M.  et al.​ (2015) 
    World Journal of Surgery, 39(9) pp. 2329​-2335​.​ DOI: https://doi.org/10.1007/s00268-015-3083-8 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Conference Abstract
    ​ ​Targeting STAT3 in vitro and in vivo reveals a novel therapeutic strategy to sensitize colorectal cancer cells to chemoradiotherapy​
    Spitzner, M. ; Roesler, B.; Bielfeld, C.; Herzberg, C.; Emons, G. ; Gaedcke, J.   & Rave-Fränk, M.  et al.​ (2014)
    Cancer Research, 74(19) ​105th Annual Meeting of the American-Association-for-Cancer-Research (AACR)​, San Diego, CA.
    Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.AM2014-855 
    ​Details  DOI  WoS 
  • 2014 | Conference Abstract
    ​ ​Targeting STAT3 as a therapeutic strategy to sensitize colorectal cancer to chemoradiotherapy​
    Grade, M. ; Spitzner, M. ; Roesler, B.; Bielfeld, C.; Gaedcke, J. ; Wolff, H. A.   & Beißbarth, T.  et al.​ (2014)
    Oncology Research and Treatment, 37 
    Basel​: Karger.
    ​Details  WoS 
  • 2014 | Conference Abstract
    ​ ​Wnt/beta-catenin signaling mediates resistance of colorectal cancer cells to chemoradiotherapy​
    Emons, G. ; Spitzner, M. ; Reineke, S. ; Möller, J.; Kendziorra, E.; Beißbarth, T.   & Rave-Fränk, M.  et al.​ (2014)
    Cancer Research, 74(19) , San Diego, CA.
    Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.AM2014-3946 
    ​Details  DOI  WoS 
  • 2014 | Journal Article | 
    ​ ​UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib​
    Landmann, H.; Proia, D. A.; He, S.; Ogden, F. L.; Kramer, F.-J. ; Beißbarth, T.   & Grade, M.  et al.​ (2014) 
    Cell Death and Disease, 5 art. e1411​.​ DOI: https://doi.org/10.1038/cddis.2014.378 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article
    ​ ​STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo​
    Spitzner, M. ; Roesler, B.; Bielfeld, C.; Emons, G. ; Gaedcke, J. ; Wolff, H. A.   & Rave-Fränk, M.  et al.​ (2014) 
    International Journal of Cancer, 134(4) pp. 997​-1007​.​ DOI: https://doi.org/10.1002/ijc.28429 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Conference Abstract
    ​ ​Association of CD133 expression levels with the k-ras mutation status in rectal cancers before and after preoperative radiochemotherapy​
    Sprenger, T. ; Gaedcke, J. ; Conradi, L.-C. ; Jo, P. ; Jung, K. ; Beißbarth, T.   & Homayounfar, K.  et al.​ (2013)
    Journal of Clinical Oncology, 31(4) ​Gastrointestinal Cancers Symposium of the American-Society-of-Clinical-Oncology (ASCO)​, San Francisco, CA.
    Alexandria​: Amer Soc Clinical Oncology.
    ​Details  WoS 
  • 2013 | Conference Paper
    ​ ​Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a,-224,-132 and let7g​
    Salendo, J. ; Spitzner, M. ; Kramer, F. ; Zhang, X.; Jo, P. ; Wolff, H. A.   & Kitz, J.  et al.​ (2013)
    Radiotherapy and Oncology, 108(3) pp. 451​-457. ​13th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology​, Ermatingen, SWITZERLAND.
    Clare​: Elsevier Ireland Ltd. DOI: https://doi.org/10.1016/j.radonc.2013.06.032 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Frequency of HER-2 Positivity in Rectal Cancer and Prognosis​
    Conradi, L.-C. ; Styczen, H.; Sprenger, T. ; Wolff, H. A. ; Roedel, C.; Nietert, M. M.   & Homayounfar, K.  et al.​ (2013) 
    American Journal of Surgical Pathology, 37(4) pp. 522​-531​.​ DOI: https://doi.org/10.1097/PAS.0b013e318272ff4d 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Conference Abstract
    ​ ​Stat3 is a potential molecular target for chemoradiosensitization of colorectal cancer cells​
    Spitzner, M. ; Roesler, B.; Bielfeld, C.; Gaedcke, J. ; Rave-Fränk, M. ; Beißbarth, T.   & Ried, T. et al.​ (2012)
    Cancer Research, 72 
    Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.AM2012-3446 
    ​Details  DOI  WoS 
  • 2012 | Conference Abstract
    ​ ​The Wnt transcription factor TCF4 mediates resistance of colorectal cancer cells to (chemo-) radiotherapy in a beta-catenin independent manner​
    Grade, M. ; Eimer, C. ; Emons, G. ; Kendziorra, E.; Spitzner, M. ; Gaedcke, J.   & Wolff, H. A.  et al.​ (2012)
    Cancer Research, 72 
    Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.AM2012-5729 
    ​Details  DOI  WoS 
  • 2012 | Journal Article
    ​ ​The Rectal Cancer microRNAome - microRNA Expression in Rectal Cancer and Matched Normal Mucosa​
    Gaedcke, J. ; Grade, M. ; Camps, J.; Sokilde, R.; Kaczkowski, B.; Schetter, A. J. & Difilippantonio, M. J. et al.​ (2012) 
    Clinical Cancer Research, 18(18) pp. 4919​-4930​.​ DOI: https://doi.org/10.1158/1078-0432.CCR-12-0016 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​Acute Toxicity of Radiochemotherapy in Rectal Cancer Patients: A Risk Particularly for Carriers of the TGFB1 Pro25 variant​
    Schirmer, M. A. ; Mergler, C. P. N.; Rave-Fränk, M. ; Herrmann, M. K. A.; Hennies, S.; Gaedcke, J.   & Conradi, L.-C.  et al.​ (2012) 
    International Journal of Radiation Oncology*Biology*Physics, 83(1) pp. 149​-157​.​ DOI: https://doi.org/10.1016/j.ijrobp.2011.05.063 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article
    ​ ​CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer​
    Jo, P. ; Jung, K. ; Grade, M. ; Conradi, L.-C. ; Wolff, H. A. ; Kitz, J.   & Becker, H. et al.​ (2012) 
    Surgery, 151(4) pp. 564​-570​.​ DOI: https://doi.org/10.1016/j.surg.2011.08.013 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Conference Abstract
    ​ ​Silencing of TCF7L2 sensitizes Wnt/beta-catenin signaling-dependent colorectal cancer cells to radiation​
    Kendziorra, E.; Ahlborn, K.; Spitzner, M. ; Rave-Fränk, M. ; Gaedcke, J. ; Emons, G.   & Kramer, F.  et al.​ (2011)
    Cancer Research, 71 
    Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.AM2011-2490 
    ​Details  DOI  WoS 
  • 2011 | Conference Abstract
    ​ ​Identification of potential relevant pathways and genes for resistance to chemoradiotherapy in colorectal cancer cells​
    Grade, M. ; Spitzner, M. ; Emons, G. ; Kramer, F. ; Gaedcke, J. ; Rave-Fränk, M.   & Scharf, J.-G. et al.​ (2011)
    Cancer Research, 71 
    Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.AM2011-2508 
    ​Details  DOI  WoS 
  • 2011 | Conference Abstract
    ​ ​TGFB1 Pro25 allele as a risk marker for higher-grade acute Organ toxicity (CTC >= Grad2) during neoadjuvant Chemoradiotherapy in patients with locally advanced Rectal cancer (UICC Stage II/III)​
    Christiansen, H.; Schirmer, M. A. ; Mergler, C. P. N.; Rave-Fränk, M. ; Hennies, S.; Gaedcke, J.   & Conradi, L.-C.  et al.​ (2011)
    Strahlentherapie und Onkologie, 187 , Wiesbaden, GERMANY.
    Munich​: Urban & Vogel.
    ​Details  WoS 
  • 2011 | Journal Article
    ​ ​Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy​
    Kendziorra, E.; Ahlborn, K.; Spitzner, M. ; Rave-Fränk, M. ; Emons, G. ; Gaedcke, J.   & Kramer, F.  et al.​ (2011) 
    Carcinogenesis, 32(12) pp. 1824​-1831​.​ DOI: https://doi.org/10.1093/carcin/bgr222 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article
    ​ ​A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets​
    Grade, M. ; Hummon, A. B.; Camps, J.; Emons, G. ; Spitzner, M. ; Gaedcke, J.   & Hoermann, P. et al.​ (2011) 
    International Journal of Cancer, 128(5) pp. 1069​-1079​.​ DOI: https://doi.org/10.1002/ijc.25453 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Conference Abstract
    ​ ​A COMBINED FUNCTIONAL AND SYSTEMS BIOLOGY APPROACH IDENTIFIES COLORECTAL CANCER GENES AS NOVEL POTENTIAL THERAPEUTIC TARGETS​
    Grade, M. ; Hummon, A. B.; Camps, J.; Emons, G.; Spitzner, M. ; Gaedcke, J.   & Hoermann, P. et al.​ (2010)
    Cellular Oncology, 32(3) pp. 164​-165. ​Congress of the International-Society-for-Cellular-Oncology​, Dresden, GERMANY.
    Amsterdam​: Ios Press.
    ​Details  WoS 
  • 2010 | Conference Abstract
    ​ ​The effect of KRAS mutations on the rectal cancer transcriptome: clinical implications​
    Gaedcke, J. ; Grade, M. ; Jung, K. ; Camps, J.; Jo, P. ; Becker, H. & Beißbarth, T.  et al.​ (2010)
    EJC SUPPLEMENTS, 8(7) ​22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics​, Berlin, GERMANY.
    Oxford​: Pergamon-elsevier Science Ltd. DOI: https://doi.org/10.1016/S1359-6349(10)71892-9 
    ​Details  DOI  WoS 
  • 2010 | Conference Abstract
    ​ ​RNAi-MEDIATED SILENCING OF TCF7L2 SENSITIZES COLORECTAL CANCER CELLS TO RADIATION​
    Kendziorra, E.; Spitzner, M. ; Emons, G.; Ahlborn, K.; Gaedcke, J. ; Rave-Fränk, M.   & Beißbarth, T.  et al.​ (2010)
    Cellular Oncology, 32(3) pp. 229​-230. ​Congress of the International-Society-for-Cellular-Oncology​, Dresden, GERMANY.
    Amsterdam​: Ios Press.
    ​Details  WoS 
  • 2010 | Journal Article
    ​ ​Mutated KRAS Results in Overexpression of DUSP4, a MAP-Kinase Phosphatase, and SMYD3, a Histone Methyltransferase, in Rectal Carcinomas​
    Gaedcke, J. ; Grade, M. ; Jung, K. ; Camps, J.; Jo, P. ; Emons, G.   & Gehoff, A. et al.​ (2010) 
    Genes Chromosomes and Cancer, 49(11) pp. 1024​-1034​.​ DOI: https://doi.org/10.1002/gcc.20811 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article
    ​ ​KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy​
    Gaedcke, J. ; Grade, M. ; Jung, K. ; Schirmer, M. A. ; Jo, P. ; Obermeyer, C. & Wolff, H. A.  et al.​ (2010) 
    Radiotherapy and Oncology, 94(1) pp. 76​-81​.​ DOI: https://doi.org/10.1016/j.radonc.2009.10.001 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | 
    ​ ​A GENE EXPRESSION SIGNATURE FOR CHEMORADIOSENSITIVITY OF COLORECTAL CANCER CELLS​
    Spitzner, M. ; Emons, G. ; Kramer, F. ; Gaedcke, J. ; Rave-Fränk, M. ; Scharf, J.-G. & Burfeind, P.  et al.​ (2010) 
    International Journal of Radiation Oncology*Biology*Physics, 78(4) pp. 1184​-1192​.​ DOI: https://doi.org/10.1016/j.ijrobp.2010.06.023 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | 
    ​ ​Impact of RNA degradation on gene expression profiling​
    Opitz, L. ; Salinas-Riester, G. ; Grade, M. ; Jung, K. ; Jo, P. ; Emons, G.   & Ghadimi, M. B.  et al.​ (2010) 
    BMC Medical Genomics, 3 art. 36​.​ DOI: https://doi.org/10.1186/1755-8794-3-36 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article
    ​ ​A new sensitivity-preferred strategy to build prediction rules for therapy response of cancer patients using gene expression data​
    Jung, K. ; Grade, M. ; Gaedcke, J. ; Jo, P. ; Opitz, L. ; Becker, H. & Ghadimi, M. B.  et al.​ (2010) 
    Computer Methods and Programs in Biomedicine, 100(2) pp. 132​-139​.​ DOI: https://doi.org/10.1016/j.cmpb.2010.03.016 
    ​Details  DOI  PMID  PMC  WoS 

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