Dr. med. Marian Grade

Staff Status
unigoe
 

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  • 2022 Journal Article | Research Paper
    ​ ​Intraoperative fluoreszenzgestützte Perfusionsmessung mit Indocyaningrün – erhöhte Sicherheit bei gastrointestinalen Anastomosen?​
    Sperling, J. ; Grade, M. ; von Heesen, M. & Ghadim, M.​ (2022) 
    Die Chirurgie,.​ DOI: https://doi.org/10.1007/s00104-022-01679-8 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​Personalmanagement und Leadership in der Chirurgie​
    Grade, M.   & Ghadimi, M. ​ (2021) 
    Der Chirurg92(3) pp. 227​-231​.​ DOI: https://doi.org/10.1007/s00104-020-01345-x 
    Details  DOI 
  • 2021 Journal Article | 
    ​ ​NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy​
    Koerdel, K.; Spitzner, M. ; Meyer, T. ; Engels, N.; Krause, F.; Gaedcke, J.   & Conradi, L.-C.  et al.​ (2021) 
    Cancers13(3) pp. 455​.​ DOI: https://doi.org/10.3390/cancers13030455 
    Details  DOI 
  • 2020 Journal Article | 
    ​ ​KRAS mutation status concordance between the primary tumor and the corresponding metastasis in patients with rectal cancer​
    Jo, P. ; Bernhardt, M. ; Nietert, M. ; König, A. ; Azizian, A. ; Schirmer, M. A.   & Grade, M.  et al.​ (2020) 
    PLoS One15(10) pp. e0239806​.​ DOI: https://doi.org/10.1371/journal.pone.0239806 
    Details  DOI 
  • 2020 Journal Article | Research Paper | 
    ​ ​TIM-3 Genetic Variants Are Associated with Altered Clinical Outcome and Susceptibility to Gram-Positive Infections in Patients with Sepsis​
    Mewes, C.; Alexander, T.; Büttner, B. ; Hinz, J. ; Alpert, A.; Popov, A.-F. & Ghadimi, M.  et al.​ (2020) 
    International Journal of Molecular Sciences21(21) pp. 8318​.​ DOI: https://doi.org/10.3390/ijms21218318 
    Details  DOI 
  • 2019 Journal Article
    ​ ​Evidenzbasierte Chirurgie des Rektumkarzinoms​
    Grade, M. ; Flebbe, H. & Ghadimi, B. M.​ (2019) 
    Der Chirurg90(5) pp. 387​-397​.​ DOI: https://doi.org/10.1007/s00104-019-0802-y 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Aktuelle Möglichkeiten und Evidenz roboterassistierter Eingriffe in der chirurgischen Onkologie​
    Grade, M. ; Flebbe, H.; Franke, F. S.; Egberts, J.; Popeneciu, I. V. ; Trojan, L.   & Rückert, J.-C. et al.​ (2019) 
    Der Onkologe25(S1) pp. 14​-27​.​ DOI: https://doi.org/10.1007/s00761-019-0622-1 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells​
    Sen, M. ; Wang, X.; Hamdan, F. H. ; Rapp, J.; Eggert, J.; Kosinsky, R. L.   & Wegwitz, F.  et al.​ (2019) 
    Clinical Epigenetics11(1).​ DOI: https://doi.org/10.1186/s13148-019-0690-5 
    Details  DOI 
  • 2019 Journal Article | 
    ​ ​Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer​
    Flebbe, H.; Hamdan, F. H. ; Kari, V. ; Kitz, J. ; Gaedcke, J. ; Ghadimi, B. M. & Johnsen, S. A.  et al.​ (2019) 
    Cancers11(8) art. 1142​.​ DOI: https://doi.org/10.3390/cancers11081142 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article
    ​ ​A case report of delayed intra-abdominal and intra-luminal haemorrhage after polypectomy​
    Neesse, A. ; Grade, M. ; Dango, S. ; Ghadimi, M. ; Ellenrieder, V. ; Kunsch, S. & Amanzada, A. ​ (2017) 
    Zeitschrift für Gastroenterologie55(10) pp. 1009​-1013​.​ DOI: https://doi.org/10.1055/s-0043-108125 
    Details  DOI 
  • 2017 Journal Article | Research Paper | 
    ​ ​Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy​
    Jo, P. ; Azizian, A. ; Salendo, J. ; Kramer, F. ; Bernhardt, M. ; Wolff, H. A.   & Gruber, J. et al.​ (2017) 
    International Journal of Molecular Sciences18(6) art. 1140​.​ DOI: https://doi.org/10.3390/ijms18061140 
    Details  DOI  WoS 
  • 2017 Journal Article
    ​ ​Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity​
    Chen, N.-M. ; Neeße, A. ; Dyck, M. L.; Steuber, B. ; König, A. O. ; Lubeseder-Martellato, C. & Winter, T. et al.​ (2017) 
    Gastroenterology152(6) pp. 1507​-+​.​ DOI: https://doi.org/10.1053/j.gastro.2017.01.043 
    Details  DOI  PMID  PMC  WoS 
  • 2017 Journal Article
    ​ ​Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling​
    Emons, G. ; Spitzner, M. ; Reineke, S. ; Möller, J.; Auslander, N.; Kramer, F.   & Hu, Y. et al.​ (2017) 
    Molecular Cancer Research15(11) pp. 1481​-1490​.​ DOI: https://doi.org/10.1158/1541-7786.MCR-17-0205 
    Details  DOI  PMID  PMC 
  • 2016 Conference Abstract
    ​ ​Neoadjuvant therapy in rectal cancer - challenges of biobanking tumor biopsies taken prior to treatment​
    Jo, P. ; Gusky, L.; Nietert, M. M. ; Kitz, J. ; Conradi, L.-C. ; Müller-Dornieden, A. & Schueler, P. et al.​ (2016)
    Oncology Research and Treatment39 
    Basel​: Karger.
    Details  WoS 
  • 2016 Journal Article | 
    ​ ​Neoadjuvant Therapy in Rectal Cancer - Biobanking of Preoperative Tumor Biopsies​
    Jo, P. ; Nietert, M. M. ; Gusky, L.; Kitz, J. ; Conradi, L.-C. ; Müller-Dornieden, A. & Schueler, P. et al.​ (2016) 
    Scientific Reports6 art. 35589​.​ DOI: https://doi.org/10.1038/srep35589 
    Details  DOI  PMID  PMC  WoS 
  • 2015 Journal Article
    ​ ​Preoperative Prediction of Lymph Node Status by Circulating Mir-18b and Mir-20a During Chemoradiotherapy in Patients with Rectal Cancer​
    Azizian, A. ; Kramer, F. ; Jo, P. ; Wolff, H. A. ; Beißbarth, T. ; Skarupke, R. & Bernhardt, M.  et al.​ (2015) 
    World Journal of Surgery39(9) pp. 2329​-2335​.​ DOI: https://doi.org/10.1007/s00268-015-3083-8 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Conference Abstract
    ​ ​Targeting STAT3 in vitro and in vivo reveals a novel therapeutic strategy to sensitize colorectal cancer cells to chemoradiotherapy​
    Spitzner, M. ; Roesler, B.; Bielfeld, C.; Herzberg, C.; Emons, G. ; Gaedcke, J.   & Rave-Fränk, M.  et al.​ (2014)
    Cancer Research74(19) ​105th Annual Meeting of the American-Association-for-Cancer-Research (AACR)​, San Diego, CA.
    Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.AM2014-855 
    Details  DOI  WoS 
  • 2014 Conference Abstract
    ​ ​Targeting STAT3 as a therapeutic strategy to sensitize colorectal cancer to chemoradiotherapy​
    Grade, M. ; Spitzner, M. ; Roesler, B.; Bielfeld, C.; Gaedcke, J. ; Wolff, H. A.   & Beißbarth, T.  et al.​ (2014)
    Oncology Research and Treatment37 
    Basel​: Karger.
    Details  WoS 
  • 2014 Conference Abstract
    ​ ​Wnt/beta-catenin signaling mediates resistance of colorectal cancer cells to chemoradiotherapy​
    Emons, G. ; Spitzner, M. ; Reineke, S. ; Möller, J.; Kendziorra, E.; Beißbarth, T.   & Rave-Fränk, M.  et al.​ (2014)
    Cancer Research74(19) , San Diego, CA.
    Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.AM2014-3946 
    Details  DOI  WoS 
  • 2014 Journal Article
    ​ ​STAT3 inhibition sensitizes colorectal cancer to chemoradiotherapy in vitro and in vivo​
    Spitzner, M. ; Roesler, B.; Bielfeld, C.; Emons, G. ; Gaedcke, J. ; Wolff, H. A.   & Rave-Fränk, M.  et al.​ (2014) 
    International Journal of Cancer134(4) pp. 997​-1007​.​ DOI: https://doi.org/10.1002/ijc.28429 
    Details  DOI  PMID  PMC  WoS 
  • 2014 Journal Article | 
    ​ ​UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib​
    Landmann, H.; Proia, D. A.; He, S.; Ogden, F. L.; Kramer, F.-J. ; Beißbarth, T.   & Grade, M.  et al.​ (2014) 
    Cell Death and Disease5 art. e1411​.​ DOI: https://doi.org/10.1038/cddis.2014.378 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article
    ​ ​Genetic Amplification of the NOTCH Modulator LNX2 Upregulates the WNT/beta-Catenin Pathway in Colorectal Cancer​
    Camps, J.; Pitt, J. J.; Emons, G. ; Hummon, A. B.; Case, C. M.; Grade, M.   & Jones, T. L. et al.​ (2013) 
    Cancer Research73(6) pp. 2003​-2013​.​ DOI: https://doi.org/10.1158/0008-5472.CAN-12-3159 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Conference Paper
    ​ ​Identification of a microRNA expression signature for chemoradiosensitivity of colorectal cancer cells, involving miRNAs-320a,-224,-132 and let7g​
    Salendo, J. ; Spitzner, M. ; Kramer, F. ; Zhang, X.; Jo, P. ; Wolff, H. A.   & Kitz, J.  et al.​ (2013)
    Radiotherapy and Oncology108(3) pp. 451​-457. ​13th International Wolfsberg Meeting on Molecular Radiation Biology/Oncology​, Ermatingen, SWITZERLAND.
    Clare​: Elsevier Ireland Ltd. DOI: https://doi.org/10.1016/j.radonc.2013.06.032 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Conference Abstract
    ​ ​Stat3 is a potential molecular target for chemoradiosensitization of colorectal cancer cells​
    Spitzner, M. ; Roesler, B.; Bielfeld, C.; Gaedcke, J. ; Rave-Fränk, M. ; Beißbarth, T.   & Ried, T. et al.​ (2012)
    Cancer Research72 
    Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.AM2012-3446 
    Details  DOI  WoS 
  • 2012 Conference Abstract
    ​ ​The Wnt transcription factor TCF4 mediates resistance of colorectal cancer cells to (chemo-) radiotherapy in a beta-catenin independent manner​
    Grade, M. ; Eimer, C. ; Emons, G. ; Kendziorra, E.; Spitzner, M. ; Gaedcke, J.   & Wolff, H. A.  et al.​ (2012)
    Cancer Research72 
    Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.AM2012-5729 
    Details  DOI  WoS 
  • 2012 Journal Article
    ​ ​CpG island methylator phenotype infers a poor disease-free survival in locally advanced rectal cancer​
    Jo, P. ; Jung, K. ; Grade, M. ; Conradi, L.-C. ; Wolff, H. A. ; Kitz, J.   & Becker, H. et al.​ (2012) 
    Surgery151(4) pp. 564​-570​.​ DOI: https://doi.org/10.1016/j.surg.2011.08.013 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article | 
    ​ ​Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells​
    Hummon, A. B.; Pitt, J. J.; Camps, J.; Emons, G. ; Skube, S. B.; Huppi, K. & Jones, T. L. et al.​ (2012) 
    Molecular Cancer11 art. 1​.​ DOI: https://doi.org/10.1186/1476-4598-11-1 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article
    ​ ​The Rectal Cancer microRNAome - microRNA Expression in Rectal Cancer and Matched Normal Mucosa​
    Gaedcke, J. ; Grade, M. ; Camps, J.; Sokilde, R.; Kaczkowski, B.; Schetter, A. J. & Difilippantonio, M. J. et al.​ (2012) 
    Clinical Cancer Research18(18) pp. 4919​-4930​.​ DOI: https://doi.org/10.1158/1078-0432.CCR-12-0016 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Conference Abstract
    ​ ​Silencing of TCF7L2 sensitizes Wnt/beta-catenin signaling-dependent colorectal cancer cells to radiation​
    Kendziorra, E.; Ahlborn, K.; Spitzner, M. ; Rave-Fränk, M. ; Gaedcke, J. ; Emons, G.   & Kramer, F.  et al.​ (2011)
    Cancer Research71 
    Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.AM2011-2490 
    Details  DOI  WoS 
  • 2011 Conference Abstract
    ​ ​Identification of potential relevant pathways and genes for resistance to chemoradiotherapy in colorectal cancer cells​
    Grade, M. ; Spitzner, M. ; Emons, G. ; Kramer, F. ; Gaedcke, J. ; Rave-Fränk, M.   & Scharf, J.-G. et al.​ (2011)
    Cancer Research71 
    Philadelphia​: Amer Assoc Cancer Research. DOI: https://doi.org/10.1158/1538-7445.AM2011-2508 
    Details  DOI  WoS 
  • 2011 Journal Article
    ​ ​Silencing of the Wnt transcription factor TCF4 sensitizes colorectal cancer cells to (chemo-) radiotherapy​
    Kendziorra, E.; Ahlborn, K.; Spitzner, M. ; Rave-Fränk, M. ; Emons, G. ; Gaedcke, J.   & Kramer, F.  et al.​ (2011) 
    Carcinogenesis32(12) pp. 1824​-1831​.​ DOI: https://doi.org/10.1093/carcin/bgr222 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article
    ​ ​A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets​
    Grade, M. ; Hummon, A. B.; Camps, J.; Emons, G. ; Spitzner, M. ; Gaedcke, J.   & Hoermann, P. et al.​ (2011) 
    International Journal of Cancer128(5) pp. 1069​-1079​.​ DOI: https://doi.org/10.1002/ijc.25453 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Conference Abstract
    ​ ​A COMBINED FUNCTIONAL AND SYSTEMS BIOLOGY APPROACH IDENTIFIES COLORECTAL CANCER GENES AS NOVEL POTENTIAL THERAPEUTIC TARGETS​
    Grade, M. ; Hummon, A. B.; Camps, J.; Emons, G.; Spitzner, M. ; Gaedcke, J.   & Hoermann, P. et al.​ (2010)
    Cellular Oncology32(3) pp. 164​-165. ​Congress of the International-Society-for-Cellular-Oncology​, Dresden, GERMANY.
    Amsterdam​: Ios Press.
    Details  WoS 
  • 2010 Conference Abstract
    ​ ​The effect of KRAS mutations on the rectal cancer transcriptome: clinical implications​
    Gaedcke, J. ; Grade, M. ; Jung, K. ; Camps, J.; Jo, P. ; Becker, H. & Beißbarth, T.  et al.​ (2010)
    EJC SUPPLEMENTS8(7) ​22nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics​, Berlin, GERMANY.
    Oxford​: Pergamon-elsevier Science Ltd. DOI: https://doi.org/10.1016/S1359-6349(10)71892-9 
    Details  DOI  WoS 
  • 2010 Conference Abstract
    ​ ​RNAi-MEDIATED SILENCING OF TCF7L2 SENSITIZES COLORECTAL CANCER CELLS TO RADIATION​
    Kendziorra, E.; Spitzner, M. ; Emons, G.; Ahlborn, K.; Gaedcke, J. ; Rave-Fränk, M.   & Beißbarth, T.  et al.​ (2010)
    Cellular Oncology32(3) pp. 229​-230. ​Congress of the International-Society-for-Cellular-Oncology​, Dresden, GERMANY.
    Amsterdam​: Ios Press.
    Details  WoS 
  • 2010 Journal Article | 
    ​ ​Impact of RNA degradation on gene expression profiling​
    Opitz, L. ; Salinas-Riester, G. ; Grade, M. ; Jung, K. ; Jo, P. ; Emons, G.   & Ghadimi, M. B.  et al.​ (2010) 
    BMC Medical Genomics3 art. 36​.​ DOI: https://doi.org/10.1186/1755-8794-3-36 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article
    ​ ​A new sensitivity-preferred strategy to build prediction rules for therapy response of cancer patients using gene expression data​
    Jung, K. ; Grade, M. ; Gaedcke, J. ; Jo, P. ; Opitz, L. ; Becker, H. & Ghadimi, M. B.  et al.​ (2010) 
    Computer Methods and Programs in Biomedicine100(2) pp. 132​-139​.​ DOI: https://doi.org/10.1016/j.cmpb.2010.03.016 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article
    ​ ​Mutated KRAS Results in Overexpression of DUSP4, a MAP-Kinase Phosphatase, and SMYD3, a Histone Methyltransferase, in Rectal Carcinomas​
    Gaedcke, J. ; Grade, M. ; Jung, K. ; Camps, J.; Jo, P. ; Emons, G.   & Gehoff, A. et al.​ (2010) 
    Genes Chromosomes and Cancer49(11) pp. 1024​-1034​.​ DOI: https://doi.org/10.1002/gcc.20811 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article
    ​ ​KRAS and BRAF mutations in patients with rectal cancer treated with preoperative chemoradiotherapy​
    Gaedcke, J. ; Grade, M. ; Jung, K. ; Schirmer, M. A. ; Jo, P. ; Obermeyer, C. & Wolff, H. A.  et al.​ (2010) 
    Radiotherapy and Oncology94(1) pp. 76​-81​.​ DOI: https://doi.org/10.1016/j.radonc.2009.10.001 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | 
    ​ ​A GENE EXPRESSION SIGNATURE FOR CHEMORADIOSENSITIVITY OF COLORECTAL CANCER CELLS​
    Spitzner, M. ; Emons, G. ; Kramer, F. ; Gaedcke, J. ; Rave-Fränk, M. ; Scharf, J.-G. & Burfeind, P.  et al.​ (2010) 
    International Journal of Radiation Oncology*Biology*Physics78(4) pp. 1184​-1192​.​ DOI: https://doi.org/10.1016/j.ijrobp.2010.06.023 
    Details  DOI  PMID  PMC  WoS 
  • 2009 Conference Abstract
    ​ ​miRNA profiles predictive for response to chemoradiotherapy in rectal cancer​
    Gaedcke, J.; Grade, M. ; Sokilde, R.; Kaczkowski, B.; Difilippantonio, M. J.; Ghadimi, M. B.   & Ried, T. et al.​ (2009)
    Cancer Research69 
    Philadelphia​: Amer Assoc Cancer Research.
    Details  WoS 
  • 2009 Conference Abstract
    ​ ​Functional validation of deregulated genes on chromosome 13 identifies novel candidate oncogenes in colon cancer​
    Camps, J.; Hummon, A.; Grade, M. ; Emons, G. ; Quang Nguyen, Q. N.; Ghadimi, B. M. & Difilippantonio, M. J. et al.​ (2009)
    Cancer Research69 
    Philadelphia​: Amer Assoc Cancer Research.
    Details  WoS 

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