Prof. Dr. med. Hans-Ulrich Schildhaus

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  • 2021 | Journal Article
    ​ ​Kemper M, Evers G, Schulze AB, Sperveslage J, Schülke C, Lenz G, et al. ​Polyclonal on- and off-target resistance mutations in an EML4-ALK positive non-small cell lung cancer patient under ALK inhibition​. ​​Oncotarget. ​2021;​12​(19):​​1946​-1952​. ​doi:10.18632/oncotarget.28062. 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Abboud T, Stork L, Schildhaus H, Stadelmann C, Rohde V, Mielke D. ​An unusual lymphoid lesion mimicking meningioma​. ​​Brain Pathology. ​2021;​31​(5). ​doi:10.1111/bpa.12995. 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Rüschoff J, Lebeau A, Sinn P, Schildhaus, Hans-Ulrich, Decker T, Ammann J, et al. ​Statistical modelling of HER2-positivity in breast cancer: Final analyses from two large, multicentre, non-interventional studies in Germany​. ​​The Breast. ​2020;​49​:​​246​-253​. ​doi:10.1016/j.breast.2019.12.005. 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Bubendorf L, Conde E, Cappuzzo F, Langfort R, Schildhaus H, Votruba J, et al. ​A noninterventional, multinational study to assess PD‐L1 expression in cytological and histological lung cancer specimens​. ​​Cancer Cytopathology. ​2020;​128​(12):​​928​-938​. ​doi:10.1002/cncy.22324. 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Elakad O, Lois A, Schmitz K, Yao S, Hugo S, Lukat L, et al. ​Fibroblast growth factor receptor 1 gene amplification and protein expression in human lung cancer​. ​​Cancer Medicine. ​2020;​9​(10):​​3574​-3583​. ​doi:10.1002/cam4.2994. 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Overbeck TR, Cron DA, Schmitz K, Rittmeyer A, Körber W, Hugo S, et al. ​Top-level MET gene copy number gain defines a subtype of poorly differentiated pulmonary adenocarcinomas with poor prognosis​. ​​Translational Lung Cancer Research. ​2020;​9​(3):​​603​-616​. ​doi:10.21037/tlcr-19-339. 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Bleckmann A, Dierks S, Schildhaus, Hans-Ulrich, Hellige N, Bacher U, Trümper L, et al. ​Treatment response to idelalisib in a patient with immunodeficiency-associated Burkitt lymphoma harboring a PIK3CA H1047R mutation​. ​​Annals of Hematology. ​2020;. ​doi:10.1007/s00277-020-03974-y. 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Jo P, Bernhardt M, Nietert M, König A, Azizian A, Schirmer MA, et al. ​KRAS mutation status concordance between the primary tumor and the corresponding metastasis in patients with rectal cancer​. ​​PLoS One. ​2020;​15​(10):​​e0239806​. ​doi:10.1371/journal.pone.0239806. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Schiwitza A, Schildhaus, Hans-Ulrich, Zwerger B, Rüschoff J, Reinhardt C, Leha A, et al. ​Monitoring efficacy of checkpoint inhibitor therapy in patients with non-small-cell lung cancer​. ​​Immunotherapy. ​2019;​11​(9):​​769​-782​. ​doi:10.2217/imt-2019-0039. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Michels S, Massutí B, Schildhaus, Hans-Ulrich, Franklin J, Sebastian M, Felip E, et al. ​Safety and Efficacy of Crizotinib in Patients With Advanced or Metastatic ROS1-Rearranged Lung Cancer (EUCROSS): A European Phase II Clinical Trial​. ​​Journal of Thoracic Oncology. ​2019;​14​(7):​​1266​-1276​. ​doi:10.1016/j.jtho.2019.03.020. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Pyczek J, Khizanishvili N, Kuzyakova M, Zabel S, Bauer J, Nitzki F, et al. ​Regulation and Role of GLI1 in Cutaneous Squamous Cell Carcinoma Pathogenesis​. ​​Frontiers in Genetics. ​2019;​10​. ​doi:10.3389/fgene.2019.01185. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Höfener H, Homeyer A, Förster M, Drieschner N, Schildhaus, Hans-Ulrich, Hahn HK. ​Automated density-based counting of FISH amplification signals for HER2 status assessment​. ​​Computer Methods and Programs in Biomedicine. ​2019;​173​:​​77​-85​. ​doi:10.1016/j.cmpb.2019.03.006. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Mühlenberg T, Ketzer J, Heinrich MC, Grunewald S, Marino-Enriquez A, Trautmann M, et al. ​KIT-Dependent and KIT-Independent Genomic Heterogeneity of Resistance in Gastrointestinal Stromal Tumors — TORC1/2 Inhibition as Salvage Strategy​. ​​Molecular Cancer Therapeutics. ​2019;​18​(11):​​1985​-1996​. ​doi:10.1158/1535-7163.MCT-18-1224. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Kosinsky RL, Chua RL, Qui M, Saul D, Mehlich D, Ströbel P, et al. ​Loss of RNF40 Decreases NF-B Activity in Colorectal Cancer Cells and Reduces Colitis Burden in Mice​. ​​Journal of Crohn's and Colitis. ​2019;​13​(3):​​362​-373​. ​doi:10.1093/ecco-jcc/jjy165. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2018 | Book Chapter
    ​ ​Wolff A, Perera-Bel J, Schildhaus, Hans-Ulrich, Homayounfar K, Schatlo B, Bleckmann A, et al. ​Using RNA-Seq Data for the Detection of a Panel of Clinically Relevant Mutations​. ​​German Medical Data Sciences: A Learning Healthcare System. ​2018. p. 217​-221​. ​(Studies in health technology and informatics;253). 
    ​Details 
  • 2018 | Journal Article
    ​ ​Schildhaus, H.-U.. ​Der prädiktive Wert der PD-L1-Diagnostik​. ​​Der Pathologe. ​2018;​39​(6):​​498​-519​. ​doi:10.1007/s00292-018-0507-x. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Fromme JE, Schildhaus, H.-U.. ​FGFR3-Überexpression ist eine relevante Alteration in kolorektalen Karzinomen​. ​​Der Pathologe. ​2018;​39​(S2):​​189​-192​. ​doi:10.1007/s00292-018-0504-0. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Hamacher R, Kämpfe D, Reuter-Jessen K, Pöttgen C, Podleska LE, Farzaliyev F, et al. ​Dramatic Response of a PD-L1–Positive Advanced Angiosarcoma of the Scalp to Pembrolizumab​. ​​JCO Precision Oncology. ​2018;(2):​​1​-7​. ​doi:10.1200/PO.17.00107. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Bremmer F, Fichtner A, Triefenbach R, Inniger R, Mayer P, Lukat L, et al. ​CIC fusion-positive sarcoma of the spermatic cord​. ​​Virchows Archiv. ​2018;​474​(2):​​253​-257​. ​doi:10.1007/s00428-018-2471-5. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Koppel C, Schwellenbach H, Zielinski D, Eckstein S, Martin-Ortega M, D’Arrigo C, et al. ​Optimization and validation of PD-L1 immunohistochemistry staining protocols using the antibody clone 28-8 on different staining platforms​. ​​Modern Pathology. ​2018;​31​(11):​​1630​-1644​. ​doi:10.1038/s41379-018-0071-1. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Ragab N, Viehweger F, Bauer J, Geyer N, Yang M, Seils A, et al. ​Canonical WNT/β-Catenin Signaling Plays a Subordinate Role in Rhabdomyosarcomas​. ​​Frontiers in Pediatrics. ​2018;​6​. ​doi:10.3389/fped.2018.00378. 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Ihle MA, Huss S, Jeske W, Hartmann W, Merkelbach-Bruse S, Schildhaus, Hans-Ulrich, et al. ​Expression of cell cycle regulators and frequency of TP53 mutations in high risk gastrointestinal stromal tumors prior to adjuvant imatinib treatment​. ​​PLoS One. ​2018;​13​(2):​​e0193048​. ​doi:10.1371/journal.pone.0193048. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Barrantes-Freer A, Engel AS, Rodríguez-Villagra OA, Winkler A, Bergmann M, Mawrin C, et al. ​Diagnostic red flags: steroid-treated malignant CNS lymphoma mimicking autoimmune inflammatory demyelination​. ​​Brain Pathology. ​2017;​28​(2):​​225​-233​. ​doi:10.1111/bpa.12496. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Petersen I, Dietel M, Geilenkeuser WJ, Mireskandari M, Weichert W, Steiger K, et al. ​EGFR immunohistochemistry as biomarker for antibody-based therapy of squamous NSCLC – Experience from the first ring trial of the German Quality Assurance Initiative for Pathology (QuIP ® )​. ​​Pathology - Research and Practice. ​2017;​213​(12):​​1530​-1535​. ​doi:10.1016/j.prp.2017.09.021. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Scheel AH, Bänfer G, Baretton GB, Dietel M, Diezko R, Henkel T, et al. ​Interlaboratory-concordance of PD-L1 IHC for NSCLC.​. ​​Journal of Clinical Oncology. ​2017;​35​(15_suppl):​​e20508​-e20508​. ​doi:10.1200/JCO.2017.35.15_suppl.e20508. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Scheel A, Baenfer G, Baretton G, Dietel M, Diezko R, Henkel T, et al. ​Interlaboratory concordance of PD-L1 immunohistochemistry for non-small-cell lung cancer​. ​​Histopathology. ​2017;​72​(3):​​449​-459​. ​doi:10.1111/his.13375. 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Chen, Nai-Ming, Neeße A, Dyck ML, Steuber B, König AO, Lubeseder-Martellato C, et al. ​Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity​. ​​Gastroenterology. ​2017;​152​(6):​​1507​-+​. ​doi:10.1053/j.gastro.2017.01.043. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Overbeck TR, Schmitz K, Engelke C, Sahlmann, Carsten-Oliver, Hugo S, Kellner L, et al. ​Partielles Ansprechen auf Crizotinib als Erstlinientherapie bei einem älteren männlichen Patienten mit ROS1-Translokations-positivem Bronchialkarzinom​. ​​Karger-Kompass Onkologie. ​2016;​3​(2):​​97​-100​. ​doi:10.1159/000449192. 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Scheel AH, Dietel M, Heukamp LC, Jöhrens K, Kirchner T, Reu S, et al. ​Diagnostic PD-L1 immunohistochemistry in NSCLC: Results of the first German harmonization study.​. ​​Journal of Clinical Oncology. ​2016;​34​(15_suppl):​​3028​-3028​. ​doi:10.1200/JCO.2016.34.15_suppl.3028. 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Schildhaus, Hans-Ulrich, Richardt P, Wilsberg L, Schmitz K. ​Occurrence of PDL1/2 copy number gains detected by FISH in adeno and squamous cell carcinomas of the lung and association with PDL1 overexpression in adenocarcinomas.​. ​​Journal of Clinical Oncology. ​2016;​34​(15_suppl):​​3031​-3031​. ​doi:10.1200/JCO.2016.34.15_suppl.3031. 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Angelika Ihle M, Merkelbach‐Bruse S, Hartmann W, Bauer S, Ratner N, Sonobe H, et al. ​HR23b expression is a potential predictive biomarker for HDAC inhibitor treatment in mesenchymal tumours and is associated with response to vorinostat​. ​​The Journal of Pathology. ​2016;​2​(2):​​59​-71​. ​doi:10.1002/cjp2.v2.2. 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Overbeck TR, Schmitz K, Engelke C, Sahlmann, Carsten-Oliver, Hugo S, Kellner L, et al. ​Partial Response to First-Line Crizotinib in an Elderly Male Patient with ROS1 Translocation-Positive Lung Cancer​. ​​Case Reports in Oncology. ​2016;​9​(1):​​158​-163​. ​doi:10.1159/000444745. 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Ortiz-Cuaran S, Scheffler M, Plenker D, Dahmen I, Scheel AH, Fernandez-Cuesta L, et al. ​Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors​. ​​Clinical Cancer Research. ​2016;​22​(19):​​4837​-4847​. ​doi:10.1158/1078-0432.CCR-15-1915. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Michels S, Scheel AHJ, Scheffler M, Schultheis AM, Gautschi OP, Aebersold F, et al. ​Clinicopathological Characteristics of RET Rearranged Lung Cancer in European Patients​. ​​Journal of Thoracic Oncology. ​2016;​11​(1):​​122​-+​. ​doi:10.1016/j.jtho.2015.09.016. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Conference Abstract
    ​ ​Bleckmann A, Wachter A, Conradi, Lena-Christin, Wolff A, Hoppenau C, Korf U, et al. ​Heterogeneity of colorectal cancer liver metastasis - analysis of WNT pathway patterns via High-throughput and bioinformatics profiling​. ​​Oncology Research and Treatment. ​2015;​38​
    ​Details  WoS 
  • 2015 | Journal Article
    ​ ​Schildhaus, Hans-Ulrich, Schultheis AM, Rüschoff JR, Binot E, Merkelbach-Bruse S, Fassunke J, et al. ​MET Amplification Status in Therapy-Naive Adeno- and Squamous Cell Carcinomas of the Lung​. ​​Clinical Cancer Research. ​2015;​21​(4):​​907​-915​. ​doi:10.1158/1078-0432.CCR-14-0450. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Conference Abstract
    ​ ​Scheffler M, Schultheis A, Michels S, Teixido C, Hartmann W, Merkelbach-Bruse S, et al. ​ROS1 rearrangement in non-small cell lung cancer (NSCLC): Prognostic and predicitve impact and genetic variability​. ​​Oncology Research and Treatment. ​2014;​37​
    ​Details  WoS 
  • 2010 | Journal Article | 
    ​ ​Merkelbach-Bruse S, Dietmaier W, Fuezesi L, Gaumann A, Haller F, Kitz J, et al. ​Pitfall in mutational testing and reporting of common KIT and PDGFRA mutations in gastrointestinal stromal tumors​. ​​BMC Medical Genetics. ​2010;​11​. ​doi:10.1186/1471-2350-11-106. 
    ​Details  DOI  PMID  PMC  WoS 

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