RG Zelarayán-Behrend (Developmental Pharmacology)

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  • 2024 | Journal Article
    ​ ​Knauer, Carolin, Henrike Haltern, Eric Schoger, Sebastian Kügler, Lennart Roos, Laura C. Zelarayán, Gerd Hasenfuss, Wolfram-Hubertus Zimmermann, Bernd Wollnik, and Lukas Cyganek. "Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants​." ​Molecular Therapy - Nucleic Acids ​35, no. 1 (2024): ​102123​. ​https://doi.org/10.1016/j.omtn.2024.102123.
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  • 2023 | Journal Article | 
    ​ ​Priesmeier, Laura, Eric Schoger, Lukas Cyganek, and Laura Cecilia Zelarayán. "Combining a tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC)​." ​Stem Cell Research ​71 (2023): ​103163​. ​https://doi.org/10.1016/j.scr.2023.103163.
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  • 2023 | Journal Article | 
    ​ ​Schoger, Eric, Federico Bleckwedel, Giulia Germena, Cheila Rocha, Petra Tucholla, Izzatullo Sobitov, Wiebke Möbius et al. "Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling​." ​Communications Biology ​6, no. 1 (2023): . ​https://doi.org/10.1038/s42003-022-04402-9.
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  • 2022 | Journal Article | Overview | 
    ​ ​Schoger, Eric, Sara Lelek, Daniela Panáková, and Laura Cecilia Zelarayan. "Tailoring Cardiac Synthetic Transcriptional Modulation Towards Precision Medicine​." ​Frontiers in Cardiovascular Medicine ​8 (2022): . ​https://doi.org/10.3389/fcvm.2021.783072.
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  • 2022 | Journal Article | Research Paper
    ​ ​Hasenfuß, Gerd P., Axel Kaul, Stephan Elmar Lehnart, Wolfgang Albrecht Linke, Laura Cecilia Zelarayan, and Wolfram-Hubertus Zimmermann. "Modulatorische Einheiten bei Herzinsuffizienz​." ​Der Kardiologe ​16, no. 2 (2022): ​109​-114​. ​https://doi.org/10.1007/s12181-022-00540-w.
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  • 2022 | Journal Article
    ​ ​Bleckwedel, Federico, Giulia Germena, Rabea Hinkel, and Laura C. Zelarayán. "An optimized protocol for the enrichment of small vesicles from murine and non-human primate heart tissue​." ​Trillium Extracellular Vesicles ​4, no. 1 (2022): ​26​-33​. ​https://doi.org/10.47184/tev.2022.01.03.
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Shomroni, Orr, Maren Sitte, Julia Schmidt, Sabnam Parbin, Fabian Ludewig, Gökhan Yigit, Laura Cecilia Zelarayan, Katrin Streckfuss-Bömeke, Bernd Wollnik, and Gabriella Salinas. "A novel single-cell RNA-sequencing approach and its applicability connecting genotype to phenotype in ageing disease​." ​Scientific Reports ​12, no. 1 (2022): ​4091​. ​https://doi.org/10.1038/s41598-022-07874-1.
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  • 2021 | Book Chapter
    ​ ​Kusch, Harald, Robert Kossen, Markus Suhr, Luca Freckmann, Linus Weber, Christian Henke, Christoph Lehmann et al. "Management of Metadata Types in Basic Cardiological Research​." ​In German Medical Data Sciences 2021: Digital Medicine: Recognize – Understand – Heal, edited by Rainer Röhrig, Tim Beißbarth, Jochem König, Claudia Ose, Geraldine Rauch, Ulrich Sax, Björn Schreiweis et al.​, 59​-68​. ​​2021. https://doi.org/10.3233/SHTI210542.
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  • 2021 | Journal Article | Research Paper
    ​ ​Zelarayan, Laura, Victor Vendrell, Elena Domínguez‐Frutos, Iris López‐Hernández, Kiril Schimmang‐Alonso, María Teresa Alonso, Yolanda Alvarez et al. "Inactivation of Fgf3 and Fgf4 within the Fgf3/Fgf4/Fgf15 gene cluster reveals their redundant requirement for mouse inner ear induction and embryonic survival​." ​Developmental Dynamics (2021): . ​https://doi.org/10.1002/dvdy.435.
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  • 2021 | Preprint
    ​ ​Shomroni, Orr, Maren Sitte, Julia Schmidt, Sabnam Parbin, Fabian Ludewig, Gökhan Yigit, Laura Cecilia Zelarayan, Katrin Streckfuss-Bömeke, Bernd Wollnik, and Gabriela Salinas​. "A novel single-cell RNA-sequencing platform and its applicability connecting genotype to phenotype in ageing-disease​." ​Preprint, submitted ​​2021. ​https://mbexc.uni-goettingen.de/literature/publications/356 https://sfb1002.med.uni-goettingen.de/production/literature/publications/409. https://doi.org/10.21203/rs.3.rs-957427/v1.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Weber, Pamina, Doris Baltus, Aline Jatho, Oliver Drews, Laura C. Zelarayan, Thomas Wieland, and Susanne Lutz. "RhoGEF17—An Essential Regulator of Endothelial Cell Death and Growth​." ​Cells ​10, no. 4 (2021): ​741​. ​https://doi.org/10.3390/cells10040741.
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  • 2021 | Journal Article | Research Paper
    ​ ​Chen, Yanpu, Felipe F. Lüttmann, Eric Schoger, Hans R. Schöler, Laura C. Zelarayán, Kee-Pyo Kim, Jody J. Haigh, Johnny Kim, and Thomas Braun. "Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice​." ​Science ​373, no. 6562 (2021): ​1537​-1540​. ​https://doi.org/10.1126/science.abg5159.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Schoger, Eric, Wolfram-Hubertus Zimmermann, Lukas Cyganek, and Laura Cecilia Zelarayán. "Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression​." ​Stem Cell Research ​55 (2021): ​S1873506121003202​. ​https://doi.org/10.1016/j.scr.2021.102473.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Schoger, Eric, Wolfram-Hubertus Zimmermann, Lukas Cyganek, and Laura Cecilia Zelarayán. "Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation​." ​Stem Cell Research ​56 (2021): ​S1873506121003652​. ​https://doi.org/10.1016/j.scr.2021.102518.
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  • 2020 | Journal Article | Research Paper
    ​ ​Hofhuis, Julia, Kristina Bersch, Stefan Wagner, Cristina Espinosa Molina, Funsho E. Fakuade, Lavanya M. Iyer, Katrin Streckfuß-Bömeke et al. "Dysferlin links excitation-contraction coupling to structure and maintenance of the cardiac transverse-axial tubule system​." ​Europace ​22, no. 7 (2020): ​1119​-1131​. ​https://doi.org/10.1093/europace/euaa093.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Rathjens, Franziska S., Alica Blenkle, Lavanya M. Iyer, Anke Renger, Fahima Syeda, Claudia Noack, Andreas Jungmann, Matthias Dewenter, Karl Toischer, and Maria Patapia Zafeiriou. "Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control​." ​Cardiovascular Research (2020): . ​https://doi.org/10.1093/cvr/cvaa239.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Schoger, Eric, Loukas Argyriou, Wolfram-Hubertus Zimmermann, Lukas Cyganek, and Laura Cecilia Zelarayán. "Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation​." ​Stem Cell Research ​48 (2020): ​101944​. ​https://doi.org/10.1016/j.scr.2020.101944.
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  • 2020 | Journal Article | Research Paper
    ​ ​Levent, Elif, Claudia Noack, Laura C. Zelarayán, Dörthe M. Katschinski, Wolfram-Hubertus Zimmermann, and Malte Tiburcy. "Inhibition of Prolyl-Hydroxylase Domain Enzymes Protects From Reoxygenation Injury in Engineered Human Myocardium​." ​Circulation ​142, no. 17 (2020): ​1694​-1696​. ​https://doi.org/10.1161/CIRCULATIONAHA.119.044471.
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  • 2020 | Journal Article | Research Paper
    ​ ​Schoger, Eric, Kelli J. Carroll, Lavanya M. Iyer, John R. McAnally, Wei Tan, Ning Liu, Claudia Noack et al. "CRISPR-Mediated Activation of Endogenous Gene Expression in the Postnatal Heart​." ​Circulation Research ​126, no. 1 (2020): ​6​-24​. ​https://doi.org/10.1161/CIRCRESAHA.118.314522.
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Schlick, Susanne F., Florian Spreckelsen, Malte Tiburcy, Lavanya M. Iyer, Tim Meyer, Laura C. Zelarayan, Stefan Luther, Ulrich Parlitz, Wolfram-Hubertus Zimmermann, and Florian Rehfeldt. "Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium​." ​Progress in Biophysics and Molecular Biology ​144 (2019): ​51​-60​. ​https://doi.org/10.1016/j.pbiomolbio.2018.11.011.
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Noack, Claudia, Lavanya M. Iyer, Norman Y. Liaw, Eric Schoger, Sara Khadjeh, Eva Wagner, Monique Woelfer et al. "KLF15-Wnt–Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart​." ​Journal of the American College of Cardiology ​74, no. 14 (2019): ​1804​-1819​. ​https://doi.org/10.1016/j.jacc.2019.07.076.
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  • 2018 | Journal Article | Overview | 
    ​ ​Gross, Julia Christina, and Laura Cecilia Zelarayan. "The Mingle-Mangle of Wnt Signaling and Extracellular Vesicles: Functional Implications for Heart Research​." ​Frontiers in Cardiovascular Medicine ​5 (2018): ​10​. ​https://doi.org/10.3389/fcvm.2018.00010.
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  • 2018 | Journal Article | Research Paper | 
    ​ ​Iyer, Lavanya M, Sankari Nagarajan, Monique Woelfer, Eric Schoger, Sara Khadjeh, Maria Patapia Zafiriou, Vijayalakshmi Kari et al. "A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart​." ​Nucleic Acids Research ​46, no. 6 (2018): ​2850​-2867​. ​https://doi.org/10.1093/nar/gky049.
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  • 2017 | Journal Article | Research Paper
    ​ ​Iyer, L. M., C. Noack, S. Nagarajan, M. Woelfer, E. Schoger, S. T. Pang, V. Kari et al. "B-catenin/TCF7L2 signaling orchestrates initiation of pathological hypertrophic cardiac remodeling by inducing chromatin modifications​." ​European Heart Journal ​38, no. suppl_1 (2017): ​P4479​. ​https://doi.org/10.1093/eurheartj/ehx504.P4479.
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Noack, Claudia, Luis Peter Haupt, Wolfram-Hubertus Zimmermann, Katrin Streckfuss-Bömeke, and Laura Cecilia Zelarayán. "Generation of a KLF15 homozygous knockout human embryonic stem cell line using paired CRISPR/Cas9n, and human cardiomyocytes derivation​." ​Stem Cell Research ​23 (2017): ​127​-131​. ​https://doi.org/10.1016/j.scr.2017.07.007.
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  • 2017 | Journal Article | Research Paper
    ​ ​Dewenter, Matthias, Stefan Neef, Christiane Vettel, Simon Lämmle, Christina Beushausen, Laura C. Zelarayan, Sylvia Katz et al. "Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure​." ​Circulation: Heart Failure ​10, no. 5 (2017): ​e003840​. ​https://doi.org/10.1161/CIRCHEARTFAILURE.117.003840.
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  • 2016 | Journal Article | Research Paper
    ​ ​Zafeiriou, Maria Patapia, Claudia Noack, and Laura Cecilia Zelarayan. "Isolation and Primary Culture of Adult Mouse Cardiac Fibroblasts​." ​bio-protocol ​6, no. 13 (2016): ​e1860​. ​https://doi.org/10.21769/BioProtoc.1860.
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  • 2014 | Journal Article | Research Paper | 
    ​ ​Zafiriou, Maria Patapia, Claudia Noack, Bernhard W. Unsoeld, Michael Didie, Elena Pavlova, Henrike J. Fischer, Holger M. Reichardt et al. "Erythropoietin Responsive Cardiomyogenic Cells Contribute to Heart Repair Post Myocardial Infarction​." ​STEM CELLS ​32, no. 9 (2014): ​2480​-2491​. ​https://doi.org/10.1002/stem.1741.
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  • 2013 | Journal Article | Research Paper | 
    ​ ​Renger, Anke, Maria-Patapia Zafiriou, Claudia Noack, Elena Pavlova, Alexander Becker, Krasimira Sharkova, Martin W. Bergmann, Ali El-Armouche, Wolfram-Hubertus Zimmermann, and Laura C. Zelarayán. "The Four and a Half LIM-Domain 2 Controls Early Cardiac Cell Commitment and Expansion Via Regulating β-Catenin-Dependent Transcription​." ​Stem Cells ​31, no. 5 (2013): ​928​-940​. ​https://doi.org/10.1002/stem.1332.
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