The prostaglandin receptor EP2 determines prognosis in EP3-negative and galectin-3-high cervical cancer cases
2020-01-24 | journal article
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Dietlmeier, S., Ye, Y., Kuhn, C., Vattai, A., Vilsmaier, T., Schröder, L., Kost, B. P. ... Heidegger, H. H. (2020). The prostaglandin receptor EP2 determines prognosis in EP3-negative and galectin-3-high cervical cancer cases. Scientific Reports, 10(1), 1154. doi: https://doi.org/10.1038/s41598-020-58095-3
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- Authors
- Dietlmeier, Sebastian; Ye, Yao; Kuhn, Christina; Vattai, Aurelia; Vilsmaier, Theresa; Schröder, Lennard; Kost, Bernd P.; Gallwas, Julia ; Jeschke, Udo; Mahner, Sven; Heidegger, Helene Hildegard
- Abstract
- Recently our study identified EP3 receptor and galectin-3 as prognosticators of cervical cancer. The aim of the present study was the analysis of EP2 as a novel marker and its association to EP3, galectin-3, clinical pathological parameters and the overall survival rate of cervical cancer patients. Cervical cancer tissues (n = 250), as also used in our previous study, were stained with anti-EP2 antibodies employing a standardized immunohistochemistry protocol. Staining results were analyzed by the IRS scores and evaluated for its association with clinical-pathological parameters. H-test of EP2 percent-score showed significantly different expression in FIGO I-IV stages and tumor stages. Kaplan-Meier survival analyses indicated that EP3-negative/EP2-high staining patients (EP2 IRS score ≥2) had a significantly higher survival rate than the EP3-negative/EP2-low staining cases (p = 0.049). In the subgroup of high galectin-3 expressing patients, the group with high EP2 levels (IRS ≥2) had significantly better survival rates compared to EP2-low expressing group (IRS <2, p = 0.044). We demonstrated that the EP2 receptor is a prognostic factor for the overall survival in the subgroup of negative EP3 and high galectin-3 expressed cervical cancer patients. EP2 in combination with EP3 or galectin-3 might act as prognostic indicators of cervical cancer. EP2, EP3, and galectin-3 could be targeted for clinical diagnosis or endocrine treatment in cervical cancer patients, which demands future investigations.
- Issue Date
- 24-January-2020
- Journal
- Scientific Reports
- ISSN
- 2045-2322
- Language
- English