SFB 1286 | B08: Definition von Kaskaden molekularer Veränderungen bei Synucleinopathien während der Neurodegeneration RSS Feed


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  • 2024 | Journal Article
    ​ ​Substitution of Met-38 to Ile in γ-synuclein found in two patients with amyotrophic lateral sclerosis induces aggregation into amyloid​
    Aubrey, L. D.; Ninkina, N.; Ulamec, S. M.; Abramycheva, N. Y.; Vasili, E.; Devine, O. M. & Wilkinson, M. et al.​ (2024) 
    Proceedings of the National Academy of Sciences of the United States of America, 121(2) art. e2309700120​.​ DOI: https://doi.org/10.1073/pnas.2309700120 
    ​Details  DOI  PMID  PMC 
  • 2024 | Journal Article
    ​ ​Inhibition of 26S proteasome activity by α‐synuclein is mediated by the proteasomal chaperone Rpn14/ PAAF1​
    Galka, D.; Ali, T. T.; Bast, A.; Niederleithinger, M.; Gerhardt, E.; Motosugi, R. & Sakata, E. et al.​ (2024) 
    Aging Cell, art. e14128​.​ DOI: https://doi.org/10.1111/acel.14128 
    ​Details  DOI  arXiv 
  • 2024 | Preprint
    ​ ​Synphilin-1 as a modulator of aSyn assembly​
    Lázaro, D. F.; Amen, T.; Gerhardt, E.; Santos, P. I.; Milovanovic, D.; Höglinger, G.& Outeiro, T. F.​ (2024). DOI: https://doi.org/10.1101/2024.03.05.583522 
    ​Details  DOI 
  • 2023 | Journal Article | 
    ​ ​The alpha-synuclein oligomers activate nuclear factor of activated T-cell (NFAT) modulating synaptic homeostasis and apoptosis​
    Sant’Anna, R.; Robbs, B. K.; de Freitas, J. A.; dos Santos, P. P.; König, A.; Outeiro, T. F. & Foguel, D.​ (2023) 
    Molecular Medicine, 29(1) art. 111​.​ DOI: https://doi.org/10.1186/s10020-023-00704-8 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | 
    ​ ​Chemical Synthesis of Alpha‐Synuclein Proteins via Solid‐Phase Peptide Synthesis and Native Chemical Ligation​
    Gatzemeier, L. M.; Meyer, F.; Diederichsen, U. & Outeiro, T. F.​ (2023) 
    Chemistry: a European Journal, 29(33) art. e202300649​.​ DOI: https://doi.org/10.1002/chem.202300649 
    ​Details  DOI  PMID  PMC 
  • 2023 | Preprint
    ​ ​Towards a Biological Definition of Parkinson’s Disease​
    Höglinger, G. U.; Adler, C. H.; Berg, D.; Klein, C.; Outeiro, T. F. ; Poewe, W.& Postuma, R. et al.​ (2023). DOI: https://doi.org/10.20944/preprints202304.0108.v1 
    ​Details  DOI 
  • 2023 | Preprint
    ​ ​Alpha-synuclein oligomers activate NFAT proteins modulating synaptic homeostasis and apoptosis​
    Sant’Anna, R.; Robbs, B. K; de Freitas, J. A.; dos Santos, P. P.; König, A.; Outeiro, T. F.  & Foguel, D.​ (2023). DOI: https://doi.org/10.1101/2023.02.21.529374 
    ​Details  DOI 
  • 2023 | Journal Article
    ​ ​Uncovering the molecular link between lead toxicity and Parkinson’s disease​
    Shvachiy, L.; Geraldes, V. & Outeiro, T. ​ (2023) 
    Antioxidants & Redox Signaling, art. ars.2022.0076​.​ DOI: https://doi.org/10.1089/ars.2022.0076 
    ​Details  DOI  PMID  PMC 
  • 2023 | Preprint
    ​ ​Impact of Phosphorylation on alpha-Synuclein Structural Determinants​
    Dorn, A. E.; de Bruyn, E.; Rossetti, G.; Fernandez, C.; Outeiro, T. F. ; Schulz, J. B.& Carloni, P.​ (2023). DOI: https://doi.org/10.1101/2023.03.10.531864 
    ​Details  DOI 
  • 2023 | Journal Article | 
    ​ ​Intermittent Lead Exposure Induces Behavioral and Cardiovascular Alterations Associated with Neuroinflammation​
    Shvachiy, L.; Amaro-Leal, Â.; Outeiro, T. F. ; Rocha, I. & Geraldes, V.​ (2023) 
    Cells, 12(5) pp. 818​.​ DOI: https://doi.org/10.3390/cells12050818 
    ​Details  DOI 
  • 2023 | Journal Article
    ​ ​Increased alpha‐synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products ( RAGE )​
    Peixoto, D. O.; Bittencourt, R. R.; Gasparotto, J.; Kessler, F. G. C.; Brum, P. O.; Somensi, N. & Girardi, C. S. et al.​ (2023) 
    Journal of Neurochemistry, art. jnc.15956​.​ DOI: https://doi.org/10.1111/jnc.15956 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | Overview
    ​ ​PrP meets alpha‐synuclein: Molecular mechanisms and implications for disease​
    Vieira, T. C. R. G.; Barros, C. A.; Domingues, R. & Outeiro, T. F.​ (2023) 
    Journal of Neurochemistry, art. jnc.15992​.​ DOI: https://doi.org/10.1111/jnc.15992 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | Overview
    ​ ​Is it all the RAGE ? Defining the role of the receptor for advanced glycation end products in Parkinson's disease​
    Gasparotto, J.; Somensi, N.; Girardi, C. S.; Bittencourt, R. R.; de Oliveira, L. M.; Hoefel, L. P. & Scheibel, I. M. et al.​ (2023) 
    Journal of Neurochemistry, art. jnc.15890​.​ DOI: https://doi.org/10.1111/jnc.15890 
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  • 2023 | Journal Article | Overview
    ​ ​Aggregation and beyond: alpha-synuclein-based biomarkers in synucleinopathies​
    Chopra, A. & Outeiro, T. F.​ (2023) 
    Brain, art. awad260​.​ DOI: https://doi.org/10.1093/brain/awad260 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article
    ​ ​Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity​
    Brás, I. C.; Khani, M. H. ; Vasili, E.; Möbius, W. ; Riedel, D. ; Parfentev, I. & Gerhardt, E.  et al.​ (2022) 
    Journal of Parkinson's Disease, pp. 1​-26​.​ DOI: https://doi.org/10.3233/JPD-223516 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Aromaticity at position 39 in α‐synuclein: A modulator of amyloid fibril assembly and membrane‐bound conformations​
    Buratti, F. A.; Boeffinger, N.; Garro, H. A.; Flores, J. S.; Hita, F. J.; Gonçalves, P. do C. & Copello, F. dos R. et al.​ (2022) 
    Protein Science, 31(7).​ DOI: https://doi.org/10.1002/pro.4360 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​From Molecular to Functional Effects of Different Environmental Lead Exposure Paradigms​
    Shvachiy, L.; Amaro-Leal, Â.; Outeiro, T. F. ; Rocha, I. & Geraldes, V.​ (2022) 
    Biology, 11(8) pp. 1164​.​ DOI: https://doi.org/10.3390/biology11081164 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Endogenous Levels of Alpha-Synuclein Modulate Seeding and Aggregation in Cultured Cells​
    Vasili, E.; Dominguez-Meijide, A.; Flores-León, M.; Al-Azzani, M.; Kanellidi, A.; Melki, R. & Stefanis, L. et al.​ (2022) 
    Molecular Neurobiology,.​ DOI: https://doi.org/10.1007/s12035-021-02713-2 
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  • 2022 | Journal Article | Research Paper
    ​ ​Ectosomes and exosomes modulate neuronal spontaneous activity​
    Brás, I. C.; Khani, M. H. ; Riedel, D. ; Parfentev, I.; Gerhardt, E. ; van Riesen, C. & Urlaub, H.  et al.​ (2022) 
    Journal of Proteomics, 269 art. 104721​.​ DOI: https://doi.org/10.1016/j.jprot.2022.104721 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Glycation modulates glutamatergic signaling and exacerbates Parkinson’s disease-like phenotypes​
    Chegão, A.; Guarda, M.; Alexandre, B. M.; Shvachiy, L.; Temido-Ferreira, M.; Marques-Morgado, I. & Fernandes Gomes, B. et al.​ (2022) 
    npj Parkinson's Disease, 8(1) art. 51​.​ DOI: https://doi.org/10.1038/s41531-022-00314-x 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article
    ​ ​JM-20, a Benzodiazepine-Dihydropyridine Hybrid Molecule, Inhibits the Formation of Alpha-Synuclein-Aggregated Species​
    Santos, C. C.; Cardim-Pires, T. R.; Shvachiy, L.; Fonseca-Fonseca, L. A.; Muñoz, P.; Almeida, Á. M. A. N. & Costa, A. C. S. et al.​ (2022) 
    Neurotoxicity Research,.​ DOI: https://doi.org/10.1007/s12640-022-00559-7 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation​
    Torres-Garcia, L.; P. Domingues, J. M.; Brandi, E.; Haikal, C.; Mudannayake, J. M.; Brás, I. C. & Gerhardt, E.  et al.​ (2022) 
    Scientific Reports, 12(1) art. 2987​.​ DOI: https://doi.org/10.1038/s41598-022-06846-9 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​Nuclear alpha-synuclein is present in the human brain and is modified in dementia with Lewy bodies​
    Koss, D. J.; Erskine, D.; Porter, A.; Palmoski, P.; Menon, H.; Todd, O. G. J. & Leite, M. et al.​ (2022) 
    Acta Neuropathologica Communications, 10(1).​ DOI: https://doi.org/10.1186/s40478-022-01403-x 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Overview | 
    ​ ​Extracellular alpha-synuclein: Sensors, receptors, and responses​
    Domingues, R.; Sant’Anna, R.; da Fonseca, A. C. C.; Robbs, B. K.; Foguel, D. & Outeiro, T. F. ​ (2022) 
    Neurobiology of Disease, 168 art. S0969996122000882​.​ DOI: https://doi.org/10.1016/j.nbd.2022.105696 
    ​Details  DOI  PMID  PMC 
  • 2021 | Preprint
    ​ ​Cofilin pathology is a new player on α-synuclein-induced spine impairment in models of hippocampal synucleinopathy​
    Oliveira da Silva, M. I.; Santejo, M.; Babcock, I. W.; Magalhães, A.; Minamide, L. S.; Castillo, E.& Gerhardt, E. et al.​ (2021). DOI: https://doi.org/10.1101/2021.02.02.425931 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Super-resolution microscopy informs on the molecular architecture of alpha-synuclein inclusions in model systems and in the human brain​
    Weish, P.; Lázaro, D. F.; Palmares, L.; Santos, P. I.; Stadelmann, C. ; Höglinger, G. U.& Rizzoli, S. O.  et al.​ (2021). DOI: https://doi.org/10.1101/2021.04.25.441304 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Monitoring Alpha-Synuclein – Tau Interactions In Vitro and In Vivo Using Bimolecular Fluorescence Complementation​
    Torres-Garcia, L.; Domingues, J. M.; Brandi, E.; Haikal, C.; Brás, I. C.; Gerhardt, E.& Li, W. et al.​ (2021). DOI: https://doi.org/10.21203/rs.3.rs-960446/v1 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Common molecular mechanisms underlie the transfer of alpha-synuclein, Tau and huntingtin and modulate spontaneous activity in neuronal cells​
    Brás, I. C.; Khani, M. H.; Vasili, E.; Möbius, W. ; Riedel, D.; Parfentev, I.& Gerhardt, E. et al.​ (2021). DOI: https://doi.org/10.1101/2021.07.18.452825 
    ​Details  DOI 
  • 2021 | Journal Article | Overview | 
    ​ ​Lipids, lysosomes and mitochondria: insights into Lewy body formation from rare monogenic disorders​
    Erskine, D.; Koss, D.; Korolchuk, V. I.; Outeiro, T. F. ; Attems, J. & McKeith, I.​ (2021) 
    Acta Neuropathologica, 141(4) pp. 511​-526​.​ DOI: https://doi.org/10.1007/s00401-021-02266-7 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Alpha-Synuclein Antibody Characterization: Why Semantics Matters​
    Outeiro, T. F. ​ (2021) 
    Molecular Neurobiology, 58(5) pp. 2202​-2203​.​ DOI: https://doi.org/10.1007/s12035-020-02269-7 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo​
    Dominguez-Meijide, A.; Parrales, V.; Vasili, E.; González-Lizárraga, F.; König, A.; Lázaro, D. F.   & Lannuzel, A. et al.​ (2021) 
    Neurobiology of Disease, 151 pp. 105256​.​ DOI: https://doi.org/10.1016/j.nbd.2021.105256 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Overview | 
    ​ ​Dysfunction of RAB39B‐ Mediated Vesicular Trafficking in Lewy Body Diseases​
    Koss, D. J.; Campesan, S.; Giorgini, F. & Outeiro, T. F. ​ (2021) 
    Movement Disorders,.​ DOI: https://doi.org/10.1002/mds.28605 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Overview | 
    ​ ​Alpha-synuclein research: defining strategic moves in the battle against Parkinson’s disease​
    Oliveira, L. M. A.; Gasser, T.; Edwards, R.; Zweckstetter, M. ; Melki, R.; Stefanis, L. & Lashuel, H. A. et al.​ (2021) 
    npj Parkinson's Disease, 7(1) art. 65​.​ DOI: https://doi.org/10.1038/s41531-021-00203-9 
    ​Details  DOI  PMID  PMC 
  • 2020 | Preprint
    ​ ​The Role of Alpha-Synuclein And Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders​
    Morato Torres, C. A.; Wassouf, Z.; Zafar, F.; Sastre, D.; Outeiro, T. F.  & Schüle, B.​ (2020). DOI: https://doi.org/10.20944/preprints202007.0334.v1 
    ​Details  DOI 
  • 2020 | Journal Article | Overview | 
    ​ ​Synucleinopathies: Where we are and where we need to go​
    Brás, I. C.; Dominguez‐Meijide, A.; Gerhardt, E. ; Koss, D.; Lázaro, D. F. ; Santos, P. I. & Vasili, E. et al.​ (2020) 
    Journal of Neurochemistry, 153(4) pp. 433​-454​.​ DOI: https://doi.org/10.1111/jnc.14965 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Protein trapping leads to altered synaptic proteostasis in synucleinopathies​
    Santos, P. I. & Outeiro, T. F. ​ (2020) 
    The FEBS Journal,.​ DOI: https://doi.org/10.1111/febs.15364 
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  • 2020 | Book Chapter
    ​ ​Mechanisms of alpha-synuclein toxicity: An update and outlook​
    Brás, I. C.; Xylaki, M.& Outeiro, T. F. ​ (2020)
    In: Recent Advances in Parkinson's Disease pp. 91​-129.  DOI: https://doi.org/10.1016/bs.pbr.2019.10.005 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Overview | 
    ​ ​The Role of Alpha-Synuclein and Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders​
    Morato Torres, C. A.; Wassouf, Z.; Zafar, F.; Sastre, D.; Outeiro, T. F.   & Schüle, B.​ (2020) 
    International Journal of Molecular Sciences, 21(16) pp. 5724​.​ DOI: https://doi.org/10.3390/ijms21165724 
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  • 2020 | Journal Article | Overview | 
    ​ ​From iPS Cells to Rodents and Nonhuman Primates: Filling Gaps in Modeling Parkinson's Disease​
    Outeiro, T. F. ; Heutink, P.; Bezard, E. & Cenci, A. M.​ (2020) 
    Movement Disorders,.​ DOI: https://doi.org/10.1002/mds.28387 
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  • 2020 | Journal Article | Research Paper
    ​ ​X1INH, an improved next-generation affinity-optimized hydrazonic ligand, attenuates abnormal copper( i )/copper( ii )-α-Syn interactions and affects protein aggregation in a cellular model of synucleinopathy​
    Cukierman, D. S.; Lázaro, D. F. ; Sacco, P.; Ferreira, P. R.; Diniz, R.; Fernández, C. O. & Outeiro, T. F.  et al.​ (2020) 
    Dalton Transactions, 49(45) pp. 16252​-16267​.​ DOI: https://doi.org/10.1039/d0dt01138j 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Editorial Contribution (Editorial, Introduction, Epilogue) | 
    ​ ​Editorial: Protein Misfolding and Spreading Pathology in Neurodegenerative Diseases​
    Lázaro, D. F. ; Bellucci, A.; Brundin, P. & Outeiro, T. F. ​ (2020) 
    Frontiers in Molecular Neuroscience, 12.​ DOI: https://doi.org/10.3389/fnmol.2019.00312 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​RAB39B is redistributed in dementia with Lewy bodies and is sequestered within aβ plaques and Lewy bodies​
    Koss, D. J.; Bondarevaite, O.; Adams, S.; Leite, M.; Giorgini, F.; Attems, J. & Outeiro, T. F. ​ (2020) 
    Brain Pathology, 31(1) pp. 120​-132​.​ DOI: https://doi.org/10.1111/bpa.12890 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Biasing the native α-synuclein conformational ensemble towards compact states abolishes aggregation and neurotoxicity​
    Carija, A.; Pinheiro, F.; Pujols, J.; Brás, I. C.; Lázaro, D. F.; Santambrogio, C. & Grandori, R. et al.​ (2019) 
    Redox Biology, 22 pp. 101135​.​ DOI: https://doi.org/10.1016/j.redox.2019.101135 
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  • 2019 | Journal Article | Research Paper
    ​ ​Nuclear localization and phosphorylation modulate pathological effects of alpha-synuclein​
    Pinho, R.; Paiva, I.; Jercic, K. G.; Fonseca-Ornelas, L.; Gerhardt, E.; Fahlbusch, C. & Garcia-Esparcia, P. et al.​ (2019) 
    Human Molecular Genetics, 28(1) pp. 31​-50​.​ DOI: https://doi.org/10.1093/hmg/ddy326 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Seeding variability of different alpha synuclein strains in synucleinopathies​
    Candelise, N.; Schmitz, M.; Llorens, F.; Villar‐Piqué, A.; Cramm, M.; Thom, T. & Silva Correia, S. M. et al.​ (2019) 
    Annals of Neurology, 85(5) pp. 691​-703​.​ DOI: https://doi.org/10.1002/ana.25446 
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  • 2019 | Journal Article | Overview
    ​ ​In vitro models of synucleinopathies: informing on molecular mechanisms and protective strategies​
    Marvian, A. T.; Koss, D. J.; Aliakbari, F.; Morshedi, D. & Outeiro, T. F. ​ (2019) 
    Journal of Neurochemistry, 150(5) pp. 535​-565​.​ DOI: https://doi.org/10.1111/jnc.14707 
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  • 2019 | Journal Article | Overview
    ​ ​LRRK2, alpha-synuclein, and tau: partners in crime or unfortunate bystanders?​
    Outeiro, T. F. ; Harvey, K.; Dominguez-Meijide, A. & Gerhardt, E. ​ (2019) 
    Biochemical Society Transactions, 47(3) pp. 827​-838​.​ DOI: https://doi.org/10.1042/BST20180466 
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  • 2019 | Journal Article | Research Paper
    ​ ​Synuclein Meeting 2019: where we are and where we need to go​
    Outeiro, T. F.   & Mestre, T. A.​ (2019) 
    Journal of Neurochemistry, 150(5) pp. 462​-466​.​ DOI: https://doi.org/10.1111/jnc.14825 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in Synucleinopathies​
    Szegő, É. M.; Dominguez-Meijide, A.; Gerhardt, E.; König, A.; Koss, D. J.; Li, W. & Pinho, R. et al.​ (2019) 
    Cell Reports, 28(1) pp. 65.e6​-77.e6​.​ DOI: https://doi.org/10.1016/j.celrep.2019.06.009 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Overview
    ​ ​Are genetic and idiopathic forms of Parkinson's disease the same disease?​
    Correia Guedes, L.; Mestre, T.; Outeiro, T. F.   & Ferreira, J. J.​ (2019) 
    Journal of Neurochemistry, 152(5) pp. 515​-522​.​ DOI: https://doi.org/10.1111/jnc.14902 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Overview
    ​ ​The role of LRRK2 in cell signalling​
    Harvey, K. & Outeiro, T. F. ​ (2019) 
    Biochemical Society Transactions, 47(1) pp. 197​-207​.​ DOI: https://doi.org/10.1042/BST20180464 
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  • 2019 | Journal Article | Overview
    ​ ​Investigating targets for neuropharmacological intervention by molecular dynamics simulations​
    Rossetti, G.; Kless, A.; Lai, L.; Outeiro, T. F.   & Carloni, P.​ (2019) 
    Biochemical Society Transactions, 47(3) pp. 909​-918​.​ DOI: https://doi.org/10.1042/BST20190048 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Membrane binding, internalization, and sorting of alpha-synuclein in the cell​
    Masaracchia, C.; Hnida, M.; Gerhardt, E.; Lopes da Fonseca, T.; Villar-Pique, A.; Branco, T. & Stahlberg, M. A. et al.​ (2018) 
    Acta Neuropathologica Communications, 6(1) art. 79​.​ DOI: https://doi.org/10.1186/s40478-018-0578-1 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Sensing α-Synuclein From the Outside via the Prion Protein: Implications for Neurodegeneration​
    Brás, I. C.; Lopes, L. V. & Outeiro, T. F. ​ (2018) 
    Movement Disorders, 33(11) pp. 1675​-1684​.​ DOI: https://doi.org/10.1002/mds.27478 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Small molecule inhibits α-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration of dopaminergic neurons​
    Pujols, J.; Peña-Díaz, S.; Lázaro, D. F. ; Peccati, F.; Pinheiro, F.; González, D. & Carija, A. et al.​ (2018) 
    Proceedings of the National Academy of Sciences, 115(41) pp. 10481​-10486​.​ DOI: https://doi.org/10.1073/pnas.1804198115 
    ​Details  DOI  PMID  PMC 

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