Prof. Dr. Mathias Bähr

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  • 2021 | Journal Article | Research Paper | 
    ​ ​AAV-mediated inhibition of ULK1 promotes axonal regeneration in the central nervous system in vitro and in vivo​
    Ribas, V. T. ; Vahsen, B. F.; Tatenhorst, L. ; Estrada, V.; Dambeck, V. ; Almeida, R. A. & Bähr, M.  et al.​ (2021) 
    Cell Death & Disease, 12(2).​ DOI: https://doi.org/10.1038/s41419-021-03503-3 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Rho‐kinase inhibition by fasudil modulates pre‐synaptic vesicle dynamics​
    Saal, K. A. ; Warth Pérez Arias, C.; Roser, A. ; Christoph Koch, J.; Bähr, M. ; Rizzoli, S. O.   & Lingor, P. ​ (2021) 
    Journal of Neurochemistry, pp. n/a​-n/a​.​ DOI: https://doi.org/10.1111/jnc.15274 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | 
    ​ ​Inhibition of the autophagic protein ULK1 attenuates axonal degeneration in vitro and in vivo, enhances translation, and modulates splicing​
    Vahsen, B. F.; Ribas, V. T. ; Sundermeyer, J.; Boecker, A.; Dambeck, V. ; Lenz, C.   & Shomroni, O.  et al.​ (2020) 
    Cell Death and Differentiation, 27(10) pp. 2810​-2827​.​ DOI: https://doi.org/10.1038/s41418-020-0543-y 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Compassionate Use of the ROCK Inhibitor Fasudil in Three Patients With Amyotrophic Lateral Sclerosis​
    Koch, J. C. ; Kuttler, J.; Maass, F. ; Lengenfeld, T.; Zielke, E.; Bähr, M.   & Lingor, P. ​ (2020) 
    Frontiers in Neurology, 11.​ DOI: https://doi.org/10.3389/fneur.2020.00173 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Increased alpha-synuclein tear fluid levels in patients with Parkinson’s disease​
    Maass, F. ; Rikker, S.; Dambeck, V. ; Warth, C.; Tatenhorst, L. ; Csoti, I. & Schmitz, M.  et al.​ (2020) 
    Scientific Reports, 10(1).​ DOI: https://doi.org/10.1038/s41598-020-65503-1 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Rho Kinase Inhibition with Fasudil in the SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis-Symptomatic Treatment Potential after Disease Onset​
    Günther, R. ; Balck, A. ; Koch, J. C. ; Nientiedt, T.; Sereda, M. ; Bähr, M.   & Lingor, P.  et al.​ (2017) 
    Frontiers in pharmacology, 8 art. 17​.​ DOI: https://doi.org/10.3389/fphar.2017.00017 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Calpain-mediated cleavage of collapsin response mediator protein-2 drives acute axonal degeneration​
    Zhang, J.-N. ; Michel, U. ; Lenz, C. ; Friedel, C. C.; Köster, S. ; D'Hedouville, Z. & Tönges, L.  et al.​ (2016) 
    Scientific Reports, 6 art. 37050​.​ DOI: https://doi.org/10.1038/srep37050 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​Fasudil attenuates aggregation of α-synuclein in models of Parkinson's disease​
    Tatenhorst, L. ; Eckermann, K.; Dambeck, V. ; Fonseca-Ornelas, L.; Walle, H.; Lopes Da Fonseca, T. & Koch, J. C.  et al.​ (2016) 
    Acta Neuropathologica Communication, 4(1) art. 39​.​ DOI: https://doi.org/10.1186/s40478-016-0310-y 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | Research Paper | 
    ​ ​Alpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons​
    Koch, J. C. ; Bitow, F.; Haack, J.; D'Hedouville, Z.; Zhang, J.-N.; Tönges, L.   & Michel, U.  et al.​ (2015) 
    Cell Death and Disease, 6 art. e1811​.​ DOI: https://doi.org/10.1038/cddis.2015.169 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​The rho kinase inhibitor Y-27632 improves motor performance in male SOD1(G93A) mice​
    Günther, R. ; Saal, K.-A. ; Suhr, M. ; Scheer, D.; Koch, J. C. ; Bähr, M.   & Lingor, P.  et al.​ (2014) 
    Frontiers in Neuroscience, 8 art. 304​.​ DOI: https://doi.org/10.3389/fnins.2014.00304 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Viral vector-mediated downregulation of RhoA increases survival and axonal regeneration of retinal ganglion cells​
    Koch, J. C. ; Tönges, L. ; Michel, U. ; Bähr, M.   & Lingor, P. ​ (2014) 
    Frontiers in Cellular Neuroscience, 8 art. 273​.​ DOI: https://doi.org/10.3389/fncel.2014.00273 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Alpha-synuclein mutations impair axonal regeneration in models of Parkinson's disease​
    Tönges, L. ; Szegö, E. M. ; Hause, P.; Saal, K.-A. ; Tatenhorst, L. ; Koch, J. C.   & D'Hedouville, Z. et al.​ (2014) 
    Frontiers in Aging Neuroscience, 6 art. UNSP 239​.​ DOI: https://doi.org/10.3389/fnagi.2014.00239 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​ROCK2 is a major regulator of axonal degeneration, neuronal death and axonal regeneration in the CNS​
    Koch, J. C. ; Tönges, L. ; Barski, E. ; Michel, U. ; Bähr, M.   & Lingor, P. ​ (2014) 
    Cell Death and Disease, 5 art. e1225​.​ DOI: https://doi.org/10.1038/cddis.2014.191 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​X-ray fluorescence analysis of iron and manganese distribution in primary dopaminergic neurons​
    Dučić, T.; Barski, E. ; Salome, M.; Koch, J. C. ; Bähr, M.   & Lingor, P. ​ (2013) 
    Journal of Neurochemistry, 124(2) pp. 250​-261​.​ DOI: https://doi.org/10.1111/jnc.12073 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Journal Article | Research Paper | 
    ​ ​Inhibition of rho kinase enhances survival of dopaminergic neurons and attenuates axonal loss in a mouse model of Parkinson's disease​
    Tönges, L. ; Frank, T. ; Tatenhorst, L. ; Saal, K. A. ; Koch, J. C. ; Szego, E. M.   & Bähr, M.  et al.​ (2012) 
    Brain, 135(11) pp. 3355​-3370​.​ DOI: https://doi.org/10.1093/brain/aws254 
    ​Details  DOI  PMID  PMC  WoS 
  • 2012 | Review | 
    ​ ​Axonal degeneration as a therapeutic target in the CNS​
    Lingor, P. ; Koch, J. C. ; Tönges, L.  & Bähr, M. ​ (2012)
    Cell and Tissue Research, 349​(1) pp. 289​-311​.​ DOI: https://doi.org/10.1007/s00441-012-1362-3 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Review | 
    ​ ​ROCKing regeneration: Rho kinase inhibition as molecular target for neurorestoration​
    Tönges, L. ; Koch, J.-C. ; Bähr, M.  & Lingor, P. ​ (2011)
    Frontiers in Molecular Neuroscience, 4​.​ DOI: https://doi.org/10.3389/fnmol.2011.00039 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Journal Article | Research Paper | 
    ​ ​JNK Isoforms Differentially Regulate Neurite Growth and Regeneration in Dopaminergic Neurons In Vitro​
    Tönges, L. ; Planchamp, V. ; Koch, J.-C. ; Herdegen, T.; Bähr, M.   & Lingor, P. ​ (2011) 
    Journal of Molecular Neuroscience, 45(2) pp. 284​-293​.​ DOI: https://doi.org/10.1007/s12031-011-9519-1 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper | 
    ​ ​Identification of new kinase clusters required for neurite outgrowth and retraction by a loss-of-function RNA interference screen​
    Loh, S. H. Y.; Francescut, L.; Lingor, P. ; Bähr, M.   & Nicotera, P.​ (2008) 
    Cell Death and Differentiation, 15(2) pp. 283​-298​.​ DOI: https://doi.org/10.1038/sj.cdd.4402258 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article | Research Paper | 
    ​ ​Cyclin-dependent kinase 5 is an upstream regulator of mitochondrial fission during neuronal apoptosis​
    Meuer, K. ; Suppanz, I. E. ; Lingor, P. ; Planchamp, V. ; Göricke, B.; Fichtner, L.   & Braus, G. H.  et al.​ (2007) 
    Cell Death and Differentiation, 14(4) pp. 651​-661​.​ DOI: https://doi.org/10.1038/sj.cdd.4402087 
    ​Details  DOI  PMID  PMC  WoS 

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