Dr. Hans-Wolfgang Klafki

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unigoe
 

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  • 2022 | Journal Article | Research Paper | 
    ​ ​Klafki, Hans-W., Jonathan Vogelgsang, Ekaterina Manuilova, Chris Bauer, Alexander Jethwa, Hermann Esselmann, Anke Jahn-Brodmann et al. "Diagnostic performance of automated plasma amyloid-β assays combined with pre-analytical immunoprecipitation​." ​Alzheimer's Research & Therapy ​14, no. 1 (2022): ​127​. ​https://doi.org/10.1186/s13195-022-01071-y.
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Oberstein, Timo Jan, Janine Utz, Philipp Spitzer, Hans Wolfgang Klafki, Jens Wiltfang, Piotr Lewczuk, Johannes Kornhuber, and Juan Manuel Maler. "The Role of Cathepsin B in the Degradation of Aβ and in the Production of Aβ Peptides Starting With Ala2 in Cultured Astrocytes​." ​Frontiers in Molecular Neuroscience ​13 (2021): . ​https://doi.org/10.3389/fnmol.2020.615740.
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Zampar, S., H. W. Klafki, K. Sritharen, T. A. Bayer, J. Wiltfang, A. Rostagno, J. Ghiso, L. A. Miles, and O. Wirths. "N‐terminal heterogeneity of parenchymal and vascular amyloid‐β deposits in Alzheimer’s disease​." ​Neuropathology and Applied Neurobiology ​46, no. 7 (2020): ​673​-685​. ​https://doi.org/10.1111/nan.12637.
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Klafki, Hans W., Petra Rieper, Anja Matzen, Silvia Zampar, Oliver Wirths, Jonathan Vogelgsang, Dirk Osterloh et al. "Development and Technical Validation of an Immunoassay for the Detection of APP669–711 (Aβ−3–40) in Biological Samples​." ​International Journal of Molecular Sciences ​21, no. 18 (2020): ​6564​. ​https://doi.org/10.3390/ijms21186564.
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Hornung, Karen, Silvia Zampar, Nadine Engel, Hans Klafki, Thomas Liepold, Thomas A. Bayer, Jens Wiltfang, Olaf Jahn, and Oliver Wirths. "N-Terminal Truncated Aβ4-42 Is a Substrate for Neprilysin Degradation in vitro and in vivo​." ​Journal of Alzheimer's Disease ​67, no. 3 (2019): ​849​-858​. ​https://doi.org/10.3233/JAD-181134.
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Giuranna, Johanna, Anna-Lena Volckmar, Anna Heinen, Triinu Peters, Börge Schmidt, Anne Spieker, Helena Straub et al. "The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus​." ​Obesity Facts ​11, no. 2 (2018): ​93​-108​. ​https://doi.org/10.1159/000486962.
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Vogelgsang, Jonathan, Dirk Wedekind, Caroline Bouter, Hans-W. Klafki, and Jens Wiltfang. "Reproducibility of Alzheimer’s Disease Cerebrospinal Fluid-Biomarker Measurements under Clinical Routine Conditions​." ​Journal of Alzheimer's Disease ​62, no. 1 (2018): ​203​-212​. ​https://doi.org/10.3233/JAD-170793.
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Kunding, Andreas H., Louise L. Busk, Helen Webb, Hans W. Klafki, Markus Otto, Jörg P. Kutter, and Martin Dufva. "Micro-droplet arrays for micro-compartmentalization using an air/water interface​." ​Lab on a Chip ​18, no. 18 (2018): ​2797​-2805​. ​https://doi.org/10.1039/C8LC00608C.
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Wirths, Oliver, Susanne Walter, Inga Kraus, Hans W. Klafki, Martina Stazi, Timo J. Oberstein, Jorge Ghiso, Jens Wiltfang, Thomas A. Bayer, and Sascha Weggen. "N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models​." ​Alzheimer's Research & Therapy ​9, no. 1 (2017): ​80​. ​https://doi.org/10.1186/s13195-017-0309-z.
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Nabers, Andreas, Julian Ollesch, Jonas Schartner, Carsten Kötting, Just Genius, Henning Hafermann, Hans Klafki, Klaus Gerwert, and Jens Wiltfang. "Amyloid-β-Secondary Structure Distribution in Cerebrospinal Fluid and Blood Measured by an Immuno-Infrared-Sensor: A Biomarker Candidate for Alzheimer’s Disease​." ​Analytical Chemistry ​88, no. 5 (2016): ​2755​-2762​. ​https://doi.org/10.1021/acs.analchem.5b04286.
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Gronewold, Janine, Olga Todica, Hans-Wolfgang Klafki, Ulla K. Seidel, Britta Kaltwasser, Jens Wiltfang, Andreas Kribben, Heike Bruck, and Dirk M. Hermann. "Association of Plasma β-Amyloid with Cognitive Performance and Decline in Chronic Kidney Disease​." ​Molecular Neurobiology (2016): . ​https://doi.org/10.1007/s12035-016-0243-2.
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Klafki, Hans-Wolfgang, Henning Hafermann, Chris Bauer, Ute Haußmann, Inga Kraus, Johannes Schuchhardt, Stephan Muck, Norbert Scherbaum, and Jens Wiltfang. "Validation of a Commercial Chemiluminescence Immunoassay for the Simultaneous Measurement of Three Different Amyloid-β Peptides in Human Cerebrospinal Fluid and Application to a Clinical Cohort​." ​Journal of Alzheimer's Disease ​54, no. 2 (2016): ​691​-705​. ​https://doi.org/10.3233/jad-160398.
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Hüttenrauch, M., A. Brauß, A. Kurdakova, H. Borgers, Florian Klinker, David Liebetanz, G. Salinas-Riester, Jens Wiltfang, Hans-Wolfgang Klafki, and Oliver Wirths. "Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model​." ​Translational Psychiatry ​6, no. 5 (2016): ​e800​. ​https://doi.org/10.1038/tp.2016.65.
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Halbgebauer, Steffen, Magdalena Nagl, Hans Klafki, Ute Haußmann, Petra Steinacker, Patrick Oeckl, Jan Kassubek et al. "Modified serpinA1 as risk marker for Parkinson’s disease dementia: Analysis of baseline data​." ​Scientific Reports ​6, no. 1 (2016): . ​https://doi.org/10.1038/srep26145.
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Beyer, Isaak, Nasrollah Rezaei-Ghaleh, Hans-Wolfgang Klafki, Olaf Jahn, Ute Haußmann, Jens Wiltfang, Markus Zweckstetter, and Hans-Joachim Knölker. "Solid-Phase Synthesis and Characterization of N-Terminally Elongated Aβ−3-x-Peptides​." ​Chemistry - A European Journal ​22, no. 25 (2016): ​8685​-8693​. ​https://doi.org/10.1002/chem.201600892.
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Reinert, Jochim, Bernhard C. Richard, Hans W. Klafki, Beate Friedrich, Thomas A. Bayer, Jens Wiltfang, Gabor G. Kovacs et al. "Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer’s disease and transgenic mouse models​." ​Acta Neuropathologica Communications ​4, no. 1 (2016): ​24​. ​https://doi.org/10.1186/s40478-016-0294-7.
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​Gronewold, Janine, Hans-Wolfgang Klafki, Enrico Baldelli, Britta Kaltwasser, Ulla K. Seidel, Olga Todica, Michaela Volsek et al. "Factors Responsible for Plasma β-Amyloid Accumulation in Chronic Kidney Disease​." ​Molecular Neurobiology ​53, no. 5 (2016): ​3136​-3145​. ​https://doi.org/10.1007/s12035-015-9218-y.
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​van Waalwijk van Doorn, Linda J. C., Marleen J. Koel-Simmelink, Ute Haußmann, Hans Klafki, Hanne Struyfs, Philipp Linning, Hans-Joachim Knölker et al. "Validation of soluble amyloid-β precursor protein assays as diagnostic CSF biomarkers for neurodegenerative diseases​." ​Journal of Neurochemistry ​137, no. 1 (2016): ​112​-121​. ​https://doi.org/10.1111/jnc.13527.
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article
    ​ ​Savastano, Adriana, Hans Klafki, Ute Haußmann, Timo Jan Oberstein, Petr Muller, Oliver Wirths, Jens Wiltfang, and Thomas A. Bayer. "N-Truncated Aβ2-X Starting with Position Two in Sporadic Alzheimer’s Disease Cases and Two Alzheimer Mouse Models​." ​Journal of Alzheimer's Disease ​49, no. 1 (2015): ​101​-110​. ​https://doi.org/10.3233/jad-150394.
    ​Details  DOI 
  • 2015 | Journal Article
    ​ ​Nabers, Andreas, Julian Ollesch, Jonas Schartner, Carsten Kötting, Just Genius, Ute Haußmann, Hans Klafki, Jens Wiltfang, and Klaus Gerwert. "An infrared sensor analysing label-free the secondary structure of the Abeta peptide in presence of complex fluids​." ​Journal of Biophotonics ​9, no. 3 (2015): ​224​-234​. ​https://doi.org/10.1002/jbio.201400145.
    ​Details  DOI 
  • 2015 | Journal Article | 
    ​ ​Kraus, Inga, Daniela Besong Agbo, Markus Otto, Jens Wiltfang, and Hans Klafki. "Detection and Differentiation of Threonine- and Tyrosine-Monophosphorylated Forms of ERK1/2 by Capillary Isoelectric Focusing-Immunoassay​." ​Scientific Reports ​5, no. 1 (2015): ​12767​. ​https://doi.org/10.1038/srep12767.
    ​Details  DOI 
  • 2014 | Journal Article
    ​ ​Poschmann, Gereon, Katrin Seyfarth, Daniela Besong Agbo, Hans-Wolfgang Klafki, Jan Rozman, Wolfgang Wurst, Jens Wiltfang, Helmut E. Meyer, Martin Klingenspor, and Kai Stühler. "High-Fat Diet Induced Isoform Changes of the Parkinson’s Disease Protein DJ-1​." ​Journal of Proteome Research ​13, no. 5 (2014): ​2339​-2351​. ​https://doi.org/10.1021/pr401157k.
    ​Details  DOI 
  • 2014 | Journal Article
    ​ ​Halbgebauer, Steffen, Ute Haußmann, Hans Klafki, Hayrettin Tumani, Jens Wiltfang, and Markus Otto. "Capillary isoelectric focusing immunoassay as a new nanoscale approach for the detection of oligoclonal bands​." ​ELECTROPHORESIS ​36, no. 2 (2014): ​355​-362​. ​https://doi.org/10.1002/elps.201400339.
    ​Details  DOI 
  • 2014 | Journal Article | 
    ​ ​Oberstein, Timo Jan, Philipp Spitzer, Hans-Wolfgang Klafki, Philipp Linning, Florian Neff, Hans-Joachim Knölker, Piotr Lewczuk, Jens Wiltfang, Johannes Kornhuber, and Juan Manuel Maler. "Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides​." ​Neurobiology of Disease ​73 (2014): ​24​-35​. ​https://doi.org/10.1016/j.nbd.2014.08.031.
    ​Details  DOI 
  • 2003 | Journal Article
    ​ ​Wiltfang, Jens, Hermann Esselmann, M. Bibl, A. Smirnov, Markus Otto, S. Paul, B. Schmidt et al. "Highly conserved and disease-specific patterns of carboxyterminally truncated Aβ peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation​." ​Journal of Neurochemistry ​81, no. 3 (2003): ​481​-496​. ​https://doi.org/10.1046/j.1471-4159.2002.00818.x.
    ​Details  DOI 

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