Dr. Hans-Wolfgang Klafki

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  • 2022 | Journal Article | Research Paper | 
    ​ ​Klafki, Hans-W., Vogelgsang J, Manuilova E, Bauer C, Jethwa A, Esselmann H, et al. ​Diagnostic performance of automated plasma amyloid-β assays combined with pre-analytical immunoprecipitation​. ​​Alzheimer's Research & Therapy. ​2022;​14​(1). ​doi:10.1186/s13195-022-01071-y. 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Oberstein TJ, Utz J, Spitzer P, Klafki HW, Wiltfang J, Lewczuk P, et al. ​The Role of Cathepsin B in the Degradation of Aβ and in the Production of Aβ Peptides Starting With Ala2 in Cultured Astrocytes​. ​​Frontiers in Molecular Neuroscience. ​2021;​13​. ​doi:10.3389/fnmol.2020.615740. 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Zampar S, Klafki HW, Sritharen K, Bayer TA, Wiltfang J, Rostagno A, et al. ​N‐terminal heterogeneity of parenchymal and vascular amyloid‐β deposits in Alzheimer’s disease​. ​​Neuropathology and Applied Neurobiology. ​2020;​46​(7):​​673​-685​. ​doi:10.1111/nan.12637. 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Klafki HW, Rieper P, Matzen A, Zampar S, Wirths O, Vogelgsang J, et al. ​Development and Technical Validation of an Immunoassay for the Detection of APP669–711 (Aβ−3–40) in Biological Samples​. ​​International Journal of Molecular Sciences. ​2020;​21​(18):​​6564​. ​doi:10.3390/ijms21186564. 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Hornung K, Zampar S, Engel N, Klafki H, Liepold T, Bayer TA, et al. ​N-Terminal Truncated Aβ4-42 Is a Substrate for Neprilysin Degradation in vitro and in vivo​. ​​Journal of Alzheimer's Disease. ​2019;​67​(3):​​849​-858​. ​doi:10.3233/JAD-181134. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Giuranna J, Volckmar, Anna-Lena, Heinen A, Peters T, Schmidt B, Spieker A, et al. ​The Effect of SH2B1 Variants on Expression of Leptin- and Insulin-Induced Pathways in Murine Hypothalamus​. ​​Obesity Facts. ​2018;​11​(2):​​93​-108​. ​doi:10.1159/000486962. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Vogelgsang J, Wedekind D, Bouter C, Klafki, Hans-W., Wiltfang J. ​Reproducibility of Alzheimer’s Disease Cerebrospinal Fluid-Biomarker Measurements under Clinical Routine Conditions​. ​​Journal of Alzheimer's Disease. ​2018;​62​(1):​​203​-212​. ​doi:10.3233/JAD-170793. 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Kunding AH, Busk LL, Webb H, Klafki HW, Otto M, Kutter JP, et al. ​Micro-droplet arrays for micro-compartmentalization using an air/water interface​. ​​Lab on a Chip. ​2018;​18​(18):​​2797​-2805​. ​doi:10.1039/C8LC00608C. 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Wirths O, Walter S, Kraus I, Klafki HW, Stazi M, Oberstein TJ, et al. ​N-truncated Aβ4–x peptides in sporadic Alzheimer’s disease cases and transgenic Alzheimer mouse models​. ​​Alzheimer's Research & Therapy. ​2017;​9​(1). ​doi:10.1186/s13195-017-0309-z. 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Nabers A, Ollesch J, Schartner J, Kötting C, Genius J, Hafermann H, et al. ​Amyloid-β-Secondary Structure Distribution in Cerebrospinal Fluid and Blood Measured by an Immuno-Infrared-Sensor: A Biomarker Candidate for Alzheimer’s Disease​. ​​Analytical Chemistry. ​2016;​88​(5):​​2755​-2762​. ​doi:10.1021/acs.analchem.5b04286. 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Gronewold J, Todica O, Klafki, Hans-Wolfgang, Seidel UK, Kaltwasser B, Wiltfang J, et al. ​Association of Plasma β-Amyloid with Cognitive Performance and Decline in Chronic Kidney Disease​. ​​Molecular Neurobiology. ​2016;. ​doi:10.1007/s12035-016-0243-2. 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Klafki, Hans-Wolfgang, Hafermann H, Bauer C, Haußmann U, Kraus I, Schuchhardt J, et al. ​Validation of a Commercial Chemiluminescence Immunoassay for the Simultaneous Measurement of Three Different Amyloid-β Peptides in Human Cerebrospinal Fluid and Application to a Clinical Cohort​. ​​Journal of Alzheimer's Disease. ​2016;​54​(2):​​691​-705​. ​doi:10.3233/jad-160398. 
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Hüttenrauch M, Brauß A, Kurdakova A, Borgers H, Klinker F, Liebetanz D, et al. ​Physical activity delays hippocampal neurodegeneration and rescues memory deficits in an Alzheimer disease mouse model​. ​​Translational Psychiatry. ​2016;​6​(5). ​doi:10.1038/tp.2016.65. 
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Halbgebauer S, Nagl M, Klafki H, Haußmann U, Steinacker P, Oeckl P, et al. ​Modified serpinA1 as risk marker for Parkinson’s disease dementia: Analysis of baseline data​. ​​Scientific Reports. ​2016;​6​(1). ​doi:10.1038/srep26145. 
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Beyer I, Rezaei-Ghaleh N, Klafki, Hans-Wolfgang, Jahn O, Haußmann U, Wiltfang J, et al. ​Solid-Phase Synthesis and Characterization of N-Terminally Elongated Aβ−3-x-Peptides​. ​​Chemistry - A European Journal. ​2016;​22​(25):​​8685​-8693​. ​doi:10.1002/chem.201600892. 
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​Reinert J, Richard BC, Klafki HW, Friedrich B, Bayer TA, Wiltfang J, et al. ​Deposition of C-terminally truncated Aβ species Aβ37 and Aβ39 in Alzheimer’s disease and transgenic mouse models​. ​​Acta Neuropathologica Communications. ​2016;​4​(1):​​1​-12​. ​doi:10.1186/s40478-016-0294-7. 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​Gronewold J, Klafki, Hans-Wolfgang, Baldelli E, Kaltwasser B, Seidel UK, Todica O, et al. ​Factors Responsible for Plasma β-Amyloid Accumulation in Chronic Kidney Disease​. ​​Molecular Neurobiology. ​2016;​53​(5):​​3136​-3145​. ​doi:10.1007/s12035-015-9218-y. 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​van Waalwijk van Doorn LJC, Koel-Simmelink MJ, Haußmann U, Klafki H, Struyfs H, Linning P, et al. ​Validation of soluble amyloid-β precursor protein assays as diagnostic CSF biomarkers for neurodegenerative diseases​. ​​Journal of Neurochemistry. ​2016;​137​(1):​​112​-121​. ​doi:10.1111/jnc.13527. 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article
    ​ ​Savastano A, Klafki H, Haußmann U, Oberstein TJ, Muller P, Wirths O, et al. ​N-Truncated Aβ2-X Starting with Position Two in Sporadic Alzheimer’s Disease Cases and Two Alzheimer Mouse Models​. ​​Journal of Alzheimer's Disease. ​2015;​49​(1):​​101​-110​. ​doi:10.3233/jad-150394. 
    ​Details  DOI 
  • 2015 | Journal Article
    ​ ​Nabers A, Ollesch J, Schartner J, Kötting C, Genius J, Haußmann U, et al. ​An infrared sensor analysing label-free the secondary structure of the Abeta peptide in presence of complex fluids​. ​​Journal of Biophotonics. ​2015;​9​(3):​​224​-234​. ​doi:10.1002/jbio.201400145. 
    ​Details  DOI 
  • 2015 | Journal Article | 
    ​ ​Kraus I, Besong Agbo D, Otto M, Wiltfang J, Klafki H. ​Detection and Differentiation of Threonine- and Tyrosine-Monophosphorylated Forms of ERK1/2 by Capillary Isoelectric Focusing-Immunoassay​. ​​Scientific Reports. ​2015;​5​(1). ​doi:10.1038/srep12767. 
    ​Details  DOI 
  • 2014 | Journal Article
    ​ ​Poschmann G, Seyfarth K, Besong Agbo D, Klafki, Hans-Wolfgang, Rozman J, Wurst W, et al. ​High-Fat Diet Induced Isoform Changes of the Parkinson’s Disease Protein DJ-1​. ​​Journal of Proteome Research. ​2014;​13​(5):​​2339​-2351​. ​doi:10.1021/pr401157k. 
    ​Details  DOI 
  • 2014 | Journal Article
    ​ ​Halbgebauer S, Haußmann U, Klafki H, Tumani H, Wiltfang J, Otto M. ​Capillary isoelectric focusing immunoassay as a new nanoscale approach for the detection of oligoclonal bands​. ​​ELECTROPHORESIS. ​2014;​36​(2):​​355​-362​. ​doi:10.1002/elps.201400339. 
    ​Details  DOI 
  • 2014 | Journal Article | 
    ​ ​Oberstein TJ, Spitzer P, Klafki, Hans-Wolfgang, Linning P, Neff F, Knölker, Hans-Joachim, et al. ​Astrocytes and microglia but not neurons preferentially generate N-terminally truncated Aβ peptides​. ​​Neurobiology of Disease. ​2014;​73​:​​24​-35​. ​doi:10.1016/j.nbd.2014.08.031. 
    ​Details  DOI 
  • 2003 | Journal Article
    ​ ​Wiltfang J, Esselmann H, Bibl M, Smirnov A, Otto M, Paul S, et al. ​Highly conserved and disease-specific patterns of carboxyterminally truncated Aβ peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation​. ​​Journal of Neurochemistry. ​2003;​81​(3):​​481​-496​. ​doi:10.1046/j.1471-4159.2002.00818.x. 
    ​Details  DOI 

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