Prof. Dr. med. Lars Siegfried Maier

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  • 2020 | Journal Article
    ​ ​Disease Phenotypes and Mechanisms of iPSC-Derived Cardiomyocytes From Brugada Syndrome Patients With a Loss-of-Function SCN5A Mutation​
    Li, W.; Stauske, M.; Luo, X.; Wagner, S. ; Vollrath, M.; Mehnert, C. S. & Schubert, M. et al.​ (2020) 
    Frontiers in Cell and Developmental Biology, 8.​ DOI: https://doi.org/10.3389/fcell.2020.592893 
    ​Details  DOI 
  • 2018 | Journal Article | Research Paper
    ​ ​Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Saadatmand, A.; Pabel, S. ; Weber, S. & Wang, Y. et al.​ (2018) 
    European Journal of Heart Failure, 20(12) pp. 1673​-1685​.​ DOI: https://doi.org/10.1002/ejhf.1297 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4​
    Perera, R. K. ; Fischer, T. H. ; Wagner, M.; Dewenter, M. ; Vettel, C. ; Bork, N. I. & Maier, L. S.  et al.​ (2017) 
    Scientific Reports, 7(1) art. 15222​.​ DOI: https://doi.org/10.1038/s41598-017-15632-x 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure​
    Dewenter, M. ; Neef, S.; Vettel, C. ; Lämmle, S.; Beushausen, C.; Zelarayan, L. C.   & Katz, S. et al.​ (2017) 
    Circulation: Heart Failure, 10(5) art. e003840​.​ DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.117.003840 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity​
    Neef, S.; Heijman, J.; Otte, K.; Dewenter, M. ; Saadatmand, A. R.; Meyer-Roxlau, S.   & Antos, C. L. et al.​ (2017) 
    Naunyn-Schmiedeberg's Archives of Pharmacology, 390(8) pp. 857​-862​.​ DOI: https://doi.org/10.1007/s00210-017-1376-1 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | Research Paper
    ​ ​Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction​
    Unsoeld, B. W.; Kaul, A.; Sbroggi, M.; Schubert, C.; Regitz-Zagrosek, V.; Brancaccio, M. & Damilano, F. et al.​ (2014) 
    Cardiovascular Research, 101(1) pp. 97​-107​.​ DOI: https://doi.org/10.1093/cvr/cvt235 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper | 
    ​ ​Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading​
    Schwoerer, A. P.; Neef, S.; Broichhausen, I.; Jacubeit, J.; Tiburcy, M. ; Wagner, M. & Biermann, D. et al.​ (2013) 
    Pflügers Archiv - European Journal of Physiology, 465(12) pp. 1763​-1773​.​ DOI: https://doi.org/10.1007/s00424-013-1316-y 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​While systolic cardiomyocyte function is preserved, diastolic myocyte function and recovery from acidosis are impaired in CaMKII delta-KO mice​
    Neef, S.; Sag, C. M.; Daut, M.; Baeumer, H.; Grefe, C.; El-Armouche, A.   & DeSantiago, J. et al.​ (2013) 
    Journal of Molecular and Cellular Cardiology, 59 pp. 107​-116​.​ DOI: https://doi.org/10.1016/j.yjmcc.2013.02.014 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes​
    Mehel, H.; Emons, J.; Vettel, C. ; Wittköpper, K.; Seppelt, D.; Dewenter, M.   & Lutz, S.  et al.​ (2013) 
    Journal of the American College of Cardiology, 62(17) pp. 1596​-1606​.​ DOI: https://doi.org/10.1016/j.jacc.2013.05.057 
    ​Details  DOI  PMID  PMC  WoS 
  • 2011 | Conference Abstract
    ​ ​Ablation of Phosphatase-1-Inhibitor-1 is Detrimental in CaMKII Overexpression Despite Reduction of SR Ca2+Leak​
    Neef, S.; Wittkoepper, K.; Brammen, C.; Sowa, T.; Zimmermann, W.-H. ; Brown, J. H. & Maier, L. S.  et al.​ (2011)
    Circulation, 124(21) 
    Philadelphia​: Lippincott Williams & Wilkins.
    ​Details  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Inhibition of Elevated Ca2+/Calmodulin-Dependent Protein Kinase II Improves Contractility in Human Failing Myocardium​
    Sossalla, S. ; Fluschnik, N.; Schotola, H.; Ort, K. R.; Neef, S.; Schulte, T. & Wittkoepper, K. et al.​ (2010) 
    Circulation Research, 107(9) pp. 1150​-U215​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.110.220418 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging​
    Wittoepper, K.; Fabritz, L.; Neef, S.; Ort, K. R.; Grefe, C.; Unsoeld, B. W. & Kirchhof, P. et al.​ (2010) 
    Journal of Clinical Investigation, 120(2) pp. 617​-626​.​ DOI: https://doi.org/10.1172/JCI40545 
    ​Details  DOI  PMID  PMC  WoS 

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