Prof. Dr. Reinhard Lührmann

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  • 2017 | Journal Article | 
    ​ ​Regulation of Prp43-mediated disassembly of spliceosomes by its cofactors Ntr1 and Ntr2​
    Fourmann, J.-B.; Tauchert, M. J. ; Ficner, R. ; Fabrizio, P. & Lührmann, R. ​ (2017) 
    Nucleic Acids Research, 45(7) pp. 4068​-4080​.​ DOI: https://doi.org/10.1093/nar/gkw1225 
    ​Details  DOI 
  • 2016 | Journal Article | 
    ​ ​The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction​
    Fourmann, J.-B.; Dybkov, O.; Agafonov, D. E; Tauchert, M. J ; Urlaub, H. ; Ficner, R.   & Fabrizio, P. et al.​ (2016) 
    eLife, 5 art. e15564​.​ DOI: https://doi.org/10.7554/eLife.15564 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity​
    Boesler, C.; Rigo, N.; Anokhina, M. M.; Tauchert, M. J. ; Agafonov, D. E.; Kastner, B. & Urlaub, H.  et al.​ (2016) 
    Nature Communications, 7 art. 11997​.​ DOI: https://doi.org/10.1038/ncomms11997 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Structural and functional analysis of the RNA helicase Prp43 from the thermophilic eukaryote Chaetomium thermophilum​
    Tauchert, M. J. ; Fourmann, J.-B.; Christian, H.; Lührmann, R.   & Ficner, R. ​ (2016) 
    Acta Crystallographica Section F Structural Biology Communications, 72(2) pp. 112​-120​.​ DOI: https://doi.org/10.1107/S2053230X15024498 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Structural and functional analysis of the human spliceosomal DEAD-box helicase Prp28​
    Moehlmann, S.; Mathew, R.; Neumann, P. ; Schmitt, A.; Luehrmann, R.   & Ficner, R. ​ (2014) 
    Acta Crystallographica Section D Biological Crystallography, 70 pp. 1622​-1630​.​ DOI: https://doi.org/10.1107/S1399004714006439 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system​
    Fourmann, J.-B.; Schmitzová, J.; Christian, H.; Urlaub, H. ; Ficner, R. ; Boon, K.-L.   & Fabrizio, P. et al.​ (2013) 
    Genes & Development, 27(4) pp. 413​-428​.​ DOI: https://doi.org/10.1101/gad.207779.112 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Phosphorylation Drives a Dynamic Switch in Serine/Arginine-Rich Proteins​
    Xiang, S.; Gapsys, V. ; Kim, H.-Y.; Bessonov, S.; Hsiao, H.-H.; Moehlmann, S. & Klaukien, V. et al.​ (2013) 
    Structure, 21(12) pp. 2162​-2174​.​ DOI: https://doi.org/10.1016/j.str.2013.09.014 
    ​Details  DOI  PMID  PMC  WoS 
  • 2009 | Journal Article | Research Paper
    ​ ​Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components​
    Warkocki, Z.; Odenwaelder, P. ; Schmitzova, J.; Platzmann, F.; Stark, H. ; Urlaub, H.   & Ficner, R.  et al.​ (2009) 
    Nature Structural & Molecular Biology, 16(12) pp. 1237​-U50​.​ DOI: https://doi.org/10.1038/nsmb.1729 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper
    ​ ​Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome​
    Mathew, R.; Hartmuth, K.; Moehlmann, S.; Urlaub, H. ; Ficner, R.   & Luehrmann, R. ​ (2008) 
    Nature Structural & Molecular Biology, 15(5) pp. 435​-443​.​ DOI: https://doi.org/10.1038/nsmb.1415 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article | Research Paper
    ​ ​Structural basis for the bifunctionality of the U5 snRNP 52K protein (CD2BP2)​
    Nielsen, T. K. ; Uu, S.; Luehrmann, R.   & Ficner, R. ​ (2007) 
    Journal of Molecular Biology, 369(4) pp. 902​-908​.​ DOI: https://doi.org/10.1016/j.jmb.2007.03.077 
    ​Details  DOI  PMID  PMC  WoS 

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