Prof. Dr. Reinhard Lührmann

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  • 2021 | Journal Article | 
    ​ ​Structural insights into how Prp5 proofreads the pre-mRNA branch site​
    Zhang, Z.; Rigo, N.; Dybkov, O.; Fourmann, J.-B.; Will, C. L.; Kumar, V. & Urlaub, H.  et al.​ (2021) 
    Nature, 596(7871) pp. 296​-300​.​ DOI: https://doi.org/10.1038/s41586-021-03789-5 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Structural Insights into the Roles of Metazoan-Specific Splicing Factors in the Human Step 1 Spliceosome​
    Bertram, K.; El Ayoubi, L.; Dybkov, O.; Agafonov, D. E.; Will, C. L.; Hartmuth, K. & Urlaub, H.  et al.​ (2020) 
    Molecular Cell, 80(1) pp. 127​-139.e6​.​ DOI: https://doi.org/10.1016/j.molcel.2020.09.012 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Molecular architecture of the human 17S U2 snRNP​
    Zhang, Z.; Will, C. L.; Bertram, K.; Dybkov, O.; Hartmuth, K.; Agafonov, D. E. & Hofele, R. et al.​ (2020) 
    Nature, 583(7815) pp. 310​-313​.​ DOI: https://doi.org/10.1038/s41586-020-2344-3 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex​
    Haselbach, D.; Komarov, I.; Agafonov, D. E.; Hartmuth, K.; Graf, B.; Dybkov, O. & Urlaub, H.  et al.​ (2018) 
    Cell, 172(3) pp. 454​-464.e11​.​ DOI: https://doi.org/10.1016/j.cell.2018.01.010 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated B act complex​
    Bao, P.; Will, C. L.; Urlaub, H. ; Boon, K.-L.   & Lührmann, R. ​ (2018) 
    Genes & Development, 31(23-24) pp. 2416​-2429​.​ DOI: https://doi.org/10.1101/gad.308163.117 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Prp19/Pso4 Is an Autoinhibited Ubiquitin Ligase Activated by Stepwise Assembly of Three Splicing Factors​
    de Moura, T. R.; Mozaffari-Jovin, S.; Szabó, C. Z. K.; Schmitzová, J.; Dybkov, O.; Cretu, C.   & Kachala, M. et al.​ (2018) 
    Molecular Cell, 69(6) pp. 979​-992.e6​.​ DOI: https://doi.org/10.1016/j.molcel.2018.02.022 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​Protein-Cross-Linking zur Aufklärung von komplexen Strukturen​
    Dybkov, O.; Stützer, A.; Bertram, K.; Kastner, B.; Stark, H. ; Lührmann, R.   & Urlaub, H. ​ (2018) 
    BIOspektrum, 24(3) pp. 278​-282​.​ DOI: https://doi.org/10.1007/s12268-018-0909-6 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation​
    Bertram, K.; Agafonov, D. E.; Dybkov, O.; Haselbach, D.; Leelaram, M. N.; Will, C. L. & Urlaub, H.  et al.​ (2017) 
    Cell, 170(4) pp. 701​-713.e11​.​ DOI: https://doi.org/10.1016/j.cell.2017.07.011 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Cryo-EM structure of a human spliceosome activated for step 2 of splicing​
    Bertram, K.; Agafonov, D. E.; Liu, W.-T.; Dybkov, O.; Will, C. L.; Hartmuth, K. & Urlaub, H.  et al.​ (2017) 
    Nature, 542(7641) pp. 318​.​ DOI: https://doi.org/10.1038/nature21079 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Molecular architecture of the human U4/U6.U5 tri-snRNP​
    Agafonov, D. E.; Kastner, B.; Dybkov, O.; Hofele, R. V.; Liu, W.-T.; Urlaub, H.   & Lührmann, R.  et al.​ (2016) 
    Science, 351(6280) pp. 1416​-1420​.​ DOI: https://doi.org/10.1126/science.aad2085 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations​
    Cretu, C. ; Schmitzova, J.; Ponce-Salvatierra, A.; Dybkov, O.; De laurentiis, E. I.; Sharma, K. & Will, C. L. et al.​ (2016) 
    Molecular Cell, 64(2) pp. 307​-319​.​ DOI: https://doi.org/10.1016/j.molcel.2016.08.036 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article
    ​ ​Molecular architecture of the Saccharomyces cerevisiae activated spliceosome​
    Rauhut, R.; Fabrizio, P.; Dybkov, O.; Hartmuth, K.; Pena, V.; Chari, A. & Kumar, V. et al.​ (2016) 
    Science, 353(6306) pp. 1399​-1405​.​ DOI: https://doi.org/10.1126/science.aag1906 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | 
    ​ ​The target of the DEAH-box NTP triphosphatase Prp43 in Saccharomyces cerevisiae spliceosomes is the U2 snRNP-intron interaction​
    Fourmann, J.-B.; Dybkov, O.; Agafonov, D. E; Tauchert, M. J ; Urlaub, H. ; Ficner, R.   & Fabrizio, P. et al.​ (2016) 
    eLife, 5 art. e15564​.​ DOI: https://doi.org/10.7554/eLife.15564 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​A spliceosome intermediate with loosely associated tri-snRNP accumulates in the absence of Prp28 ATPase activity​
    Boesler, C.; Rigo, N.; Anokhina, M. M.; Tauchert, M. J. ; Agafonov, D. E.; Kastner, B. & Urlaub, H.  et al.​ (2016) 
    Nature Communications, 7 art. 11997​.​ DOI: https://doi.org/10.1038/ncomms11997 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Protein cofactor competition regulates the action of a multifunctional RNA helicase in different pathways​
    Heininger, A. U. ; Hackert, P. ; Andreou, A. Z.; Boon, K.-L. ; Memet, I. ; Prior, M.   & Clancy, A.  et al.​ (2016) 
    RNA Biology, 13(3) pp. 320​-330​.​ DOI: https://doi.org/10.1080/15476286.2016.1142038 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Conference Abstract
    ​ ​Sequestering and protein cofactor competition regulate a multifunctional RNA helicase in different pathways​
    Heininger, A. U. ; Hackert, P. ; Andreou, A.-Z.; Boon, K.-L. ; Prior, M. ; Schmidt, B. & Urlaub, H.  et al.​ (2015)
    FEBS Journal, 282 pp. 209​-210. , Berlin, GERMANY.
    Hoboken​: Wiley-blackwell.
    ​Details  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Dissection of the factor requirements for spliceosome disassembly and the elucidation of its dissociation products using a purified splicing system​
    Fourmann, J.-B.; Schmitzová, J.; Christian, H.; Urlaub, H. ; Ficner, R. ; Boon, K.-L.   & Fabrizio, P. et al.​ (2013) 
    Genes & Development, 27(4) pp. 413​-428​.​ DOI: https://doi.org/10.1101/gad.207779.112 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Phosphorylation Drives a Dynamic Switch in Serine/Arginine-Rich Proteins​
    Xiang, S.; Gapsys, V. ; Kim, H.-Y.; Bessonov, S.; Hsiao, H.-H.; Moehlmann, S. & Klaukien, V. et al.​ (2013) 
    Structure, 21(12) pp. 2162​-2174​.​ DOI: https://doi.org/10.1016/j.str.2013.09.014 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article
    ​ ​Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis​
    Bessonov, S.; Anokhina, M.; Krasauskas, A.; Golas, M. M.; Sander, B.; Will, C. L. & Urlaub, H.  et al.​ (2010) 
    RNA, 16(12) pp. 2384​-2403​.​ DOI: https://doi.org/10.1261/rna.2456210 
    ​Details  DOI 
  • 2009 | Journal Article | Research Paper
    ​ ​Reconstitution of both steps of Saccharomyces cerevisiae splicing with purified spliceosomal components​
    Warkocki, Z.; Odenwaelder, P. ; Schmitzova, J.; Platzmann, F.; Stark, H. ; Urlaub, H.   & Ficner, R.  et al.​ (2009) 
    Nature Structural & Molecular Biology, 16(12) pp. 1237​-U50​.​ DOI: https://doi.org/10.1038/nsmb.1729 
    ​Details  DOI  PMID  PMC  WoS 
  • 2009 | Journal Article
    ​ ​The Evolutionarily Conserved Core Design of the Catalytic Activation Step of the Yeast Spliceosome​
    Fabrizio, P.; Dannenberg, J. ; Dube, P.; Kastner, B.; Stark, H. ; Urlaub, H.   & Lührmann, R. ​ (2009) 
    Molecular Cell, 36(4) pp. 593​-608​.​ DOI: https://doi.org/10.1016/j.molcel.2009.09.040 
    ​Details  DOI  PMID  PMC  WoS 
  • 2008 | Journal Article | Research Paper
    ​ ​Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome​
    Mathew, R.; Hartmuth, K.; Moehlmann, S.; Urlaub, H. ; Ficner, R.   & Luehrmann, R. ​ (2008) 
    Nature Structural & Molecular Biology, 15(5) pp. 435​-443​.​ DOI: https://doi.org/10.1038/nsmb.1415 
    ​Details  DOI  PMID  PMC  WoS 
  • 2007 | Journal Article
    ​ ​GraFix: sample preparation for single-particle electron cryomicroscopy​
    Kastner, B.; Fischer, N. ; Golas, M. M.; Sander, B.; Dube, P.; Boehringer, D. & Hartmuth, K. et al.​ (2007) 
    Nature Methods, 5(1) pp. 53​-55​.​ DOI: https://doi.org/10.1038/nmeth1139 
    ​Details  DOI 
  • 2007 | Journal Article
    ​ ​Composition and three-dimensional EM structure of double affinity-purified, human prespliceosomal A complexes​
    Behzadnia, N.; Golas, M. M.; Hartmuth, K.; Sander, B.; Kastner, B.; Deckert, J. & Dube, P. et al.​ (2007) 
    The EMBO Journal, 26(6) pp. 1737​-1748​.​ DOI: https://doi.org/10.1038/sj.emboj.7601631 
    ​Details  DOI 
  • 2006 | Journal Article
    ​ ​Protein Composition and Electron Microscopy Structure of Affinity-Purified Human Spliceosomal B Complexes Isolated under Physiological Conditions​
    Deckert, J.; Hartmuth, K.; Boehringer, D.; Behzadnia, N.; Will, C. L.; Kastner, B. & Stark, H.  et al.​ (2006) 
    Molecular and Cellular Biology, 26(14) pp. 5528​-5543​.​ DOI: https://doi.org/10.1128/MCB.00582-06 
    ​Details  DOI 

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