Prof. Dr. Wolfgang A. Linke

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  • 2022 | Journal Article | Research Paper | 
    ​ ​Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)​
    de Boer, R. A.; Heymans, S.; Backs, J.; Carrier, L.; Coats, A. J. S.; Dimmeler, S. & Eschenhagen, T. et al.​ (2022) 
    European Journal of Heart Failure, 24(3) pp. 406​-420​.​ DOI: https://doi.org/10.1002/ejhf.2414 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​Fine‐mapping of the major locus for vicine and convicine in faba bean (Vicia faba) and marker‐assisted breeding of a novel, low vicine and convicine winter faba bean population​
    Tacke, R.; Ecke, W.; Höfer, M.; Sass, O. & Linke, W. ​ (2022) 
    Plant Breeding, 141(5) art. pbr.13039​.​ DOI: https://doi.org/10.1111/pbr.13039 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Unraveling the mysteries of the titin-N2A signalosome​
    Hessel, A. L. & Linke, W. A. ​ (2021) 
    The Journal of General Physiology, 153(8).​ DOI: https://doi.org/10.1085/jgp.202112967 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | 
    ​ ​Identification of Regulatory SNPs Associated with Vicine and Convicine Content of Vicia faba Based on Genotyping by Sequencing Data Using Deep Learning​
    Heinrich, F.; Wutke, M.; Das, P. P.; Kamp, M.; Gültas, M.; Link, W.   & Schmitt, A. O. ​ (2020) 
    Genes, 11(6) pp. 614​.​ DOI: https://doi.org/10.3390/genes11060614 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Growth Performance of Local Chicken Breeds, a High-Performance Genotype and Their Crosses Fed with Regional Faba Beans to Replace Soy​
    Nolte, T.; Jansen, S.; Weigend, S.; Moerlein, D. ; Halle, I.; Link, W.   & Hummel, J.  et al.​ (2020) 
    Animals, 10(4) pp. 702​.​ DOI: https://doi.org/10.3390/ani10040702 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients​
    Dai, Y.; Amenov, A.; Ignatyeva, N.; Koschinski, A.; Xu, H.; Soong, P. L.   & Tiburcy, M.  et al.​ (2020) 
    Scientific Reports, 10(1) art. 209​.​ DOI: https://doi.org/10.1038/s41598-019-56597-3 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin​
    Swist, S.; Unger, A.; Li, Y.; Vöge, A.; von Frieling-Salewsky, M.; Skärlén, Å. & Cacciani, N. et al.​ (2020) 
    Nature Communications, 11(1) pp. 4479​.​ DOI: https://doi.org/10.1038/s41467-020-18131-2 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | 
    ​ ​Eliminating vicine and convicine, the main anti-nutritional factors restricting faba bean usage​
    Khazaei, H.; Purves, R. W.; Hughes, J.; Link, W. ; O'Sullivan, D. M.; Schulman, A. H. & Björnsdotter, E. et al.​ (2019) 
    Trends in Food Science & Technology, 91 pp. 549​-556​.​ DOI: https://doi.org/10.1016/j.tifs.2019.07.051 
    ​Details  DOI 
  • 2019 | Journal Article | Overview | 
    ​ ​Posttranslational modifications of titin from cardiac muscle: how, where, and what for?​
    Koser, F.; Loescher, C. & Linke, W. A. ​ (2019) 
    The FEBS Journal, 286(12) pp. 2240​-2260​.​ DOI: https://doi.org/10.1111/febs.14854 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes​
    Krysiak, J.; Unger, A.; Beckendorf, L.; Hamdani, N.; Frieling-Salewsky, M. von; Redfield, M. M. & Remedios, C. G. dos et al.​ (2018) 
    Nature Communications, 9(1) art. 262​.​ DOI: https://doi.org/10.1038/s41467-017-02483-3 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Dietary spermidine for lowering high blood pressure​
    Eisenberg, T.; Abdellatif, M.; Zimmermann, A.; Schroeder, S.; Pendl, T.; Harger, A. & Stekovic, S. et al.​ (2017) 
    Autophagy, 13(4) pp. 767​-769​.​ DOI: https://doi.org/10.1080/15548627.2017.1280225 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Overview | 
    ​ ​Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes​
    Hamdani, N.; Herwig, M. & Linke, W. A. ​ (2017) 
    Biophysical Reviews, 9(3) pp. 225​-237​.​ DOI: https://doi.org/10.1007/s12551-017-0263-9 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes​
    Streckfuss-Bömeke, K. ; Tiburcy, M. ; Fomin, A.; Luo, X.; Li, W.; Fischer, C. & Özcelik, C. et al.​ (2017) 
    Journal of Molecular and Cellular Cardiology, 113 pp. 9​-21​.​ DOI: https://doi.org/10.1016/j.yjmcc.2017.09.008 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Molecular and structural transition mechanisms in long-term volume overload​
    Mohamed, B. A. ; Schnelle, M. ; Khadjeh, S. ; Lbik, D.; Herwig, M.; Linke, W. A.   & Hasenfuß, G.  et al.​ (2016) 
    European Journal of Heart Failure, 18(4) pp. 362​-371​.​ DOI: https://doi.org/10.1002/ejhf.465 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Overview | 
    ​ ​Emerging importance of oxidative stress in regulating striated muscle elasticity​
    Beckendorf, L. & Linke, W. A. ​ (2015) 
    Journal of Muscle Research and Cell Motility, 36(1) pp. 25​-36​.​ DOI: https://doi.org/10.1007/s10974-014-9392-y 
    ​Details  DOI 
  • 2011 | Journal Article | Research Paper | 
    ​ ​Terminal Differentiation, Advanced Organotypic Maturation, and Modeling of Hypertrophic Growth in Engineered Heart Tissue​
    Tiburcy, M. ; Didie, M. ; Boy, O.; Christalla, P.; Doeker, S.; Naito, H. & Karikkineth, B. C. et al.​ (2011) 
    Circulation Research, 109(10) pp. 1105​-U46​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.111.251843 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper | 
    ​ ​Differential Cardiac Remodeling in Preload Versus Afterload​
    Toischer, K. ; Rokita, A. G.; Unsoeld, B. W.; Zhu, W.; Kararigas, G.; Sossalla, S.   & Reuter, S. P. et al.​ (2010) 
    Circulation, 122(10) pp. 993​-1003​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.110.943431 
    ​Details  DOI  PMID  PMC  WoS 

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