Prof. Dr. rer. nat. Mladen Tzvetkov

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  • 2020 | Journal Article | 
    ​ ​A double-Flp-in method for stable overexpression of two genes​
    Jensen, O. ; Ansari, S.; Gebauer, L.; Müller, S. F.; Lowjaga, K. A. A. T.; Geyer, J. & Tzvetkov, M. V.  et al.​ (2020) 
    Scientific Reports, 10(1).​ DOI: https://doi.org/10.1038/s41598-020-71051-5 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Inherited and Acquired Determinants of Hepatic CYP3A Activity in Humans​
    Matthaei, J. ; Bonat, W. H.; Kerb, R.; Tzvetkov, M. V. ; Strube, J.; Brunke, S. & Sachse-Seeboth, C. et al.​ (2020) 
    Frontiers in Genetics, 11.​ DOI: https://doi.org/10.3389/fgene.2020.00944 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper
    ​ ​Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters​
    Jensen, O. ; Rafehi, M. ; Tzvetkov, M. V.   & Brockmöller, J. ​ (2020) 
    Biochemical Pharmacology, 171 pp. 113731​.​ DOI: https://doi.org/10.1016/j.bcp.2019.113731 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article
    ​ ​Opioids as Substrates and Inhibitors of the Genetically Highly Variable Organic Cation Transporter OCT1​
    Meyer, M. J. ; Neumann, V. E.; Friesacher, H. R.; Zdrazil, B.; Brockmöller, J.   & Tzvetkov, M. V. ​ (2019) 
    Journal of Medicinal Chemistry, 62(21) pp. 9890​-9905​.​ DOI: https://doi.org/10.1021/acs.jmedchem.9b01301 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​An in vitro study on interaction of anisodine and monocrotaline with organic cation transporters of the SLC22 and SLC47 families​
    CHEN, J.-Y.; Brockmöller, J. ; Tzvetkov, M. V. ; Wang, L.-J. & Chen, X.-J.​ (2019) 
    Chinese Journal of Natural Medicines, 17(7) pp. 490​-497​.​ DOI: https://doi.org/10.1016/S1875-5364(19)30070-6 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil​
    Matthaei, J. ; Seitz, T. ; Jensen, O. ; Tann, A.; Prukop, T. ; Tadjerpisheh, S. & Brockmöller, J.  et al.​ (2019) 
    Clinical Pharmacology and Therapeutics, 105(1) pp. 190​-200​.​ DOI: https://doi.org/10.1002/cpt.1128 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | 
    ​ ​Variability and heritability of thiamine pharmacokinetics with focus on OCT1 effects on membrane transport and pharmacokinetics in humans​
    Jensen, O. ; Matthaei, J. ; Blome, F.; Schwab, M.; Tzvetkov, M. V.   & Brockmöller, J. ​ (2019) 
    Clinical Pharmacology and Therapeutics, 107(3) pp. 628​-638​.​ DOI: https://doi.org/10.1002/cpt.1666 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Highly Variable Pharmacokinetics of Tyramine in Humans and Polymorphisms in OCT1, CYP2D6, and MAO-A​
    Rafehi, M. ; Faltraco, F.; Matthaei, J. ; Prukop, T. ; Jensen, O. ; Grytzmann, A. & Berger, R. G. et al.​ (2019) 
    Frontiers in Pharmacology, 10 pp. 1297​.​ DOI: https://doi.org/10.3389/fphar.2019.01297 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​Impact of Promoter Polymorphisms on the Transcriptional Regulation of the Organic Cation Transporter OCT1 (SLC22A1)​
    Bokelmann, K.; Brockmöller, J.   & Tzvetkov, M. ​ (2018) 
    Journal of Personalized Medicine, 8(4) pp. 42​.​ DOI: https://doi.org/10.3390/jpm8040042 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​Increased Systemic Exposure and Stronger Cardiovascular and Metabolic Adverse Reactions to Fenoterol in Individuals with Heritable OCT1 Deficiency​
    Tzvetkov, M. V. ; Matthaei, J. ; Pojar, S.; Faltraco, F.; Vogler, S.; Prukop, T.   & Seitz, T.  et al.​ (2017) 
    Clinical Pharmacology & Therapeutics, 103(5) pp. 868​-878​.​ DOI: https://doi.org/10.1002/cpt.812 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine​
    Meyer, M. J. ; Seitz, T. ; Brockmöller, J.   & Tzvetkov, M. V. ​ (2017) 
    PLOS ONE, 12(12) art. e0189521​.​ DOI: https://doi.org/10.1371/journal.pone.0189521 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article
    ​ ​Heritability of Metoprolol and Torsemide Pharmacokinetics​
    Matthaei, J. ; Brockmöller, J. ; Tzvetkov, M. V. ; Sehrt, D.; Sachse-Seeboth, C.; Hjelmborg, J. B. & Möller, S. et al.​ (2015) 
    Clinical Pharmacology & Therapeutics, 98(6) pp. 611​-621​.​ DOI: https://doi.org/10.1002/cpt.258 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​NAD(P)H oxidase and multidrug resistance protein genetic polymorphisms are associated with doxorubicin-induced cardiotoxicity​
    Wojnowski, L.; Kulle, B.; Schirmer, M. ; Schlüter, G.; Schmidt, A.; Rosenberger, A.   & Vonhof, S. et al.​ (2005) 
    Circulation, 112(24) pp. 3754​-3762​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.576850 
    ​Details  DOI  PMID  PMC  WoS 
  • 2005 | Journal Article | Research Paper
    ​ ​Application of genomewide SNP arrays for detection of simulated susceptibility loci​
    Kulle, B.; Schirmer, M. ; Toliat, M. R.; Suk, A.; Becker, C.; Tzvetkov, M.   & Brockmöller, J.  et al.​ (2005) 
    Human Mutation, 25(6) pp. 557​-565​.​ DOI: https://doi.org/10.1002/humu.20174 
    ​Details  DOI  PMID  PMC  WoS 

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