PD Dr. med. Elisabeth Heßmann

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  • 2022 | Journal Article | Research Paper | 
    ​ ​TP53-Status-Dependent Oncogenic EZH2 Activity in Pancreatic Cancer​
    Versemann, L. ; Patil, S.; Steuber, B. ; Zhang, Z.; Kopp, W.; Krawczyk, H. E. & Kaulfuß, S.  et al.​ (2022) 
    Cancers, 14(14).​ DOI: https://doi.org/10.3390/cancers14143451 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper
    ​ ​STIM1 Mediates Calcium-dependent Epigenetic Reprogramming in Pancreatic Cancer​
    Kutschat, A. P.; Hamdan, F. H.; Wang, X.; Wixom, A. Q.; Najafova, Z.; Gibhardt, C. S. & Kopp, W. et al.​ (2021) 
    Cancer Research, art. canres.2874.2020​.​ DOI: https://doi.org/10.1158/0008-5472.CAN-20-2874 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article
    ​ ​Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer​
    Gout, J.; Perkhofer, L.; Morawe, M.; Arnold, F.; Ihle, M.; Biber, S. & Lange, S. et al.​ (2021) 
    Gut, 70(4) pp. 743​-760​.​ DOI: https://doi.org/10.1136/gutjnl-2019-319970 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Enhancer of Zeste Homolog 2 in Colorectal Cancer Development and Progression​
    Bremer, S. C. B.; Mechie, N.-C.; Mavropoulou, E.; Ellenrieder, V.; Hessmann, E. ; Conradi, L.-C. & Amanzada, A. et al.​ (2021) 
    Digestion, 102(2) pp. 227​-235​.​ DOI: https://doi.org/10.1159/000504093 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article
    ​ ​Microenvironmental Determinants of Pancreatic Cancer​
    Hessmann, E. ; Buchholz, S. M.; Demir, I. E.; Singh, S. K.; Gress, T. M.; Ellenrieder, V.   & Neesse, A. ​ (2020) 
    Physiological Reviews, 100(4) pp. 1707​-1751​.​ DOI: https://doi.org/10.1152/physrev.00042.2019 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6​
    Patil, S.; Steuber, B. ; Kopp, W.; Kari, V. ; Urbach, L.; Wang, X. & Küffer, S.  et al.​ (2020) 
    Cancer Research, 80(21) pp. 4620​-4632​.​ DOI: https://doi.org/10.1158/0008-5472.CAN-20-0672 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​Depletion of Macrophages Improves Therapeutic Response to Gemcitabine in Murine Pancreas Cancer​
    Buchholz, S. M.; Goetze, R. G.; Singh, S. K.; Ammer-Herrmenau, C.; Richards, F. M.; Jodrell, D. I. & Buchholz, M. et al.​ (2020) 
    Cancers, 12(7) pp. 1978​.​ DOI: https://doi.org/10.3390/cancers12071978 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Chromatin remodelling controls pancreatic tissue fate​
    Hessmann, E.   & Ellenrieder, V. ​ (2019) 
    Gut, 68(7) pp. 1139​-1140​.​ DOI: https://doi.org/10.1136/gutjnl-2018-317486 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Preclinical Evaluation of 1,2-Diamino-4,5-Dibromobenzene in Genetically Engineered Mouse Models of Pancreatic Cancer​
    Goetze, R. G.; Buchholz, S. M.; Ou, N.; Zhang, Q.; Patil, S.; Schirmer, M.   & Singh, S. K. et al.​ (2019) 
    Cells, 8(6) pp. 563​.​ DOI: https://doi.org/10.3390/cells8060563 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells​
    Sen, M. ; Wang, X.; Hamdan, F. H. ; Rapp, J.; Eggert, J.; Kosinsky, R. L.   & Wegwitz, F.  et al.​ (2019) 
    Clinical Epigenetics, 11(1).​ DOI: https://doi.org/10.1186/s13148-019-0690-5 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Nuclear factor of activated T-cells, NFATC1, governs FLT3ITD-driven hematopoietic stem cell transformation and a poor prognosis in AML​
    Solovey, M.; Wang, Y.; Michel, C.; Metzeler, K. H.; Herold, T.; Göthert, J. R. & Ellenrieder, V.  et al.​ (2019) 
    Journal of Hematology & Oncology, 12(1).​ DOI: https://doi.org/10.1186/s13045-019-0765-y 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​SPARC dependent collagen deposition and gemcitabine delivery in a genetically engineered mouse model of pancreas cancer​
    Ramu, I.; Buchholz, S. M.; Patzak, M. S.; Goetze, R. G.; Singh, S. K.; Richards, F. M. & Jodrell, D. I. et al.​ (2019) 
    EBioMedicine, 48 pp. 161​-168​.​ DOI: https://doi.org/10.1016/j.ebiom.2019.09.024 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Aberrant NFATc1 signaling counteracts TGFβ-mediated growth arrest and apoptosis induction in pancreatic cancer progression​
    Hasselluhn, M. C.; Schmidt, G. E.; Ellenrieder, V.; Johnsen, S. A. & Hessmann, E. ​ (2019) 
    Cell Death & Disease, 10(6) pp. 446​.​ DOI: https://doi.org/10.1038/s41419-019-1682-2 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | 
    ​ ​Cytosolic 5'-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites.​
    Patzak, M. S.; Kari, V.; Patil, S.; Hamdan, F. H.; Goetze, R. G.; Brunner, M. & Gaedcke, J. et al.​ (2019) 
    EBioMedicine, 40 pp. 394​-405​.​ DOI: https://doi.org/10.1016/j.ebiom.2019.01.037 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article
    ​ ​Utilizing High Resolution Ultrasound to Monitor Tumor Onset and Growth in Genetically Engineered Pancreatic Cancer Models​
    Goetze, R.-G.; Buchholz, S. M.; Patil, S.; Petzold, G. ; Ellenrieder, V. ; Hessmann, E.   & Neesse, A. ​ (2018) 
    Journal of Visualized Experiments,(134).​ DOI: https://doi.org/10.3791/56979 
    ​Details  DOI 
  • 2018 | Journal Article
    ​ ​Fibroblast drug scavenging increases intratumoural gemcitabine accumulation in murine pancreas cancer​
    Hessmann, E. ; Patzak, M S; Klein, L.; Chen, N. ; Kari, V. ; Ramu, I. & Bapiro, T E et al.​ (2018) 
    Gut, 67(3) pp. 497​-507​.​ DOI: https://doi.org/10.1136/gutjnl-2016-311954 
    ​Details  DOI 
  • 2018 | Journal Article | 
    ​ ​To be or not to be​
    Zhang, Z. & Hessmann, E. ​ (2018) 
    eLife, 7.​ DOI: https://doi.org/10.7554/eLife.38967 
    ​Details  DOI 
  • 2017 | Journal Article
    ​ ​ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage​
    Perkhofer, L.; Schmitt, A.; Romero Carrasco, M. C.; Ihle, M.; Hampp, S.; Ruess, D. A. & Hessmann, E.  et al.​ (2017) 
    Cancer Research, 77(20) pp. 5576​-5590​.​ DOI: https://doi.org/10.1158/0008-5472.CAN-17-0634 
    ​Details  DOI 
  • 2017 | Journal Article | 
    ​ ​Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4-and MYC-dependent manner​
    Mishra, V. K.; Wegwitz, F.; Kosinsky, R. L.; Sen, M. ; Baumgartner, R.; Wulff, T. & Siveke, J. T. et al.​ (2017) 
    Nucleic Acids Research, 45(11) pp. 6334​-6349​.​ DOI: https://doi.org/10.1093/nar/gkx212 
    ​Details  DOI  WoS 
  • 2017 | Journal Article
    ​ ​Epigenetic treatment of pancreatic cancer: is there a therapeutic perspective on the horizon?​
    Hessmann, E. ; Johnsen, S. A.; Siveke, J. T. & Ellenrieder, V.​ (2017) 
    Gut, 66(1) pp. 168​-179​.​ DOI: https://doi.org/10.1136/gutjnl-2016-312539 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article
    ​ ​Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity​
    Chen, N.-M. ; Neeße, A. ; Dyck, M. L.; Steuber, B. ; König, A. O. ; Lubeseder-Martellato, C. & Winter, T. et al.​ (2017) 
    Gastroenterology, 152(6) pp. 1507​-+​.​ DOI: https://doi.org/10.1053/j.gastro.2017.01.043 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article
    ​ ​Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling​
    Emons, G. ; Spitzner, M. ; Reineke, S. ; Möller, J.; Auslander, N.; Kramer, F.   & Hu, Y. et al.​ (2017) 
    Molecular Cancer Research, 15(11) pp. 1481​-1490​.​ DOI: https://doi.org/10.1158/1541-7786.MCR-17-0205 
    ​Details  DOI  PMID  PMC 
  • 2016 | Conference Abstract
    ​ ​EZH2-dependent post transcriptional Regulation of the NFATc1-Expression in the colorectal Carcinoma​
    Bremer, S.; Bohnenberger, H.; Hasselluhn, M.; Reutlinger, K.; Hanheide, S.; Gaedcke, J. & Stroebel, P. et al.​ (2016)
    Der Internist, 57 
    New york​: Springer.
    ​Details  WoS 
  • 2016 | Conference Abstract
    ​ ​mTOR Controls an Epigenetic Program Leading to Autophagy and Cell Growth Control​
    Koenig, A.; Heßmann, E. ; Hanheide, S.; Gaedcke, J. ; Zhang, J.; Billadeau, D. D. & Ellenrieder, V. ​ (2016)
    Neuroendocrinology, 103 ​13th Annual ENETS Conference for the Diagnosis and Treatment of Neuroendocrine Tumor Disease​, Barcelona, SPAIN.
    Basel​: Karger.
    ​Details  WoS 
  • 2016 | Journal Article
    ​ ​Nuclear NFATc1 Causes Development of Fms-like Receptor Tyrosine Kinase 3 Receptor (FLT3) Internal Tandem Duplication Mutation-Positive (FLT3-ITD) Acute Myeloid Leukemia (AML) and Mediates Drug Resistance​
    Solovey, M. A.; Wang, Y.; Gattenloehner, S.; Hessmann, E. ; Metzelder, S.; Michel, C. & Ellenrieder, V.  et al.​ (2016) 
    Blood, 128(22) pp. 1722​-1722​.​ DOI: https://doi.org/10.1182/blood.V128.22.1722.1722 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Epigenetic strategies in cancer therapy​
    Hessmann, E. ; Johnsen, S. A. & Ellenrieder, V.​ (2016) 
    Der Onkologe, 22(1) pp. 19​-+​.​ DOI: https://doi.org/10.1007/s00761-015-2998-x 
    ​Details  DOI  WoS 
  • 2016 | Journal Article | 
    ​ ​NFATc4 Regulates Sox9 Gene Expression in Acinar Cell Plasticity and Pancreatic Cancer Initiation​
    Heßmann, E. ; Zhang, J.; Chen, N.-M. ; Hasselluhn, M.; Liou, G.-Y.; Storz, P. & Ellenrieder, V.  et al.​ (2016) 
    Stem Cells International, art. 5272498​.​ DOI: https://doi.org/10.1155/2016/5272498 
    ​Details  DOI  WoS 
  • 2016 | Journal Article
    ​ ​GSK-3 beta Governs Inflammation-Induced NFATc2 Signaling Hubs to Promote Pancreatic Cancer Progression​
    Zhang, L.; Baumgart, S.; Chen, N.-M. ; Zhang, J.; Billadeau, D. D.; Gaisina, I. N. & Kozikowski, A. P. et al.​ (2016) 
    Molecular Cancer Therapeutics, 15(3) pp. 491​-502​.​ DOI: https://doi.org/10.1158/1535-7163.MCT-15-0309 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Review
    ​ ​MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies​
    Hessmann, E. ; Schneider, G.; Ellenrieder, V.& Siveke, J. T.​ (2016)
    Oncogene, 35​(13) pp. 1609​-1618​.​
    Nature Publishing Group. DOI: https://doi.org/10.1038/onc.2015.216 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Electron Transfer-Based Compounds: A Novel Weapon in the Cancer Battlespace?​
    Neesse, A. & Hessmann, E. ​ (2015) 
    EBioMedicine, 2(6) pp. 484​-485​.​ DOI: https://doi.org/10.1016/j.ebiom.2015.05.017 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article
    ​ ​Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma​
    Mazur, P. K.; Herner, A.; Mello, S. S.; Wirth, M.; Hausmann, S.; Sanchez-Rivera, F. J. & Lofgren, S. M. et al.​ (2015) 
    Nature Medicine, 21(10) pp. 1163​-+​.​ DOI: https://doi.org/10.1038/nm.3952 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | 
    ​ ​Loss of ATM accelerates pancreatic cancer formation and epithelial-mesenchymal transition​
    Russell, R.; Perkhofer, L.; Liebau, S.; Lin, Q.; Lechel, A.; Feld, F. M. & Hessmann, E.  et al.​ (2015) 
    Nature Communications, 6 art. 7677​.​ DOI: https://doi.org/10.1038/ncomms8677 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​Antithetical NFATc1-Sox2 and p53-miR200 signaling networks govern pancreatic cancer cell plasticity​
    Singh, S. K.; Chen, N.-M. ; Heßmann, E. ; Siveke, J. T.; Lahmann, M.; Singh, G. & Voelker, N. et al.​ (2015) 
    The EMBO Journal, 34(4) pp. 517​-530​.​ DOI: https://doi.org/10.15252/embj.201489574 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​NFATc1 Links EGFR Signaling to Induction of Sox9 Transcription and Acinar-Ductal Transdifferentiation in the Pancreas​
    Chen, N.-M.; Singh, G.; Koenig, A. O.; Liou, G.-Y.; Storz, P.; Zhang, J. & Regul, L. et al.​ (2015) 
    Gastroenterology, 148(5) pp. 1024​-U502​.​ DOI: https://doi.org/10.1053/j.gastro.2015.01.033 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article
    ​ ​NFATc1 as a therapeutic target in FLT3-ITD-positive AML​
    Metzelder, S. K.; Michel, C.; von Bonin, M.; Rehberger, M.; Hessmann, E. ; Inselmann, S. & Solovey, M. et al.​ (2015) 
    Leukemia, 29(7) pp. 1470​-1477​.​ DOI: https://doi.org/10.1038/leu.2015.95 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article
    ​ ​Inflammation-Induced NFATc1-STAT3 Transcription Complex Promotes Pancreatic Cancer Initiation by Kras(G12D)​
    Baumgart, S.; Chen, N.-M. ; Siveke, J. T.; Koenig, A. O. ; Zhang, J.; Singh, S. K. & Wolf, E. et al.​ (2014) 
    Cancer Discovery, 4(6) pp. 688​-701​.​ DOI: https://doi.org/10.1158/2159-8290.CD-13-0593 
    ​Details  DOI  PMID  PMC  WoS 

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