RG Griesinger

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  • 2024 | Journal Article
    ​ ​Frieg, Benedikt, Mookyoung Han, Karin Giller, Christian Dienemann, Dietmar Riedel, Stefan Becker, Loren B. Andreas, Christian Griesinger, and Gunnar F. Schröder. "Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)​." ​Nature Communications ​15, no. 1 (2024): . ​https://doi.org/10.1038/s41467-023-43822-x.
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  • 2023 | Journal Article
    ​ ​Dervişoğlu, Rıza, Leif Antonschmidt, Evgeny Nimerovsky, Vrinda Sant, Myeongkyu Kim, Sergey Ryazanov, Andrei Leonov et al. "Anle138b interaction in α-synuclein aggregates by dynamic nuclear polarization NMR​." ​Methods (2023): . ​https://doi.org/10.1016/j.ymeth.2023.04.002.
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  • 2023 | Preprint
    ​ ​Frieg, Benedikt, Mookyoung Han, Karin Giller, Christian Dienemann, Dietmar Riedel, Stefan Becker, Loren B. Andreas, Christian Griesinger, and Gunnar F. Schröder​. "Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)​." ​Preprint, submitted ​​2023. ​https://mbexc.uni-goettingen.de/literature/publications/722. https://doi.org/10.1101/2023.06.28.546947.
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  • 2022 | Preprint
    ​ ​Frieg, Benedikt, Leif Antonschmidt, Christian Dienemann, James A. Geraets, Eszter E. Najbauer, Dirk Matthes, Bert L. de Groot et al​. "The 3D structure of lipidic fibrils of α-synuclein​." ​Preprint, submitted ​​2022. ​https://mbexc.uni-goettingen.de/literature/publications/538. https://doi.org/10.1101/2022.03.02.481946.
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Ding, Yonghong, Sergey Korchak, Salvatore Mamone, Anil P. Jagtap, Gabriele Stevanato, Sonja Sternkopf, Denis Moll et al. "Rapidly Signal‐enhanced Metabolites for Atomic Scale Monitoring of Living Cells with Magnetic Resonance​." ​Chemistry Methods ​2, no. 7 (2022): . ​https://doi.org/10.1002/cmtd.202200023.
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  • 2022 | Journal Article | 
    ​ ​Karschin, Niels, Stefan Becker, and Christian Griesinger. "Interdomain Dynamics via Paramagnetic NMR on the Highly Flexible Complex Calmodulin/Munc13-1​." ​Journal of the American Chemical Society ​144, no. 37 (2022): ​17041​-17053​. ​https://doi.org/10.1021/jacs.2c06611.
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Buratti, Fiamma A., Nicola Boeffinger, Hugo A. Garro, Jesica S. Flores, Francisco J. Hita, Phelippe do Carmo Gonçalves, Federico dos Reis Copello et al. "Aromaticity at position 39 in α‐synuclein: A modulator of amyloid fibril assembly and membrane‐bound conformations​." ​Protein Science ​31, no. 7 (2022): . ​https://doi.org/10.1002/pro.4360.
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  • 2022 | Journal Article | 
    ​ ​Frieg, Benedikt, Leif Antonschmidt, Christian Dienemann, James A. Geraets, Eszter E. Najbauer, Dirk Matthes, Bert L. de Groot et al. "The 3D structure of lipidic fibrils of α-synuclein​." ​Nature Communications ​13, no. 1 (2022): . ​https://doi.org/10.1038/s41467-022-34552-7.
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Levin, Johannes, Nand Sing, Sue Melbourne, Amber Morgan, Carla Mariner, Maria Grazia Spillantini, Michal Wegrzynowicz et al. "Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial​." ​eBioMedicine ​80 (2022): ​S2352396422002055​. ​https://doi.org/10.1016/j.ebiom.2022.104021.
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  • 2022 | Journal Article | 
    ​ ​Antonschmidt, Leif, Dirk Matthes, Rıza Dervişoğlu, Benedikt Frieg, Christian Dienemann, Andrei Leonov, Evgeny Nimerovsky et al. "The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils​." ​Nature Communications ​13, no. 1 (2022): . ​https://doi.org/10.1038/s41467-022-32797-w.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Martinez Hernandez, Ana, Ivan Silbern, Insa Geffers, Lars Tatenhorst, Stefan Becker, Henning Urlaub, Markus Zweckstetter, Christian Griesinger, and Gregor Eichele. "Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein​." ​Frontiers in Neuroscience ​15 (2021): . ​https://doi.org/10.3389/fnins.2021.643391.
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Antonschmidt, Leif, Rıza Dervişoğlu, Vrinda Sant, Kumar Tekwani Movellan, Ingo P. Mey, Dietmar Riedel, Claudia Steinem, Stefan T. Becker, Loren B. Andreas, and Christian Griesinger. "Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes​." ​Science Advances ​7, no. 20 (2021): ​eabg2174​. ​https://doi.org/10.1126/sciadv.abg2174.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Raina, Anupam, Kristian Leite, Sofia Guerin, Sameehan U. Mahajani, Kalyan S. Chakrabarti, Diana Voll, Stefan Becker, Christian Griesinger, Mathias Bähr, and Sebastian Kügler. "Dopamine promotes the neurodegenerative potential of β‐synuclein​." ​Journal of Neurochemistry ​156, no. 5 (2020): ​674​-691​. ​https://doi.org/10.1111/jnc.15134.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Maurer, Andreas, Andrei Leonov, Sergey Ryazanov, Kristina Herfert, Laura Kuebler, Sabrina Buss, Felix Schmidt et al. "11 C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to α-Synuclein Fibrils in vitro and Crosses the Blood-Brain Barrier​." ​ChemMedChem ​15, no. 5 (2020): ​411​-415​. ​https://doi.org/10.1002/cmdc.201900689.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Kuebler, Laura, Sabrina Buss, Andrei Leonov, Sergey Ryazanov, Felix Schmidt, Andreas Maurer, Daniel Weckbecker et al. "[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates​." ​European Journal of Nuclear Medicine and Molecular Imaging (2020): . ​https://doi.org/10.1007/s00259-020-05133-x.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Dominguez-Meijide, Antonio, Eftychia Vasili, Annekatrin König, Maria-Sol Cima-Omori, Alain Ibáñez de Opakua, Andrei Leonov, Sergey Ryazanov, Markus Zweckstetter, Christian Griesinger, and Tiago F. Outeiro. "Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization​." ​Scientific Reports ​10, no. 1 (2020): . ​https://doi.org/10.1038/s41598-020-69744-y.
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Brendel, Matthias, Maximilian Deussing, Tanja Blume, Lena Kaiser, Federico Probst, Felix Overhoff, Finn Peters et al. "Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau​." ​Alzheimer's Research & Therapy ​11, no. 1 (2019): . ​https://doi.org/10.1186/s13195-019-0522-z.
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Saravanan, Manikam S., Sergey Ryazanov, Andrei Leonov, Janine Nicolai, Patrique Praest, Armin Giese, Roland Winter, Lucie Khemtemourian, Christian Griesinger, and J. Antoinette Killian. "The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers​." ​Scientific Reports ​9, no. 1 (2019): . ​https://doi.org/10.1038/s41598-019-54919-z.
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Heras-Garvin, Antonio, Daniel Weckbecker, Sergey Ryazanov, Andrei Leonov, Christian Griesinger, Armin Giese, Gregor K. Wenning, and Nadia Stefanova. "Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy​." ​Movement Disorders ​34, no. 2 (2019): ​255​-263​. ​https://doi.org/10.1002/mds.27562.
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Wegrzynowicz, Michal, Dana Bar-On, Laura Calo’, Oleg Anichtchik, Mariangela Iovino, Jing Xia, Sergey Ryazanov et al. "Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model​." ​Acta Neuropathologica ​138, no. 4 (2019): ​575​-595​. ​https://doi.org/10.1007/s00401-019-02023-x.
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