RG Griesinger

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  • 2024 | Journal Article
    ​ ​Frieg B, Han M, Giller K, Dienemann C, Riedel D, Becker S, et al. ​Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)​. ​​Nature Communications. ​2024;​15​(1). ​doi:10.1038/s41467-023-43822-x. 
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  • 2023 | Journal Article
    ​ ​Dervişoğlu R, Antonschmidt L, Nimerovsky E, Sant V, Kim M, Ryazanov S, et al. ​Anle138b interaction in α-synuclein aggregates by dynamic nuclear polarization NMR​. ​​Methods. ​2023;. ​doi:10.1016/j.ymeth.2023.04.002. 
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  • 2023 | Preprint
    ​ ​Frieg B, Han M, Giller K, Dienemann C, Riedel D, Becker S, et al. ​Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)​. ​​2023. Available from: https://mbexc.uni-goettingen.de/literature/publications/722 doi: https://doi.org/10.1101/2023.06.28.546947​
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  • 2022 | Preprint
    ​ ​Frieg B, Antonschmidt L, Dienemann C, Geraets JA, Najbauer EE, Matthes D, et al. ​The 3D structure of lipidic fibrils of α-synuclein​. ​​2022. Available from: https://mbexc.uni-goettingen.de/literature/publications/538 doi: https://doi.org/10.1101/2022.03.02.481946​
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Ding Y, Korchak S, Mamone S, Jagtap AP, Stevanato G, Sternkopf S, et al. ​Rapidly Signal‐enhanced Metabolites for Atomic Scale Monitoring of Living Cells with Magnetic Resonance​. ​​Chemistry Methods. ​2022;​2​(7). ​doi:10.1002/cmtd.202200023. 
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  • 2022 | Journal Article | 
    ​ ​Karschin N, Becker S, Griesinger C. ​Interdomain Dynamics via Paramagnetic NMR on the Highly Flexible Complex Calmodulin/Munc13-1​. ​​Journal of the American Chemical Society. ​2022;​144​(37):​​17041​-17053​. ​doi:10.1021/jacs.2c06611. 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Buratti FA, Boeffinger N, Garro HA, Flores JS, Hita FJ, Gonçalves PC, et al. ​Aromaticity at position 39 in α‐synuclein: A modulator of amyloid fibril assembly and membrane‐bound conformations​. ​​Protein Science. ​2022;​31​(7). ​doi:10.1002/pro.4360. 
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  • 2022 | Journal Article | 
    ​ ​Frieg B, Antonschmidt L, Dienemann C, Geraets JA, Najbauer EE, Matthes D, et al. ​The 3D structure of lipidic fibrils of α-synuclein​. ​​Nature Communications. ​2022;​13​(1). ​doi:10.1038/s41467-022-34552-7. 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Levin J, Sing N, Melbourne S, Morgan A, Mariner C, Spillantini MG, et al. ​Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial​. ​​eBioMedicine. ​2022;​80​:​​104021​. ​doi:10.1016/j.ebiom.2022.104021. 
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  • 2022 | Journal Article | 
    ​ ​Antonschmidt L, Matthes D, Dervişoğlu R, Frieg B, Dienemann C, Leonov A, et al. ​The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils​. ​​Nature Communications. ​2022;​13​(1). ​doi:10.1038/s41467-022-32797-w. 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Martinez Hernandez A, Silbern I, Geffers I, Tatenhorst L, Becker S, Urlaub H, et al. ​Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein​. ​​Frontiers in Neuroscience. ​2021;​15​. ​doi:10.3389/fnins.2021.643391. 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Antonschmidt L, Dervişoğlu R, Sant V, Tekwani Movellan K, Mey IP, Riedel D, et al. ​Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes​. ​​Science Advances. ​2021;​7​(20):​​eabg2174​. ​doi:10.1126/sciadv.abg2174. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Raina A, Leite K, Guerin S, Mahajani SU, Chakrabarti KS, Voll D, et al. ​Dopamine promotes the neurodegenerative potential of β‐synuclein​. ​​Journal of Neurochemistry. ​2020;​156​(5):​​674​-691​. ​doi:10.1111/jnc.15134. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Maurer A, Leonov A, Ryazanov S, Herfert K, Kuebler L, Buss S, et al. ​11 C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to α-Synuclein Fibrils in vitro and Crosses the Blood-Brain Barrier​. ​​ChemMedChem. ​2020;​15​(5):​​411​-415​. ​doi:10.1002/cmdc.201900689. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Kuebler L, Buss S, Leonov A, Ryazanov S, Schmidt F, Maurer A, et al. ​[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates​. ​​European Journal of Nuclear Medicine and Molecular Imaging. ​2020;. ​doi:10.1007/s00259-020-05133-x. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Dominguez-Meijide A, Vasili E, König A, Cima-Omori, Maria-Sol, Ibáñez de Opakua A, Leonov A, et al. ​Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization​. ​​Scientific Reports. ​2020;​10​(1). ​doi:10.1038/s41598-020-69744-y. 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Brendel M, Deussing M, Blume T, Kaiser L, Probst F, Overhoff F, et al. ​Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau​. ​​Alzheimer's Research & Therapy. ​2019;​11​(1). ​doi:10.1186/s13195-019-0522-z. 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Saravanan MS, Ryazanov S, Leonov A, Nicolai J, Praest P, Giese A, et al. ​The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers​. ​​Scientific Reports. ​2019;​9​(1). ​doi:10.1038/s41598-019-54919-z. 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Heras-Garvin A, Weckbecker D, Ryazanov S, Leonov A, Griesinger C, Giese A, et al. ​Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy​. ​​Movement Disorders. ​2019;​34​(2):​​255​-263​. ​doi:10.1002/mds.27562. 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Wegrzynowicz M, Bar-On D, Calo’ L, Anichtchik O, Iovino M, Xia J, et al. ​Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model​. ​​Acta Neuropathologica. ​2019;​138​(4):​​575​-595​. ​doi:10.1007/s00401-019-02023-x. 
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