RG Griesinger

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  • 2024 | Journal Article
    ​ ​Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)​
    Frieg, B.; Han, M.; Giller, K.; Dienemann, C.; Riedel, D.; Becker, S. & Andreas, L. B. et al.​ (2024) 
    Nature Communications, 15(1).​ DOI: https://doi.org/10.1038/s41467-023-43822-x 
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  • 2023 | Journal Article
    ​ ​Anle138b interaction in α-synuclein aggregates by dynamic nuclear polarization NMR​
    Dervişoğlu, R.; Antonschmidt, L.; Nimerovsky, E.; Sant, V.; Kim, M.; Ryazanov, S. & Leonov, A. et al.​ (2023) 
    Methods,.​ DOI: https://doi.org/10.1016/j.ymeth.2023.04.002 
    ​Details  DOI  PMID  PMC 
  • 2023 | Preprint
    ​ ​Cryo-EM structures of lipidic fibrils of amyloid-β (1-40)​
    Frieg, B.; Han, M.; Giller, K.; Dienemann, C.; Riedel, D.; Becker, S.& Andreas, L. B. et al.​ (2023). DOI: https://doi.org/10.1101/2023.06.28.546947 
    ​Details  DOI 
  • 2022 | Preprint
    ​ ​The 3D structure of lipidic fibrils of α-synuclein​
    Frieg, B.; Antonschmidt, L.; Dienemann, C.; Geraets, J. A.; Najbauer, E. E.; Matthes, D.& de Groot, B. L.  et al.​ (2022). DOI: https://doi.org/10.1101/2022.03.02.481946 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Rapidly Signal‐enhanced Metabolites for Atomic Scale Monitoring of Living Cells with Magnetic Resonance​
    Ding, Y.; Korchak, S.; Mamone, S.; Jagtap, A. P.; Stevanato, G.; Sternkopf, S. & Moll, D. et al.​ (2022) 
    Chemistry Methods, 2(7).​ DOI: https://doi.org/10.1002/cmtd.202200023 
    ​Details  DOI 
  • 2022 | Journal Article | 
    ​ ​Interdomain Dynamics via Paramagnetic NMR on the Highly Flexible Complex Calmodulin/Munc13-1​
    Karschin, N.; Becker, S.   & Griesinger, C. ​ (2022) 
    Journal of the American Chemical Society, 144(37) pp. 17041​-17053​.​ DOI: https://doi.org/10.1021/jacs.2c06611 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Aromaticity at position 39 in α‐synuclein: A modulator of amyloid fibril assembly and membrane‐bound conformations​
    Buratti, F. A.; Boeffinger, N.; Garro, H. A.; Flores, J. S.; Hita, F. J.; Gonçalves, P. do C. & Copello, F. dos R. et al.​ (2022) 
    Protein Science, 31(7).​ DOI: https://doi.org/10.1002/pro.4360 
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  • 2022 | Journal Article | 
    ​ ​The 3D structure of lipidic fibrils of α-synuclein​
    Frieg, B.; Antonschmidt, L.; Dienemann, C.; Geraets, J. A.; Najbauer, E. E.; Matthes, D. & de Groot, B. L.  et al.​ (2022) 
    Nature Communications, 13(1).​ DOI: https://doi.org/10.1038/s41467-022-34552-7 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Safety, tolerability and pharmacokinetics of the oligomer modulator anle138b with exposure levels sufficient for therapeutic efficacy in a murine Parkinson model: A randomised, double-blind, placebo-controlled phase 1a trial​
    Levin, J.; Sing, N.; Melbourne, S.; Morgan, A.; Mariner, C.; Spillantini, M. G. & Wegrzynowicz, M. et al.​ (2022) 
    eBioMedicine, 80 art. S2352396422002055​.​ DOI: https://doi.org/10.1016/j.ebiom.2022.104021 
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  • 2022 | Journal Article | 
    ​ ​The clinical drug candidate anle138b binds in a cavity of lipidic α-synuclein fibrils​
    Antonschmidt, L.; Matthes, D. ; Dervişoğlu, R.; Frieg, B.; Dienemann, C. ; Leonov, A.   & Nimerovsky, E. et al.​ (2022) 
    Nature Communications, 13(1).​ DOI: https://doi.org/10.1038/s41467-022-32797-w 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Low-Expressing Synucleinopathy Mouse Models Based on Oligomer-Forming Mutations and C-Terminal Truncation of α-Synuclein​
    Martinez Hernandez, A. ; Silbern, I.; Geffers, I.; Tatenhorst, L. ; Becker, S. ; Urlaub, H.   & Zweckstetter, M.  et al.​ (2021) 
    Frontiers in Neuroscience, 15.​ DOI: https://doi.org/10.3389/fnins.2021.643391 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Insights into the molecular mechanism of amyloid filament formation: Segmental folding of α-synuclein on lipid membranes​
    Antonschmidt, L.; Dervişoğlu, R.; Sant, V.; Tekwani Movellan, K.; Mey, I. P. ; Riedel, D.   & Steinem, C.  et al.​ (2021) 
    Science Advances, 7(20) pp. eabg2174​.​ DOI: https://doi.org/10.1126/sciadv.abg2174 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Dopamine promotes the neurodegenerative potential of β‐synuclein​
    Raina, A.; Leite, K.; Guerin, S.; Mahajani, S. U.; Chakrabarti, K. S.; Voll, D. & Becker, S.  et al.​ (2020) 
    Journal of Neurochemistry, 156(5) pp. 674​-691​.​ DOI: https://doi.org/10.1111/jnc.15134 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​11 C Radiolabeling of anle253b: a Putative PET Tracer for Parkinson's Disease That Binds to α-Synuclein Fibrils in vitro and Crosses the Blood-Brain Barrier​
    Maurer, A.; Leonov, A.; Ryazanov, S.; Herfert, K.; Kuebler, L.; Buss, S. & Schmidt, F. et al.​ (2020) 
    ChemMedChem, 15(5) pp. 411​-415​.​ DOI: https://doi.org/10.1002/cmdc.201900689 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates​
    Kuebler, L.; Buss, S.; Leonov, A. ; Ryazanov, S. ; Schmidt, F.; Maurer, A. & Weckbecker, D. et al.​ (2020) 
    European Journal of Nuclear Medicine and Molecular Imaging,.​ DOI: https://doi.org/10.1007/s00259-020-05133-x 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Effects of pharmacological modulators of α-synuclein and tau aggregation and internalization​
    Dominguez-Meijide, A.; Vasili, E.; König, A.; Cima-Omori, M.-S.; Ibáñez de Opakua, A.; Leonov, A.   & Ryazanov, S.  et al.​ (2020) 
    Scientific Reports, 10(1).​ DOI: https://doi.org/10.1038/s41598-020-69744-y 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Late-stage Anle138b treatment ameliorates tau pathology and metabolic decline in a mouse model of human Alzheimer’s disease tau​
    Brendel, M.; Deussing, M.; Blume, T.; Kaiser, L.; Probst, F.; Overhoff, F. & Peters, F. et al.​ (2019) 
    Alzheimer's Research & Therapy, 11(1).​ DOI: https://doi.org/10.1186/s13195-019-0522-z 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers​
    Saravanan, M. S.; Ryazanov, S. ; Leonov, A. ; Nicolai, J.; Praest, P.; Giese, A. & Winter, R. et al.​ (2019) 
    Scientific Reports, 9(1).​ DOI: https://doi.org/10.1038/s41598-019-54919-z 
    ​Details  DOI 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Anle138b modulates α-synuclein oligomerization and prevents motor decline and neurodegeneration in a mouse model of multiple system atrophy​
    Heras-Garvin, A.; Weckbecker, D.; Ryazanov, S.; Leonov, A.; Griesinger, C. ; Giese, A. & Wenning, G. K. et al.​ (2019) 
    Movement Disorders, 34(2) pp. 255​-263​.​ DOI: https://doi.org/10.1002/mds.27562 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson’s disease model​
    Wegrzynowicz, M.; Bar-On, D.; Calo’, L.; Anichtchik, O.; Iovino, M.; Xia, J. & Ryazanov, S.  et al.​ (2019) 
    Acta Neuropathologica, 138(4) pp. 575​-595​.​ DOI: https://doi.org/10.1007/s00401-019-02023-x 
    ​Details  DOI  PMID  PMC 

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