RG Guan (Application of patient-specific induced pluripotent stem cells in disease modelling)

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  • 2022 | Journal Article | Research Paper | 
    ​ ​Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration​
    Li, W.; Luo, X.; Poetsch, M. S.; Oertel, R.; Nichani, K.; Schneider, M. & Strano, A. et al.​ (2022) 
    Pharmaceuticals, 15(2).​ DOI: https://doi.org/10.3390/ph15020220 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​IP3R-Mediated Compensatory Mechanism for Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes With Cardiac Ryanodine Receptor Deficiency​
    Luo, X.; Li, W.; Künzel, K.; Henze, S. ; Cyganek, L. ; Strano, A. & Poetsch, M. S. et al.​ (2020) 
    Frontiers in Cell and Developmental Biology, 8.​ DOI: https://doi.org/10.3389/fcell.2020.00772 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia​
    Chowdhury, A. ; Aich, A. ; Jain, G.; Wozny, K.; Lüchtenborg, C.; Hartmann, M.   & Bernhard, O.  et al.​ (2018) 
    Cell Reports, 25(3) pp. 561​-570.e6​.​ DOI: https://doi.org/10.1016/j.celrep.2018.09.057 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Deep phenotyping of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes​
    Cyganek, L. ; Tiburcy, M. ; Sekeres, K.; Gerstenberg, K.; Bohnenberger, H. ; Lenz, C.   & Henze, S.  et al.​ (2018) 
    JCI Insight, 3(12) art. e99941​.​ DOI: https://doi.org/10.1172/jci.insight.99941 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression​
    Mohamed, B. A. ; Hartmann, N. ; Tirilomis, P.; Sekeres, K.; Li, W.; Neef, S. & Richter, C.  et al.​ (2018) 
    Science Translational Medicine, 10(458) art. eaan0724​.​ DOI: https://doi.org/10.1126/scitranslmed.aan0724 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​The reduced activity of PP-1α under redox stress condition is a consequence of GSH-mediated transient disulfide formation​
    Singh, S.; Lämmle, S.; Giese, H.; Kämmerer, S.; Meyer-Roxlau, S. ; Alfar, E. A. & Dihazi, H.  et al.​ (2018) 
    Scientific Reports, 8(1) art. 17711​.​ DOI: https://doi.org/10.1038/s41598-018-36267-6 
    ​Details  DOI  PMID  PMC 
  • 2017 | Conference Abstract
    ​ ​P1334 - The relevant role of SR Ca leak in the development of heart failure​
    Mohamed, B. A.; Kattner, L.; Guan, K. ; Lehnart, S. E. ; Luther, S. ; Sossalla, S.   & Hasenfuß, G.  et al.​ (2017)
    European Journal of Heart Failure, 19(Suppl. 1) ​Heart Failure 2017 and the 4th World Congress on Acute Heart Failure​, Paris.
    ​Details 
  • 2017 | Journal Article | Overview
    ​ ​PDE2 at the crossway between cAMP and cGMP signalling in the heart​
    Weber, S.; Zeller, M.; Guan, K. ; Wunder, F.; Wagner, M. & El-Armouche, A. ​ (2017) 
    Cellular Signalling, 38 pp. 76​-84​.​ DOI: https://doi.org/10.1016/j.cellsig.2017.06.020 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Efficient Killing of Murine Pluripotent Stem Cells by Natural Killer (NK) Cells Requires Activation by Cytokines and Partly Depends on the Activating NK Receptor NKG2D​
    Gröschel, C.; Hübscher, D.; Nolte, J.; Monecke, S.; Sasse, A.; Elsner, L. & Paulus, W. et al.​ (2017) 
    Frontiers in Immunology, 8 art. 870​.​ DOI: https://doi.org/10.3389/fimmu.2017.00870 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes​
    Streckfuss-Bömeke, K. ; Tiburcy, M. ; Fomin, A.; Luo, X.; Li, W.; Fischer, C. & Özcelik, C. et al.​ (2017) 
    Journal of Molecular and Cellular Cardiology, 113 pp. 9​-21​.​ DOI: https://doi.org/10.1016/j.yjmcc.2017.09.008 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​The Tumorigenicity of Multipotent Adult Germline Stem Cells Transplanted into the Heart Is Affected by Natural Killer Cells and by Cyclosporine A Independent of Its Immunosuppressive Effects​
    Huebscher, D.; Kaiser, D.; Elsner, L.; Monecke, S.; Dressel, R.   & Guan, K. ​ (2017) 
    Frontiers in Immunology, 8 art. 67​.​ DOI: https://doi.org/10.3389/fimmu.2017.00067 
    ​Details  DOI  PMID  PMC  WoS 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy​
    Borchert, T. ; Hübscher, D. ; Guessoum, C. I. ; Lam, T. Lam, Tuan-Dinh D.; Ghadri, J. R.; Schellinger, I. N.   & Tiburcy, M.  et al.​ (2017) 
    Journal of the American College of Cardiology, 70(8) pp. 975​-991​.​ DOI: https://doi.org/10.1016/j.jacc.2017.06.061 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Cardiac-specific succinate dehydrogenase deficiency in Barth syndrome​
    Dudek, J. ; Cheng, I.-F. ; Chowdhury, A. ; Wozny, K.; Balleininger, M.; Reinhold, R.   & Grunau, S.  et al.​ (2016) 
    EMBO Molecular Medicine, 8(2) pp. 139​-154​.​ DOI: https://doi.org/10.15252/emmm.201505644 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | Research Paper | 
    ​ ​Ion channelopathies in human induced pluripotent stem cell derived cardiomyocytes: a dynamic clamp study with virtual I-K1​
    van Putten, R. M. E. M.; Mengarelli, I.; Guan, K. ; Zegers, J. G.; van Ginneken, A. C. G.; Verkerk, A. O. & Wilders, R.​ (2015) 
    Frontiers in Physiology, 6 art. UNSP 7​.​ DOI: https://doi.org/10.3389/fphys.2015.00007 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper
    ​ ​Sensing Cardiac Electrical Activity With a Cardiac Myocyte-Targeted Optogenetic Voltage Indicator​
    Chang Liao, M.-L.; Boer, T. P. de; Mutoh, H.; Raad, N.; Richter, C. ; Wagner, E.   & Downie, B. R. et al.​ (2015) 
    Circulation Research, 117(5) pp. 401​-412​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.117.306143 
    ​Details  DOI  PMID  PMC  WoS 
  • 2015 | Journal Article | Research Paper | 
    ​ ​Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1​
    Kruse, V.; Hamann, C.; Monecke, S.; Cyganek, L. ; Elsner, L.; Huebscher, D. & Walter, L. et al.​ (2015) 
    PLoS One, 10(5) art. e0125544​.​ DOI: https://doi.org/10.1371/journal.pone.0125544 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​Cardiac Progenitor Cells and their Therapeutic Application for Cardiac Repair​
    Cyganek, L. ; Chen, S.; Borchert, T.   & Guan, K. ​ (2013) 
    Journal of Clinical & Experimental Cardiology, S11 art. 008​.​ DOI: https://doi.org/10.4172/2155-9880.S11-008 
    ​Details  DOI 
  • 2013 | Journal Article | Research Paper | 
    ​ ​Cardiolipin deficiency affects respiratory chain function and organization in an induced pluripotent stem cell model of Barth syndrome​
    Dudek, J. ; Cheng, I.-F. ; Balleininger, M.; Vaz, F. M.; Streckfuss-Bömeke, K. ; Hübscher, D.   & Vukotic, M.  et al.​ (2013) 
    Stem Cell Research, 11(2) pp. 806​-819​.​ DOI: https://doi.org/10.1016/j.scr.2013.05.005 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Comparative study of human-induced pluripotent stem cells derived from bone marrow cells, hair keratinocytes, and skin fibroblasts​
    Streckfuss-Boemeke, K. ; Wolf, F.; Azizian, A. ; Stauske, M.; Tiburcy, M. ; Wagner, S.   & Huebscher, D.  et al.​ (2013) 
    European heart journal, 34(33) pp. 2618​-2629​.​ DOI: https://doi.org/10.1093/eurheartj/ehs203 
    ​Details  DOI  PMID  PMC  WoS 

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