RG Linke (Kardiovaskuläre Physiologie)

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  • 2023 | Journal Article | Overview
    ​ ​Titin takes centerstage among cytoskeletal contributions to myocardial passive stiffness​
    Loescher, C. M. & Linke, W. A.​ (2023) 
    Cytoskeleton,.​ DOI: https://doi.org/10.1002/cm.21827 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article
    ​ ​The history-dependent features of muscle force production: A challenge to the cross-bridge theory and their functional implications​
    Hahn, D.; Han, S.-W. & Joumaa, V.​ (2023) 
    Journal of Biomechanics, 152 art. 111579​.​ DOI: https://doi.org/10.1016/j.jbiomech.2023.111579 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article
    ​ ​Titin governs myocardial passive stiffness with major support from microtubules and actin and the extracellular matrix​
    Loescher, C. M.; Freundt, J. K.; Unger, A.; Hessel, A. L.; Kühn, M.; Koser, F. & Linke, W. A.​ (2023) 
    Nature cardiovascular research, 2(11) pp. 991​-1002​.​ DOI: https://doi.org/10.1038/s44161-023-00348-1 
    ​Details  DOI 
  • 2022 | Journal Article
    ​ ​Titin force in muscle cells alters lattice order, thick and thin filament protein formation​
    Hessel, A. L.; Ma, W.; Mazara, N.; Rice, P. E.; Nissen, D.; Gong, H. & Kuehn, M. et al.​ (2022) 
    Proceedings of the National Academy of Sciences of the United States of America, 119(48) art. e2209441119​.​ DOI: https://doi.org/10.1073/pnas.2209441119 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | 
    ​ ​Engineered skeletal muscle recapitulates human muscle development, regeneration and dystrophy​
    Shahriyari, M.; Islam, M. R.; Sakib, S. M.; Rinn, M.; Rika, A.; Krüger, D. & Kaurani, L. et al.​ (2022) 
    Journal of Cachexia, Sarcopenia and Muscle, 13(6) art. jcsm.13094​.​ DOI: https://doi.org/10.1002/jcsm.13094 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)​
    de Boer, R. A.; Heymans, S.; Backs, J.; Carrier, L.; Coats, A. J. S.; Dimmeler, S. & Eschenhagen, T. et al.​ (2022) 
    European Journal of Heart Failure, 24(3) pp. 406​-420​.​ DOI: https://doi.org/10.1002/ejhf.2414 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper
    ​ ​Modulatorische Einheiten bei Herzinsuffizienz​
    Hasenfuß, G. P. ; Kaul, A.; Lehnart, S. E. ; Linke, W. A. ; Zelarayan, L. C.   & Zimmermann, W.-H. ​ (2022) 
    Der Kardiologe, 16(2) pp. 109​-114​.​ DOI: https://doi.org/10.1007/s12181-022-00540-w 
    ​Details  DOI 
  • 2021 | Preprint
    ​ ​Human engineered skeletal muscle of hypaxial origin from pluripotent stem cells with advanced function and regenerative capacity​
    Shahriyari, M.; Islam, M. R.; Sakib, M. S.; Rika, A.; Krüger, D.; Kaurani, L.& Anandakumar, H. et al.​ (2021). DOI: https://doi.org/10.1101/2021.07.12.452030 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper
    ​ ​Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations​
    Fomin, A.; Gärtner, A.; Cyganek, L. ; Tiburcy, M. ; Tuleta, I.; Wellers, L. & Folsche, L. et al.​ (2021) 
    Science Translational Medicine, 13(618).​ DOI: https://doi.org/10.1126/scitranslmed.abd3079 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Unraveling the mysteries of the titin-N2A signalosome​
    Hessel, A. L. & Linke, W. A. ​ (2021) 
    The Journal of General Physiology, 153(8).​ DOI: https://doi.org/10.1085/jgp.202112967 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Troponin destabilization impairs sarcomere-cytoskeleton interactions in iPSC-derived cardiomyocytes from dilated cardiomyopathy patients​
    Dai, Y.; Amenov, A.; Ignatyeva, N.; Koschinski, A.; Xu, H.; Soong, P. L.   & Tiburcy, M.  et al.​ (2020) 
    Scientific Reports, 10(1) art. 209​.​ DOI: https://doi.org/10.1038/s41598-019-56597-3 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin​
    Swist, S.; Unger, A.; Li, Y.; Vöge, A.; von Frieling-Salewsky, M.; Skärlén, Å. & Cacciani, N. et al.​ (2020) 
    Nature Communications, 11(1) pp. 4479​.​ DOI: https://doi.org/10.1038/s41467-020-18131-2 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Overview | 
    ​ ​Posttranslational modifications of titin from cardiac muscle: how, where, and what for?​
    Koser, F.; Loescher, C. & Linke, W. A. ​ (2019) 
    The FEBS Journal, 286(12) pp. 2240​-2260​.​ DOI: https://doi.org/10.1111/febs.14854 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​The Translational Landscape of the Human Heart​
    van Heesch, S.; Witte, F.; Schneider-Lunitz, V.; Schulz, J. F; Adami, E.; Faber, A. B. & Kirchner, M. et al.​ (2019) 
    Cell, 178(1) pp. 242.e29​-260.e29​.​ DOI: https://doi.org/10.1016/j.cell.2019.05.010 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper
    ​ ​Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function​
    Zaunbrecher, R. J.; Abel, A. N.; Beussman, K.; Leonard, A.; von Frieling-Salewsky, M.; Fields, P. A. & Pabon, L. et al.​ (2019) 
    Circulation, 140(20) pp. 1647​-1660​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.039521 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Overview
    ​ ​Titin as a force generating muscle protein under regulatory control​
    Freundt, J. K. & Linke, W. A. ​ (2018) 
    Journal of Applied Physiology,.​ DOI: https://doi.org/10.1152/japplphysiol.00865.2018 
    ​Details  DOI 
  • 2018 | Journal Article | Research Paper
    ​ ​A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance​
    Huttner, I. G.; Wang, L. W.; Santiago, C. F.; Horvat, C.; Johnson, R.; Cheng, D. & von Frieling-Salewsky, M. et al.​ (2018) 
    Circulation: Genomic and Precision Medicine, 11(8) art. e002135​.​ DOI: https://doi.org/10.1161/CIRCGEN.118.002135 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Treatments targeting inotropy​
    Maack, C.; Eschenhagen, T. ; Hamdani, N.; Heinzel, F. R.; Lyon, A. R.; Manstein, D. J. & Metzger, J. et al.​ (2018) 
    European Heart Journal, art. ehy600​.​ DOI: https://doi.org/10.1093/eurheartj/ehy600 
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  • 2018 | Journal Article | Overview
    ​ ​Titin Gene and Protein Functions in Passive and Active Muscle​
    Linke, W. A. ​ (2018) 
    Annual Review of Physiology, 80(1) pp. 389​-411​.​ DOI: https://doi.org/10.1146/annurev-physiol-021317-121234 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes​
    Krysiak, J.; Unger, A.; Beckendorf, L.; Hamdani, N.; Frieling-Salewsky, M. von; Redfield, M. M. & Remedios, C. G. dos et al.​ (2018) 
    Nature Communications, 9(1) art. 262​.​ DOI: https://doi.org/10.1038/s41467-017-02483-3 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Dietary spermidine for lowering high blood pressure​
    Eisenberg, T.; Abdellatif, M.; Zimmermann, A.; Schroeder, S.; Pendl, T.; Harger, A. & Stekovic, S. et al.​ (2017) 
    Autophagy, 13(4) pp. 767​-769​.​ DOI: https://doi.org/10.1080/15548627.2017.1280225 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair​
    Tiburcy, M. ; Hudson, J. E.; Balfanz, P.; Schlick, S.; Meyer, T. ; Chang Liao, M.-L. & Levent, E. et al.​ (2017) 
    Circulation, 135(19) pp. 1832​-1847​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.116.024145 
    ​Details  DOI 
  • 2017 | Journal Article | Overview | 
    ​ ​Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes​
    Hamdani, N.; Herwig, M. & Linke, W. A. ​ (2017) 
    Biophysical Reviews, 9(3) pp. 225​-237​.​ DOI: https://doi.org/10.1007/s12551-017-0263-9 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes​
    Streckfuss-Bömeke, K. ; Tiburcy, M. ; Fomin, A.; Luo, X.; Li, W.; Fischer, C. & Özcelik, C. et al.​ (2017) 
    Journal of Molecular and Cellular Cardiology, 113 pp. 9​-21​.​ DOI: https://doi.org/10.1016/j.yjmcc.2017.09.008 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper
    ​ ​Titin-truncating variants affect heart function in disease cohorts and the general population​
    Schäfer, S. ; de Marvao, A.; Adami, E.; Fiedler, L. R.; Ng, B.; Khin, E. & Rackham, O. J. L. et al.​ (2017) 
    Nature Genetics, 49(1) pp. 46​-53​.​ DOI: https://doi.org/10.1038/ng.3719 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article | Research Paper | 
    ​ ​Molecular and structural transition mechanisms in long-term volume overload​
    Mohamed, B. A. ; Schnelle, M. ; Khadjeh, S. ; Lbik, D.; Herwig, M.; Linke, W. A.   & Hasenfuß, G.  et al.​ (2016) 
    European Journal of Heart Failure, 18(4) pp. 362​-371​.​ DOI: https://doi.org/10.1002/ejhf.465 
    ​Details  DOI  PMID  PMC  WoS 
  • 2016 | Journal Article | Research Paper
    ​ ​Cardioprotection and lifespan extension by the natural polyamine spermidine​
    Eisenberg, T.; Abdellatif, M.; Schroeder, S.; Primessnig, U.; Stekovic, S.; Pendl, T. & Harger, A. et al.​ (2016) 
    Nature Medicine, 22(12) pp. 1428​-1438​.​ DOI: https://doi.org/10.1038/nm.4222 
    ​Details  DOI  PMID  PMC 
  • 2015 | Journal Article | Overview | 
    ​ ​Emerging importance of oxidative stress in regulating striated muscle elasticity​
    Beckendorf, L. & Linke, W. A. ​ (2015) 
    Journal of Muscle Research and Cell Motility, 36(1) pp. 25​-36​.​ DOI: https://doi.org/10.1007/s10974-014-9392-y 
    ​Details  DOI 
  • 2015 | Journal Article | Research Paper
    ​ ​Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy​
    Hinson, J. T.; Chopra, A.; Nafissi, N.; Polacheck, W. J.; Benson, C. C.; Swist, S. & Gorham, J. et al.​ (2015) 
    Science, 349(6251) pp. 982​-986​.​ DOI: https://doi.org/10.1126/science.aaa5458 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | Overview
    ​ ​Gigantic Business: ​Titin Properties and Function Through Thick and Thin​
    Linke, W. A.   & Hamdani, N.​ (2014) 
    Circulation Research, 114(6) pp. 1052​-1068​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.114.301286 
    ​Details  DOI 
  • 2014 | Journal Article | Research Paper
    ​ ​Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins​
    Kötter, S.; Unger, A.; Hamdani, N.; Lang, P.; Vorgerd, M.; Nagel-Steger, L. & Linke, W. A. ​ (2014) 
    The Journal of Cell Biology, 204(2) pp. 187​-202​.​ DOI: https://doi.org/10.1083/jcb.201306077 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | Research Paper
    ​ ​S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding​
    Alegre-Cebollada, J.; Kosuri, P.; Giganti, D.; Eckels, E.; Rivas-Pardo, J. A.; Hamdani, N. & Warren, C. M. et al.​ (2014) 
    Cell, 156(6) pp. 1235​-1246​.​ DOI: https://doi.org/10.1016/j.cell.2014.01.056 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Research Paper
    ​ ​Crucial Role for Ca2+/Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation​
    Hamdani, N.; Krysiak, J.; Kreusser, M. M.; Neef, S.; dos Remedios, C. G.; Maier, L. S. & Krueger, M. et al.​ (2013) 
    Circulation Research, 112(4) pp. 664​-+​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.111.300105 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Research Paper
    ​ ​Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction​
    Hamdani, N.; Bishu, K. G.; von Frieling-Salewsky, M.; Redfield, M. M. & Linke, W. A. ​ (2013) 
    Cardiovascular Research, 97(3) pp. 464​-471​.​ DOI: https://doi.org/10.1093/cvr/cvs353 
    ​Details  DOI  PMID  PMC 
  • 2013 | Journal Article | Research Paper
    ​ ​Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function​
    Voelkel, T.; Andresen, C.; Unger, A.; Just, S.; Rottbauer, W. & Linke, W. A. ​ (2013) 
    Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1833(4) pp. 812​-822​.​ DOI: https://doi.org/10.1016/j.bbamcr.2012.09.012 
    ​Details  DOI  PMID  PMC  WoS 

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