Prof. Dr. Thomas Eschenhagen

Staff Status
campusgoe
 

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  • 2019 Journal Article
    ​ ​Mechanistic role of the CREB-regulated transcription coactivator 1 in cardiac hypertrophy​
    Morhenn, K.; Quentin, T.; Wichmann, H.; Steinmetz, M. ; Prondzynski, M.; Söhren, K.-D. & Christ, T. et al.​ (2019) 
    Journal of Molecular and Cellular Cardiology127 pp. 31​-43​.​ DOI: https://doi.org/10.1016/j.yjmcc.2018.12.001 
    Details  DOI 
  • 2019 Journal Article | Overview
    ​ ​ESC Working Group on Cellular Biology of the Heart: position paper for Cardiovascular Research: tissue engineering strategies combined with cell therapies for cardiac repair in ischaemic heart disease and heart failure​
    Madonna, R.; Van Laake, L. W; Botker, H. E.; Davidson, S. M; De Caterina, R.; Engel, F. B & Eschenhagen, T.  et al.​ (2019) 
    Cardiovascular Research115(3) pp. 488​-500​.​ DOI: https://doi.org/10.1093/cvr/cvz010 
    Details  DOI  PMID  PMC 
  • 2018 Journal Article | Research Paper
    ​ ​Treatments targeting inotropy​
    Maack, C.; Eschenhagen, T. ; Hamdani, N.; Heinzel, F. R.; Lyon, A. R.; Manstein, D. J. & Metzger, J. et al.​ (2018) 
    European Heart Journal, art. ehy600​.​ DOI: https://doi.org/10.1093/eurheartj/ehy600 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article | Research Paper | 
    ​ ​I-1-deficiency negatively impacts survival in a cardiomyopathy mouse model​
    Friedrich, F. W.; Sotoud, H.; Geertz, B.; Weber, S.; Flenner, F.; Reischmann, S. & Eschenhagen, T.  et al.​ (2015) 
    IJC Heart & Vasculature8 pp. 87​-94​.​ DOI: https://doi.org/10.1016/j.ijcha.2015.05.010 
    Details  DOI  PMID  PMC 
  • 2014 Journal Article | Research Paper
    ​ ​Melusin protects from cardiac rupture and improves functional remodelling after myocardial infarction​
    Unsoeld, B. W.; Kaul, A.; Sbroggi, M.; Schubert, C.; Regitz-Zagrosek, V.; Brancaccio, M. & Damilano, F. et al.​ (2014) 
    Cardiovascular Research101(1) pp. 97​-107​.​ DOI: https://doi.org/10.1093/cvr/cvt235 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper | 
    ​ ​Enhanced Ca2+ influx through cardiac L-type Ca2+ channels maintains the systolic Ca2+ transient in early cardiac atrophy induced by mechanical unloading​
    Schwoerer, A. P.; Neef, S.; Broichhausen, I.; Jacubeit, J.; Tiburcy, M. ; Wagner, M. & Biermann, D. et al.​ (2013) 
    Pflügers Archiv - European Journal of Physiology465(12) pp. 1763​-1773​.​ DOI: https://doi.org/10.1007/s00424-013-1316-y 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Parthenogenetic stem cells for tissue-engineered heart repair​
    Didie, M. ; Christalla, P.; Rubart, M.; Muppala, V. ; Doeker, S.; Unsoeld, B. W. & El-Armouche, A.  et al.​ (2013) 
    Journal of Clinical Investigation123(3) pp. 1285​-1298​.​ DOI: https://doi.org/10.1172/JCI66854 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Research Paper
    ​ ​Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes​
    Mehel, H.; Emons, J.; Vettel, C. ; Wittköpper, K.; Seppelt, D.; Dewenter, M.   & Lutz, S.  et al.​ (2013) 
    Journal of the American College of Cardiology62(17) pp. 1596​-1606​.​ DOI: https://doi.org/10.1016/j.jacc.2013.05.057 
    Details  DOI  PMID  PMC  WoS 
  • 2012 Journal Article
    ​ ​Gene expression of the cardiac Na(+)-Ca2+ exchanger in end-stage human heart failure​
    Studer, R.; Reinecke, H.; Bilger, J.; Eschenhagen, T. ; Böhm, M.; Hasenfuss, G.   & Just, H.  et al.​ (2012) 
    Circulation Research75(3) pp. 443​-453​.​ DOI: https://doi.org/10.1161/01.res.75.3.443 
    Details  DOI 
  • 2012 Journal Article | Research Paper | 
    ​ ​Increased myocardial SERCA expression in early type 2 diabetes mellitus is insulin dependent: In vivo and in vitro data​
    Fredersdorf, S.; Thumann, C.; Zimmermann, W.-H. ; Vetter, R.; Graf, T.; Luchner, A. & Riegger, G. A. J. et al.​ (2012) 
    Cardiovascular Diabetology11 art. 57​.​ DOI: https://doi.org/10.1186/1475-2840-11-57 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article
    ​ ​Cardiac tissue engineering: a clinical perspective​
    Zimmermann, W.-H. ; Tiburcy, M.   & Eschenhagen, T. ​ (2011) 
    Future Cardiology3(4) pp. 435​-445​.​ DOI: https://doi.org/10.2217/14796678.3.4.435 
    Details  DOI 
  • 2011 Journal Article | Research Paper
    ​ ​Engineering bioartificial tracheal tissue using hybrid fibroblast-mesenchymal stem cell cultures in collagen hydrogels​
    Naito, H.; Tojo, T.; Kimura, M.; Dohi, Y.; Zimmermann, W.-H. ; Eschenhagen, T.   & Taniguchi, S.​ (2011) 
    Interactive CardioVascular and Thoracic Surgery12(2) pp. 156​-161​.​ DOI: https://doi.org/10.1510/icvts.2010.253559 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper | 
    ​ ​Terminal Differentiation, Advanced Organotypic Maturation, and Modeling of Hypertrophic Growth in Engineered Heart Tissue​
    Tiburcy, M. ; Didie, M. ; Boy, O.; Christalla, P.; Doeker, S.; Naito, H. & Karikkineth, B. C. et al.​ (2011) 
    Circulation Research109(10) pp. 1105​-U46​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.111.251843 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper
    ​ ​Human Engineered Heart Tissue as a Versatile Tool in Basic Research and Preclinical Toxicology​
    Schaaf, S.; Shibamiya, A.; Mewe, M.; Eder, A.; Stoehr, A.; Hirt, M. N. & Rau, T. et al.​ (2011) 
    PLoS ONE6(10) art. e26397​.​ DOI: https://doi.org/10.1371/journal.pone.0026397 
    Details  DOI  PMID  PMC  WoS 
  • 2011 Journal Article | Research Paper
    ​ ​The Effect of Mesenchymal Stem Cell Osteoblastic Differentiation on the Mechanical Properties of Engineered Bone-Like Tissue​
    Naito, H.; Dohi, Y.; Zimmermann, W.-H. ; Tojo, T.; Takasawa, S.; Eschenhagen, T.   & Taniguchi, S.​ (2011) 
    Tissue Engineering Part A17(17-18) pp. 2321​-2329​.​ DOI: https://doi.org/10.1089/ten.tea.2011.0099 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging​
    Wittoepper, K.; Fabritz, L.; Neef, S.; Ort, K. R.; Grefe, C.; Unsoeld, B. W. & Kirchhof, P. et al.​ (2010) 
    Journal of Clinical Investigation120(2) pp. 617​-626​.​ DOI: https://doi.org/10.1172/JCI40545 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Common MicroRNA Signatures in Cardiac Hypertrophic and Atrophic Remodeling Induced by Changes in Hemodynamic Load​
    El-Armouche, A. ; Schwoerer, A. P.; Neuber, C.; Emmons, J.; Biermann, D.; Christalla, T. & Grundhoff, A. et al.​ (2010) 
    PLoS ONE5(12) art. e14263​.​ DOI: https://doi.org/10.1371/journal.pone.0014263 
    Details  DOI  PMID  PMC  WoS 
  • 2010 Journal Article | Research Paper | 
    ​ ​Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation​
    Rudolph, V.; Andrié, R. P.; Rudolph, T. K.; Friedrichs, K.; Klinke, A.; Hirsch-Hoffmann, B. & Schwoerer, A. P. et al.​ (2010) 
    Nature Medicine16(4) pp. 470​-474​.​ DOI: https://doi.org/10.1038/nm.2124 
    Details  DOI  PMID  PMC  WoS 
  • 2009 Conference Paper | Research Paper
    ​ ​Hepatocyte Growth Factor or Vascular Endothelial Growth Factor Gene Transfer Maximizes Mesenchymal Stem Cell-Based Myocardial Salvage After Acute Myocardial Infarction​
    Deuse, T.; Peter, C.; Fedak, P. W. M.; Doyle, T.; Reichenspurner, H.; Zimmermann, W.-H.   & Eschenhagen, T.  et al.​ (2009)
    ​Circulation (11) pp. S247​-S254. (Vol. 120). ​81st Annual Scientific Session of the American-Heart-Association​, New Orleans, LA.
    Philadelphia​: Lippincott Williams & Wilkins. DOI: https://doi.org/10.1161/CIRCULATIONAHA.108.843680 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​Thyroid hormone regulates developmental titin isoform transitions via the phosphatidylinositol-3-kinase/AKT pathway​
    Krueger, M. ; Sachse, C.; Zimmermann, W.-H. ; Eschenhagen, T. ; Klede, S. & Linke, W. A. ​ (2008) 
    Circulation Research102(4) pp. 439​-447​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.107.162719 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy​
    El-Armouche, A. ; Wittkoepper, K.; Degenhardt, F.; Weinberger, F.; Didie, M. ; Melnychenko, I. & Grimm, M.  et al.​ (2008) 
    Cardiovascular Research80(3) pp. 396​-406​.​ DOI: https://doi.org/10.1093/cvr/cvn208 
    Details  DOI  PMID  PMC  WoS 
  • 2008 Journal Article | Research Paper
    ​ ​Real-time myocardial contrast echocardiography for assessing perfusion and function in healthy and infarcted Wistar rats​
    Wasmeier, G. H.; Zimmermann, W.-H. ; Schineis, N.; Melnychenko, I.; Voigt, J.-U.; Eschenhagen, T.   & Flachskampf, F. A. et al.​ (2008) 
    Ultrasound in Medicine & Biology34(1) pp. 47​-55​.​ DOI: https://doi.org/10.1016/j.ultrasmedbio.2007.06.027 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Journal Article
    ​ ​Embryonic Stem Cells for Cardiac Muscle Engineering​
    Zimmermann, W.-H.   & Eschenhagen, T. ​ (2007) 
    Trends in Cardiovascular Medicine17(4) pp. 134​-140​.​ DOI: https://doi.org/10.1016/j.tcm.2007.02.007 
    Details  DOI 
  • 2007 Journal Article | Research Paper
    ​ ​Adenovirus-delivered short hairpin RNA targeting contractile function in reconstituted heart PKC alpha improves tissue​
    El-Armouche, A. ; Singh, J.; Naito, H.; Wittkoepper, K.; Didie, M. ; Laatsch, A. & Zimmermann, W.-H.  et al.​ (2007) 
    Journal of Molecular and Cellular Cardiology43(3) pp. 371​-376​.​ DOI: https://doi.org/10.1016/j.yjmcc.2007.05.021 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Journal Article | Research Paper
    ​ ​Reproducibility of transthoracic echocardiography in small animals using clinical equipment​
    Wasmeier, G. H.; Melnychenko, I.; Voigt, J.-U.; Zimmermann, W.-H. ; Eschenhagen, T. ; Schineis, N. & Reulbach, U. et al.​ (2007) 
    Coronary Artery Disease18(4) pp. 283​-291​.​ DOI: https://doi.org/10.1097/MCA.0b013e3280d5a7e3 
    Details  DOI  PMID  PMC  WoS 
  • 2007 Conference Paper | Research Paper
    ​ ​Development of a biological ventricular assist device - Preliminary data from a small animal model​
    Yildirim, Y.; Naito, H.; Didie, M. ; Karikkineth, B. C.; Biermann, D.; Eschenhagen, T.   & Zimmermann, W.-H. ​ (2007)
    ​Circulation (11) pp. I16​-I23. (Vol. 116). ​79th Annual Scientific Session of the American-Heart-Association​, Chicago, IL.
    Philadelphia​: Lippincott Williams & Wilkins. DOI: https://doi.org/10.1161/CIRCULATIONAHA.106.679688 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Engineered heart tissue grafts improve systolic and diastolic function in infarcted rat hearts​
    Zimmermann, W.-H. ; Melnychenko, I.; Wasmeier, G. H.; Didie, M. ; Naito, H.; Nixdorff, U. & Hess, A. et al.​ (2006) 
    Nature Medicine12(4) pp. 452​-458​.​ DOI: https://doi.org/10.1038/nm1394 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Conference Paper | Research Paper
    ​ ​Optimizing engineered heart tissue for therapeutic applications as surrogate heart muscle​
    Naito, H.; Melnychenko, I.; Didie, M. ; Schneiderbanger, K.; Schubert, P.; Rosenkranz, S. & Eschenhagen, T.  et al.​ (2006)
    ​Circulation pp. I72​-I78. (Vol. 114). , Dallas, TX.
    Philadelphia​: Lippincott Williams & Wilkins. DOI: https://doi.org/10.1161/CIRCULATIONAHA.105.001560 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Review
    ​ ​Heart muscle engineering: An update on cardiac muscle replacement therapy​
    Zimmermann, W.-H. ; Didie, M. ; Doeker, S.; Melnychenko, I.; Naito, H.; Rogge, C.& Tiburcy, M.  et al.​ (2006)
    Cardiovascular Research, 71​(3) pp. 419​-429​.​
    Oxford Univ Press. DOI: https://doi.org/10.1016/j.cardiores.2006.03.023 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Letter Note
    ​ ​Electrical coupling of cardiac myocyte cell sheets to the heart​
    Eschenhagen, T. ; Zimmermann, W.-H.   & Kleber, A. G.​ (2006) 
    Circulation Research98(5) pp. 573​-575​.​ DOI: https://doi.org/10.1161/01.RES.0000215627.13049.5d 
    Details  DOI  PMID  PMC  WoS 
  • 2006 Journal Article | Research Paper
    ​ ​Alterations of the preproenkephalin system in cardiac hypertrophy and its role in atrioventricular conduction​
    Weil, J.; Zolk, O.; Griepentrog, J.; Wenzel, U.; Zimmermann, W.-H.   & Eschenhagen, T. ​ (2006) 
    Cardiovascular Research69(2) pp. 412​-422​.​ DOI: https://doi.org/10.1016/j.cardiores.2005.10.016 
    Details  DOI  PMID  PMC  WoS 
  • 2005 Journal Article | Research Paper
    ​ ​Endothelin-1 and isoprenaline co-stimulation causes contractile failure which is partially reversed by MEK inhibition​
    Münzel, F.; Muhlhauser, U.; Zimmermann, W.-H. ; Didie, M. ; Schneiderbanger, K.; Schubert, P. & Engmann, S. et al.​ (2005) 
    Cardiovascular Research68(3) pp. 464​-474​.​ DOI: https://doi.org/10.1016/j.cardiores.2005.06.020 
    Details  DOI  PMID  PMC  WoS 
  • 2005 Review
    ​ ​Engineering myocardial tissue​
    Eschenhagen, T.  & Zimmermann, W.-H. ​ (2005)
    Circulation Research, 97​(12) pp. 1220​-1231​.​
    Lippincott Williams & Wilkins. DOI: https://doi.org/10.1161/01.RES.0000196562.73231.7d 
    Details  DOI  PMID  PMC  WoS 
  • 2005 Journal Article | Letter Note
    ​ ​Questioning the relevance of circulating cardiac progenitor cells in cardiac regeneration​
    Zimmermann, W.-H.   & Eschenhagen, T. ​ (2005) 
    Cardiovascular Research68(3) pp. 344​-346​.​ DOI: https://doi.org/10.1016/j.cardiores.2005.09.010 
    Details  DOI  PMID  PMC  WoS 
  • 2005 Journal Article | Research Paper
    ​ ​Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha(1)-adrenergic positive inotropic effect in human atrium​
    Grimm, M. ; Haas, P.; Willipinski-Stapelfeldt, B.; Zimmermann, W.-H. ; Rau, T.; Pantel, K . & Weyand, M. et al.​ (2005) 
    Cardiovascular Research65(1) pp. 211​-220​.​ DOI: https://doi.org/10.1016/j.cardiores.2004.09.019 
    Details  DOI  PMID  PMC  WoS 
  • 2004 Journal Article | Research Paper
    ​ ​Engineered heart tissue for regeneration of diseased hearts​
    Zimmermann, W.-H. ; Melnychenko, I. & Eschenhagen, T. ​ (2004) 
    Biomaterials25(9) pp. 1639​-1647​.​ DOI: https://doi.org/10.1016/S0142-9612(03)00521-0 
    Details  DOI  PMID  PMC  WoS 
  • 2003 Journal Article
    ​ ​Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice​
    Sass, G.; Soares, M. C. P.; Yamashita, K.; Seyfried, S.; Zimmermann, W.-H. ; Eschenhagen, T.   & Kaczmarek, E. et al.​ (2003) 
    Hepatology38(4) pp. 909​-918​.​ DOI: https://doi.org/10.1002/hep.1840380417 
    Details  DOI 
  • 2003 Journal Article | Letter Note
    ​ ​Tissue engineering of aortic heart valves​
    Zimmermann, W.-H.   & Eschenhagen, T. ​ (2003) 
    Cardiovascular Research60(3) pp. 460​-462​.​ DOI: https://doi.org/10.1016/j.cardiores.2003.10.007 
    Details  DOI  PMID  PMC  WoS 
  • 2003 Review
    ​ ​Cardiac tissue engineering for replacement therapy​
    Zimmermann, W.-H.  & Eschenhagen, T. ​ (2003)
    Heart Failure Reviews, 8​(3) pp. 259​-269​.​
    Kluwer Academic Publ. DOI: https://doi.org/10.1023/A:1024725818835 
    Details  DOI  PMID  PMC  WoS 
  • 2003 Journal Article | Research Paper
    ​ ​24-h Langendorff-perfused neonatal rat heart used to study the impact of adenoviral gene transfer​
    Wiechert, S.; El-Armouche, A. ; Rau, T.; Zimmermann, W.-H.   & Eschenhagen, T. ​ (2003) 
    American Journal of Physiology - Heart and Circulatory Physiology285(2) pp. H907​-H914​.​ DOI: https://doi.org/10.1152/ajpheart.00856.2002 
    Details  DOI  PMID  PMC  WoS 
  • 2003 Journal Article
    ​ ​Evidence for protein phosphatase inhibitor-1 playing an amplifier role in β-adrenergic signaling in cardiac myocytes​
    El-Armouche, A. ; Rau, T.; Zolk, O.; Ditz, D.; Pamminger, T.; Zimmermann, W.-H.   & Jäckel, E.  et al.​ (2003) 
    The FASEB Journal17(3) pp. 437​-439​.​ DOI: https://doi.org/10.1096/fj.02-0057fje 
    Details  DOI  PMID  PMC 
  • 2002 Conference Abstract
    ​ ​Adenoviral GI-protein overexpression: Impact on beta-adrenergic signaling in cardiac myocytes and intact trabeculae​
    Rau, T.; Janssen, P. M. L.; Peppel, K.; Hasenfuss, G. ; Koch, W. & Eschenhagen, T. ​ (2002)
    Journal of Molecular and Cellular Cardiology34(6) 
    London​: Academic Press Ltd- Elsevier Science Ltd. DOI: https://doi.org/10.1016/S0022-2828(02)90935-1 
    Details  DOI  WoS 
  • 2002 Journal Article
    ​ ​3D engineered heart tissue for replacement therapy​
    Eschenhagen, T. ; Didié, M. ; Münzel, F.; Schubert, P.; Schneiderbanger, K. & Zimmermann, W.-H. ​ (2002) 
    Basic Research in Cardiology97 pp. I146​-I152​.​ DOI: https://doi.org/10.1007/s003950200043 
    Details  DOI 
  • 2002 Journal Article | Research Paper
    ​ ​Tissue engineering of a differentiated cardiac muscle construct​
    Zimmermann, W.-H. ; Schneiderbanger, K.; Schubert, P.; Didié, M. ; Münzel, F.; Heubach, J. & Kostin, S. et al.​ (2002) 
    Circulation Research90(2) pp. 223​-230​.​ DOI: https://doi.org/10.1161/hh0202.103644 
    Details  DOI  PMID  PMC  WoS 
  • 2002 Journal Article | Research Paper
    ​ ​Intracellular beta-blockade: overexpression of G alpha(i2) depresses the beta-adrenergic response in intact myocardium​
    Janssen, P. M. L.; Schillinger, W. ; Donahue, J. K.; Zeitz, O.; Embry, S. L.; Lehnart, S. E.   & Weil, J. et al.​ (2002) 
    Cardiovascular Research55(2) art. PII S0008-6363(02)00406-6​.​ DOI: https://doi.org/10.1016/S0008-6363(02)00406-6 
    Details  DOI  PMID  PMC  WoS 
  • 2002 Journal Article | Research Paper
    ​ ​Cardiac tissue engineering​
    Eschenhagen, T. ; Didie, M. ; Heubach, J.; Ravens, U. & Zimmermann, W.-H. ​ (2002) 
    Transplant Immunology9(2-4) art. PII S0966-3274(02)00011-4​.​ DOI: https://doi.org/10.1016/S0966-3274(02)00011-4 
    Details  DOI  PMID  PMC  WoS 
  • 2000 Journal Article | Research Paper
    ​ ​Three-dimensional engineered heart tissue from neonatal rat cardiac myocytes​
    Zimmermann, W. H. ; Fink, C.; Kralisch, D.; Remmers, U.; Weil, J. & Eschenhagen, T. ​ (2000) 
    Biotechnology and Bioengineering68(1) pp. 106​-114​.​ DOI: https://doi.org/10.1002/(SICI)1097-0290(20000405)68:1<106::AID-BIT13>3.0.CO;2-3 
    Details  DOI  WoS 
  • 1997 Journal Article | Research Paper
    ​ ​Three-dimensional reconstitution of embryonic cardiomyocytes in a collagen matrix: a new heart muscle model system​
    Eschenhagen, T. ; Fink, C.; Remmers, U.; Scholz, H.; Wattchow, J.; Weil, J. & Zimmermann, W.-H.  et al.​ (1997) 
    The FASEB journal11(8) pp. 683​-694​.​ DOI: https://doi.org/10.1096/fasebj.11.8.9240969 
    Details  DOI  PMID  PMC  WoS 

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