RG Sossalla (Kardiovaskuläre experimentelle Elektrophysiologie und Bildgebung)

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  • 2023 | Journal Article
    ​ ​Dai, Yuanyuan, et al. "An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes​." ​Circulation Research, ​2023, , ​doi: 10.1161/CIRCRESAHA.122.321157. 
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  • 2022 | Journal Article
    ​ ​Lebek, Simon, et al. "Na v 1.8 Dysregulates Na and Ca Leading to Arrhythmias in Patients with Sleep-disordered Breathing​." ​American Journal of Respiratory and Critical Care Medicine, ​2022, , ​doi: 10.1164/rccm.202205-0981LE. 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Bengel, Philipp, et al. "Detrimental proarrhythmogenic interaction of Ca2+/calmodulin-dependent protein kinase II and NaV1.8 in heart failure​." ​Nature Communications, vol. 12, no. 1, ​2021, , ​doi: 10.1038/s41467-021-26690-1. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Eiringhaus, Jörg, et al. "Sacubitrilat reduces pro‐arrhythmogenic sarcoplasmic reticulum Ca 2+ leak in human ventricular cardiomyocytes of patients with end‐stage heart failure​." ​ESC Heart Failure, vol. 7, no. 5, ​2020, pp. 2992​-3002​, ​doi: 10.1002/ehf2.12918. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Pabel, Steffen, et al. "Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice​." ​Basic Research in Cardiology, vol. 115, no. 2, ​2020, , ​doi: 10.1007/s00395-020-0780-8. 
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  • 2019 | Conference Paper
    ​ ​Eiringhaus, J., et al. "P3829 Antiarrhythmic effects of Sacubitrilat (LBQ657) on Ca2+ homeostasis in ventricular cardiomyocytes​." ​European Heart Journal, vol. 40, no. Suppl. 1, ​2019, . ​doi: 10.1093/eurheartj/ehz745.0671. 
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  • 2019 | Journal Article | Research Paper
    ​ ​Voigt, Niels, Katharina Ort, and Samuel Sossalla. "Arzneimittelinteraktionen, die man kennen muss!​." ​Deutsche medizinische Wochenschrift, vol. 144, no. 04, ​2019, pp. 264​-275​, ​doi: 10.1055/a-0160-8413. 
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  • 2019 | Journal Article | Research Paper
    ​ ​Eiringhaus, Jörg, et al. "Protein kinase/phosphatase balance mediates the effects of increased late sodium current on ventricular calcium cycling​." ​Basic Research in Cardiology, vol. 114, no. 2, ​2019, p. 13​, ​doi: 10.1007/s00395-019-0720-7. 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Voigt, Niels, Katharina Ort, and Samuel Sossalla. "Arzneimittelinteraktionen, die man kennen muss!​." ​Fortschritte der Neurologie · Psychiatrie, vol. 87, no. 05, ​2019, pp. 320​-332​, ​doi: 10.1055/a-0894-9924. 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Brandenburg, Sören, et al. "Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis​." ​JCI insight, vol. 4, no. 12, ​2019, , ​doi: 10.1172/jci.insight.127116. 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Noack, Claudia, et al. "KLF15-Wnt–Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart​." ​Journal of the American College of Cardiology, vol. 74, no. 14, ​2019, pp. 1804​-1819​, ​doi: 10.1016/j.jacc.2019.07.076. 
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  • 2019 | Journal Article | Research Paper | 
    ​ ​Ahmad, Shakil, et al. "The functional consequences of sodium channel NaV1.8 in human left ventricular hypertrophy​." ​ESC Heart Failure, vol. 6, no. 1, ​2019, pp. 154​-163​, ​doi: 10.1002/ehf2.12378. 
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  • 2018 | Research Data | Research Paper | 
    ​ ​Brandenburg, Sören, et al. Axial Tubule Junctions Activate Atrial Ca2+ Release across Species​. ​​2018, doi: 10.3389/fphys.2018.01227. 
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  • 2018 | Journal Article | Research Paper
    ​ ​Pabel, Steffen, et al. "Empagliflozin directly improves diastolic function in human heart failure​." ​European Journal of Heart Failure, vol. 20, no. 12, ​2018, pp. 1690​-1700​, ​doi: 10.1002/ejhf.1328. 
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  • 2018 | Journal Article | Research Paper
    ​ ​Dybkova, Nataliya, et al. "Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart​." ​Cardiovascular Research, vol. 114, no. 13, ​2018, pp. 1728​-1737​, ​doi: 10.1093/cvr/cvy152. 
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  • 2018 | Journal Article | Research Paper
    ​ ​Mohamed, Belal A., et al. "Sarcoplasmic reticulum calcium leak contributes to arrhythmia but not to heart failure progression​." ​Science Translational Medicine, vol. 10, no. 458, ​2018, , ​doi: 10.1126/scitranslmed.aan0724. 
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  • 2018 | Journal Article | Research Paper
    ​ ​Fischer, Thomas H., et al. "Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure​." ​European Journal of Heart Failure, vol. 20, no. 12, ​2018, pp. 1673​-1685​, ​doi: 10.1002/ejhf.1297. 
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  • 2017 | Conference Abstract
    ​ ​Mohamed, B. A., et al. "P1334 - The relevant role of SR Ca leak in the development of heart failure​." ​European Journal of Heart Failure, vol. 19, no. Suppl. 1, ​2017, . ​
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  • 2017 | Journal Article | Research Paper
    ​ ​Eiringhaus, J., et al. "PP1 activation as novel antiarrhythmic approach in human heart failure​." ​European Heart Journal, vol. 38, no. suppl_1, ​2017, p. 1236​, ​doi: 10.1093/eurheartj/ehx493.P5841. 
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  • 2017 | Journal Article | Overview
    ​ ​Mason, Fleur E., and Samuel Sossalla. "The Significance of the Late Na+ Current for Arrhythmia Induction and the Therapeutic Antiarrhythmic Potential of Ranolazine​." ​Journal of Cardiovascular Pharmacology and Therapeutics, vol. 22, no. 1, ​2017, pp. 40​-50​, ​doi: 10.1177/1074248416644989. 
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  • 2017 | Journal Article | Research Paper
    ​ ​Vettel, Christiane, et al. "Phosphodiesterase 2 Protects Against Catecholamine-Induced Arrhythmia and Preserves Contractile Function After Myocardial Infarction​." ​Circulation Research, vol. 120, no. 1, ​2017, pp. 120​-132​, ​doi: 10.1161/CIRCRESAHA.116.310069. 
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  • 2017 | Journal Article | Research Paper
    ​ ​Dewenter, Matthias, et al. "Calcium/Calmodulin-Dependent Protein Kinase II Activity Persists During Chronic β-Adrenoceptor Blockade in Experimental and Human Heart Failure​." ​Circulation: Heart Failure, vol. 10, no. 5, ​2017, pp. 1​-9​, ​doi: 10.1161/CIRCHEARTFAILURE.117.003840. 
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Borchert, Thomas, et al. "Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy​." ​Journal of the American College of Cardiology, vol. 70, no. 8, ​2017, pp. 975​-991​, ​doi: 10.1016/j.jacc.2017.06.061. 
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Schotola, Hanna, et al. "The contractile adaption to preload depends on the amount of afterload​." ​ESC Heart Failure, ​2017, , ​doi: 10.1002/ehf2.12164. 
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Streckfuss-Bömeke, Katrin, et al. "Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes​." ​Journal of Molecular and Cellular Cardiology, vol. 113, ​2017, pp. 9​-21​, ​doi: 10.1016/j.yjmcc.2017.09.008. 
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  • 2016 | Journal Article | Research Paper
    ​ ​Fischer, Thomas H., et al. "Sex-dependent alterations of Ca2+ cycling in human cardiac hypertrophy and heart failure​." ​EP Europace, vol. 18, no. 9, ​2016, pp. 1440​-1448​, ​doi: 10.1093/europace/euv313. 
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  • 2016 | Journal Article | Research Paper
    ​ ​Fischer, Thomas H., et al. "Inhibition of CaMKII Attenuates Progressing Disruption of Ca2+ Homeostasis Upon Left Ventricular Assist Device Implantation in Human Heart Failure​." ​Artificial Organs, vol. 40, no. 8, ​2016, pp. 719​-726​, ​doi: 10.1111/aor.12677. 
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  • 2016 | Journal Article | Research Paper
    ​ ​Hartmann, Nico H., et al. "The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology​." ​Journal of Molecular and Cellular Cardiology, vol. 94, ​2016, pp. 95​-106​, ​doi: 10.1016/j.yjmcc.2016.03.012. 
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  • 2016 | Journal Article | Research Paper
    ​ ​Hartmann, Nico H., et al. "Antiarrhythmic effects of dantrolene in human diseased cardiomyocytes​." ​Heart Rhythm, vol. 14, no. 3, ​2016, pp. 412​-419​, ​doi: 10.1016/j.hrthm.2016.09.014. 
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  • 2015 | Journal Article | Research Paper
    ​ ​Fischer, Thomas H., et al. "Late INa increases diastolic SR-Ca2+-leak in atrial myocardium by activating PKA and CaMKII​." ​Cardiovascular Research, vol. 107, no. 1, ​2015, pp. 184​-196​, ​doi: 10.1093/cvr/cvv153. 
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  • 2015 | Journal Article | Research Paper
    ​ ​Xu, Xingbo, et al. "Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis​." ​Cardiovascular Research, vol. 105, no. 3, ​2015, pp. 279​-291​, ​doi: 10.1093/cvr/cvv015. 
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  • 2014 | Journal Article | Research Paper
    ​ ​Sag, Can M., et al. "Enhanced late INa induces proarrhythmogenic SR Ca leak in a CaMKII-dependent manner​." ​Journal of Molecular and Cellular Cardiology, vol. 76, ​2014, pp. 94​-105​, ​doi: 10.1016/j.yjmcc.2014.08.016. 
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  • 2014 | Journal Article | Research Paper | 
    ​ ​Sossalla, Samuel Tobias, et al. "Effects of Ranolazine on Torsades de Pointes Tachycardias in a Healthy Isolated Rabbit Heart Model​." ​Cardiovascular Therapeutics, vol. 32, no. 4, ​2014, pp. 170​-177​, ​doi: 10.1111/1755-5922.12078. 
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  • 2014 | Journal Article | Research Paper | 
    ​ ​Fischer, Thomas H., et al. "Ca2+/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy​." ​European Journal of Heart Failure, vol. 16, no. 12, ​2014, pp. 1292​-1300​, ​doi: 10.1002/ejhf.163. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Luo, Min, et al. "Diabetes increases mortality after myocardial infarction by oxidizing CaMKII​." ​Journal of Clinical Investigation, vol. 123, no. 3, ​2013, pp. 1262​-1274​, ​doi: 10.1172/JCI65268. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Mehel, Hind, et al. "Phosphodiesterase-2 Is Up-Regulated in Human Failing Hearts and Blunts β-Adrenergic Responses in Cardiomyocytes​." ​Journal of the American College of Cardiology, vol. 62, no. 17, ​2013, pp. 1596​-1606​, ​doi: 10.1016/j.jacc.2013.05.057. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Toischer, Karl, et al. "Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease​." ​Journal of Molecular and Cellular Cardiology, vol. 61, ​2013, pp. 111​-122​, ​doi: 10.1016/j.yjmcc.2013.03.021. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Fischer, Thomas H., et al. "Ca2+/Calmodulin-Dependent Protein Kinase II and Protein Kinase A Differentially Regulate Sarcoplasmic Reticulum Ca2+ Leak in Human Cardiac Pathology​." ​Circulation, vol. 128, no. 9, ​2013, pp. 970​-981​, ​doi: 10.1161/CIRCULATIONAHA.113.001746. 
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  • 2013 | Journal Article | Overview | 
    ​ ​Fischer, Thomas H., Lars S. Maier, and Samuel Tobias Sossalla. "The ryanodine receptor leak: how a tattered receptor plunges the failing heart into crisis​." ​Heart Failure Reviews, vol. 18, no. 4, ​2013, pp. 475​-483​, ​doi: 10.1007/s10741-012-9339-6. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Sossalla, Samuel, et al. "Ranolazine Maintained Sinus Rhythm in a Patient with Refractory Symptomatic Atrial Fibrillation​." ​Cardiovascular Therapeutics, vol. 31, no. 5, ​2013, pp. 303​-306​, ​doi: 10.1111/1755-5922.12017. 
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  • 2013 | Journal Article | Overview | 
    ​ ​Maier, Lars S., and Samuel Tobias Sossalla. "The late Na current as a therapeutic target: Where are we?​." ​Journal of Molecular and Cellular Cardiology, vol. 61, ​2013, pp. 44​-50​, ​doi: 10.1016/j.yjmcc.2013.03.001. 
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