SFB 1002 | A08: Translationale und posttranslationale Kontrolle trunkierter Titinproteine in Kardiomyozyten von Patienten mit dilatativer Kardiomyopathie RSS Feed


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  • 2023 | Journal Article | Overview
    ​ ​Loescher, Christine M., and Wolfgang A. Linke. "Titin takes centerstage among cytoskeletal contributions to myocardial passive stiffness​." ​Cytoskeleton (2023): . ​https://doi.org/10.1002/cm.21827.
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  • 2023 | Journal Article
    ​ ​Hahn, Daniel, Seong-Won Han, and Venus Joumaa. "The history-dependent features of muscle force production: A challenge to the cross-bridge theory and their functional implications​." ​Journal of Biomechanics ​152 (2023): ​111579​. ​https://doi.org/10.1016/j.jbiomech.2023.111579.
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  • 2022 | Journal Article
    ​ ​Hessel, Anthony L., Weikang Ma, Nicole Mazara, Paige E. Rice, Devin Nissen, Henry Gong, Michel Kuehn, Thomas Irving, and Wolfgang A. Linke. "Titin force in muscle cells alters lattice order, thick and thin filament protein formation​." ​Proceedings of the National Academy of Sciences of the United States of America ​119, no. 48 (2022): ​e2209441119​. ​https://doi.org/10.1073/pnas.2209441119.
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  • 2022 | Journal Article | Research Paper | 
    ​ ​de Boer, Rudolf A., Stephane Heymans, Johannes Backs, Lucie Carrier, Andrew J. S. Coats, Stefanie Dimmeler, Thomas Eschenhagen et al. "Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)​." ​European Journal of Heart Failure ​24, no. 3 (2022): ​406​-420​. ​https://doi.org/10.1002/ejhf.2414.
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  • 2021 | Journal Article | 
    ​ ​Hessel, Anthony L., and Wolfgang A. Linke. "Unraveling the mysteries of the titin-N2A signalosome​." ​The Journal of General Physiology ​153, no. 8 (2021): . ​https://doi.org/10.1085/jgp.202112967.
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Swist, Sandra, Andreas Unger, Yong Li, Anja Vöge, Marion von Frieling-Salewsky, Åsa Skärlén, Nicola Cacciani, Thomas Braun, Lars Larsson, and Wolfgang A. Linke. "Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin​." ​Nature Communications ​11, no. 1 (2020): ​4479​. ​https://doi.org/10.1038/s41467-020-18131-2.
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  • 2019 | Journal Article | Overview | 
    ​ ​Koser, Franziska, Christine Loescher, and Wolfgang A. Linke. "Posttranslational modifications of titin from cardiac muscle: how, where, and what for?​." ​The FEBS Journal ​286, no. 12 (2019): ​2240​-2260​. ​https://doi.org/10.1111/febs.14854.
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  • 2019 | Journal Article | Research Paper
    ​ ​van Heesch, Sebastiaan, Franziska Witte, Valentin Schneider-Lunitz, Jana F Schulz, Eleonora Adami, Allison B. Faber, Marieluise Kirchner et al. "The Translational Landscape of the Human Heart​." ​Cell ​178, no. 1 (2019): ​242.e29​-260.e29​. ​https://doi.org/10.1016/j.cell.2019.05.010.
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  • 2019 | Journal Article | Research Paper
    ​ ​Zaunbrecher, Rebecca J., Ashley N. Abel, Kevin Beussman, Andrea Leonard, Marion von Frieling-Salewsky, Paul A. Fields, Lil Pabon, Hans Reinecke, Xiulan Yang, and Charles E. Murry. "Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function​." ​Circulation ​140, no. 20 (2019): ​1647​-1660​. ​https://doi.org/10.1161/CIRCULATIONAHA.119.039521.
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  • 2018 | Journal Article | Overview
    ​ ​Freundt, Johanna K., and Wolfgang A. Linke. "Titin as a force generating muscle protein under regulatory control​." ​Journal of Applied Physiology (2018): . ​https://doi.org/10.1152/japplphysiol.00865.2018.
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  • 2018 | Journal Article | Research Paper
    ​ ​Huttner, Inken G., Louis W. Wang, Celine F. Santiago, Claire Horvat, Renee Johnson, Delfine Cheng, Marion von Frieling-Salewsky et al. "A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance​." ​Circulation: Genomic and Precision Medicine ​11, no. 8 (2018): ​e002135​. ​https://doi.org/10.1161/CIRCGEN.118.002135.
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  • 2018 | Journal Article | Research Paper
    ​ ​Long, Chengzu, Hui Li, Malte Tiburcy, Cristina Rodriguez-Caycedo, Viktoriia Kyrychenko, Huanyu Zhou, Yu Zhang et al. "Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing​." ​Science Advances ​4, no. 1 (2018): ​eaap9004​. ​https://doi.org/10.1126/sciadv.aap9004.
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  • 2018 | Journal Article | Overview
    ​ ​Linke, Wolfgang A.. "Titin Gene and Protein Functions in Passive and Active Muscle​." ​Annual Review of Physiology ​80, no. 1 (2018): ​389​-411​. ​https://doi.org/10.1146/annurev-physiol-021317-121234.
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  • 2018 | Journal Article | Research Paper | 
    ​ ​Krysiak, Judith, Andreas Unger, Lisa Beckendorf, Nazha Hamdani, Marion von Frieling-Salewsky, Margaret M. Redfield, Cris G. dos Remedios et al. "Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes​." ​Nature Communications ​9, no. 1 (2018): ​262​. ​https://doi.org/10.1038/s41467-017-02483-3.
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Eisenberg, Tobias, Mahmoud Abdellatif, Andreas Zimmermann, Sabrina Schroeder, Tobias Pendl, Alexandra Harger, Slaven Stekovic et al. "Dietary spermidine for lowering high blood pressure​." ​Autophagy ​13, no. 4 (2017): ​767​-769​. ​https://doi.org/10.1080/15548627.2017.1280225.
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  • 2017 | Journal Article | Research Paper
    ​ ​Tiburcy, Malte, James E. Hudson, Paul Balfanz, Susanne Schlick, Tim Meyer, Mei-Ling Chang Liao, Elif Levent et al. "Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair​." ​Circulation ​135, no. 19 (2017): ​1832​-1847​. ​https://doi.org/10.1161/CIRCULATIONAHA.116.024145.
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  • 2017 | Journal Article | Overview | 
    ​ ​Hamdani, Nazha, Melissa Herwig, and Wolfgang A. Linke. "Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes​." ​Biophysical Reviews ​9, no. 3 (2017): ​225​-237​. ​https://doi.org/10.1007/s12551-017-0263-9.
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Streckfuss-Bömeke, Katrin, Malte Tiburcy, Andrey Fomin, Xiaojing Luo, Wener Li, Claudia Fischer, Cemil Özcelik et al. "Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes​." ​Journal of Molecular and Cellular Cardiology ​113 (2017): ​9​-21​. ​https://doi.org/10.1016/j.yjmcc.2017.09.008.
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  • 2017 | Journal Article | Research Paper
    ​ ​Schäfer, Sebastian, Antonio de Marvao, Eleonora Adami, Lorna R. Fiedler, Benjamin Ng, Ester Khin, Owen J. L. Rackham et al. "Titin-truncating variants affect heart function in disease cohorts and the general population​." ​Nature Genetics ​49, no. 1 (2017): ​46​-53​. ​https://doi.org/10.1038/ng.3719.
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  • 2016 | Journal Article | Research Paper | 
    ​ ​Mohamed, Belal A., Moritz Schnelle, Sara Khadjeh, Dawid Lbik, Melissa Herwig, Wolfgang A. Linke, Gerd Hasenfuß, and Karl Toischer. "Molecular and structural transition mechanisms in long-term volume overload​." ​European Journal of Heart Failure ​18, no. 4 (2016): ​362​-371​. ​https://doi.org/10.1002/ejhf.465.
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  • 2016 | Journal Article | Research Paper
    ​ ​Eisenberg, Tobias, Mahmoud Abdellatif, Sabrina Schroeder, Uwe Primessnig, Slaven Stekovic, Tobias Pendl, Alexandra Harger et al. "Cardioprotection and lifespan extension by the natural polyamine spermidine​." ​Nature Medicine ​22, no. 12 (2016): ​1428​-1438​. ​https://doi.org/10.1038/nm.4222.
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  • 2015 | Journal Article | Overview | 
    ​ ​Beckendorf, Lisa, and Wolfgang A. Linke. "Emerging importance of oxidative stress in regulating striated muscle elasticity​." ​Journal of Muscle Research and Cell Motility ​36, no. 1 (2015): ​25​-36​. ​https://doi.org/10.1007/s10974-014-9392-y.
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  • 2015 | Journal Article | Research Paper
    ​ ​Hinson, John T., Anant Chopra, Navid Nafissi, William J. Polacheck, Craig C. Benson, Sandra Swist, Joshua Gorham et al. "Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy​." ​Science ​349, no. 6251 (2015): ​982​-986​. ​https://doi.org/10.1126/science.aaa5458.
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  • 2014 | Journal Article | Overview
    ​ ​Linke, Wolfgang A., and Nazha Hamdani. "Gigantic Business: ​Titin Properties and Function Through Thick and Thin​." ​Circulation Research ​114, no. 6 (2014): ​1052​-1068​. ​https://doi.org/10.1161/CIRCRESAHA.114.301286.
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  • 2014 | Journal Article | Research Paper
    ​ ​Kötter, Sebastian, Andreas Unger, Nazha Hamdani, Patrick Lang, Matthias Vorgerd, Luitgard Nagel-Steger, and Wolfgang A. Linke. "Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins​." ​The Journal of Cell Biology ​204, no. 2 (2014): ​187​-202​. ​https://doi.org/10.1083/jcb.201306077.
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  • 2014 | Journal Article | Research Paper
    ​ ​Alegre-Cebollada, Jorge, Pallav Kosuri, David Giganti, Edward Eckels, Jaime Andrés Rivas-Pardo, Nazha Hamdani, Chad M. Warren, R. John Solaro, Wolfgang A. Linke, and Julio M. Fernández. "S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding​." ​Cell ​156, no. 6 (2014): ​1235​-1246​. ​https://doi.org/10.1016/j.cell.2014.01.056.
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  • 2013 | Journal Article | Research Paper
    ​ ​Hamdani, Nazha, Judith Krysiak, Michael M. Kreusser, Stefan Neef, Cristobal G. dos Remedios, Lars. S. Maier, Markus Krueger, Johannes Backs, and Wolfgang A. Linke. "Crucial Role for Ca2+/Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation​." ​Circulation Research ​112, no. 4 (2013): ​664​-+​. ​https://doi.org/10.1161/CIRCRESAHA.111.300105.
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  • 2013 | Journal Article | Research Paper
    ​ ​Hamdani, Nazha, Kalkidan G. Bishu, Marion von Frieling-Salewsky, Margaret M. Redfield, and Wolfgang A. Linke. "Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction​." ​Cardiovascular Research ​97, no. 3 (2013): ​464​-471​. ​https://doi.org/10.1093/cvr/cvs353.
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  • 2013 | Journal Article | Research Paper
    ​ ​Voelkel, Tobias, Christian Andresen, Andreas Unger, Steffen Just, Wolfgang Rottbauer, and Wolfgang A. Linke. "Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function​." ​Biochimica et Biophysica Acta (BBA) - Molecular Cell Research ​1833, no. 4 (2013): ​812​-822​. ​https://doi.org/10.1016/j.bbamcr.2012.09.012.
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