SFB 1002 | A08: Translationale und posttranslationale Kontrolle trunkierter Titinproteine in Kardiomyozyten von Patienten mit dilatativer Kardiomyopathie RSS Feed


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  • 2023 | Journal Article | Overview
    ​ ​Loescher CM, Linke WA. ​Titin takes centerstage among cytoskeletal contributions to myocardial passive stiffness​. ​​Cytoskeleton. ​2023;. ​doi:10.1002/cm.21827. 
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  • 2023 | Journal Article
    ​ ​Hahn D, Han, Seong-Won, Joumaa V. ​The history-dependent features of muscle force production: A challenge to the cross-bridge theory and their functional implications​. ​​Journal of Biomechanics. ​2023;​152​. ​doi:10.1016/j.jbiomech.2023.111579. 
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  • 2022 | Journal Article
    ​ ​Hessel AL, Ma W, Mazara N, Rice PE, Nissen D, Gong H, et al. ​Titin force in muscle cells alters lattice order, thick and thin filament protein formation​. ​​Proceedings of the National Academy of Sciences of the United States of America. ​2022;​119​(48). ​doi:10.1073/pnas.2209441119. 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​de Boer RA, Heymans S, Backs J, Carrier L, Coats AJS, Dimmeler S, et al. ​Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)​. ​​European Journal of Heart Failure. ​2022;​24​(3):​​406​-420​. ​doi:10.1002/ejhf.2414. 
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  • 2021 | Journal Article | 
    ​ ​Hessel AL, Linke WA. ​Unraveling the mysteries of the titin-N2A signalosome​. ​​The Journal of General Physiology. ​2021;​153​(8). ​doi:10.1085/jgp.202112967. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Swist S, Unger A, Li Y, Vöge A, von Frieling-Salewsky M, Skärlén Å, et al. ​Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin​. ​​Nature Communications. ​2020;​11​(1):​​4479​. ​doi:10.1038/s41467-020-18131-2. 
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  • 2019 | Journal Article | Overview | 
    ​ ​Koser F, Loescher C, Linke WA. ​Posttranslational modifications of titin from cardiac muscle: how, where, and what for?​. ​​The FEBS Journal. ​2019;​286​(12):​​2240​-2260​. ​doi:10.1111/febs.14854. 
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  • 2019 | Journal Article | Research Paper
    ​ ​van Heesch S, Witte F, Schneider-Lunitz V, Schulz J, Adami E, Faber AB, et al. ​The Translational Landscape of the Human Heart​. ​​Cell. ​2019;​178​(1):​​242.e29​-260.e29​. ​doi:10.1016/j.cell.2019.05.010. 
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  • 2019 | Journal Article | Research Paper
    ​ ​Zaunbrecher RJ, Abel AN, Beussman K, Leonard A, von Frieling-Salewsky M, Fields PA, et al. ​Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function​. ​​Circulation. ​2019;​140​(20):​​1647​-1660​. ​doi:10.1161/CIRCULATIONAHA.119.039521. 
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  • 2018 | Journal Article | Overview
    ​ ​Freundt JK, Linke WA. ​Titin as a force generating muscle protein under regulatory control​. ​​Journal of Applied Physiology. ​2018;. ​doi:10.1152/japplphysiol.00865.2018. 
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  • 2018 | Journal Article | Research Paper
    ​ ​Huttner IG, Wang LW, Santiago CF, Horvat C, Johnson R, Cheng D, et al. ​A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance​. ​​Circulation: Genomic and Precision Medicine. ​2018;​11​(8):​​1​-11​. ​doi:10.1161/CIRCGEN.118.002135. 
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  • 2018 | Journal Article | Research Paper
    ​ ​Long C, Li H, Tiburcy M, Rodriguez-Caycedo C, Kyrychenko V, Zhou H, et al. ​Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing​. ​​Science Advances. ​2018;​4​(1). ​doi:10.1126/sciadv.aap9004. 
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  • 2018 | Journal Article | Overview
    ​ ​Linke WA. ​Titin Gene and Protein Functions in Passive and Active Muscle​. ​​Annual Review of Physiology. ​2018;​80​(1):​​389​-411​. ​doi:10.1146/annurev-physiol-021317-121234. 
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  • 2018 | Journal Article | Research Paper | 
    ​ ​Krysiak J, Unger A, Beckendorf L, Hamdani N, Frieling-Salewsky M, Redfield MM, et al. ​Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes​. ​​Nature Communications. ​2018;​9​(1):​​1​-14​. ​doi:10.1038/s41467-017-02483-3. 
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Eisenberg T, Abdellatif M, Zimmermann A, Schroeder S, Pendl T, Harger A, et al. ​Dietary spermidine for lowering high blood pressure​. ​​Autophagy. ​2017;​13​(4):​​767​-769​. ​doi:10.1080/15548627.2017.1280225. 
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  • 2017 | Journal Article | Research Paper
    ​ ​Tiburcy M, Hudson JE, Balfanz P, Schlick S, Meyer T, Chang Liao, Mei-Ling, et al. ​Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair​. ​​Circulation. ​2017;​135​(19):​​1832​-1847​. ​doi:10.1161/CIRCULATIONAHA.116.024145. 
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  • 2017 | Journal Article | Overview | 
    ​ ​Hamdani N, Herwig M, Linke WA. ​Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes​. ​​Biophysical Reviews. ​2017;​9​(3):​​225​-237​. ​doi:10.1007/s12551-017-0263-9. 
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Streckfuss-Bömeke K, Tiburcy M, Fomin A, Luo X, Li W, Fischer C, et al. ​Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes​. ​​Journal of Molecular and Cellular Cardiology. ​2017;​113​:​​9​-21​. ​doi:10.1016/j.yjmcc.2017.09.008. 
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  • 2017 | Journal Article | Research Paper
    ​ ​Schäfer S, de Marvao A, Adami E, Fiedler LR, Ng B, Khin E, et al. ​Titin-truncating variants affect heart function in disease cohorts and the general population​. ​​Nature Genetics. ​2017;​49​(1):​​46​-53​. ​doi:10.1038/ng.3719. 
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  • 2016 | Journal Article | Research Paper | 
    ​ ​Mohamed BA, Schnelle M, Khadjeh S, Lbik D, Herwig M, Linke WA, et al. ​Molecular and structural transition mechanisms in long-term volume overload​. ​​European Journal of Heart Failure. ​2016;​18​(4):​​362​-371​. ​doi:10.1002/ejhf.465. 
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  • 2016 | Journal Article | Research Paper
    ​ ​Eisenberg T, Abdellatif M, Schroeder S, Primessnig U, Stekovic S, Pendl T, et al. ​Cardioprotection and lifespan extension by the natural polyamine spermidine​. ​​Nature Medicine. ​2016;​22​(12):​​1428​-1438​. ​doi:10.1038/nm.4222. 
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  • 2015 | Journal Article | Overview | 
    ​ ​Beckendorf L, Linke WA. ​Emerging importance of oxidative stress in regulating striated muscle elasticity​. ​​Journal of Muscle Research and Cell Motility. ​2015;​36​(1):​​25​-36​. ​doi:10.1007/s10974-014-9392-y. 
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  • 2015 | Journal Article | Research Paper
    ​ ​Hinson JT, Chopra A, Nafissi N, Polacheck WJ, Benson CC, Swist S, et al. ​Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy​. ​​Science. ​2015;​349​(6251):​​982​-986​. ​doi:10.1126/science.aaa5458. 
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  • 2014 | Journal Article | Overview
    ​ ​Linke WA, Hamdani N. ​Gigantic Business: ​Titin Properties and Function Through Thick and Thin​. ​​Circulation Research. ​2014;​114​(6):​​1052​-1068​. ​doi:10.1161/CIRCRESAHA.114.301286. 
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  • 2014 | Journal Article | Research Paper
    ​ ​Kötter S, Unger A, Hamdani N, Lang P, Vorgerd M, Nagel-Steger L, et al. ​Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins​. ​​The Journal of Cell Biology. ​2014;​204​(2):​​187​-202​. ​doi:10.1083/jcb.201306077. 
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  • 2014 | Journal Article | Research Paper
    ​ ​Alegre-Cebollada J, Kosuri P, Giganti D, Eckels E, Rivas-Pardo JA, Hamdani N, et al. ​S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding​. ​​Cell. ​2014;​156​(6):​​1235​-1246​. ​doi:10.1016/j.cell.2014.01.056. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Hamdani N, Krysiak J, Kreusser MM, Neef S, dos Remedios CG, Maier LS, et al. ​Crucial Role for Ca2+/Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation​. ​​Circulation Research. ​2013;​112​(4):​​664​-+​. ​doi:10.1161/CIRCRESAHA.111.300105. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Hamdani N, Bishu KG, von Frieling-Salewsky M, Redfield MM, Linke WA. ​Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction​. ​​Cardiovascular Research. ​2013;​97​(3):​​464​-471​. ​doi:10.1093/cvr/cvs353. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Voelkel T, Andresen C, Unger A, Just S, Rottbauer W, Linke WA. ​Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function​. ​​Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. ​2013;​1833​(4):​​812​-822​. ​doi:10.1016/j.bbamcr.2012.09.012. 
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