SFB 1002 | A08: Translationale und posttranslationale Kontrolle trunkierter Titinproteine in Kardiomyozyten von Patienten mit dilatativer Kardiomyopathie RSS Feed


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  • 2023 | Journal Article | Overview
    ​ ​Loescher, Christine M., and Wolfgang A. Linke. "Titin takes centerstage among cytoskeletal contributions to myocardial passive stiffness​." ​Cytoskeleton, ​2023, , ​doi: 10.1002/cm.21827. 
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  • 2023 | Journal Article
    ​ ​Hahn, Daniel, Seong-Won Han, and Venus Joumaa. "The history-dependent features of muscle force production: A challenge to the cross-bridge theory and their functional implications​." ​Journal of Biomechanics, vol. 152, ​2023, , ​doi: 10.1016/j.jbiomech.2023.111579. 
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  • 2022 | Journal Article
    ​ ​Hessel, Anthony L., et al. "Titin force in muscle cells alters lattice order, thick and thin filament protein formation​." ​Proceedings of the National Academy of Sciences of the United States of America, vol. 119, no. 48, ​2022, , ​doi: 10.1073/pnas.2209441119. 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​de Boer, Rudolf A., et al. "Targeted therapies in genetic dilated and hypertrophic cardiomyopathies: from molecular mechanisms to therapeutic targets. A position paper from the Heart Failure Association (HFA) and the Working Group on Myocardial Function of the European Society of Cardiology (ESC)​." ​European Journal of Heart Failure, vol. 24, no. 3, ​2022, pp. 406​-420​, ​doi: 10.1002/ejhf.2414. 
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  • 2021 | Journal Article | 
    ​ ​Hessel, Anthony L., and Wolfgang A. Linke. "Unraveling the mysteries of the titin-N2A signalosome​." ​The Journal of General Physiology, vol. 153, no. 8, ​2021, , ​doi: 10.1085/jgp.202112967. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Swist, Sandra, et al. "Maintenance of sarcomeric integrity in adult muscle cells crucially depends on Z-disc anchored titin​." ​Nature Communications, vol. 11, no. 1, ​2020, p. 4479​, ​doi: 10.1038/s41467-020-18131-2. 
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  • 2019 | Journal Article | Overview | 
    ​ ​Koser, Franziska, Christine Loescher, and Wolfgang A. Linke. "Posttranslational modifications of titin from cardiac muscle: how, where, and what for?​." ​The FEBS Journal, vol. 286, no. 12, ​2019, pp. 2240​-2260​, ​doi: 10.1111/febs.14854. 
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  • 2019 | Journal Article | Research Paper
    ​ ​van Heesch, Sebastiaan, et al. "The Translational Landscape of the Human Heart​." ​Cell, vol. 178, no. 1, ​2019, pp. 242.e29​-260.e29​, ​doi: 10.1016/j.cell.2019.05.010. 
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  • 2019 | Journal Article | Research Paper
    ​ ​Zaunbrecher, Rebecca J., et al. "Cronos Titin Is Expressed in Human Cardiomyocytes and Necessary for Normal Sarcomere Function​." ​Circulation, vol. 140, no. 20, ​2019, pp. 1647​-1660​, ​doi: 10.1161/CIRCULATIONAHA.119.039521. 
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  • 2018 | Journal Article | Overview
    ​ ​Freundt, Johanna K., and Wolfgang A. Linke. "Titin as a force generating muscle protein under regulatory control​." ​Journal of Applied Physiology, ​2018, , ​doi: 10.1152/japplphysiol.00865.2018. 
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  • 2018 | Journal Article | Research Paper
    ​ ​Huttner, Inken G., et al. "A-Band Titin Truncation in Zebrafish Causes Dilated Cardiomyopathy and Hemodynamic Stress Intolerance​." ​Circulation: Genomic and Precision Medicine, vol. 11, no. 8, ​2018, pp. 1​-11​, ​doi: 10.1161/CIRCGEN.118.002135. 
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  • 2018 | Journal Article | Research Paper
    ​ ​Long, Chengzu, et al. "Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing​." ​Science Advances, vol. 4, no. 1, ​2018, , ​doi: 10.1126/sciadv.aap9004. 
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  • 2018 | Journal Article | Overview
    ​ ​Linke, Wolfgang A.. "Titin Gene and Protein Functions in Passive and Active Muscle​." ​Annual Review of Physiology, vol. 80, no. 1, ​2018, pp. 389​-411​, ​doi: 10.1146/annurev-physiol-021317-121234. 
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  • 2018 | Journal Article | Research Paper | 
    ​ ​Krysiak, Judith, et al. "Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes​." ​Nature Communications, vol. 9, no. 1, ​2018, pp. 1​-14​, ​doi: 10.1038/s41467-017-02483-3. 
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Eisenberg, Tobias, et al. "Dietary spermidine for lowering high blood pressure​." ​Autophagy, vol. 13, no. 4, ​2017, pp. 767​-769​, ​doi: 10.1080/15548627.2017.1280225. 
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  • 2017 | Journal Article | Research Paper
    ​ ​Tiburcy, Malte, et al. "Defined Engineered Human Myocardium With Advanced Maturation for Applications in Heart Failure Modeling and Repair​." ​Circulation, vol. 135, no. 19, ​2017, pp. 1832​-1847​, ​doi: 10.1161/CIRCULATIONAHA.116.024145. 
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  • 2017 | Journal Article | Overview | 
    ​ ​Hamdani, Nazha, Melissa Herwig, and Wolfgang A. Linke. "Tampering with springs: phosphorylation of titin affecting the mechanical function of cardiomyocytes​." ​Biophysical Reviews, vol. 9, no. 3, ​2017, pp. 225​-237​, ​doi: 10.1007/s12551-017-0263-9. 
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Streckfuss-Bömeke, Katrin, et al. "Severe DCM phenotype of patient harboring RBM20 mutation S635A can be modeled by patient-specific induced pluripotent stem cell-derived cardiomyocytes​." ​Journal of Molecular and Cellular Cardiology, vol. 113, ​2017, pp. 9​-21​, ​doi: 10.1016/j.yjmcc.2017.09.008. 
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  • 2017 | Journal Article | Research Paper
    ​ ​Schäfer, Sebastian, et al. "Titin-truncating variants affect heart function in disease cohorts and the general population​." ​Nature Genetics, vol. 49, no. 1, ​2017, pp. 46​-53​, ​doi: 10.1038/ng.3719. 
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  • 2016 | Journal Article | Research Paper | 
    ​ ​Mohamed, Belal A., et al. "Molecular and structural transition mechanisms in long-term volume overload​." ​European Journal of Heart Failure, vol. 18, no. 4, ​2016, pp. 362​-371​, ​doi: 10.1002/ejhf.465. 
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  • 2016 | Journal Article | Research Paper
    ​ ​Eisenberg, Tobias, et al. "Cardioprotection and lifespan extension by the natural polyamine spermidine​." ​Nature Medicine, vol. 22, no. 12, ​2016, pp. 1428​-1438​, ​doi: 10.1038/nm.4222. 
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  • 2015 | Journal Article | Overview | 
    ​ ​Beckendorf, Lisa, and Wolfgang A. Linke. "Emerging importance of oxidative stress in regulating striated muscle elasticity​." ​Journal of Muscle Research and Cell Motility, vol. 36, no. 1, ​2015, pp. 25​-36​, ​doi: 10.1007/s10974-014-9392-y. 
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  • 2015 | Journal Article | Research Paper
    ​ ​Hinson, John T., et al. "Titin mutations in iPS cells define sarcomere insufficiency as a cause of dilated cardiomyopathy​." ​Science, vol. 349, no. 6251, ​2015, pp. 982​-986​, ​doi: 10.1126/science.aaa5458. 
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  • 2014 | Journal Article | Overview
    ​ ​Linke, Wolfgang A., and Nazha Hamdani. "Gigantic Business: ​Titin Properties and Function Through Thick and Thin​." ​Circulation Research, vol. 114, no. 6, ​2014, pp. 1052​-1068​, ​doi: 10.1161/CIRCRESAHA.114.301286. 
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  • 2014 | Journal Article | Research Paper
    ​ ​Kötter, Sebastian, et al. "Human myocytes are protected from titin aggregation-induced stiffening by small heat shock proteins​." ​The Journal of Cell Biology, vol. 204, no. 2, ​2014, pp. 187​-202​, ​doi: 10.1083/jcb.201306077. 
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  • 2014 | Journal Article | Research Paper
    ​ ​Alegre-Cebollada, Jorge, et al. "S-Glutathionylation of Cryptic Cysteines Enhances Titin Elasticity by Blocking Protein Folding​." ​Cell, vol. 156, no. 6, ​2014, pp. 1235​-1246​, ​doi: 10.1016/j.cell.2014.01.056. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Hamdani, Nazha, et al. "Crucial Role for Ca2+/Calmodulin-Dependent Protein Kinase-II in Regulating Diastolic Stress of Normal and Failing Hearts via Titin Phosphorylation​." ​Circulation Research, vol. 112, no. 4, ​2013, pp. 664​-+​, ​doi: 10.1161/CIRCRESAHA.111.300105. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Hamdani, Nazha, et al. "Deranged myofilament phosphorylation and function in experimental heart failure with preserved ejection fraction​." ​Cardiovascular Research, vol. 97, no. 3, ​2013, pp. 464​-471​, ​doi: 10.1093/cvr/cvs353. 
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  • 2013 | Journal Article | Research Paper
    ​ ​Voelkel, Tobias, et al. "Lysine methyltransferase Smyd2 regulates Hsp90-mediated protection of the sarcomeric titin springs and cardiac function​." ​Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, vol. 1833, no. 4, ​2013, pp. 812​-822​, ​doi: 10.1016/j.bbamcr.2012.09.012. 
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