SFB 1002 | S01: In vivo und in vitro Krankheitsmodelle RSS Feed


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  • 2023 | Journal Article | 
    ​ ​Combining a tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC)​
    Priesmeier, L.; Schoger, E.; Cyganek, L. & Zelarayán, L. C. ​ (2023) 
    Stem Cell Research, 71 pp. 103163​.​ DOI: https://doi.org/10.1016/j.scr.2023.103163 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | 
    ​ ​Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues​
    Nakhaei-Rad, S.; Haghighi, F.; Bazgir, F.; Dahlmann, J.; Busley, A. V.; Buchholzer, M. & Kleemann, K. et al.​ (2023) 
    Communications Biology, 6(1).​ DOI: https://doi.org/10.1038/s42003-023-05013-8 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | 
    ​ ​Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome​
    Chowdhury, A.; Boshnakovska, A.; Aich, A.; Methi, A.; Vergel Leon, A. M.; Silbern, I. & Lüchtenborg, C. et al.​ (2023) 
    EMBO Molecular Medicine, art. e17399​.​ DOI: https://doi.org/10.15252/emmm.202317399 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration​
    Li, W.; Luo, X.; Poetsch, M. S.; Oertel, R.; Nichani, K.; Schneider, M. & Strano, A. et al.​ (2022) 
    Pharmaceuticals, 15(2).​ DOI: https://doi.org/10.3390/ph15020220 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming​
    Lyra-Leite, D. M.; Gutiérrez-Gutiérrez, Ó.; Wang, M.; Zhou, Y.; Cyganek, L.   & Burridge, P. W.​ (2022) 
    STAR Protocols, 3(3) art. 101560​.​ DOI: https://doi.org/10.1016/j.xpro.2022.101560 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Modulating the Biomechanical Properties of Engineered Connective Tissues by Chitosan-Coated Multiwall Carbon Nanotubes​
    Kittana, N.; Assali, M.; Zimmermann, W.-H. ; Liaw, N. ; Santos, G. L. ; Rehman, A. & Lutz, S. ​ (2021) 
    International Journal of Nanomedicine, Volume 16 pp. 989​-1000​.​ DOI: https://doi.org/10.2147/IJN.S289107 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes​
    Sattler, K.; El-Battrawy, I.; Cyganek, L. ; Lang, S.; Lan, H.; Li, X. & Zhao, Z. et al.​ (2021) 
    Scientific Reports, 11(1) art. 14689​.​ DOI: https://doi.org/10.1038/s41598-021-93958-3 
    ​Details  DOI 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7 ‐related osteopetrosis​
    Rössler, U.; Hennig, A. F.; Stelzer, N.; Bose, S.; Kopp, J.; Søe, K. & Cyganek, L.  et al.​ (2021) 
    Journal of Bone and Mineral Research, 36(8) pp. 1621​-1635​.​ DOI: https://doi.org/10.1002/jbmr.4322 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression​
    Schoger, E.; Zimmermann, W.-H. ; Cyganek, L.   & Zelarayán, L. C. ​ (2021) 
    Stem Cell Research, 55 art. S1873506121003202​.​ DOI: https://doi.org/10.1016/j.scr.2021.102473 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation​
    Schoger, E.; Zimmermann, W.-H. ; Cyganek, L.   & Zelarayán, L. C. ​ (2021) 
    Stem Cell Research, 56 art. S1873506121003652​.​ DOI: https://doi.org/10.1016/j.scr.2021.102518 
    ​Details  DOI  PMID  PMC 
  • 2021 | Journal Article | Research Paper | 
    ​ ​Monitoring mitochondrial translation in living cells​
    Yousefi, R.; Fornasiero, E. F ; Cyganek, L. ; Montoya, J.; Jakobs, S. ; Rizzoli, S. O   & Rehling, P.  et al.​ (2021) 
    EMBO reports, 22(4).​ DOI: https://doi.org/10.15252/embr.202051635 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Preclinical evidence for the therapeutic value of TBX5 normalization in arrhythmia control​
    Rathjens, F. S. ; Blenkle, A.; Iyer, L. M. ; Renger, A.; Syeda, F.; Noack, C.   & Jungmann, A. et al.​ (2020) 
    Cardiovascular Research,.​ DOI: https://doi.org/10.1093/cvr/cvaa239 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Extracellular Vesicles Derived from Neural Progenitor Cells––a Preclinical Evaluation for Stroke Treatment in Mice​
    Zheng, X.; Zhang, L.; Kuang, Y.; Venkataramani, V. ; Jin, F.; Hein, K. & Zafeiriou, M. P.  et al.​ (2020) 
    Translational Stroke Research, 12(1) pp. 185​-203​.​ DOI: https://doi.org/10.1007/s12975-020-00814-z 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Generation of Engineered Human Myocardium in a Multi-well Format​
    Tiburcy, M. ; Meyer, T. ; Liaw, N. Y. & Zimmermann, W.-H. ​ (2020) 
    STAR Protocols, 1(1) art. 100032​.​ DOI: https://doi.org/10.1016/j.xpro.2020.100032 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Long‐term human IgG treatment improves heart and muscle function in a mouse model of Duchenne muscular dystrophy​
    Zschüntzsch, J. ; Jouvenal, P. V.; Zhang, Y.; Klinker, F. ; Tiburcy, M. ; Liebetanz, D.   & Malzahn, D.  et al.​ (2020) 
    Journal of Cachexia, Sarcopenia and Muscle, 11(4) pp. 1018​-1031​.​ DOI: https://doi.org/10.1002/jcsm.12569 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes​
    Kleinsorge, M. & Cyganek, L. ​ (2020) 
    STAR Protocols, 1(1) art. 100026​.​ DOI: https://doi.org/10.1016/j.xpro.2020.100026 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids​
    Zafeiriou, M.-P. ; Bao, G. ; Hudson, J. ; Halder, R. ; Blenkle, A.; Schreiber, M.-K. & Fischer, A.  et al.​ (2020) 
    Nature Communications, 11(1).​ DOI: https://doi.org/10.1038/s41467-020-17521-w 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Genetic deletion of calcium/calmodulin-dependent protein kinase type II delta does not mitigate adverse myocardial remodeling in volume-overloaded hearts​
    Mohamed, B. A. ; Elkenani, M.; Jakubiczka-Smorag, J. ; Buchholz, E.; Koszewa, S.; Lbik, D. & Schnelle, M.  et al.​ (2019) 
    Scientific Reports, 9(1) art. 9889​.​ DOI: https://doi.org/10.1038/s41598-019-46332-3 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Agonistic and antagonistic roles of fibroblasts and cardiomyocytes on viscoelastic stiffening of engineered human myocardium​
    Schlick, S. F. ; Spreckelsen, F.; Tiburcy, M. ; Iyer, L. M. ; Meyer, T. ; Zelarayan, L. C.   & Luther, S.  et al.​ (2019) 
    Progress in Biophysics and Molecular Biology, 144 pp. 51​-60​.​ DOI: https://doi.org/10.1016/j.pbiomolbio.2018.11.011 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis​
    Brandenburg, S. ; Pawlowitz, J.; Eikenbusch, B.; Peper, J.; Kohl, T. ; Mitronova, G. Y.   & Sossalla, S.  et al.​ (2019) 
    JCI insight, 4(12).​ DOI: https://doi.org/10.1172/jci.insight.127116 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​KLF15-Wnt–Dependent Cardiac Reprogramming Up-Regulates SHISA3 in the Mammalian Heart​
    Noack, C. ; Iyer, L. M. ; Liaw, N. Y. ; Schoger, E.; Khadjeh, S. ; Wagner, E.   & Woelfer, M. et al.​ (2019) 
    Journal of the American College of Cardiology, 74(14) pp. 1804​-1819​.​ DOI: https://doi.org/10.1016/j.jacc.2019.07.076 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Inhibition of Rho-associated kinases suppresses cardiac myofibroblast function in engineered connective and heart muscle tissues​
    Santos, G. L. ; Hartmann, S.; Zimmermann, W.-H. ; Ridley, A. & Lutz, S. ​ (2019) 
    Journal of Molecular and Cellular Cardiology, 134 pp. 13​-28​.​ DOI: https://doi.org/10.1016/j.yjmcc.2019.06.015 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish​
    Burczyk, M. S.; Burkhalter, M. D.; Tena, T. C.; Grisanti, L. A.; Kauk, M.; Matysik, S. & Donow, C. et al.​ (2019) 
    JCI Insight, 4(20).​ DOI: https://doi.org/10.1172/jci.insight.121971 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​Optogenetic Monitoring of the Glutathione Redox State in Engineered Human Myocardium​
    Trautsch, I.; Heta, E.; Soong, P. L. ; Levent, E. ; Nikolaev, V. O. ; Bogeski, I.   & Katschinski, D. M.  et al.​ (2019) 
    Frontiers in Physiology, 10.​ DOI: https://doi.org/10.3389/fphys.2019.00272 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​A context-specific cardiac β-catenin and GATA4 interaction influences TCF7L2 occupancy and remodels chromatin driving disease progression in the adult heart​
    Iyer, L. M ; Nagarajan, S. ; Woelfer, M.; Schoger, E.; Khadjeh, S. ; Zafiriou, M. P.   & Kari, V.  et al.​ (2018) 
    Nucleic Acids Research, 46(6) pp. 2850​-2867​.​ DOI: https://doi.org/10.1093/nar/gky049 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Deep phenotyping of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes​
    Cyganek, L. ; Tiburcy, M. ; Sekeres, K.; Gerstenberg, K.; Bohnenberger, H. ; Lenz, C.   & Henze, S.  et al.​ (2018) 
    JCI Insight, 3(12) art. e99941​.​ DOI: https://doi.org/10.1172/jci.insight.99941 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia​
    Chowdhury, A. ; Aich, A. ; Jain, G.; Wozny, K.; Lüchtenborg, C.; Hartmann, M.   & Bernhard, O.  et al.​ (2018) 
    Cell Reports, 25(3) pp. 561​-570.e6​.​ DOI: https://doi.org/10.1016/j.celrep.2018.09.057 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper | 
    ​ ​CD8+-T Cells With Specificity for a Model Antigen in Cardiomyocytes Can Become Activated After Transverse Aortic Constriction but Do Not Accelerate Progression to Heart Failure​
    Gröschel, C.; Sasse, A.; Monecke, S.; Röhrborn, C.; Elsner, L.; Didié, M. & Reupke, V. et al.​ (2018) 
    Frontiers in Immunology, 9 art. 2665​.​ DOI: https://doi.org/10.3389/fimmu.2018.02665 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Immunological Properties of Murine Parthenogenetic Stem Cell-Derived Cardiomyocytes and Engineered Heart Muscle​
    Didié, M. ; Galla, S. ; Muppala, V. ; Dressel, R.   & Zimmermann, W.-H. ​ (2017) 
    Frontiers in Immunology, 8 art. 955​.​ DOI: https://doi.org/10.3389/fimmu.2017.00955 
    ​Details  DOI 
  • 2017 | Journal Article | Overview | 
    ​ ​Cardiac optogenetics: using light to monitor cardiac physiology​
    Koopman, C. D.; Zimmermann, W. H. ; Knöpfel, T. & de Boer, T. P.​ (2017) 
    Basic Research in Cardiology, 112(5) art. 56​.​ DOI: https://doi.org/10.1007/s00395-017-0645-y 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper | 
    ​ ​T helper cells with specificity for an antigen in cardiomyocytes promote pressure overload-induced progression from hypertrophy to heart failure​
    Gröschel, C. ; Sasse, A. ; Röhrborn, C. ; Monecke, S. ; Didié, M. ; Elsner, L.   & Kruse, V.  et al.​ (2017) 
    Scientific Reports, 7(1) art. 15998​.​ DOI: https://doi.org/10.1038/s41598-017-16147-1 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Immunological Properties of Murine Parthenogenetic Stem Cells and Their Differentiation Products​
    Johannsen, H. ; Muppala, V. ; Gröschel, C. ; Monecke, S. ; Elsner, L. ; Didié, M.   & Zimmermann, W.-H.  et al.​ (2017) 
    Frontiers in Immunology, 8 art. 924​.​ DOI: https://doi.org/10.3389/fimmu.2017.00924 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Generation of a KLF15 homozygous knockout human embryonic stem cell line using paired CRISPR/Cas9n, and human cardiomyocytes derivation​
    Noack, C. ; Haupt, L. P. ; Zimmermann, W.-H. ; Streckfuss-Bömeke, K.   & Zelarayán, L. C. ​ (2017) 
    Stem Cell Research, 23 pp. 127​-131​.​ DOI: https://doi.org/10.1016/j.scr.2017.07.007 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Cardiomyocyte proliferation prevents failure in pressure overload but not volume overload​
    Toischer, K. ; Zhu, W.; Hünlich, M.; Mohamed, B. A.; Khadjeh, S.; Reuter, S. P. & Schäfer, K.  et al.​ (2017) 
    Journal of Clinical Investigation, 127(12) pp. 4285​-4296​.​ DOI: https://doi.org/10.1172/JCI81870 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Functional correction of dystrophin actin binding domain mutations by genome editing​
    Kyrychenko, V.; Kyrychenko, S.; Tiburcy, M. ; Shelton, J. M.; Long, C.; Schneider, J. W. & Zimmermann, W.-H.  et al.​ (2017) 
    JCI Insight, 2(18) art. e95918​.​ DOI: https://doi.org/10.1172/jci.insight.95918 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Lights on for HIF-1 alpha: Genetically Enhanced Mouse Cardiomyocytes for Heart Tissue Imaging​
    Hesse, A. R.; Levent, E. ; Zieseniss, A. ; Tiburcy, M. ; Zimmermann, W.-H.   & Katschinski, D. M. ​ (2014) 
    Cellular Physiology and Biochemistry, 34(2) pp. 455​-462​.​ DOI: https://doi.org/10.1159/000363014 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​miR-133a Enhances the Protective Capacity of Cardiac Progenitors Cells after Myocardial Infarction​
    Izarra, A.; Moscoso, I.; Levent, E. ; Canon, S.; Cerrada, I.; Diez-Juan, A. & Blanca, V. et al.​ (2014) 
    Stem Cell Reports, 3(6) pp. 1029​-1042​.​ DOI: https://doi.org/10.1016/j.stemcr.2014.10.010 
    ​Details  DOI  PMID  PMC  WoS 

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