Prof. Dr. med. Lars Siegfried Maier

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  • 2020 | Journal Article
    ​ ​Dantrolene reduces CaMKIIδC-mediated atrial arrhythmias​
    Pabel, S. ; Mustroph, J.; Stehle, T.; Lebek, S.; Dybkova, N.; Keyser, A. & Rupprecht, L. et al.​ (2020) 
    Europace, 22(7) pp. 1111​-1118​.​ DOI: https://doi.org/10.1093/europace/euaa079 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Contribution of the neuronal sodium channel NaV1.8 to sodium- and calcium-dependent cellular proarrhythmia​
    Bengel, P. ; Ahmad, S. ; Tirilomis, P.; Trum, M.; Dybkova, N.; Wagner, S.   & Maier, L. S.  et al.​ (2020) 
    Journal of Molecular and Cellular Cardiology, 144 pp. 35​-46​.​ DOI: https://doi.org/10.1016/j.yjmcc.2020.05.002 
    ​Details  DOI 
  • 2020 | Journal Article | Research Paper | 
    ​ ​Inhibition of NaV1.8 prevents atrial arrhythmogenesis in human and mice​
    Pabel, S. ; Ahmad, S. ; Tirilomis, P.; Stehle, T.; Mustroph, J.; Knierim, M. & Dybkova, N. et al.​ (2020) 
    Basic Research in Cardiology, 115(2).​ DOI: https://doi.org/10.1007/s00395-020-0780-8 
    ​Details  DOI  PMID  PMC 
  • 2019 | Journal Article | Research Paper | 
    ​ ​The functional consequences of sodium channel NaV1.8 in human left ventricular hypertrophy​
    Ahmad, S. ; Tirilomis, P.; Pabel, S. ; Dybkova, N.; Hartmann, N. ; Molina, C. E.   & Tirilomis, T.  et al.​ (2019) 
    ESC Heart Failure, 6(1) pp. 154​-163​.​ DOI: https://doi.org/10.1002/ehf2.12378 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Differential regulation of sodium channels as a novel proarrhythmic mechanism in the human failing heart​
    Dybkova, N.; Ahmad, S. ; Pabel, S. ; Tirilomis, P.; Hartmann, N. ; Fischer, T. H   & Bengel, P.  et al.​ (2018) 
    Cardiovascular Research, 114(13) pp. 1728​-1737​.​ DOI: https://doi.org/10.1093/cvr/cvy152 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | Research Paper
    ​ ​Activation of protein phosphatase 1 by a selective phosphatase disrupting peptide reduces sarcoplasmic reticulum Ca2+ leak in human heart failure​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Saadatmand, A.; Pabel, S. ; Weber, S. & Wang, Y. et al.​ (2018) 
    European Journal of Heart Failure, 20(12) pp. 1673​-1685​.​ DOI: https://doi.org/10.1002/ejhf.1297 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | Research Paper
    ​ ​NADPH oxidase 2 mediates angiotensin II-dependent cellular arrhythmias via PKA and CaMKII​
    Wagner, S.; Dantz, C.; Flebbe, H.; Azizian, A.; Sag, C. M.; Engels, S. & Moellencamp, J. et al.​ (2014) 
    Journal of Molecular and Cellular Cardiology, 75 pp. 206​-215​.​ DOI: https://doi.org/10.1016/j.yjmcc.2014.07.011 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper
    ​ ​Tubulin polymerization disrupts cardiac beta-adrenergic regulation of late I-Na​
    Dybkova, N.; Wagner, S.; Backs, J.; Hund, T. J.; Mohler, P. J.; Sowa, T. & Nikolaev, V. O.  et al.​ (2014) 
    Cardiovascular Research, 103(1) pp. 168​-177​.​ DOI: https://doi.org/10.1093/cvr/cvu120 
    ​Details  DOI  PMID  PMC  WoS 
  • 2014 | Journal Article | Research Paper | 
    ​ ​Ca2+/calmodulin-dependent protein kinase II equally induces sarcoplasmic reticulum Ca2+ leak in human ischaemic and dilated cardiomyopathy​
    Fischer, T. H. ; Eiringhaus, J. ; Dybkova, N.; Foerster, A.; Herting, J. ; Kleinwaechter, A. & Ljubojevic, S. et al.​ (2014) 
    European Journal of Heart Failure, 16(12) pp. 1292​-1300​.​ DOI: https://doi.org/10.1002/ejhf.163 
    ​Details  DOI  PMID  PMC  WoS 
  • 2010 | Journal Article | Research Paper
    ​ ​CaMKII-Dependent Diastolic SR Ca2+ Leak and Elevated Diastolic Ca2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation​
    Neef, S.; Dybkova, N.; Sossalla, S. ; Ort, K. R.; Fluschnik, N.; Neumann, K. & Seipelt, R. et al.​ (2010) 
    Circulation Research, 106(6) pp. 1134​-1144​.​ DOI: https://doi.org/10.1161/CIRCRESAHA.109.203836 
    ​Details  DOI  PMID  PMC  WoS 
  • 2006 | Journal Article | Research Paper
    ​ ​Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels​
    Wagner, S. ; Dybkova, N.; Rasenack, E. C. L.; Jacobshagen, C. ; Fabritz, L.; Kirchhof, P. & Maier, S. K. G. et al.​ (2006) 
    Journal of Clinical Investigation, 116(12) pp. 3127​-3138​.​ DOI: https://doi.org/10.1172/JCI26620 
    ​Details  DOI  PMID  PMC  WoS 

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