Prof. Dr. med. Jochen Gaedcke

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  • 2023 | Journal Article | 
    ​ ​Incidence and impact of new-onset postoperative arrhythmia after surgery of the lower gastrointestinal tract​
    Rühlmann, F.; Hedicke, M. S.; Engelhardt, D.; Mackert, A. F.; Tichelbäcker, T.; Leha, A. & Bernhardt, M. et al.​ (2023) 
    Scientific Reports, 13(1).​ DOI: https://doi.org/10.1038/s41598-023-27508-4 
    ​Details  DOI 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Enhancer of Zeste Homolog 2 (EZH2) Is a Marker of High-Grade Neuroendocrine Neoplasia in Gastroenteropancreatic and Pulmonary Tract and Predicts Poor Prognosis​
    Bremer, S. C. B. ; Bittner, G.; Elakad, O.; Dinter, H.; Gaedcke, J. ; König, A. O.   & Amanzada, A.  et al.​ (2022) 
    Cancers, 14(12) pp. 2828​.​ DOI: https://doi.org/10.3390/cancers14122828 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​Effects of the Novel PFKFB3 Inhibitor KAN0438757 on Colorectal Cancer Cells and Its Systemic Toxicity Evaluation In Vivo​
    De Oliveira, T.; Goldhardt, T.; Edelmann, M.; Rogge, T. ; Rauch, K. ; Kyuchukov, N. D. & Menck, K.  et al.​ (2021) 
    Cancers, 13(5) pp. 1011​.​ DOI: https://doi.org/10.3390/cancers13051011 
    ​Details  DOI 
  • 2021 | Journal Article | 
    ​ ​NOTCH Activation via gp130/STAT3 Signaling Confers Resistance to Chemoradiotherapy​
    Koerdel, K.; Spitzner, M. ; Meyer, T. ; Engels, N.; Krause, F.; Gaedcke, J.   & Conradi, L.-C.  et al.​ (2021) 
    Cancers, 13(3) pp. 455​.​ DOI: https://doi.org/10.3390/cancers13030455 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Intensified Histopathological Work-Up after Pancreatic Head Resection Reveals Relevant Prognostic Markers​
    Dusch, N.; Oldani, M.; Steffen, T.; Kitz, J. ; Koenig, U.; Azizian, A.   & König, A. et al.​ (2020) 
    Digestion, pp. 1​-9​.​ DOI: https://doi.org/10.1159/000504648 
    ​Details  DOI  PMID  PMC 
  • 2020 | Journal Article
    ​ ​EZH2 Regulates Pancreatic Cancer Subtype Identity and Tumor Progression via Transcriptional Repression of GATA6​
    Patil, S.; Steuber, B. ; Kopp, W.; Kari, V. ; Urbach, L.; Wang, X. & Küffer, S.  et al.​ (2020) 
    Cancer Research, 80(21) pp. 4620​-4632​.​ DOI: https://doi.org/10.1158/0008-5472.CAN-20-0672 
    ​Details  DOI 
  • 2020 | Journal Article
    ​ ​Repeated resection for recurrent intrahepatic cholangiocarcinoma: A retrospective German multicentre study​
    Bartsch, F.; Eberhard, J.; Rückert, F.; Schmelzle, M.; Lehwald‐Tywuschik, N.; Fichtner‐Feigl, S. & Gaedcke, J.  et al.​ (2020) 
    Liver International, 41(1) pp. 180​-191​.​ DOI: https://doi.org/10.1111/liv.14682 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​CA19-9 for detecting recurrence of pancreatic cancer​
    Azizian, A. ; Rühlmann, F. ; Krause, T.; Bernhardt, M. ; Jo, P. ; König, A.   & Kleiß, M. et al.​ (2020) 
    Scientific Reports, 10(1).​ DOI: https://doi.org/10.1038/s41598-020-57930-x 
    ​Details  DOI 
  • 2020 | Journal Article | 
    ​ ​KRAS mutation status concordance between the primary tumor and the corresponding metastasis in patients with rectal cancer​
    Jo, P. ; Bernhardt, M. ; Nietert, M. ; König, A. ; Azizian, A. ; Schirmer, M. A.   & Grade, M.  et al.​ (2020) 
    PLoS One, 15(10) pp. e0239806​.​ DOI: https://doi.org/10.1371/journal.pone.0239806 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​Risk stratification for postoperative pancreatic fistula using the pancreatic surgery registry StuDoQ​
    Petrova, E.; Lapshyn, H.; Bausch, D.; D'Haese, J.; Werner, J.; Klier, T. & Nüssler, N. C. et al.​ (2019) 
    Pancreatology, 19(1) pp. 17​-25​.​ DOI: https://doi.org/10.1016/j.pan.2018.11.008 
    ​Details  DOI 
  • 2019 | Journal Article
    ​ ​The impact of preoperative biliary stenting in pancreatic cancer: A case-matched study from the German nationwide pancreatic surgery registry (DGAV StuDoQ​
    Bolm, L.; Petrova, E.; Woehrmann, L.; Werner, J.; Uhl, W.; Nuessler, N. & Ghadimi, M.  et al.​ (2019) 
    Pancreatology, 19(7) pp. 985​-993​.​ DOI: https://doi.org/10.1016/j.pan.2019.09.007 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​ARID1A facilitates KRAS signaling-regulated enhancer activity in an AP1-dependent manner in colorectal cancer cells​
    Sen, M. ; Wang, X.; Hamdan, F. H. ; Rapp, J.; Eggert, J.; Kosinsky, R. L.   & Wegwitz, F.  et al.​ (2019) 
    Clinical Epigenetics, 11(1).​ DOI: https://doi.org/10.1186/s13148-019-0690-5 
    ​Details  DOI 
  • 2019 | Journal Article | 
    ​ ​Epigenome Mapping Identifies Tumor-Specific Gene Expression in Primary Rectal Cancer​
    Flebbe, H.; Hamdan, F. H. ; Kari, V. ; Kitz, J. ; Gaedcke, J. ; Ghadimi, B. M. & Johnsen, S. A.  et al.​ (2019) 
    Cancers, 11(8) art. 1142​.​ DOI: https://doi.org/10.3390/cancers11081142 
    ​Details  DOI  PMID  PMC 
  • 2018 | Journal Article | 
    ​ ​A comparative study of RNA-Seq and microarray data analysis on the two examples of rectal-cancer patients and Burkitt Lymphoma cells.​
    Wolff, A. ; Bayerlová, M. ; Gaedcke, J. ; Kube, D.   & Beißbarth, T. ​ (2018) 
    PLOS ONE, 13(5) art. e0197162​.​ DOI: https://doi.org/10.1371/journal.pone.0197162 
    ​Details  DOI  PMID  PMC 
  • 2017 | Journal Article
    ​ ​ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage​
    Perkhofer, L.; Schmitt, A.; Romero Carrasco, M. C.; Ihle, M.; Hampp, S.; Ruess, D. A. & Hessmann, E.  et al.​ (2017) 
    Cancer Research, 77(20) pp. 5576​-5590​.​ DOI: https://doi.org/10.1158/0008-5472.CAN-17-0634 
    ​Details  DOI 
  • 2017 | Journal Article | Research Paper | 
    ​ ​Changes of Microrna Levels in Plasma of Patients with Rectal Cancer during Chemoradiotherapy​
    Jo, P. ; Azizian, A. ; Salendo, J. ; Kramer, F. ; Bernhardt, M. ; Wolff, H. A.   & Gruber, J. et al.​ (2017) 
    International Journal of Molecular Sciences, 18(6) art. 1140​.​ DOI: https://doi.org/10.3390/ijms18061140 
    ​Details  DOI  WoS 
  • 2017 | Journal Article
    ​ ​Chemoradiotherapy Resistance in Colorectal Cancer Cells is Mediated by Wnt/β-catenin Signaling​
    Emons, G. ; Spitzner, M. ; Reineke, S. ; Möller, J.; Auslander, N.; Kramer, F.   & Hu, Y. et al.​ (2017) 
    Molecular Cancer Research, 15(11) pp. 1481​-1490​.​ DOI: https://doi.org/10.1158/1541-7786.MCR-17-0205 
    ​Details  DOI  PMID  PMC 
  • 2016 | Journal Article
    ​ ​EP-2057: Radiotoxicity prediction by gene expression profiling when simulating therapy in matched fibroblasts​
    Schirmer, M.; Mergler, C.; Droege, L.; Guhlich, M.; Gaedcke, J. ; Ghadimi, M.   & Rave-Fränk, M. ​ (2016) 
    Radiotherapy and Oncology, 119 pp. S970​-S971​.​ DOI: https://doi.org/10.1016/S0167-8140(16)33308-4 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​MicroRNA in rectal cancer​
    Azizian, A. ; Gruber, J.; Ghadimi, B M. & Gaedcke, J. ​ (2016) 
    World Journal of Gastrointestinal Oncology, 8(5) pp. 416​.​ DOI: https://doi.org/10.4251/wjgo.v8.i5.416 
    ​Details  DOI 
  • 2016 | Journal Article
    ​ ​Endothelial Nitric Oxide Synthase Traffic Inducer (NOSTRIN) is a Negative Regulator of Disease Aggressiveness in Pancreatic Cancer​
    Wang, J. ; Yang, S.; He, P.; Schetter, A. J.; Gaedcke, J. ; Ghadimi, B. M. & Ried, T. et al.​ (2016) 
    Clinical Cancer Research, 22(24) pp. 5992​-6001​.​ DOI: https://doi.org/10.1158/1078-0432.CCR-16-0511 
    ​Details  DOI 
  • 2015 | Journal Article | 
    ​ ​5-Fluorouracil sensitizes colorectal tumor cells towards double stranded DNA breaks by interfering with homologous recombination repair.​
    Srinivas, U. S.; Dyczkowski, J.; Beißbarth, T. ; Gaedcke, J. ; Mansour, W. Y.; Borgmann, K. & Dobbelstein, M. ​ (2015) 
    Oncotarget, 6(14) pp. 12574​-12586​.​ DOI: https://doi.org/10.18632/oncotarget.3728 
    ​Details  DOI  PMID  PMC 
  • 2014 | Journal Article | 
    ​ ​UDP glucuronosyltransferase 1A expression levels determine the response of colorectal cancer cells to the heat shock protein 90 inhibitor ganetespib​
    Landmann, H.; Proia, D. A.; He, S.; Ogden, F. L.; Kramer, F.-J. ; Beißbarth, T.   & Grade, M.  et al.​ (2014) 
    Cell Death and Disease, 5 art. e1411​.​ DOI: https://doi.org/10.1038/cddis.2014.378 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article
    ​ ​Digital droplet PCR for rapid quantification of donor DNA in the circulation of transplant recipients as a potential universal biomarker of graft injury​
    Beck, J.; Bierau, S.; Balzer, S.; Andag, R.; Kanzow, P. ; Schmitz, J.   & Gaedcke, J.  et al.​ (2013) 
    Clinical Chemistry, 59(12) pp. 1732​-1741​.​ DOI: https://doi.org/10.1373/clinchem.2013.210328 
    ​Details  DOI  PMID  PMC 

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