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  • 2024 Journal Article
    ​ ​Non-invasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM​
    Rapöhn, M.; Cyganek, L.; Voigt, N.; Hasenfuß, G.; Lehnart, S. E & Wegener, J. W​ (2024) 
    American Journal of Physiology. Heart and Circulatory Physiology,.​ DOI: https://doi.org/10.1152/ajpheart.00527.2023 
    Details  DOI  PMID  PMC 
  • 2024 Journal Article
    ​ ​Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants​
    Knauer, C.; Haltern, H.; Schoger, E.; Kügler, S.; Roos, L.; Zelarayán, L. C. & Hasenfuss, G. et al.​ (2024) 
    Molecular Therapy - Nucleic Acids35(1) art. 102123​.​ DOI: https://doi.org/10.1016/j.omtn.2024.102123 
    Details  DOI  PMID  PMC 
  • 2024 Journal Article
    ​ ​mtDNA analysis using Mitopore​
    Dobner, J.; Nguyen, T.; Pavez-Giani, M. G.; Cyganek, L.; Distelmaier, F.; Krutmann, J. & Prigione, A. et al.​ (2024) 
    Molecular Therapy. Methods & Clinical Development32(2) art. 101231​.​ DOI: https://doi.org/10.1016/j.omtm.2024.101231 
    Details  DOI 
  • 2023 Journal Article | 
    ​ ​Combining a tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC)​
    Priesmeier, L.; Schoger, E.; Cyganek, L. & Zelarayán, L. C. ​ (2023) 
    Stem Cell Research71 pp. 103163​.​ DOI: https://doi.org/10.1016/j.scr.2023.103163 
    Details  DOI  PMID  PMC 
  • 2023 Journal Article | 
    ​ ​Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes​
    Seibertz, F.; Sutanto, H.; Dülk, R.; Pronto, J. R. D.; Springer, R.; Rapedius, M. & Liutkute, A. et al.​ (2023) 
    Basic Research in Cardiology118(1) pp. 14​.​ DOI: https://doi.org/10.1007/s00395-022-00973-0 
    Details  DOI  PMID  PMC 
  • 2023 Preprint
    ​ ​LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome​
    Busley, A. V.; Gutiérrez-Gutiérrez, Ó.; Hammer, E.; Steinegger, M.; Böhmer, L.; Schroeder, H.& Kleinsorge, M. et al.​ (2023). DOI: https://doi.org/10.1101/2023.01.10.523203 
    Details  DOI 
  • 2023 Journal Article
    ​ ​Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V​
    Busley, A. V. & Cyganek, L.​ (2023) 
    Stem Cell Research69 art. 103108​.​ DOI: https://doi.org/10.1016/j.scr.2023.103108 
    Details  DOI  null 
  • 2023 Journal Article
    ​ ​Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V​
    Busley, A. V.; Kleinsorge, M. & Cyganek, L.​ (2023) 
    Stem Cell Research69 art. 103105​.​ DOI: https://doi.org/10.1016/j.scr.2023.103105 
    Details  DOI 
  • 2023 Journal Article | 
    ​ ​Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues​
    Nakhaei-Rad, S.; Haghighi, F.; Bazgir, F.; Dahlmann, J.; Busley, A. V.; Buchholzer, M. & Kleemann, K. et al.​ (2023) 
    Communications Biology6(1).​ DOI: https://doi.org/10.1038/s42003-023-05013-8 
    Details  DOI  PMID  PMC 
  • 2023 Journal Article
    ​ ​Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development​
    Seibertz, F.; Rubio, T.; Springer, R.; Popp, F.; Ritter, M.; Liutkute, A. & Bartelt, L. et al.​ (2023) 
    Cardiovascular Research, art. cvad143​.​ DOI: https://doi.org/10.1093/cvr/cvad143 
    Details  DOI  PMID  PMC 
  • 2023 Preprint
    ​ ​Secreted-Frizzled-Related Protein 5 Modulates Calcium Handling in Human Ipsc-Cardiomyocytes​
    Weber, F.; Klas, S.; Hindmarsh, V.; Salinas, G.; Toischer, K.; Hasenfuss, G.& Cyganek, L.​ (2023). DOI: https://doi.org/10.2139/ssrn.4544232 
    Details  DOI 
  • 2023 Journal Article | 
    ​ ​Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome​
    Chowdhury, A.; Boshnakovska, A.; Aich, A.; Methi, A.; Vergel Leon, A. M.; Silbern, I. & Lüchtenborg, C. et al.​ (2023) 
    EMBO Molecular Medicine, art. e17399​.​ DOI: https://doi.org/10.15252/emmm.202317399 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article | Research Paper | 
    ​ ​Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration​
    Li, W.; Luo, X.; Poetsch, M. S.; Oertel, R.; Nichani, K.; Schneider, M. & Strano, A. et al.​ (2022) 
    Pharmaceuticals15(2).​ DOI: https://doi.org/10.3390/ph15020220 
    Details  DOI 
  • 2022 Journal Article | Overview | 
    ​ ​Recent Advances in Modeling Mitochondrial Cardiomyopathy Using Human Induced Pluripotent Stem Cells​
    Pavez-Giani, M. G. & Cyganek, L. ​ (2022) 
    Frontiers in Cell and Developmental Biology9 art. 800529​.​ DOI: https://doi.org/10.3389/fcell.2021.800529 
    Details  DOI  PMID  PMC 
  • 2022 Journal Article
    ​ ​Epigenetic mechanism of L-type calcium channel β-subunit downregulation in short QT human induced pluripotent stem cell-derived cardiomyocytes with CACNB2 mutation​
    Zhong, R.; Zhang, F.; Yang, Z.; Li, Y.; Xu, Q.; Lan, H. & Cyganek, L.  et al.​ (2022) 
    EP Europace, art. euac091​.​ DOI: https://doi.org/10.1093/europace/euac091 
    Details  DOI 
  • 2022 Journal Article | Research Paper | 
    ​ ​A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming​
    Lyra-Leite, D. M.; Gutiérrez-Gutiérrez, Ó.; Wang, M.; Zhou, Y.; Cyganek, L.   & Burridge, P. W.​ (2022) 
    STAR Protocols3(3) art. 101560​.​ DOI: https://doi.org/10.1016/j.xpro.2022.101560 
    Details  DOI 
  • 2022 Preprint
    ​ ​Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs​
    Nakhaei-Rad, S.; Bazgir, F.; Dahlmann, J.; Busley, A. V.; Buchholzer, M.; Haghighi, F.& Schänzer, A. et al.​ (2022). DOI: https://doi.org/10.1101/2022.01.22.477319 
    Details  DOI 
  • 2022 Journal Article | 
    ​ ​A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes​
    Seibertz, F.; Rapedius, M.; Fakuade, F. E.; Tomsits, P.; Liutkute, A.; Cyganek, L.   & Becker, N. et al.​ (2022) 
    Communications Biology5(1).​ DOI: https://doi.org/10.1038/s42003-022-03871-2 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper | 
    ​ ​Proteomic mapping of atrial and ventricular heart tissue in patients with aortic valve stenosis​
    Barbarics, B.; Eildermann, K.; Kaderali, L.; Cyganek, L.; Plessmann, U.; Bodemeyer, J. & Paul, T. et al.​ (2021) 
    Scientific Reports11(1) art. 24389​.​ DOI: https://doi.org/10.1038/s41598-021-03907-3 
    Details  DOI  PMID  PMC 
  • 2021 Book Chapter
    ​ ​Management of Metadata Types in Basic Cardiological Research​
    Kusch, H. ; Kossen, R. ; Suhr, M.; Freckmann, L.; Weber, L.; Henke, C.& Lehmann, C. et al.​ (2021)
    In:​Röhrig, Rainer; Beißbarth, Tim; König, Jochem; Ose, Claudia; Rauch, Geraldine; Sax, Ulrich; Schreiweis, Björn, et al.​ (Eds.), German Medical Data Sciences 2021: Digital Medicine: Recognize – Understand – Heal pp. 59​-68.  DOI: https://doi.org/10.3233/SHTI210542 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper
    ​ ​Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations​
    Fomin, A.; Gärtner, A.; Cyganek, L. ; Tiburcy, M. ; Tuleta, I.; Wellers, L. & Folsche, L. et al.​ (2021) 
    Science Translational Medicine13(618).​ DOI: https://doi.org/10.1126/scitranslmed.abd3079 
    Details  DOI 
  • 2021 Journal Article | Research Paper | 
    ​ ​TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes​
    Sattler, K.; El-Battrawy, I.; Cyganek, L. ; Lang, S.; Lan, H.; Li, X. & Zhao, Z. et al.​ (2021) 
    Scientific Reports11(1) art. 14689​.​ DOI: https://doi.org/10.1038/s41598-021-93958-3 
    Details  DOI 
  • 2021 Journal Article | Research Paper | 
    ​ ​Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7 ‐related osteopetrosis​
    Rössler, U.; Hennig, A. F.; Stelzer, N.; Bose, S.; Kopp, J.; Søe, K. & Cyganek, L.  et al.​ (2021) 
    Journal of Bone and Mineral Research36(8) pp. 1621​-1635​.​ DOI: https://doi.org/10.1002/jbmr.4322 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper | 
    ​ ​Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression​
    Schoger, E.; Zimmermann, W.-H. ; Cyganek, L.   & Zelarayán, L. C. ​ (2021) 
    Stem Cell Research55 art. S1873506121003202​.​ DOI: https://doi.org/10.1016/j.scr.2021.102473 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper | 
    ​ ​Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation​
    Schoger, E.; Zimmermann, W.-H. ; Cyganek, L.   & Zelarayán, L. C. ​ (2021) 
    Stem Cell Research56 art. S1873506121003652​.​ DOI: https://doi.org/10.1016/j.scr.2021.102518 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper | 
    ​ ​Monitoring mitochondrial translation in living cells​
    Yousefi, R.; Fornasiero, E. F ; Cyganek, L. ; Montoya, J.; Jakobs, S. ; Rizzoli, S. O   & Rehling, P.  et al.​ (2021) 
    EMBO reports22(4).​ DOI: https://doi.org/10.15252/embr.202051635 
    Details  DOI  PMID  PMC 
  • 2021 Journal Article | Research Paper
    ​ ​Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes​
    Peper, J.; Kownatzki-Danger, D.; Weninger, G.; Seibertz, F.; Pronto, J. R. D.; Sutanto, H. & Pacheu-Grau, D. et al.​ (2021) 
    Circulation Research128(6).​ DOI: https://doi.org/10.1161/CIRCRESAHA.119.316547 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper | 
    ​ ​Interdisciplinary Research on Aortic Valve Stenosis: A Longitudinal Collection of Biospecimens and Clinical Data of Patients Undergoing Transcatheter Aortic Valve Replacement​
    Beuthner, B. E. C.; Topci, R.; Derks, M.; Franke, T.; Seelke, S.; Puls, M. & Schuster, A. et al.​ (2020) 
    Open Journal of Bioresources7.​ DOI: https://doi.org/10.5334/ojb.65 
    Details  DOI 
  • 2020 Journal Article | Research Paper
    ​ ​Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome–Associated Cardiomyopathy​
    Hanses, U.; Kleinsorge, M.; Roos, L.; Yigit, G. ; Li, Y. ; Barbarics, B. & El-Battrawy, I. et al.​ (2020) 
    Circulation142(11) pp. 1059​-1076​.​ DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.044794 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper | 
    ​ ​Bi-allelic missense disease-causing variants in RPL3L associate neonatal dilated cardiomyopathy with muscle-specific ribosome biogenesis​
    Ganapathi, M.; Argyriou, L.; Martínez-Azorín, F.; Morlot, S.; Yigit, G. ; Lee, T. M. & Auber, B. et al.​ (2020) 
    Human Genetics139(11) pp. 1443​-1454​.​ DOI: https://doi.org/10.1007/s00439-020-02188-6 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper | 
    ​ ​Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes​
    Kleinsorge, M. & Cyganek, L. ​ (2020) 
    STAR Protocols1(1) art. 100026​.​ DOI: https://doi.org/10.1016/j.xpro.2020.100026 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper | 
    ​ ​IP3R-Mediated Compensatory Mechanism for Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes With Cardiac Ryanodine Receptor Deficiency​
    Luo, X.; Li, W.; Künzel, K.; Henze, S. ; Cyganek, L. ; Strano, A. & Poetsch, M. S. et al.​ (2020) 
    Frontiers in Cell and Developmental Biology8.​ DOI: https://doi.org/10.3389/fcell.2020.00772 
    Details  DOI  PMID  PMC 
  • 2020 Journal Article | Research Paper | 
    ​ ​Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation​
    Schoger, E.; Argyriou, L.; Zimmermann, W.-H. ; Cyganek, L.   & Zelarayán, L. C. ​ (2020) 
    Stem Cell Research48 pp. 101944​.​ DOI: https://doi.org/10.1016/j.scr.2020.101944 
    Details  DOI  PMID  PMC 
  • 2020 Preprint
    ​ ​Local translation in synaptic mitochondria influences synaptic transmission​
    Yousefi, R.; Fornasiero, E. F.; Cyganek, L.; Jakobs, S. ; Rizzoli, S. O. ; Rehling, P.  & Pacheu-Grau, D.​ (2020). DOI: https://doi.org/10.1101/2020.07.22.215194 
    Details  DOI 
  • 2020 Journal Article | Research Paper | 
    ​ ​CRISPLD1: a novel conserved target in the transition to human heart failure​
    Khadjeh, S. ; Hindmarsh, V.; Weber, F.; Cyganek, L. ; Vidal, R. O. ; Torkieh, S. & Streckfuss-Bömeke, K.  et al.​ (2020) 
    Basic Research in Cardiology115(3).​ DOI: https://doi.org/10.1007/s00395-020-0784-4 
    Details  DOI  PMID  PMC 
  • 2019 Conference Paper
    ​ ​P1235Acetylcholine-activated inward-rectifier potassium currents in atrial cardiomyocytes derived from induced pluripotent stem cells and atrial engineered heart muscle preparations​
    Springer, R.; Seibertz, F.; Solano, R. A.; Rubio, T.; Cyganek, L. ; Zimmermann, W.-H.   & Voigt, N. ​ (2019)
    European Heart Journal40(Suppl. 1) ​ESC Congress 2019 together with World Congress of Cardiology​, Paris. DOI: https://doi.org/10.1093/eurheartj/ehz748.0193 
    Details  DOI 
  • 2019 Conference Abstract
    ​ ​Leaving spreadsheets behind – FAIR documentation and representation of human stem cell lines in the Collaborative Research Centre 1002 Meeting Abstract​
    Lehmann, C.; Suhr, M. ; Umbach, N.; Cyganek, L. ; Kleinsorge, M.; Nussbeck, S. Y.   & Kusch, H. ​ (2019)
    GMS German Medical Science, ​64. Jahrestagung der Deutschen Gesellschaft für Medizinische Informatik, Biometrie und Epidemiologie e.V. (GMDS)​, Dortmund. DOI: https://doi.org/10.3205/19gmds037 
    Details  DOI 
  • 2018 Journal Article | Research Paper | 
    ​ ​Deep phenotyping of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes​
    Cyganek, L. ; Tiburcy, M. ; Sekeres, K.; Gerstenberg, K.; Bohnenberger, H. ; Lenz, C.   & Henze, S.  et al.​ (2018) 
    JCI Insight3(12) art. e99941​.​ DOI: https://doi.org/10.1172/jci.insight.99941 
    Details  DOI  PMID  PMC 
  • 2017 Journal Article | Research Paper | 
    ​ ​Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy​
    Borchert, T. ; Hübscher, D. ; Guessoum, C. I. ; Lam, T. Lam, Tuan-Dinh D.; Ghadri, J. R.; Schellinger, I. N.   & Tiburcy, M.  et al.​ (2017) 
    Journal of the American College of Cardiology70(8) pp. 975​-991​.​ DOI: https://doi.org/10.1016/j.jacc.2017.06.061 
    Details  DOI  PMID  PMC 
  • 2015 Journal Article | Research Paper | 
    ​ ​Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1​
    Kruse, V.; Hamann, C.; Monecke, S.; Cyganek, L. ; Elsner, L.; Huebscher, D. & Walter, L. et al.​ (2015) 
    PLoS One10(5) art. e0125544​.​ DOI: https://doi.org/10.1371/journal.pone.0125544 
    Details  DOI  PMID  PMC  WoS 
  • 2013 Journal Article | Overview | 
    ​ ​Cardiac Progenitor Cells and their Therapeutic Application for Cardiac Repair​
    Cyganek, L. ; Chen, S.; Borchert, T.   & Guan, K. ​ (2013) 
    Journal of Clinical & Experimental CardiologyS11 art. 008​.​ DOI: https://doi.org/10.4172/2155-9880.S11-008 
    Details  DOI 

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