RG Cyganek (Stem Cell Unit)

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  • 2024 | Journal Article
    ​ ​Rapöhn, Marcel, et al. "Non-invasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM​." ​American Journal of Physiology. Heart and Circulatory Physiology, ​2024, , ​doi: 10.1152/ajpheart.00527.2023. 
    ​Details  DOI  PMID  PMC 
  • 2024 | Journal Article
    ​ ​Dobner, Jochen, et al. "mtDNA analysis using Mitopore​." ​Molecular Therapy. Methods & Clinical Development, vol. 32, no. 2, ​2024, , ​doi: 10.1016/j.omtm.2024.101231. 
    ​Details  DOI 
  • 2024 | Journal Article
    ​ ​Knauer, Carolin, et al. "Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants​." ​Molecular Therapy - Nucleic Acids, vol. 35, no. 1, ​2024, , ​doi: 10.1016/j.omtn.2024.102123. 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | 
    ​ ​Priesmeier, Laura, et al. "Combining a tetracycline (Tet)-inducible gRNA system and CRISPRa for titratable and timely controlled enhancement of endogenous SHISA3 activation in human induced pluripotent stem cells (hiPSC)​." ​Stem Cell Research, vol. 71, ​2023, p. 103163​, ​doi: 10.1016/j.scr.2023.103163. 
    ​Details  DOI  PMID  PMC 
  • 2023 | Journal Article | 
    ​ ​Seibertz, Fitzwilliam, et al. "Electrophysiological and calcium-handling development during long-term culture of human-induced pluripotent stem cell-derived cardiomyocytes​." ​Basic Research in Cardiology, vol. 118, no. 1, ​2023, p. 14​, ​doi: 10.1007/s00395-022-00973-0. 
    ​Details  DOI  PMID  PMC 
  • 2023 | Preprint
    ​ ​Busley, Alexandra Viktoria, et al. "LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome​." ​​2023. ​https://mbexc.uni-goettingen.de/literature/publications/646 https://sfb1002.med.uni-goettingen.de/production/literature/publications/465. doi: 10.1101/2023.01.10.523203. 
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  • 2023 | Journal Article
    ​ ​Busley, Alexandra Viktoria, and Lukas Cyganek. "Generation of a genetically-modified induced pluripotent stem cell line harboring a Noonan syndrome-associated gene variant MRAS p.G23V​." ​Stem Cell Research, vol. 69, ​2023, , ​doi: 10.1016/j.scr.2023.103108. 
    ​Details  DOI  null 
  • 2023 | Journal Article
    ​ ​Busley, Alexandra Viktoria, Mandy Kleinsorge, and Lukas Cyganek. "Generation of a genetically-modified induced pluripotent stem cell line harboring an oncogenic gene variant KRAS p.G12V​." ​Stem Cell Research, vol. 69, ​2023, , ​doi: 10.1016/j.scr.2023.103105. 
    ​Details  DOI 
  • 2023 | Preprint
    ​ ​Weber, Frederike, et al. "Secreted-Frizzled-Related Protein 5 Modulates Calcium Handling in Human Ipsc-Cardiomyocytes​." ​​2023. ​https://mbexc.uni-goettingen.de/literature/publications/903. doi: 10.2139/ssrn.4544232. 
    ​Details  DOI 
  • 2023 | Journal Article | 
    ​ ​Nakhaei-Rad, Saeideh, et al. "Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues​." ​Communications Biology, vol. 6, no. 1, ​2023, , ​doi: 10.1038/s42003-023-05013-8. 
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  • 2023 | Journal Article
    ​ ​Seibertz, Fitzwilliam, et al. "Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development​." ​Cardiovascular Research, ​2023, , ​doi: 10.1093/cvr/cvad143. 
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  • 2023 | Journal Article | 
    ​ ​Chowdhury, Arpita, et al. "Metabolic switch from fatty acid oxidation to glycolysis in knock‐in mouse model of Barth syndrome​." ​EMBO Molecular Medicine, ​2023, , ​doi: 10.15252/emmm.202317399. 
    ​Details  DOI  PMID  PMC 
  • 2022 | Journal Article | Research Paper | 
    ​ ​Li, Wener, et al. "Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration​." ​Pharmaceuticals, vol. 15, no. 2, ​2022, , ​doi: 10.3390/ph15020220. 
    ​Details  DOI 
  • 2022 | Journal Article | Overview | 
    ​ ​Pavez-Giani, Mario G., and Lukas Cyganek. "Recent Advances in Modeling Mitochondrial Cardiomyopathy Using Human Induced Pluripotent Stem Cells​." ​Frontiers in Cell and Developmental Biology, vol. 9, ​2022, , ​doi: 10.3389/fcell.2021.800529. 
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  • 2022 | Journal Article
    ​ ​Zhong, Rujia, et al. "Epigenetic mechanism of L-type calcium channel β-subunit downregulation in short QT human induced pluripotent stem cell-derived cardiomyocytes with CACNB2 mutation​." ​EP Europace, ​2022, , ​doi: 10.1093/europace/euac091. 
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  • 2022 | Journal Article | Research Paper | 
    ​ ​Lyra-Leite, Davi M., et al. "A review of protocols for human iPSC culture, cardiac differentiation, subtype-specification, maturation, and direct reprogramming​." ​STAR Protocols, vol. 3, no. 3, ​2022, , ​doi: 10.1016/j.xpro.2022.101560. 
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  • 2022 | Preprint
    ​ ​Nakhaei-Rad, Saeideh, et al. "Alteration of myocardial structure and function in RAF1-associated Noonan syndrome: Insights from cardiac disease modeling based on patient-derived iPSCs​." ​​2022. ​https://mbexc.uni-goettingen.de/literature/publications/575 https://sfb1002.med.uni-goettingen.de/production/literature/publications/477. doi: 10.1101/2022.01.22.477319. 
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  • 2022 | Journal Article | 
    ​ ​Seibertz, Fitzwilliam, et al. "A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes​." ​Communications Biology, vol. 5, no. 1, ​2022, , ​doi: 10.1038/s42003-022-03871-2. 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Barbarics, Boris, et al. "Proteomic mapping of atrial and ventricular heart tissue in patients with aortic valve stenosis​." ​Scientific Reports, vol. 11, no. 1, ​2021, , ​doi: 10.1038/s41598-021-03907-3. 
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  • 2021 | Book Chapter
    ​ ​Kusch, Harald, et al. "Management of Metadata Types in Basic Cardiological Research​." ​German Medical Data Sciences 2021: Digital Medicine: Recognize – Understand – Heal, edited by Rainer Röhrig, Tim Beißbarth, Jochem König, Claudia Ose, Geraldine Rauch, Ulrich Sax, Björn Schreiweis et al., ​2021, pp. 59​-68​. ​doi: 10.3233/SHTI210542. 
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  • 2021 | Journal Article | Research Paper
    ​ ​Fomin, Andrey, et al. "Truncated titin proteins and titin haploinsufficiency are targets for functional recovery in human cardiomyopathy due to TTN mutations​." ​Science Translational Medicine, vol. 13, no. 618, ​2021, , ​doi: 10.1126/scitranslmed.abd3079. 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Sattler, Katherine, et al. "TRPV1 activation and internalization is part of the LPS-induced inflammation in human iPSC-derived cardiomyocytes​." ​Scientific Reports, vol. 11, no. 1, ​2021, , ​doi: 10.1038/s41598-021-93958-3. 
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  • 2021 | Journal Article | Research Paper
    ​ ​Peper, Jonas, et al. "Caveolin3 Stabilizes McT1-Mediated Lactate/Proton Transport in Cardiomyocytes​." ​Circulation Research, vol. 128, no. 6, ​2021, , ​doi: 10.1161/CIRCRESAHA.119.316547. 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Rössler, Uta, et al. "Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7 ‐related osteopetrosis​." ​Journal of Bone and Mineral Research, vol. 36, no. 8, ​2021, pp. 1621​-1635​, ​doi: 10.1002/jbmr.4322. 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Schoger, Eric, et al. "Establishment of two homozygous CRISPR interference (CRISPRi) knock-in human induced pluripotent stem cell (hiPSC) lines for titratable endogenous gene repression​." ​Stem Cell Research, vol. 55, ​2021, p. 102473​, ​doi: 10.1016/j.scr.2021.102473. 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Schoger, Eric, et al. "Establishment of a second generation homozygous CRISPRa human induced pluripotent stem cell (hiPSC) line for enhanced levels of endogenous gene activation​." ​Stem Cell Research, vol. 56, ​2021, p. 102518​, ​doi: 10.1016/j.scr.2021.102518. 
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  • 2021 | Journal Article | Research Paper | 
    ​ ​Yousefi, Roya, et al. "Monitoring mitochondrial translation in living cells​." ​EMBO reports, vol. 22, no. 4, ​2021, , ​doi: 10.15252/embr.202051635. 
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  • 2020 | Preprint
    ​ ​Yousefi, Roya, et al. "Local translation in synaptic mitochondria influences synaptic transmission​." ​​2020. ​https://mbexc.uni-goettingen.de/literature/publications/168 https://sfb1002.med.uni-goettingen.de/production/literature/publications/382 https://sfb1286.uni-goettingen.de/literature/publications/93. doi: 10.1101/2020.07.22.215194. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Beuthner, Bo E. C., et al. "Interdisciplinary Research on Aortic Valve Stenosis: A Longitudinal Collection of Biospecimens and Clinical Data of Patients Undergoing Transcatheter Aortic Valve Replacement​." ​Open Journal of Bioresources, vol. 7, ​2020, , ​doi: 10.5334/ojb.65. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Schoger, Eric, et al. "Generation of homozygous CRISPRa human induced pluripotent stem cell (hiPSC) lines for sustained endogenous gene activation​." ​Stem Cell Research, vol. 48, ​2020, p. 101944​, ​doi: 10.1016/j.scr.2020.101944. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Khadjeh, Sara, et al. "CRISPLD1: a novel conserved target in the transition to human heart failure​." ​Basic Research in Cardiology, vol. 115, no. 3, ​2020, , ​doi: 10.1007/s00395-020-0784-4. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Luo, Xiaojing, et al. "IP3R-Mediated Compensatory Mechanism for Calcium Handling in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes With Cardiac Ryanodine Receptor Deficiency​." ​Frontiers in Cell and Developmental Biology, vol. 8, ​2020, , ​doi: 10.3389/fcell.2020.00772. 
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  • 2020 | Journal Article | Research Paper
    ​ ​Hanses, Ulrich, et al. "Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome–Associated Cardiomyopathy​." ​Circulation, vol. 142, no. 11, ​2020, pp. 1059​-1076​, ​doi: 10.1161/CIRCULATIONAHA.119.044794. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Ganapathi, Mythily, et al. "Bi-allelic missense disease-causing variants in RPL3L associate neonatal dilated cardiomyopathy with muscle-specific ribosome biogenesis​." ​Human Genetics, vol. 139, no. 11, ​2020, pp. 1443​-1454​, ​doi: 10.1007/s00439-020-02188-6. 
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  • 2020 | Journal Article | Research Paper | 
    ​ ​Kleinsorge, Mandy, and Lukas Cyganek. "Subtype-Directed Differentiation of Human iPSCs into Atrial and Ventricular Cardiomyocytes​." ​STAR Protocols, vol. 1, no. 1, ​2020, , ​doi: 10.1016/j.xpro.2020.100026. 
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  • 2019 | Conference Paper
    ​ ​Springer, R., et al. "P1235Acetylcholine-activated inward-rectifier potassium currents in atrial cardiomyocytes derived from induced pluripotent stem cells and atrial engineered heart muscle preparations​." ​European Heart Journal, vol. 40, no. Suppl. 1, ​2019, . ​doi: 10.1093/eurheartj/ehz748.0193. 
    ​Details  DOI 
  • 2019 | Conference Abstract
    ​ ​Lehmann, Christoph, et al. "Leaving spreadsheets behind – FAIR documentation and representation of human stem cell lines in the Collaborative Research Centre 1002 Meeting Abstract​." ​GMS German Medical Science, ​2019, . ​doi: 10.3205/19gmds037. 
    ​Details  DOI 
  • 2018 | Journal Article | Research Paper | 
    ​ ​Cyganek, Lukas, et al. "Deep phenotyping of human induced pluripotent stem cell–derived atrial and ventricular cardiomyocytes​." ​JCI Insight, vol. 3, no. 12, ​2018, pp. 1​-17​, ​doi: 10.1172/jci.insight.99941. 
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  • 2017 | Journal Article | Research Paper | 
    ​ ​Borchert, Thomas, et al. "Catecholamine-Dependent β-Adrenergic Signaling in a Pluripotent Stem Cell Model of Takotsubo Cardiomyopathy​." ​Journal of the American College of Cardiology, vol. 70, no. 8, ​2017, pp. 975​-991​, ​doi: 10.1016/j.jacc.2017.06.061. 
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  • 2015 | Journal Article | Research Paper | 
    ​ ​Kruse, Vanessa, et al. "Human Induced Pluripotent Stem Cells Are Targets for Allogeneic and Autologous Natural Killer (NK) Cells and Killing Is Partly Mediated by the Activating NK Receptor DNAM-1​." ​PLoS One, vol. 10, no. 5, ​2015, , ​doi: 10.1371/journal.pone.0125544. 
    ​Details  DOI  PMID  PMC  WoS 
  • 2013 | Journal Article | Overview | 
    ​ ​Cyganek, Lukas, et al. "Cardiac Progenitor Cells and their Therapeutic Application for Cardiac Repair​." ​Journal of Clinical & Experimental Cardiology, vol. S11, ​2013, pp. 1​-12​, ​doi: 10.4172/2155-9880.S11-008. 
    ​Details  DOI 

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